Multidimensional liquid chromatography: theory and applications in industrial chemistry and the life sciences
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley-Interscience
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes index |
| Beschreibung: | XX, 456 S. Ill., graph. Darst. |
| ISBN: | 0471738476 9780471738473 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV023358659 | ||
| 003 | DE-604 | ||
| 005 | 20150216 | ||
| 007 | t | ||
| 008 | 080623s2008 ad|| |||| 00||| eng d | ||
| 020 | |a 0471738476 |c (hbk.) : £52.95 hbk. : £52.95 : CIP entry (Apr.) |9 0-471-73847-6 | ||
| 020 | |a 9780471738473 |9 978-0-471-73847-3 | ||
| 035 | |a (OCoLC)144525715 | ||
| 035 | |a (DE-599)BSZ278320279 | ||
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| 041 | 0 | |a eng | |
| 049 | |a DE-19 |a DE-11 |a DE-703 | ||
| 050 | 0 | |a QD79.C454 | |
| 082 | 0 | |a 543/.84 |2 22 | |
| 084 | |a VG 7500 |0 (DE-625)147206:253 |2 rvk | ||
| 245 | 1 | 0 | |a Multidimensional liquid chromatography |b theory and applications in industrial chemistry and the life sciences |c ed. by Steven A. Cohen ... |
| 264 | 1 | |a Hoboken, NJ |b Wiley-Interscience |c 2008 | |
| 300 | |a XX, 456 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes index | ||
| 650 | 7 | |a Biochemie |2 gtt | |
| 650 | 7 | |a Hydrodynamische chromatografie |2 gtt | |
| 650 | 7 | |a Vloeistofchromatografie |2 gtt | |
| 650 | 4 | |a Liquid chromatography | |
| 650 | 4 | |a Chemical engineering | |
| 650 | 4 | |a Chemistry, Technical | |
| 650 | 4 | |a Biochemistry | |
| 650 | 0 | 7 | |a Flüssigkeitschromatographie |0 (DE-588)4017622-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a HPLC |0 (DE-588)4072641-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Flüssigkeitschromatographie |0 (DE-588)4017622-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a HPLC |0 (DE-588)4072641-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Cohen, Steven A. |d 1953- |e Sonstige |0 (DE-588)1019352353 |4 oth | |
| 856 | 4 | 2 | |m OEBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016542156&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016542156 | ||
Datensatz im Suchindex
| _version_ | 1804137720257183744 |
|---|---|
| adam_text | * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *
* * * * * * * * * * * * * * * * * * * * **** * * * * * * * * * * * * * *
* * * * * * * * * * * * * * * * * * * * * * * * **** * * * * * * * * * *
* * * * *** * * * * * * * * * * * * * * * * * * * * * * * PART I T H
E O R Y 2 * E L E M E N T S O F THE T H E O R Y O F M
U L T I D I M E N S I O N A L * L I Q U I D C H R O M A T O G R A
P H Y * 2.1 I N T R O D U C T I O N 2 . 2 P E A K C A P A C
I T Y 2 . 3 R E S O L U T I O N 2 . 4 O R T H O G O N A L I
T Y 2 . 5 T W O - D I M E N S I O N A L T H E O R Y O F P
E A K O V E R L A P 2 . 6 D I M E N S I O N A L I T Y , P E
A K O R D E R I N G , A N D C L U S T E R I N G 2. 7 T H
E O R Y O F Z O N E S A M P L I N G 2 . 8 D I L U T I O N
A N D L I M I T O F D E T E C T I O N 2 . 9 C H E M O
M E T R I C A N A L Y S I S X I I I * X V * X V I I * 1 *
4 * 5 * 6 * 9 * 11* 11* 13* 17* 19* 21* 23* 2 4 * 2 6
* 2 7 * V * VI C O N T E N T S 2 . 1 0 F U T U R E D I
R E C T I O N S 28 R E F E R E N C E S 3 0 3 * P E A K C
A P A C I T Y I N T W O - D I M E N S I O N A L L I Q U I D
C H R O M A T O G R A P H Y 3S 3.1* I N T R O D U C T I O N 35
3.2* T H E O R Y 37 3.3* P R O C E D U R E S 41 3 . 4 * R E S U
L T S A N D D I S C U S S I O N 4 2 3 . 5 C O N C L U S I
O N S 49 A P P E N D I X 3 A G E N E R A T I O N O F R A
N D O M C O R R E L A T E D C O O R D I N A T E S 5 0 A P P
E N D I X 3B D E R I V A T I O N O F L I M I T I N G C O R R
E L A T I O N C O E F F I C I E N T R 5 4 R E F E R E N C E
S 5 6 4 * D E C O D I N G C O M P L E X 2 D S E P A R
A T I O N S S9 4.1* I N T R O D U C T I O N 5 9 4 . 2 * F U
N D A M E N T A L S : T H E S T A T I S T I C A L D E S C R I P
T I O N O F C O M P L E X M U L T I C O M P O N E N T S E P
A R A T I O N S 6 2 4.3* D E C O D I N G ID A N D 2D M U L T
I C O M P O N E N T S E P A R A T I O N S B Y U S I N G T H
E S M O P O I S S O N S T A T I S T I C S 6 8 4 . 4 *
D E C O D I N G M U L T I C O M P O N E N T S E P A R A T I O N S
B Y T H E A U T O C O V A R I A N C E F U N C T I O N 74
4 . 5 * A P P L I C A T I O N TO 2 D S E P A R A T I O N S
78 4.5.1* R E S U L T S F R O M S M O M E T H O D 81 4 . 5 .
2 * R E S U L T S F R O M 2D A U T O C O V A R I A N C E F U N
C T I O N M E T H O D 84 4 . 6 C O N C L U D I N G R E M A R
K S 88 A C K N O W L E D G M E N T S 88 R E F E R E N C E S 88
PART 11 C O L U M N S , I N S T R U M E N T A T I O N A N D M E
T H O D S D E V E L O P M E N T 91 S * I N S T R U M E N T A T
I O N FOR C O M P R E H E N S I V E M U I T I D I M E N S I O N A
L L I Q U I D C H R O M A T O G R A P H Y 93 5.1* I N T R O D U
C T I O N 93 5 . 2 * H E A R T - C U T T I N G VERSUS C O M P R
E H E N S I V E M O D E 95 5 . 3 * C H R O M A T O G R A P H I
E H A R D W A R E 97 5.3.1* VALVES 97 5 . 4 * C E I N T E R
F A C E S 104 5.4.1* G A T E D I N T E R F A C E FOR H P L C -
C E 104 5 . 4 . 2 * M I C R O F L U I D I C VALVES FOR O N - C
H I P M U L T I D I M E N S I O N A L A N A L Y S I S 105 C O N
T E N T S V I I 5.5 C O L U M N S A N D C O M B I N A T I O
N S * 106 5.5.1* C O L U M N S Y S T E M S . D I L U T I O N .
