Metabolomics, metabonomics and metabolite profiling:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
RSC Publishing
2008
|
| Schriftenreihe: | RSC biomolecular sciences
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 323 S. Ill. 25cm |
| ISBN: | 0854042997 9780854042999 |
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| 245 | 1 | 0 | |a Metabolomics, metabonomics and metabolite profiling |c edited by William J. Griffiths |
| 264 | 1 | |a Cambridge |b RSC Publishing |c 2008 | |
| 300 | |a XI, 323 S. |b Ill. |c 25cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a RSC biomolecular sciences | |
| 650 | 4 | |a Diagnostics moléculaires | |
| 650 | 4 | |a Métabolites | |
| 650 | 4 | |a Protéomique | |
| 650 | 4 | |a Metabolites | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Molecular diagnosis | |
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| 700 | 1 | |a Griffiths, William J. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804137713890230272 |
|---|---|
| adam_text | Contents
Chapter 1 Mass Spectrometry for Metabolite Identification
Yuqin Wang and William J. Griffiths
1.1 Introduction 1
1.2 Mass Spectrometry 1
1.2.1 Principles 1
1.2.2 Ionisation 2
1.2.3 Mass Analysers 14
1.2.4 Gas Chromatography/Mass Spectrometry
(GC-MS) 22
1.2.5 Tandem Mass Spectrometry (MS/MS) 26
1.2.6 Liquid Chromatography-Mass Spectrometry
(LC-MS) 27
1.3 Future Perspectives 29
Acknowledgements 31
References 31
Chapter 2 ID and 2D NMR Spectroscopy: From Metabolic
Fingerprinting to Profiling
Mark R. Viant, Christian Ludwig and Ulrich L. Gunther
2.1 Introduction 44
2.2 NMR Methods in Metabolomics 46
2.2.1 Sample Preparation 46
2.2.2 ID NMR Methods 47
2.2.3 2D NMR Methods 51
2.3 NMR Data Analysis 56
2.3.1 NMR Fingerprinting 56
2.3.2 Multi-dimensional Analysis of 2D NMR
Spectra 63
2.3.3 NMR Profiling 63
vi
Contents vji
2.3.4 Reporting Requirements for NMR
Metabolomics 65
2.4 Conclusions and Future Developments 66
Acknowledgements 67
References 67
Chapter 3 Steroids, Sterols and the Nervous System
Yuqin Wang and William J. Griffiths
3.1 Introduction 71
3.2 Steroids, Neurosteroids, Oxysterols and
Neurosterols 78
3.2.1 Steroids 78
3.2.2 Neurosteroids 78
3.2.3 Oxysterols 78
3.2.4 Neurosterols 85
3.2.5 Biological Activity of Oxysterols 86
3.3 Analysis by Mass Spectrometry 87
3.3.1 GC-MS Analysis 88
3.3.2 LC-MS Analysis 90
3.4 Metabolite Profiling in Brain: Neurosteroids and
Neurosterols 96
3.5 Linking Proteomics with Lipidomics 101
3.6 Future Prospective 106
Acknowledgement 106
Appendix 106
References 108
Chapter 4 Phospholipid Profiling
Anthony D. Postle
4.1 General Overview of Lipidomic Characterisation of
Membrane Function 116
4.2 Phospholipid Structures 117
4.3 Electrospray lonisation Mass Spectrometry of
Phospholipids 118
4.4 Phospholipid Metabolism 121
4.5 Phospholipids of Lung Surfactant 122
4.5.1 Lung Structure and Surfactant Function 123
4.5.2 ESI/MS Analysis of Lung Surfactant
Phospholipid 125
4.6 Conclusions 131
References 131
viii Contents
Chapter 5 New Developments in Multi-dimensional Mass Spectrometry
Based Shotgun Lipidomics
Xianlin Han and Richard W. Gross
5.1 Introduction 134
5.2 The Principles of Multi-dimensional Mass
Spectrometry Based Shotgun Lipidomics 137
5.2.1 Multiplexed Extractions 137
