Diverse roles of integrin receptors in articular cartilage:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
|
| Schriftenreihe: | Advances in anatomy, embryology and cell biology
197 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VI, 62 S. Ill., graph. Darst. |
| ISBN: | 3540787704 9783540787709 |
Internformat
MARC
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| 016 | 7 | |a 987617125 |2 DE-101 | |
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| 020 | |a 9783540787709 |c Pb. : EUR 93.04 (freier Pr.), sfr 151.50 (freier Pr.) |9 978-3-540-78770-9 | ||
| 035 | |a (OCoLC)213384280 | ||
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| 082 | 0 | |a 612.75 |2 22 | |
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| 100 | 1 | |a Shakibaei, Mehdi |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Diverse roles of integrin receptors in articular cartilage |c M. Shakibaei ; C. Csaki ; A. Mobasheri |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a VI, 62 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in anatomy, embryology and cell biology |v 197 | |
| 650 | 4 | |a Articular cartilage | |
| 650 | 4 | |a Cartilage, Articular |x physiology | |
| 650 | 4 | |a Cell receptors | |
| 650 | 4 | |a Chondrocytes |x physiology | |
| 650 | 4 | |a Integrin beta Chains |x physiology | |
| 650 | 4 | |a Integrins | |
| 650 | 0 | 7 | |a Gelenkknorpel |0 (DE-588)4156450-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Rezeptor |0 (DE-588)4049722-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Integrine |0 (DE-588)4278201-6 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Gelenkknorpel |0 (DE-588)4156450-9 |D s |
| 689 | 0 | 1 | |a Integrine |0 (DE-588)4278201-6 |D s |
| 689 | 0 | 2 | |a Rezeptor |0 (DE-588)4049722-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Csaki, Constanze |e Verfasser |4 aut | |
| 700 | 1 | |a Mobasheri, Ali |e Verfasser |4 aut | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-3-540-78771-6 |
| 830 | 0 | |a Advances in anatomy, embryology and cell biology |v 197 |w (DE-604)BV002528506 |9 197 | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538528&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016538528 | ||
Datensatz im Suchindex
| _version_ | 1804137714636816384 |
|---|---|
| adam_text | List of
Contents
1
Introduction
.................................................. 1
1.1
Integrins: Multifunctional Adhesion Molecules
.................... 4
1.2
Integrin
Structure-Function Relationships
........................ 6
1.3
Structure of Integrins
.......................................... 7
1.4
EGF Domains in
ßl-tntegrins.................................... 10
2
Integrins in Articular Cartilage
.................................. 10
2.1
Monolayer Cultures
............................................ 10
2.1.1
Expression Pattern and Changes of Integrins
on Chondrocytes in Monolayer Culture
........................... 10
2.1.2
Integrin
Expression and Collagen Type II are Implicated
in the Maintenance of Chondrocyte Morphology
in Monolayer Culture
........................................... 12
2.1.3
Signal Transduction by
ßl-Integrin
Receptors in Chondrocytes
In Vitro: Collaboration with IGF-IR
.............................. 15
2.1.4
Inhibition of
МАРК
Pathway Induces Chondrocyte Apoptosis
....... 19
2.1.5
Expression of the VEGF
Recepto
r-3 in Osteoarthritic
Chondrocytes and Association with
ßl-Integrins................... 22
2.1.6
Effects of Curcumin on
IL-lß-Induced
Inhibition of Collagen
Type II,
β
1
-integrin
Synthesis and Activation of Caspase-3 in
Human Chondrocytes In Vitro
................................... 25
2.2
High-Density Cultures
.......................................... 30
2.2.1
ECM Changes Following Long-Term Cultivation of Cartilage
(Organoid/High-Density Cultures)
............................... 30
2.2.2
Expression of Integrins in Ageing Cartilage Tissue In Vitro
.......... 31
2.2.3
Changes in
Integrin
Expression During Chondrogenesis In Vitro
..... 32
2.2.4
Inhibition of Chondrogenesis by Incubating Chondrocyte
Cultures with an Anti-integrin Antibody
.......................... 35
2.2.5
Integrin
Expression During Differentiation of Mesenchymal
Limb Bud Cells to Chondrocytes in Alginate Culture
................ 36
2.2.6 ßl-Integrins
Exist in the Cartilage Matrix
......................... 38
2.2.7
Integrins and Matrix Metalloproteinases Co-localise in the
Extracellular Matrix of Chondrocyte Cultures
..................... 40
vi
List of Contents
2.2.8
Integrins
and Stretch-Activated Cation Channels:
Putative Components of Chondrocyte Mechanoreceptors
.......... 42
2.2.9 ßl-Integrins
Co-localise with Selected Ion Channels in
Mechanoreceptor Complexes of Mouse Limb-Bud Chondrocytes
___ 44
2.2.10
Inhibition of
Integrin
Function Results in Chondrocyte Apoptosis.