A N D S P L I T T I N G 108 5.6 D E T E E T I O N * 109 5.7
C O M P U T E R H A R D W A R E A N D S O F T W A R E * 109
5.7.1* S O F T W A R E D E V E I O P M E N T 110 5 . 7 . 2 *
VALVE S E Q U E N E I N G 111 5.7.3* D A T A F O R M A T A N D
S T O R A G E 113 5.8 Z O N E V I S U A L I Z A T I O N *
115 5.8.1* C O N T O U R V I S U A L I Z A T I O N 115 5 . 8 . 2 *
2D P E A K P R E S E N T A T I O N 117 5 . 8 . 3 * Z O N E
V I S U A L I Z A T I O N IN S P E E I F I E C H E M I E A L
( P I ) R E G I O N S 117 5 . 8 . 4 * E X T E M A L P L O T
T I N G P R O G R A M S 117 5 . 8 . 5 * D I F F E R E N E E
P L O T S 118 5 . 8 . 6 * M U L T I - E H A N N E L D A T A
118 5.9 D A T A A N A L Y S I S A N D S I G N A L P R O E E
S S I N G * 119 5 . 1 0 F U T U R E P R O S P E E T S 120 R
E F E R E N E E S 121 6 * METHOD DEVELOPMENT IN COMPREHENSIVE
MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY 127 6.1 I N T R O D U E T I O N *
127 6.2 P R E V I O U S WORK* 128 6.3 C O L U M N VARIABLES*
130 6.4 M E T H O D D E V E L O P M E N T * 130 6.4.1* T H E C
A R D I N A L R U L E S O F 2 D L C M E T H O D D E V E L
O P M E N T 132 6.5 P L A N N I N G T H E E X P E R I M E N T *
143 6.6* G E N E R A L C O M M E N T S O N O P T I M I Z I N
G T H E 2 D L C E X P E R I M E N T : S P E E D - R E S O L
U T I O N T R A D E - O F F 143 AEKNOW L E D G M E N T 144 R E
F E R E N E E S 144 7 MONOLITHIC COLUMNS AND THEIR 2D-HPLC
APPLICATIONS 147 7.1 I N T R O D U E T I O N * 147 7.2 M O N O L I T
H I E P O L Y M E R C O L U M N S * 148 7.2.1* S T R U E T U R
A L P R O P E R T I E S O F P O L Y M E R M O N O L I T H S
148 7 . 2 . 2 * C H R O M A T O G R A P H I E P R O P E R T I E
S O F P O L Y M E R M O N O L I T H I E C O L U M N S 150
7.2.3* T W O - D I M E N S I O N A L H P L C U S I N G P O L Y
M E R M O N O L I T H S 152 7.3 M O N O L I T H I E S I L I E A
C O L U M N S * 153 7.3.1* P R E P A R A T I O N 154 7 . 3 . 2
* S T R U E T U R A L P R O P E R T I E S O F M O N O L I T
H I E S I L I E A C O L U M N S 154 7.3.3* C H R O M A T O G R
A P H I E P R O P E R T I E S O F M O N O L I T H I E S I L
I E A C O L U M N S 156 VFFI* C O N T E N T S 7 . 4 * P E A
K C A P A C I T Y I N C R E A S E BY USING M O N O L I T H I C
S I L I C A C O L U M N S IN G R A D I E N T E L U T I O N
158 7.5* 2D H P L C U S I N G M O N O L I T H I C S I L I C
A C O L U M N S 159 7.5.1* R P - R P 2 D H P L C U S I N
G TWO D I F F E R E N T C O L U M N S 161 7 . 5 . 2 * R P -
R P 2 D H P L C U S I N G TWO S I M I L A R C O L U M N S
164 7.5.3* ION E X C H A N G E - R E V E R S E D - P H A S E 2D
HPLC U S I N G A M O N O L I T H I E C O L U M N FOR T H E
2ND-D 166 7 . 5 . 4 * I E X - R P 2 D H P L C U S I N G
A M O N O L I T H I C RP C A P I L L A R Y C O L U M N
FOR THE 2 N D - D 168 7.6 S U M M A R Y AND F U T U R E I M P R
O V E M E N T O F 2D H P L C 171 R E F E R E N E E S 171 8
ULTRAHIGH P R E S S U R E MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY
177 8.1* B A C K G R O U N D : M D L C IN T H E J O R G E N S O
N L A B 177 8.1.1* C A T I O N E X C H A N G E - S I Z E E X
C L U S I O N 178 8. I. 2 * ANION E X C H A N G E - R E V E R S E
D P H A S E 180 8 . 1 . 3 * C A T I O N E X C H A N G E - R
E V E R S E D P H A S E 181 8 . 1 . 4 * S I Z E E X C L U S
I O N - R E V E R S E D P H A S E 183 8 . 2 * O N L I N E
VERSUS O F F - L I NE M D L C 188 8.3* M D L C U S I N G U L T
R A H I G H P R E S S U R E L I Q U I D C H R O M A T O G R A P
H Y : B E N E F I T S AND C H A L L E N G E S 189 8.3.1* AN I N
T R O D U E T I O N TO U H P L C 190 8 . 3 . 2 * U H P L C
FOR LC X LC: HIGH S P E E D VERSUS HIGH P E A K C A P A E I T Y
191 8.3.3* LC X U H P L C FOR S E P A R A T I O N S O F I
N T A C T P R O T E I N S 191 8 . 4 * E X P E R I M E N T A L
D E T A I L S 193 8.4.1* I N S T R U M E N T A T I O N 193 8 .