5.2.2 Intrasource Separation 138
5.2.3 Identification of Lipid Molecular Species by
Multi-dimensional Mass Spectrometry and
Array Analysis 139
5.2.4 Quantitation of Lipid Molecular Species Using
a Two-step Procedure 141
5.2.5 Analysis in the Low Concentration Regime by
Shotgun Lipidomics 141
5.3 The Chemical Mechanisms Underlying Intrasource
Separation 142
5.4 An Enhanced Shotgun Lipidomics for Cardiolipin
Analysis 145
5.5 Derivatization as an Additional Dimension of
Multi-dimension Mass Spectrometry in Shotgun
Lipidomics 150
5.5.1 Derivatization of Phosphoethanolamine-
containing Lipid Molecular Species for
Shotgun Lipidomics 152
5.5.2 Derivatization of Cholesterol with Methoxy-
acetic Acid for Quantitation by Shotgun
Lipidomics 156
5.6 Summary 158
Acknowledgements 158
References 158
Chapter 6 Neutral Lipidomics and Mass Spectrometry
Robert C. Murphy, Mark Fitzgerald and Robert M. Barkley
6.1 Introduction 161
6.1.1 Neutral Lipid Analysis and Lipidomics 161
6.2 Glyceryl Lipids 162
6.2.1 Overview 162
6.2.2 Electron Ionization (El) 164
6.2.3 Negative-ion Chemical Ionization (NCI) 165
6.2.4 Electrospray Ionization/Tandem Mass
Spectrometry 166
6.2.5 Atmospheric Pressure Chemical Ionization 173
Contents ;x
6.3 Cholesterol Esters 177
6.3.1 Electron Ionization 179
6.3.2 Chemical Ionization 180
6.3.3 Electrospray Ionization 180
6.4 Wax Esters 181
6.4.1 Electron Ionization 183
6.4.2 Electrospray and Desorption Ionization 188
6.5 Conclusions 189
Acknowledgement 189
References 189
Chapter 7 Bioinformatics of Lipids
Eoin Fahy
7.1 Introduction 195
7.2 Lipid Classification, Nomenclature, and Structure
Representation 196
7.2.1 Classification 196
7.2.2 Nomenclature 199
7.2.3 Structure Representation 200
7.3 Lipid Molecular Databases 200
7.4 Lipid-associated Protein/Gene Databases 202
7.5 Lipid-associated Pathways and Networks 203
7.5.1 Lipidomic Data 204
7.6 Bioinformatics Tools for Lipidomics Research 204
7.6.1 Data Collection 204
7.6.2 Standards Libraries 205
7.6.3 MS Prediction Tools 206
7.6.4 Automated Structure Drawing 207
7.7 Conclusion 208
Acknowledgements 208
References 208
Chapter 8 Mass Spectrometry in Glycobiology
Jodo Rodrigues, Carla Antonio, Sarah Robinson and Jane
Thomas-Oates
8.1 Introduction 210
8.2 Glycolytic Intermediates and Sugar Phosphates 212
8.2.1 Sampling and Extraction 212
8.2.2 Sample Handling and Derivatisation 213
8.2.3 Analytical Methods 213
8.2.4 Data Analysis 217
x Contents
8.3 Metabolic Disorders of Carbohydrate Metabolism 218
8.3.1 Sampling and Extraction 219
8.3.2 Sample Handling and Derivatisation 220
8.3.3 Analytical Methods 221
8.3.4 Data Analysis 224
8.4 Glucuronidated Metabolites as Biomarkers for Drug
and Alcohol Abuse 224
8.4.1 Sampling and Extraction 225
8.4.2 Sample Handling and Derivatisation 226
8.4.3 Analytical Methods 226
8.5 Conclusions 230
References 231
Chapter 9 Matrix Assisted Laser Desorption Ionisation Mass
Spectrometric Imaging - Principles and Applications
Caroline J. Earnshaw, Sally J. Atkinson, Michael Burrell and
Malcolm R. Clench
9.1 Introduction 234
9.2 Practical Aspects of MALDI Mass Spectrometric
Imaging (MALDI-MSI) 235
9.2.1 Instrumentation for MALDI-MSI 235
9.2.2 Sample Preparation Procedures 238
9.3 Applications of MALDI-MSI 240
