Proteomic biology using LC-MS: large scale analysis of cellular dynamics and function
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2008
|
| Schriftenreihe: | Wiley-Interscience series on mass spectrometry
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | X, 254, [8] S. Ill., graph. Darst. |
| ISBN: | 0471662585 9780471662587 |
Internformat
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| 100 | 1 | |a Takahashi, Nobuhiro |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Proteomic biology using LC-MS |b large scale analysis of cellular dynamics and function |c Nobuhiro Takahashi ; Toshiaki Isobe |
| 264 | 1 | |a Hoboken, NJ |b Wiley |c 2008 | |
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| 650 | 4 | |a Mass spectrometry | |
| 650 | 4 | |a Proteomics / methods | |
| 650 | 4 | |a Chromatography, Liquid / methods | |
| 650 | 4 | |a Mass Spectrometry / methods | |
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Datensatz im Suchindex
| _version_ | 1804137714035982336 |
|---|---|
| adam_text | CONTENTS
Introduction vii
1 Overview of Proteomics 1
1-1 What Is Proteomics?, 1
1-2 Establishment of Proteomics Using Mass Spectrometry, 3
1-2-1 Protein Separations by Two-Dimensional Electrophoresis, 3
1-2-2 Development of the Technologies for Protein Identification, 5
1-2-3 Protein Identification Based on Gel Separation and Mass
Spectrometry, 6
1-3 Strategies for Characterizing Proteomes and Understanding Proteome
Function, 15
1-3-1 Modification-Specific Proteomics, 17
1-3-2 Activity-Based Protein Profiling/Enzyme Substrate
Proteomics, 31
1-3-3 Subcellular (Organellar) Proteomics, 41
1-3-4 Machinery or Complex Interaction Proteomics, 45
1-3-5 Dynamic Proteomics, 46
References, 49
2 Proteomic Tools for Analysis of Cellular Dynamics 63
2-1 LC-Based Proteomics Technologies, 63
2-1-1 LC-MS system for Peptide Separation and Identification, 71
2-1-2 Application of LC-MS Methods to Functional Proteomics, 101
2-2 Development of Quantitative Proteomics, 131
v
vi CONTENTS
2-2-1 Isotope Labeling for Quantitative Analysis Using MS, 132
2-2-2 Quantification Strategy for LC-MS Analysis of Isotope-Labeled
Peptide Mixture and Software for Computer Analysis, 140
2-2-3 Label-Free Quantification Software, 145
2-2-4 Absolute Quantification, 147
References, 153
3 Dynamics of Functional Cellular Machinery: From Statics to
Dynamics in Proteomic Biology 167
3-1 Dynamic Analysis of Cellular Function, 167
3-1-1 Strategy for Dynamic Analysis of Cellular Machinery
(Multiprotein Complexes), 168
3-1-2 Methods for the Isolation of a Cellular Machine/Multiprotein
Complex, 174
3-1-3 Cellular Machinery (Multiprotein Complex), 196
3-2 Dynamics of Ribosome Biogenesis, 198
3-2-1 Snapshot Analysis of Preribosomal Particles in Yeast, 201
3-2-2 Snapshot Analysis of Preribosomal Particles in Mammals, 207
3-2-3 Quantitative (Dynamic) Analysis Using Isotope-Labeled
Reagents, 224
3-2-4 Outline of Human/Mammalian Ribosome Biogenesis, 231
3-3 Dynamic Analysis of Subcellular Structures, 232
3-3-1 Proteome Dynamics of the Nucleolus, 233
References, 236
Index 249
|
| adam_txt |
CONTENTS
Introduction vii
1 Overview of Proteomics 1
1-1 What Is Proteomics?, 1
1-2 Establishment of Proteomics Using Mass Spectrometry, 3
1-2-1 Protein Separations by Two-Dimensional Electrophoresis, 3
1-2-2 Development of the Technologies for Protein Identification, 5
1-2-3 Protein Identification Based on Gel Separation and Mass
Spectrometry, 6
1-3 Strategies for Characterizing Proteomes and Understanding Proteome
Function, 15
1-3-1 Modification-Specific Proteomics, 17
1-3-2 Activity-Based Protein Profiling/Enzyme Substrate
Proteomics, 31
1-3-3 Subcellular (Organellar) Proteomics, 41
1-3-4 Machinery or Complex Interaction Proteomics, 45
1-3-5 Dynamic Proteomics, 46
References, 49
2 Proteomic Tools for Analysis of Cellular Dynamics 63
2-1 LC-Based Proteomics Technologies, 63
2-1-1 LC-MS system for Peptide Separation and Identification, 71
2-1-2 Application of LC-MS Methods to Functional Proteomics, 101
2-2 Development of Quantitative Proteomics, 131
v
vi CONTENTS
2-2-1 Isotope Labeling for Quantitative Analysis Using MS, 132
2-2-2 Quantification Strategy for LC-MS Analysis of Isotope-Labeled
Peptide Mixture and Software for Computer Analysis, 140