4 . 2 * D A T A A N A L Y S I S 194 8.4.3* C H R O M A T O G R
A P H I E C O N D I T I O N S 195 8 . 4 . 4 * S A M P L E S
196 8.5* RESU1TS A N D D I S C U S S I O N 196 8 . 6 F U T U R
E D I R E C T I O N S F O R U H P - M D L C 202 R E F E R E
N C E S 203 PART III L L F E S C I E N C E A P P L I C A T I O
N S * 205 9 PEPTIDOMIES* 207 9.1* S T A T E O F THE A R T -
W H Y P E P T I D O M I C S ? 207 9 . 2 * S T R A T E G I E S
A N D S O L U T I O N S 208 9 . 3 S U M M A R Y A N D
C O N C L U S I O N S 218 R E F E R E N C E S 218 C O N T E N T S
I X 10* A T W O - D I M E N S I O N A L L I Q U I D M A S
S M A P P I N G T E C H N I Q U E F O R B I O M A R K E R
D I S C O V E R Y 221 10.1* I N T R O D U C T I O N 221 10.2* M E
T H O D S FOR S E P A R A T I N G A N D I D E N T I F Y I N G
P R O T E I N S 223 10.2.1* PI- B A S E D M E T H O D S O F
S E P A R A T I O N 223 10.2.2 C H R O M A T O F O C U S I N G - A
C O L U M N B A S E D P R S E P A R A T I O N 225 J 0 . 2
. 3 N O N P O R O U S S E P A R A T I O N O F P R O T E I N
S 2 2 6 1 0 . 2 . 4 * E L E C T R O S P R A Y - T I M E O F
F L I G H T - M A S S S P E C T R O M E T R Y 228 10.2.5* M A L
D I P E P T I D E M A S S F I N G E R P R I N T I N G 2 2 9
10.2.6* D A T A A N A L Y S I S A N D R E C O M B I N A T I
O N 2 3 0 10.3* A P P L I C A T I O N S 2 3 0 10.3.1* P R O
T E O M I C M A P P I N G A N D C L U S T E R I N G O F M
U L T I P L E S A M P L E S - A P P L I C A T I O N TO O V A R I A
N C A N C E R C E L L L I N E S 2 3 0 1 0 . 3 . 2 * 2D
L I Q U I D M A S S M A P P I N G O F T U M O R C E L L
L I N E S E C R E T E D S A M P I E S , A P P L I C A T I O
N T O M E T A S T A S I S - A S S O C I A T E D P R O T E I N
P R O F I L E S 233 10.3.3* I D E N T I F I C A T I O N A N N O
T A T I O N A N D D A T A C O R R E L A T I O N IN MCFIO H U
M A N B R E A S T C A N C E R C E L L L I N E S 235 10.4
S U M M A R Y A N D C O N C L U S I O N S 237 A C K N O W L E D
G M E N T S 238 R E F E R E N C E S 2 3 8 11* C O U P L E D
M U L T I D I M E N S I O N A L C H R O M A T O G R A P H Y A N D
T A N D E M M A S S S P E C T R O M E T R Y S Y S T E M S
F O R C O M P L E X P E P T I D E M I X T U R E A N A L Y S
I S 243 11.1* S C X - R P / M S / M S 245 11.2 S C X / R P / M S /
M S * 248 11.3* M U D P I T 251 11.4* A L T E R N A T I V E F I
R S T D I M E N S I O N A P P R O A C H E S 2 5 4 11.5 C O N
C L U S I O N 255 R E F E R E N C E S 255 12* D E V E L O P M E N
T O F O R T H O G O N A L 2 D L C M E T H O D S F O R
S E P A R A T I O N O F P E P T I D E S 261 12.1* I N T R O D U
C T I O N 2 6 J 12.2* P R E V I O U S WORK 263 12.3* D E V E
L O P I N G O R T H O G O N A L 2 D L C M E T H O D S 2 6 4
12.3.1* L C S E L E C T I V I T Y F O R P E P T I D E S :
E X P E R I M E N T A L D E S I G N 2 6 4 12.3.2* I N V E S T I
G A T I O N O F 2 D L C O R T H O G O N A L I T Y FOR S E P
A R A T I O N O F P E P T I D E S 2 6 6 12.3.3* G E O M E T
R I C A P P R O A C H TO O R T H O G O N A L I T Y IN 2 D L C
271 1 2 . 3 . 4 * P R A C T I C A L 2 D L C C O N S I D E R
A T I O N S IN P R O T E O M E R E S E A R C H 275 12.3.5* E V
A L U A T I O N O F S E L E C T E D 2 D L C M S I M S S Y
S T E M S 2 7 6 X * C O N T E N T S 12.3.6* P E A K C A P
A C I T Y IN 2 D L C - M S / M S 2 8 0 12.3.7* C O N S I D E R
A T I O N S O F C O N E E N T R A T I O N D Y N A M I E R A
N G E 282 12.4 C O N C L U S I O N S 2 8 4 A E K N O W L E D G
M E N T 2 8 4 R E F E R E N E E S 2 8 4 13* M U L T I D I M
E N S I O N A L S E P A R A T I O N O F P R O T E I N S W I
T H O N L I N E E L E C T R O S P R A Y T I M E - O F - F L I G
H T M A S S S P E C T R O M E T R I C D E T E C T I O N 291
13.1* I N T R O D U C T I O N 291 1 3 . 2 * C H R O M A T O G R A
P H I E P A R A M E T E R S 293 13.3* A N A L Y T E D E T E E T
I O N A N D S U B S E Q U E N T A N A L Y S I S 293 13.4* B
U I L D I N G A M U L T I D I M E N S I O N A L PRO T E I N
S E P A R A T I O N 2 9 4 13.4.1* S E L E E T I O N O F A N
I O N - E X E H A N G E - R E V E R S E D - P H A S E S E P A R A
T I O N S Y S T E M F O R P R O T E I N - L E V E L S E P A
R A T I O N S 295 13.4.2* C H R O M A T O G R A P H I E S O R B E
N T C O N S I D E R A T I O N S 295 13.4.3* C H R O M A T O G R A
P H I E B E H A V I O R O F P R O T E I N S 2 9 6 13.5* C
O M P R E H E N S I V E M U L T I D I M E N S I O N A L C H R O M
A T O G R A P H I E S Y S T E M S 2 9 6 1 3 . 6 * C O U P L
I N G 2 D L C W I T H O N L I N E E S I - M S D E T E E T
I O N 299 13.6.1* I N T E R A C T I O N S B E T W E E N T H E
TWO D I M E N S I O N S O F C H R O M A T O G R A P H Y ( S
T E P VS. L I N E A R ) 3 0 4 1 3 . 6 . 2 * R E E O G N I Z
I N G I N E R E A S E D S E L E E T I V I T Y IN 2 D L C S E