9.3.1 MALDI-MSI in the Study of Proteins in
Diseased and Healthy Tissue 240
9.3.2 MALDI-MSI in the Study of Drug/Xenobiotic
Distribution 240
9.3.3 MALDI-MSI and Phospholipids 244
9.3.4 MALDI-MSI and Metabonomics 246
9.4 Data Handling and Data Interpretation Issues 249
9.5 Conclusions 251
Acknowledgements 251
References 251
Chapter 10 Plant Metabolomics
Thomas Moritz and Annika I. Johansson
10.1 Introduction 254
10.2 Analytical Technology 255
10.2.1 General Considerations 255
10.2.2 Sample Preparation 256
10.2.3 GC/MS 257
10.2.4 LC/MS 259
Contents xj
10.3 Applications of Plant Metabolomics 261
10.3.1 Phenotyping Plants Using Metabolomics 261
10.3.2 Genetic Metabolomics: Identification of
Metabolic QTLs 264
10.3.3 Plant Metabolomics and Gene Identification 265
10.3.4 Other Applications of Plant Metabolomics 268
10.4 Conclusions and Future Directions 268
References 269
Chapter 11 Data Mining for Metabolomics
Anders Nordstrom
11.1 Introduction 273
11.1.1 Data Extraction - Generating Variables 274
11.1.2 Data Pre-treatment 278
11.2 Data Mining 279
11.2.1 Multivariate Data Mining 280
11.2.2 Exploratory Data Mining 283
11.2.3 Databases 284
11.3 Conclusions 288
Acknowledgement 288
References 288
Chapter 12 Metabonomics and Global Systems Biology
Ian D Wilson and Jeremy K. Nicholson
12.1 Introduction 295
12.2 Biological Fluids as a Window on the Global
System 297
12.3 Examples of the Use of Metabonomics in Normal
and Disease Models 298
12.4 The Microbiome - an Integral Part of the Global
System 303
12.5 Pharmaco-metabonomics 306
12.6 Combining Omics 307
12.7 Conclusions 314
References 314
Subject Index 317
|
| adam_txt |
Contents
Chapter 1 Mass Spectrometry for Metabolite Identification
Yuqin Wang and William J. Griffiths
1.1 Introduction 1
1.2 Mass Spectrometry 1
1.2.1 Principles 1
1.2.2 Ionisation 2
1.2.3 Mass Analysers 14
1.2.4 Gas Chromatography/Mass Spectrometry
(GC-MS) 22
1.2.5 Tandem Mass Spectrometry (MS/MS) 26
1.2.6 Liquid Chromatography-Mass Spectrometry
(LC-MS) 27
1.3 Future Perspectives 29
Acknowledgements 31
References 31
Chapter 2 ID and 2D NMR Spectroscopy: From Metabolic
Fingerprinting to Profiling
Mark R. Viant, Christian Ludwig and Ulrich L. Gunther
2.1 Introduction 44
2.2 NMR Methods in Metabolomics 46
2.2.1 Sample Preparation 46
2.2.2 ID NMR Methods 47
2.2.3 2D NMR Methods 51
2.3 NMR Data Analysis 56
2.3.1 NMR Fingerprinting 56
2.3.2 Multi-dimensional Analysis of 2D NMR
Spectra 63
2.3.3 NMR Profiling 63
vi
Contents vji
2.3.4 Reporting Requirements for NMR
Metabolomics 65
2.4 Conclusions and Future Developments 66
Acknowledgements 67
References 67
Chapter 3 Steroids, Sterols and the Nervous System
Yuqin Wang and William J. Griffiths
3.1 Introduction 71
3.2 Steroids, Neurosteroids, Oxysterols and
Neurosterols 78
3.2.1 Steroids 78
3.2.2 Neurosteroids 78
3.2.3 Oxysterols 78
3.2.4 Neurosterols 85
3.2.5 Biological Activity of Oxysterols 86
3.3 Analysis by Mass Spectrometry 87
3.3.1 GC-MS Analysis 88
3.3.2 LC-MS Analysis 90
3.4 Metabolite Profiling in Brain: Neurosteroids and
Neurosterols 96
3.5 Linking Proteomics with Lipidomics 101
3.6 Future Prospective 106
Acknowledgement 106
Appendix 106
References 108
Chapter 4 Phospholipid Profiling
Anthony D. Postle
4.1 General Overview of Lipidomic Characterisation of