2-2-3 Label-Free Quantification Software, 145
2-2-4 Absolute Quantification, 147
References, 153
3 Dynamics of Functional Cellular Machinery: From Statics to
Dynamics in Proteomic Biology 167
3-1 Dynamic Analysis of Cellular Function, 167
3-1-1 Strategy for Dynamic Analysis of Cellular Machinery
(Multiprotein Complexes), 168
3-1-2 Methods for the Isolation of a Cellular Machine/Multiprotein
Complex, 174
3-1-3 Cellular Machinery (Multiprotein Complex), 196
3-2 Dynamics of Ribosome Biogenesis, 198
3-2-1 Snapshot Analysis of Preribosomal Particles in Yeast, 201
3-2-2 Snapshot Analysis of Preribosomal Particles in Mammals, 207
3-2-3 Quantitative (Dynamic) Analysis Using Isotope-Labeled
Reagents, 224
3-2-4 Outline of Human/Mammalian Ribosome Biogenesis, 231
3-3 Dynamic Analysis of Subcellular Structures, 232
3-3-1 Proteome Dynamics of the Nucleolus, 233
References, 236
Index 249 |
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| index_date | 2024-07-02T21:06:29Z |
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| institution | BVB |
| isbn | 0471662585 9780471662587 |
| language | English |
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| physical | X, 254, [8] S. Ill., graph. Darst. |
| publishDate | 2008 |
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| publisher | Wiley |
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| spelling | Takahashi, Nobuhiro Verfasser aut Proteomic biology using LC-MS large scale analysis of cellular dynamics and function Nobuhiro Takahashi ; Toshiaki Isobe Hoboken, NJ Wiley 2008 X, 254, [8] S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley-Interscience series on mass spectrometry Includes bibliographical references and index Proteomics Liquid chromatography Mass spectrometry Proteomics / methods Chromatography, Liquid / methods Mass Spectrometry / methods Flüssigkeitschromatographie (DE-588)4017622-8 gnd rswk-swf Proteomanalyse (DE-588)4596545-6 gnd rswk-swf Massenspektrometrie (DE-588)4037882-2 gnd rswk-swf Proteomanalyse (DE-588)4596545-6 s Flüssigkeitschromatographie (DE-588)4017622-8 s Massenspektrometrie (DE-588)4037882-2 s DE-604 Isobe, Toshiaki Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538131&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Takahashi, Nobuhiro Isobe, Toshiaki Proteomic biology using LC-MS large scale analysis of cellular dynamics and function Proteomics Liquid chromatography Mass spectrometry Proteomics / methods Chromatography, Liquid / methods Mass Spectrometry / methods Flüssigkeitschromatographie (DE-588)4017622-8 gnd Proteomanalyse (DE-588)4596545-6 gnd Massenspektrometrie (DE-588)4037882-2 gnd |
| subject_GND | (DE-588)4017622-8 (DE-588)4596545-6 (DE-588)4037882-2 |
| title | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function |
| title_auth | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function |
| title_exact_search | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function |
| title_exact_search_txtP | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function |
| title_full | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function Nobuhiro Takahashi ; Toshiaki Isobe |
| title_fullStr | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function Nobuhiro Takahashi ; Toshiaki Isobe |
| title_full_unstemmed | Proteomic biology using LC-MS large scale analysis of cellular dynamics and function Nobuhiro Takahashi ; Toshiaki Isobe |
| title_short | Proteomic biology using LC-MS |
| title_sort | proteomic biology using lc ms large scale analysis of cellular dynamics and function |
| title_sub | large scale analysis of cellular dynamics and function |
| topic | Proteomics Liquid chromatography Mass spectrometry Proteomics / methods Chromatography, Liquid / methods Mass Spectrometry / methods Flüssigkeitschromatographie (DE-588)4017622-8 gnd Proteomanalyse (DE-588)4596545-6 gnd Massenspektrometrie (DE-588)4037882-2 gnd |
| topic_facet | Proteomics Liquid chromatography Mass spectrometry Proteomics / methods Chromatography, Liquid / methods Mass Spectrometry / methods Flüssigkeitschromatographie Proteomanalyse Massenspektrometrie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538131&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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