P A R A T I O N S 3 0 6 13.7* E X P A N D I N G M U L T I D I M
E N S I O N A L S E P A R A T I O N S I N T O A MIDDLE-OUT
A P P R O A C H TO P R O T E O M I E A N A L Y S I S 308 13.8*
F U T U R E D I R E E T I O N S IN P R O T E I N M D L C 311
13.8.1* P R O T E I N C H R O M A T O G R A P H Y 3 1 2 13.8.2*
MS A N A L Y S I S O F P R O T E I N S 313 13.8.3* D A T A I
N T E R P R E T A T I O N 3 1 4 1 3 . 9 C O N C L U S I O N
3 1 4 R E F E R E N E E S 315 14* A N A L Y S I S O F E N A
N T I O M E R I C C O M P O U N D S U S I N G M U L T I D I M E
N S I O N A L L I Q U I D C H R O M A T O G R A P H Y 319 14.1*
O N L I N E A E H I R A L - C H I R A L L C - L C 3 2 0 1 4
. 2 * A P P L I E A T I O N S 323 14.2.1* A N A L Y S I S O F
E N A N T I O M E R S IN P L A S M A AND URINE 323 14.3* A M I
N O A C I D S 3 2 8 14.3.1* P H Y S I O L O G I E A L F L U
I D S O R T I S S U E S 328 1 4 . 3 . 2 * IN F O O D , B
E V E R A G E S , A N D O T H E R P R O D U E T S 3 3 3
14.4* O T H E R A P P L I E A T I O N S 3 3 4 14.4.1* A N A L Y
S I S O F E N A N T I O M E R S F R O M P L A N T A N D
E N V I R O N M E N T A L S O U R C E S 3 3 4 14.5* M I S E
E L L A N E O U S A P P L I E A T I O N S 3 3 6 14.6 C O N C L
U S I O N 338 R E F E R E N E E S 339 X I C O N T E N T S
PART IV MULTIDIMENSIONAL SEPARATION USING CAPILLARY E L E C T R O P H O
R E S I S 3 4 5 15* TWO-DIMENSIONAL CAPILLARY E L E C T R O P H O
R E S I S FOR THE COMPREHENSIVE ANALYSIS O F C O M P L E X P R
O T E I N M I X T U R E S 3 4 7 15.1* I N T R O D U C T I O N
347 15.2* P R E V I O U S WORK 3 4 8 15.2.1* M I N I A T U R I
Z E D I E F / S D S - P A G E 348 15.2.2* O N E - D I M E N S I O
N A L C A P I L L A R Y E L E C T R O P H O R E S I S FOR P R O
T E I N A N A L Y S I S 349 15.3* T W O - D I M E N S I O N A L
C A P I L L A R Y S E P A R A T I O N S FOR A N A L Y S I S O F
P E P T I D E S A N D P R O T E I N S 352 15.3.1* C A P I L
L A R Y L I Q U I D C H R O M A T O G R A P H Y C O U P L E D
W I T H C A P I L L A R Y E L E C T R O P H O R E S I S F O
R A N A L Y S I S O F U N L A B E L E D P E P T I D E S
AND P R O T E I N S 3 5 2 15.3.2* T W O - D I M E N S I O N A L
C A P I L L A R Y E L E C T R O P H O R E S I S F O R A N A L Y
S I S O F P R O T E I N S 3 5 2 15.3.3* H I G H - S P E E D
T W O - D I M E N S I O N A L C A P I L L A R Y E L E C T R O P
H O R E S I S 3 5 6 15.3.4* T H E A N A L Y S I S O F A
S I N G L E F I X E D C E L L 3 5 8 15.4* C O N C L U S I
O N S 3 6 0 15.5 A B B R E V I A T I O N S 3 6 0 R E F E R E
N C E S 3 6 0 16* TWO-DIMENSIONAL H P L C - C E M E T H O D S
FOR PROTEINIPEPTIDE S E P A R A T I O N 3 6 5 16.1* I N T R O D
U C T I O N 365 16.2* O F F - L I N E VERSUS O N L I N E 3 6 6
16.3* H P L C F R A C T I O N A T I O N 3 6 6 16.4* 2D H P L
C - C E 367 16.5* C E - M S D E T E C T I O N 368 16.6* A P P L
I C A T I O N S 3 7 0 16.7 C O N C L U D I N G R E M A R K S
3 8 0 A C K N O W L E D G M E N T 381 R E F E R E N C E S 381
PART V INDUSTRIAL APPLICATIONS* 3 8 5 17* MULTIDIMENSIONAL LIQUID
C H R O M A T O G R A P H Y IN INDUSTRIAL A P P L I C A T I O N S
3 8 7 17.1* I N T R O D U C T I O N 3 8 7 17.2* P R I N C I P L
E S O F M U L T I D I M E N S I O N A L L I Q U I D C H R O
M A T O G R A P H Y AS A P P L I E D TO P O L Y M E R A N A L Y
S I S 3 9 0 XII C O N T E N T S 17.3 E X P E R I M E N T A L *
393 17.4 A N A L Y S I S O F A L K Y L E N E O X I D E - B A
S E D P O L Y M E R S * 395 17.4.1 A M P H I P H I L I C P O L
Y A L K Y L E N E O X I D E S * 395 17.5 E X C I P I E N T S * 3 9
9 17.6 P O L Y E T H E R P O L Y O L S * 403 17.7 A N A L Y S I
S O F C O N D E N S A T I O N P O L Y M E R S * 4 0 6
17.8 P O L Y A M I D E S * 407 1 7 . 9 A R O M A T I C P O L Y
E S T E R S * 414 1 7 . 1 0 A L I P H A T I C P O L Y E S T E R
S 417 R E F E R E N C E S 4 2 0 18* T H E A N A L Y S I S
O F S U R F A C T A N T S B Y M U L T I D I M E N S I O N A L
L I Q U I D C H R O M A T O G R A P H Y 4 2 5 18.1 I N T R O
D U C T I O N * 425 1 8 . 2 A N A L Y T I C A L C H A R A C T E
R I Z A T I O N M E T H O D S * 428 18.2.1 C E AND C G E *
429 1 8 . 2 . 2 S E C * 4 3 0 18.2.3 N P L C * 431 18.2.4 R
P L C * 433 18.3 D E T E C T I O N M E T H O D S * 434 18.4 2 D
L C * 434 18.4.1 R P L C C O U P L E D TO S E C * 435 18.4.2
N P L C C O U P L E D TO R P L C * 435 18.5 C O N C L U S I O N
S 4 4 2 R E F E R E N C E S 443 I N D E X * 4 4 7
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| adam_txt |
* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *
* * * * * * * * * * * * * * * * * * * * **** * * * * * * * * * * * * * *
* * * * * * * * * * * * * * * * * * * * * * * * **** * * * * * * * * * *
* * * * *** * * * * * * * * * * * * * * * * * * * * * * * PART I T H