.. 46
3
Concluding Remarks
.......................................... 47
Acknowledgements
................................................... 49
References
.......................................................... 50
Subject Index
........................................................ 61
|
| adam_txt |
List of
Contents
1
Introduction
. 1
1.1
Integrins: Multifunctional Adhesion Molecules
. 4
1.2
Integrin
Structure-Function Relationships
. 6
1.3
Structure of Integrins
. 7
1.4
EGF Domains in
ßl-tntegrins. 10
2
Integrins in Articular Cartilage
. 10
2.1
Monolayer Cultures
. 10
2.1.1
Expression Pattern and Changes of Integrins
on Chondrocytes in Monolayer Culture
. 10
2.1.2
Integrin
Expression and Collagen Type II are Implicated
in the Maintenance of Chondrocyte Morphology
in Monolayer Culture
. 12
2.1.3
Signal Transduction by
ßl-Integrin
Receptors in Chondrocytes
In Vitro: Collaboration with IGF-IR
. 15
2.1.4
Inhibition of
МАРК
Pathway Induces Chondrocyte Apoptosis
. 19
2.1.5
Expression of the VEGF
Recepto
r-3 in Osteoarthritic
Chondrocytes and Association with
ßl-Integrins. 22
2.1.6
Effects of Curcumin on
IL-lß-Induced
Inhibition of Collagen
Type II,
β
1
-integrin
Synthesis and Activation of Caspase-3 in
Human Chondrocytes In Vitro
. 25
2.2
High-Density Cultures
. 30
2.2.1
ECM Changes Following Long-Term Cultivation of Cartilage
(Organoid/High-Density Cultures)
. 30
2.2.2
Expression of Integrins in Ageing Cartilage Tissue In Vitro
. 31
2.2.3
Changes in
Integrin
Expression During Chondrogenesis In Vitro
. 32
2.2.4
Inhibition of Chondrogenesis by Incubating Chondrocyte
Cultures with an Anti-integrin Antibody
. 35
2.2.5
Integrin
Expression During Differentiation of Mesenchymal
Limb Bud Cells to Chondrocytes in Alginate Culture
. 36
2.2.6 ßl-Integrins
Exist in the Cartilage Matrix
. 38
2.2.7
Integrins and Matrix Metalloproteinases Co-localise in the
Extracellular Matrix of Chondrocyte Cultures
. 40
vi
List of Contents
2.2.8
Integrins
and Stretch-Activated Cation Channels:
Putative Components of Chondrocyte Mechanoreceptors
. 42
2.2.9 ßl-Integrins
Co-localise with Selected Ion Channels in
Mechanoreceptor Complexes of Mouse Limb-Bud Chondrocytes
_ 44
2.2.10
Inhibition of
Integrin
Function Results in Chondrocyte Apoptosis.
. 46
3
Concluding Remarks
. 47
Acknowledgements
. 49
References
. 50
Subject Index
. 61 |
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| illustrated | Illustrated |
| index_date | 2024-07-02T21:06:40Z |
| indexdate | 2024-07-09T21:16:41Z |
| institution | BVB |
| isbn | 3540787704 9783540787709 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016538528 |
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| physical | VI, 62 S. Ill., graph. Darst. |
| publishDate | 2008 |
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| series | Advances in anatomy, embryology and cell biology |
| series2 | Advances in anatomy, embryology and cell biology |
| spelling | Shakibaei, Mehdi Verfasser aut Diverse roles of integrin receptors in articular cartilage M. Shakibaei ; C. Csaki ; A. Mobasheri Berlin [u.a.] Springer 2008 VI, 62 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology and cell biology 197 Articular cartilage Cartilage, Articular physiology Cell receptors Chondrocytes physiology Integrin beta Chains physiology Integrins Gelenkknorpel (DE-588)4156450-9 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Integrine (DE-588)4278201-6 gnd rswk-swf Gelenkknorpel (DE-588)4156450-9 s Integrine (DE-588)4278201-6 s Rezeptor (DE-588)4049722-7 s DE-604 Csaki, Constanze Verfasser aut Mobasheri, Ali Verfasser aut Erscheint auch als Online-Ausgabe 978-3-540-78771-6 Advances in anatomy, embryology and cell biology 197 (DE-604)BV002528506 197 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538528&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Shakibaei, Mehdi Csaki, Constanze Mobasheri, Ali Diverse roles of integrin receptors in articular cartilage Advances in anatomy, embryology and cell biology Articular cartilage Cartilage, Articular physiology Cell receptors Chondrocytes physiology Integrin beta Chains physiology Integrins Gelenkknorpel (DE-588)4156450-9 gnd Rezeptor (DE-588)4049722-7 gnd Integrine (DE-588)4278201-6 gnd |
| subject_GND | (DE-588)4156450-9 (DE-588)4049722-7 (DE-588)4278201-6 |
| title | Diverse roles of integrin receptors in articular cartilage |
| title_auth | Diverse roles of integrin receptors in articular cartilage |
| title_exact_search | Diverse roles of integrin receptors in articular cartilage |
| title_exact_search_txtP | Diverse roles of integrin receptors in articular cartilage |
| title_full | Diverse roles of integrin receptors in articular cartilage M. Shakibaei ; C. Csaki ; A. Mobasheri |
| title_fullStr | Diverse roles of integrin receptors in articular cartilage M. Shakibaei ; C. Csaki ; A. Mobasheri |
| title_full_unstemmed | Diverse roles of integrin receptors in articular cartilage M. Shakibaei ; C. Csaki ; A. Mobasheri |
| title_short | Diverse roles of integrin receptors in articular cartilage |
| title_sort | diverse roles of integrin receptors in articular cartilage |
| topic | Articular cartilage Cartilage, Articular physiology Cell receptors Chondrocytes physiology Integrin beta Chains physiology Integrins Gelenkknorpel (DE-588)4156450-9 gnd Rezeptor (DE-588)4049722-7 gnd Integrine (DE-588)4278201-6 gnd |
| topic_facet | Articular cartilage Cartilage, Articular physiology Cell receptors Chondrocytes physiology Integrin beta Chains physiology Integrins Gelenkknorpel Rezeptor Integrine |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538528&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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