E O R Y 2 * E L E M E N T S O F THE T H E O R Y O F M
U L T I D I M E N S I O N A L * L I Q U I D C H R O M A T O G R A
P H Y * 2.1 I N T R O D U C T I O N 2 . 2 P E A K C A P A C
I T Y 2 . 3 R E S O L U T I O N 2 . 4 O R T H O G O N A L I
T Y 2 . 5 T W O - D I M E N S I O N A L T H E O R Y O F P
E A K O V E R L A P 2 . 6 D I M E N S I O N A L I T Y , P E
A K O R D E R I N G , A N D C L U S T E R I N G 2. 7 T H
E O R Y O F Z O N E S A M P L I N G 2 . 8 D I L U T I O N
A N D L I M I T O F D E T E C T I O N 2 . 9 C H E M O
M E T R I C A N A L Y S I S X I I I * X V * X V I I * 1 *
4 * 5 * 6 * 9 * 11* 11* 13* 17* 19* 21* 23* 2 4 * 2 6
* 2 7 * V * VI C O N T E N T S 2 . 1 0 F U T U R E D I
R E C T I O N S 28 R E F E R E N C E S 3 0 3 * P E A K C
A P A C I T Y I N T W O - D I M E N S I O N A L L I Q U I D
C H R O M A T O G R A P H Y 3S 3.1* I N T R O D U C T I O N 35
3.2* T H E O R Y 37 3.3* P R O C E D U R E S 41 3 . 4 * R E S U
L T S A N D D I S C U S S I O N 4 2 3 . 5 C O N C L U S I
O N S 49 A P P E N D I X 3 A G E N E R A T I O N O F R A
N D O M C O R R E L A T E D C O O R D I N A T E S 5 0 A P P
E N D I X 3B D E R I V A T I O N O F L I M I T I N G C O R R
E L A T I O N C O E F F I C I E N T R 5 4 R E F E R E N C E
S 5 6 4 * D E C O D I N G C O M P L E X 2 D S E P A R
A T I O N S S9 4.1* I N T R O D U C T I O N 5 9 4 . 2 * F U
N D A M E N T A L S : T H E S T A T I S T I C A L D E S C R I P
T I O N O F C O M P L E X M U L T I C O M P O N E N T S E P
A R A T I O N S 6 2 4.3* D E C O D I N G ID A N D 2D M U L T
I C O M P O N E N T S E P A R A T I O N S B Y U S I N G T H
E S M O P O I S S O N S T A T I S T I C S 6 8 4 . 4 *
D E C O D I N G M U L T I C O M P O N E N T S E P A R A T I O N S
B Y T H E A U T O C O V A R I A N C E F U N C T I O N 74
4 . 5 * A P P L I C A T I O N TO 2 D S E P A R A T I O N S
78 4.5.1* R E S U L T S F R O M S M O M E T H O D 81 4 . 5 .
2 * R E S U L T S F R O M 2D A U T O C O V A R I A N C E F U N
C T I O N M E T H O D 84 4 . 6 C O N C L U D I N G R E M A R
K S 88 A C K N O W L E D G M E N T S 88 R E F E R E N C E S 88
PART 11 C O L U M N S , I N S T R U M E N T A T I O N A N D M E
T H O D S D E V E L O P M E N T 91 S * I N S T R U M E N T A T
I O N FOR C O M P R E H E N S I V E M U I T I D I M E N S I O N A
L L I Q U I D C H R O M A T O G R A P H Y 93 5.1* I N T R O D U
C T I O N 93 5 . 2 * H E A R T - C U T T I N G VERSUS C O M P R
E H E N S I V E M O D E 95 5 . 3 * C H R O M A T O G R A P H I
E H A R D W A R E 97 5.3.1* VALVES 97 5 . 4 * C E I N T E R
F A C E S 104 5.4.1* G A T E D I N T E R F A C E FOR H P L C -
C E 104 5 . 4 . 2 * M I C R O F L U I D I C VALVES FOR O N - C
H I P M U L T I D I M E N S I O N A L A N A L Y S I S 105 C O N
T E N T S V I I 5.5 C O L U M N S A N D C O M B I N A T I O
N S * 106 5.5.1* C O L U M N S Y S T E M S . D I L U T I O N .
A N D S P L I T T I N G 108 5.6 D E T E E T I O N * 109 5.7
C O M P U T E R H A R D W A R E A N D S O F T W A R E * 109
5.7.1* S O F T W A R E D E V E I O P M E N T 110 5 . 7 . 2 *
VALVE S E Q U E N E I N G 111 5.7.3* D A T A F O R M A T A N D
S T O R A G E 113 5.8 Z O N E V I S U A L I Z A T I O N *
115 5.8.1* C O N T O U R V I S U A L I Z A T I O N 115 5 . 8 . 2 *
2D P E A K P R E S E N T A T I O N 117 5 . 8 . 3 * Z O N E
V I S U A L I Z A T I O N IN S P E E I F I E C H E M I E A L
( P I ) R E G I O N S 117 5 . 8 . 4 * E X T E M A L P L O T
T I N G P R O G R A M S 117 5 . 8 . 5 * D I F F E R E N E E
P L O T S 118 5 . 8 . 6 * M U L T I - E H A N N E L D A T A
118 5.9 D A T A A N A L Y S I S A N D S I G N A L P R O E E
S S I N G * 119 5 . 1 0 F U T U R E P R O S P E E T S 120 R
E F E R E N E E S 121 6 * METHOD DEVELOPMENT IN COMPREHENSIVE
MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY 127 6.1 I N T R O D U E T I O N *
127 6.2 P R E V I O U S WORK* 128 6.3 C O L U M N VARIABLES*
130 6.4 M E T H O D D E V E L O P M E N T * 130 6.4.1* T H E C
A R D I N A L R U L E S O F 2 D L C M E T H O D D E V E L
O P M E N T 132 6.5 P L A N N I N G T H E E X P E R I M E N T *
143 6.6* G E N E R A L C O M M E N T S O N O P T I M I Z I N
G T H E 2 D L C E X P E R I M E N T : S P E E D - R E S O L
U T I O N T R A D E - O F F 143 AEKNOW L E D G M E N T 144 R E
F E R E N E E S 144 7 MONOLITHIC COLUMNS AND THEIR 2D-HPLC
APPLICATIONS 147 7.1 I N T R O D U E T I O N * 147 7.2 M O N O L I T
H I E P O L Y M E R C O L U M N S * 148 7.2.1* S T R U E T U R
A L P R O P E R T I E S O F P O L Y M E R M O N O L I T H S
148 7 . 2 . 2 * C H R O M A T O G R A P H I E P R O P E R T I E
S O F P O L Y M E R M O N O L I T H I E C O L U M N S 150
7.2.3* T W O - D I M E N S I O N A L H P L C U S I N G P O L Y
M E R M O N O L I T H S 152 7.3 M O N O L I T H I E S I L I E A
C O L U M N S * 153 7.3.1* P R E P A R A T I O N 154 7 . 3 . 2
* S T R U E T U R A L P R O P E R T I E S O F M O N O L I T
H I E S I L I E A C O L U M N S 154 7.3.3* C H R O M A T O G R
A P H I E P R O P E R T I E S O F M O N O L I T H I E S I L
I E A C O L U M N S 156 VFFI* C O N T E N T S 7 . 4 * P E A
K C A P A C I T Y I N C R E A S E BY USING M O N O L I T H I C
S I L I C A C O L U M N S IN G R A D I E N T E L U T I O N
158 7.5* 2D H P L C U S I N G M O N O L I T H I C S I L I C
A C O L U M N S 159 7.5.1* R P - R P 2 D H P L C U S I N
G TWO D I F F E R E N T C O L U M N S 161 7 . 5 . 2 * R P -
R P 2 D H P L C U S I N G TWO S I M I L A R C O L U M N S
164 7.5.3* ION E X C H A N G E - R E V E R S E D - P H A S E 2D
HPLC U S I N G A M O N O L I T H I E C O L U M N FOR T H E
2ND-D 166 7 . 5 . 4 * I E X - R P 2 D H P L C U S I N G
A M O N O L I T H I C RP C A P I L L A R Y C O L U M N
FOR THE 2 N D - D 168 7.6 S U M M A R Y AND F U T U R E I M P R
O V E M E N T O F 2D H P L C 171 R E F E R E N E E S 171 8
ULTRAHIGH P R E S S U R E MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY
177 8.1* B A C K G R O U N D : M D L C IN T H E J O R G E N S O
N L A B 177 8.1.1* C A T I O N E X C H A N G E - S I Z E E X
C L U S I O N 178 8. I. 2 * ANION E X C H A N G E - R E V E R S E
D P H A S E 180 8 . 1 . 3 * C A T I O N E X C H A N G E - R
E V E R S E D P H A S E 181 8 . 1 . 4 * S I Z E E X C L U S
I O N - R E V E R S E D P H A S E 183 8 . 2 * O N L I N E
VERSUS O F F - L I NE M D L C 188 8.3* M D L C U S I N G U L T
R A H I G H P R E S S U R E L I Q U I D C H R O M A T O G R A P
H Y : B E N E F I T S AND C H A L L E N G E S 189 8.3.1* AN I N
T R O D U E T I O N TO U H P L C 190 8 . 3 . 2 * U H P L C
FOR LC X LC: HIGH S P E E D VERSUS HIGH P E A K C A P A E I T Y
191 8.3.3* LC X U H P L C FOR S E P A R A T I O N S O F I
N T A C T P R O T E I N S 191 8 . 4 * E X P E R I M E N T A L
D E T A I L S 193 8.4.1* I N S T R U M E N T A T I O N 193 8 .
4 . 2 * D A T A A N A L Y S I S 194 8.4.3* C H R O M A T O G R
A P H I E C O N D I T I O N S 195 8 . 4 . 4 * S A M P L E S
196 8.5* RESU1TS A N D D I S C U S S I O N 196 8 . 6 F U T U R
E D I R E C T I O N S F O R U H P - M D L C 202 R E F E R E
N C E S 203 PART III L L F E S C I E N C E A P P L I C A T I O
N S * 205 9 PEPTIDOMIES* 207 9.1* S T A T E O F THE A R T -
W H Y P E P T I D O M I C S ? 207 9 . 2 * S T R A T E G I E S
A N D S O L U T I O N S 208 9 . 3 S U M M A R Y A N D
C O N C L U S I O N S 218 R E F E R E N C E S 218 C O N T E N T S
I X 10* A T W O - D I M E N S I O N A L L I Q U I D M A S
S M A P P I N G T E C H N I Q U E F O R B I O M A R K E R
D I S C O V E R Y 221 10.1* I N T R O D U C T I O N 221 10.2* M E
T H O D S FOR S E P A R A T I N G A N D I D E N T I F Y I N G
P R O T E I N S 223 10.2.1* PI- B A S E D M E T H O D S O F
S E P A R A T I O N 223 10.2.2 C H R O M A T O F O C U S I N G - A
C O L U M N B A S E D P R S E P A R A T I O N 225 J 0 . 2
. 3 N O N P O R O U S S E P A R A T I O N O F P R O T E I N
S 2 2 6 1 0 . 2 . 4 * E L E C T R O S P R A Y - T I M E O F
F L I G H T - M A S S S P E C T R O M E T R Y 228 10.2.5* M A L
D I P E P T I D E M A S S F I N G E R P R I N T I N G 2 2 9
10.2.6* D A T A A N A L Y S I S A N D R E C O M B I N A T I
O N 2 3 0 10.3* A P P L I C A T I O N S 2 3 0 10.3.1* P R O
T E O M I C M A P P I N G A N D C L U S T E R I N G O F M
U L T I P L E S A M P L E S - A P P L I C A T I O N TO O V A R I A
N C A N C E R C E L L L I N E S 2 3 0 1 0 . 3 . 2 * 2D
L I Q U I D M A S S M A P P I N G O F T U M O R C E L L
L I N E S E C R E T E D S A M P I E S , A P P L I C A T I O
N T O M E T A S T A S I S - A S S O C I A T E D P R O T E I N
P R O F I L E S 233 10.3.3* I D E N T I F I C A T I O N A N N O
T A T I O N A N D D A T A C O R R E L A T I O N IN MCFIO H U
M A N B R E A S T C A N C E R C E L L L I N E S 235 10.4
S U M M A R Y A N D C O N C L U S I O N S 237 A C K N O W L E D
G M E N T S 238 R E F E R E N C E S 2 3 8 11* C O U P L E D
M U L T I D I M E N S I O N A L C H R O M A T O G R A P H Y A N D
T A N D E M M A S S S P E C T R O M E T R Y S Y S T E M S
F O R C O M P L E X P E P T I D E M I X T U R E A N A L Y S
I S 243 11.1* S C X - R P / M S / M S 245 11.2 S C X / R P / M S /
M S * 248 11.3* M U D P I T 251 11.4* A L T E R N A T I V E F I
R S T D I M E N S I O N A P P R O A C H E S 2 5 4 11.5 C O N
C L U S I O N 255 R E F E R E N C E S 255 12* D E V E L O P M E N
T O F O R T H O G O N A L 2 D L C M E T H O D S F O R
S E P A R A T I O N O F P E P T I D E S 261 12.1* I N T R O D U
C T I O N 2 6 J 12.2* P R E V I O U S WORK 263 12.3* D E V E
L O P I N G O R T H O G O N A L 2 D L C M E T H O D S 2 6 4
12.3.1* L C S E L E C T I V I T Y F O R P E P T I D E S :
E X P E R I M E N T A L D E S I G N 2 6 4 12.3.2* I N V E S T I
G A T I O N O F 2 D L C O R T H O G O N A L I T Y FOR S E P
A R A T I O N O F P E P T I D E S 2 6 6 12.3.3* G E O M E T
R I C A P P R O A C H TO O R T H O G O N A L I T Y IN 2 D L C
271 1 2 . 3 . 4 * P R A C T I C A L 2 D L C C O N S I D E R
A T I O N S IN P R O T E O M E R E S E A R C H 275 12.3.5* E V
A L U A T I O N O F S E L E C T E D 2 D L C M S I M S S Y
S T E M S 2 7 6 X * C O N T E N T S 12.3.6* P E A K C A P
A C I T Y IN 2 D L C - M S / M S 2 8 0 12.3.7* C O N S I D E R
A T I O N S O F C O N E E N T R A T I O N D Y N A M I E R A
N G E 282 12.4 C O N C L U S I O N S 2 8 4 A E K N O W L E D G
M E N T 2 8 4 R E F E R E N E E S 2 8 4 13* M U L T I D I M
E N S I O N A L S E P A R A T I O N O F P R O T E I N S W I
T H O N L I N E E L E C T R O S P R A Y T I M E - O F - F L I G
H T M A S S S P E C T R O M E T R I C D E T E C T I O N 291
13.1* I N T R O D U C T I O N 291 1 3 . 2 * C H R O M A T O G R A
P H I E P A R A M E T E R S 293 13.3* A N A L Y T E D E T E E T
I O N A N D S U B S E Q U E N T A N A L Y S I S 293 13.4* B
U I L D I N G A M U L T I D I M E N S I O N A L PRO T E I N
S E P A R A T I O N 2 9 4 13.4.1* S E L E E T I O N O F A N
I O N - E X E H A N G E - R E V E R S E D - P H A S E S E P A R A
T I O N S Y S T E M F O R P R O T E I N - L E V E L S E P A
R A T I O N S 295 13.4.2* C H R O M A T O G R A P H I E S O R B E
N T C O N S I D E R A T I O N S 295 13.4.3* C H R O M A T O G R A
P H I E B E H A V I O R O F P R O T E I N S 2 9 6 13.5* C
O M P R E H E N S I V E M U L T I D I M E N S I O N A L C H R O M
A T O G R A P H I E S Y S T E M S 2 9 6 1 3 . 6 * C O U P L
I N G 2 D L C W I T H O N L I N E E S I - M S D E T E E T
I O N 299 13.6.1* I N T E R A C T I O N S B E T W E E N T H E
TWO D I M E N S I O N S O F C H R O M A T O G R A P H Y ( S
T E P VS. L I N E A R ) 3 0 4 1 3 . 6 . 2 * R E E O G N I Z
I N G I N E R E A S E D S E L E E T I V I T Y IN 2 D L C S E
P A R A T I O N S 3 0 6 13.7* E X P A N D I N G M U L T I D I M
E N S I O N A L S E P A R A T I O N S I N T O A "MIDDLE-OUT"
A P P R O A C H TO P R O T E O M I E A N A L Y S I S 308 13.8*
F U T U R E D I R E E T I O N S IN P R O T E I N M D L C 311
13.8.1* P R O T E I N C H R O M A T O G R A P H Y 3 1 2 13.8.2*
MS A N A L Y S I S O F P R O T E I N S 313 13.8.3* D A T A I
N T E R P R E T A T I O N 3 1 4 1 3 . 9 C O N C L U S I O N
3 1 4 R E F E R E N E E S 315 14* A N A L Y S I S O F E N A
N T I O M E R I C C O M P O U N D S U S I N G M U L T I D I M E
N S I O N A L L I Q U I D C H R O M A T O G R A P H Y 319 14.1*
O N L I N E A E H I R A L - C H I R A L L C - L C 3 2 0 1 4
. 2 * A P P L I E A T I O N S 323 14.2.1* A N A L Y S I S O F
E N A N T I O M E R S IN P L A S M A AND URINE 323 14.3* A M I
N O A C I D S 3 2 8 14.3.1* P H Y S I O L O G I E A L F L U
I D S O R T I S S U E S 328 1 4 . 3 . 2 * IN F O O D , B
E V E R A G E S , A N D O T H E R P R O D U E T S 3 3 3
14.4* O T H E R A P P L I E A T I O N S 3 3 4 14.4.1* A N A L Y
S I S O F E N A N T I O M E R S F R O M P L A N T A N D
E N V I R O N M E N T A L S O U R C E S 3 3 4 14.5* M I S E
E L L A N E O U S A P P L I E A T I O N S 3 3 6 14.6 C O N C L
U S I O N 338 R E F E R E N E E S 339 X I C O N T E N T S
PART IV MULTIDIMENSIONAL SEPARATION USING CAPILLARY E L E C T R O P H O
R E S I S 3 4 5 15* TWO-DIMENSIONAL CAPILLARY E L E C T R O P H O
R E S I S FOR THE COMPREHENSIVE ANALYSIS O F C O M P L E X P R
O T E I N M I X T U R E S 3 4 7 15.1* I N T R O D U C T I O N
347 15.2* P R E V I O U S WORK 3 4 8 15.2.1* M I N I A T U R I
Z E D I E F / S D S - P A G E 348 15.2.2* O N E - D I M E N S I O
N A L C A P I L L A R Y E L E C T R O P H O R E S I S FOR P R O
T E I N A N A L Y S I S 349 15.3* T W O - D I M E N S I O N A L
C A P I L L A R Y S E P A R A T I O N S FOR A N A L Y S I S O F
P E P T I D E S A N D P R O T E I N S 352 15.3.1* C A P I L
L A R Y L I Q U I D C H R O M A T O G R A P H Y C O U P L E D
W I T H C A P I L L A R Y E L E C T R O P H O R E S I S F O
R A N A L Y S I S O F U N L A B E L E D P E P T I D E S
AND P R O T E I N S 3 5 2 15.3.2* T W O - D I M E N S I O N A L
C A P I L L A R Y E L E C T R O P H O R E S I S F O R A N A L Y
S I S O F P R O T E I N S 3 5 2 15.3.3* H I G H - S P E E D
T W O - D I M E N S I O N A L C A P I L L A R Y E L E C T R O P
H O R E S I S 3 5 6 15.3.4* T H E A N A L Y S I S O F A
S I N G L E F I X E D C E L L 3 5 8 15.4* C O N C L U S I
O N S 3 6 0 15.5 A B B R E V I A T I O N S 3 6 0 R E F E R E
N C E S 3 6 0 16* TWO-DIMENSIONAL H P L C - C E M E T H O D S
FOR PROTEINIPEPTIDE S E P A R A T I O N 3 6 5 16.1* I N T R O D
U C T I O N 365 16.2* O F F - L I N E VERSUS O N L I N E 3 6 6
16.3* H P L C F R A C T I O N A T I O N 3 6 6 16.4* 2D H P L
C - C E 367 16.5* C E - M S D E T E C T I O N 368 16.6* A P P L
I C A T I O N S 3 7 0 16.7 C O N C L U D I N G R E M A R K S
3 8 0 A C K N O W L E D G M E N T 381 R E F E R E N C E S 381
PART V INDUSTRIAL APPLICATIONS* 3 8 5 17* MULTIDIMENSIONAL LIQUID
C H R O M A T O G R A P H Y IN INDUSTRIAL A P P L I C A T I O N S
3 8 7 17.1* I N T R O D U C T I O N 3 8 7 17.2* P R I N C I P L
E S O F M U L T I D I M E N S I O N A L L I Q U I D C H R O
M A T O G R A P H Y AS A P P L I E D TO P O L Y M E R A N A L Y
S I S 3 9 0 XII C O N T E N T S 17.3 E X P E R I M E N T A L *
393 17.4 A N A L Y S I S O F A L K Y L E N E O X I D E - B A
S E D P O L Y M E R S * 395 17.4.1 A M P H I P H I L I C P O L
Y A L K Y L E N E O X I D E S * 395 17.5 E X C I P I E N T S * 3 9
9 17.6 P O L Y E T H E R P O L Y O L S * 403 17.7 A N A L Y S I
S O F C O N D E N S A T I O N P O L Y M E R S * 4 0 6
17.8 P O L Y A M I D E S * 407 1 7 . 9 A R O M A T I C P O L Y
E S T E R S * 414 1 7 . 1 0 A L I P H A T I C P O L Y E S T E R
S 417 R E F E R E N C E S 4 2 0 18* T H E A N A L Y S I S
O F S U R F A C T A N T S B Y M U L T I D I M E N S I O N A L
L I Q U I D C H R O M A T O G R A P H Y 4 2 5 18.1 I N T R O
D U C T I O N * 425 1 8 . 2 A N A L Y T I C A L C H A R A C T E
R I Z A T I O N M E T H O D S * 428 18.2.1 C E AND C G E *
429 1 8 . 2 . 2 S E C * 4 3 0 18.2.3 N P L C * 431 18.2.4 R
P L C * 433 18.3 D E T E C T I O N M E T H O D S * 434 18.4 2 D
L C * 434 18.4.1 R P L C C O U P L E D TO S E C * 435 18.4.2
N P L C C O U P L E D TO R P L C * 435 18.5 C O N C L U S I O N
S 4 4 2 R E F E R E N C E S 443 I N D E X * 4 4 7 |
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| id | DE-604.BV023358659 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:08:15Z |
| indexdate | 2024-07-09T21:16:47Z |
| institution | BVB |
| isbn | 0471738476 9780471738473 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016542156 |
| oclc_num | 144525715 |
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| owner_facet | DE-19 DE-BY-UBM DE-11 DE-703 |
| physical | XX, 456 S. Ill., graph. Darst. |
| publishDate | 2008 |
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| publisher | Wiley-Interscience |
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| spelling | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences ed. by Steven A. Cohen ... Hoboken, NJ Wiley-Interscience 2008 XX, 456 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes index Biochemie gtt Hydrodynamische chromatografie gtt Vloeistofchromatografie gtt Liquid chromatography Chemical engineering Chemistry, Technical Biochemistry Flüssigkeitschromatographie (DE-588)4017622-8 gnd rswk-swf HPLC (DE-588)4072641-1 gnd rswk-swf Flüssigkeitschromatographie (DE-588)4017622-8 s DE-604 HPLC (DE-588)4072641-1 s Cohen, Steven A. 1953- Sonstige (DE-588)1019352353 oth OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016542156&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences Biochemie gtt Hydrodynamische chromatografie gtt Vloeistofchromatografie gtt Liquid chromatography Chemical engineering Chemistry, Technical Biochemistry Flüssigkeitschromatographie (DE-588)4017622-8 gnd HPLC (DE-588)4072641-1 gnd |
| subject_GND | (DE-588)4017622-8 (DE-588)4072641-1 |
| title | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences |
| title_auth | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences |
| title_exact_search | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences |
| title_exact_search_txtP | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences |
| title_full | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences ed. by Steven A. Cohen ... |
| title_fullStr | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences ed. by Steven A. Cohen ... |
| title_full_unstemmed | Multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences ed. by Steven A. Cohen ... |
| title_short | Multidimensional liquid chromatography |
| title_sort | multidimensional liquid chromatography theory and applications in industrial chemistry and the life sciences |
| title_sub | theory and applications in industrial chemistry and the life sciences |
| topic | Biochemie gtt Hydrodynamische chromatografie gtt Vloeistofchromatografie gtt Liquid chromatography Chemical engineering Chemistry, Technical Biochemistry Flüssigkeitschromatographie (DE-588)4017622-8 gnd HPLC (DE-588)4072641-1 gnd |
| topic_facet | Biochemie Hydrodynamische chromatografie Vloeistofchromatografie Liquid chromatography Chemical engineering Chemistry, Technical Biochemistry Flüssigkeitschromatographie HPLC |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016542156&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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