Membrane Function 116
4.2 Phospholipid Structures 117
4.3 Electrospray lonisation Mass Spectrometry of
Phospholipids 118
4.4 Phospholipid Metabolism 121
4.5 Phospholipids of Lung Surfactant 122
4.5.1 Lung Structure and Surfactant Function 123
4.5.2 ESI/MS Analysis of Lung Surfactant
Phospholipid 125
4.6 Conclusions 131
References 131
viii Contents
Chapter 5 New Developments in Multi-dimensional Mass Spectrometry
Based Shotgun Lipidomics
Xianlin Han and Richard W. Gross
5.1 Introduction 134
5.2 The Principles of Multi-dimensional Mass
Spectrometry Based Shotgun Lipidomics 137
5.2.1 Multiplexed Extractions 137
5.2.2 Intrasource Separation 138
5.2.3 Identification of Lipid Molecular Species by
Multi-dimensional Mass Spectrometry and
Array Analysis 139
5.2.4 Quantitation of Lipid Molecular Species Using
a Two-step Procedure 141
5.2.5 Analysis in the Low Concentration Regime by
Shotgun Lipidomics 141
5.3 The Chemical Mechanisms Underlying Intrasource
Separation 142
5.4 An Enhanced Shotgun Lipidomics for Cardiolipin
Analysis 145
5.5 Derivatization as an Additional Dimension of
Multi-dimension Mass Spectrometry in Shotgun
Lipidomics 150
5.5.1 Derivatization of Phosphoethanolamine-
containing Lipid Molecular Species for
Shotgun Lipidomics 152
5.5.2 Derivatization of Cholesterol with Methoxy-
acetic Acid for Quantitation by Shotgun
Lipidomics 156
5.6 Summary 158
Acknowledgements 158
References 158
Chapter 6 Neutral Lipidomics and Mass Spectrometry
Robert C. Murphy, Mark Fitzgerald and Robert M. Barkley
6.1 Introduction 161
6.1.1 Neutral Lipid Analysis and Lipidomics 161
6.2 Glyceryl Lipids 162
6.2.1 Overview 162
6.2.2 Electron Ionization (El) 164
6.2.3 Negative-ion Chemical Ionization (NCI) 165
6.2.4 Electrospray Ionization/Tandem Mass
Spectrometry 166
6.2.5 Atmospheric Pressure Chemical Ionization 173
Contents ;x
6.3 Cholesterol Esters 177
6.3.1 Electron Ionization 179
6.3.2 Chemical Ionization 180
6.3.3 Electrospray Ionization 180
6.4 Wax Esters 181
6.4.1 Electron Ionization 183
6.4.2 Electrospray and Desorption Ionization 188
6.5 Conclusions 189
Acknowledgement 189
References 189
Chapter 7 Bioinformatics of Lipids
Eoin Fahy
7.1 Introduction 195
7.2 Lipid Classification, Nomenclature, and Structure
Representation 196
7.2.1 Classification 196
7.2.2 Nomenclature 199
7.2.3 Structure Representation 200
7.3 Lipid Molecular Databases 200
7.4 Lipid-associated Protein/Gene Databases 202
7.5 Lipid-associated Pathways and Networks 203
7.5.1 Lipidomic Data 204
7.6 Bioinformatics Tools for Lipidomics Research 204
7.6.1 Data Collection 204
7.6.2 Standards Libraries 205
7.6.3 MS Prediction Tools 206
7.6.4 Automated Structure Drawing 207
7.7 Conclusion 208
Acknowledgements 208
References 208
Chapter 8 Mass Spectrometry in Glycobiology
Jodo Rodrigues, Carla Antonio, Sarah Robinson and Jane
Thomas-Oates
8.1 Introduction 210
8.2 Glycolytic Intermediates and Sugar Phosphates 212
8.2.1 Sampling and Extraction 212
8.2.2 Sample Handling and Derivatisation 213
8.2.3 Analytical Methods 213
8.2.4 Data Analysis 217
x Contents
8.3 Metabolic Disorders of Carbohydrate Metabolism 218
8.3.1 Sampling and Extraction 219
8.3.2 Sample Handling and Derivatisation 220
8.3.3 Analytical Methods 221
8.3.4 Data Analysis 224
8.4 Glucuronidated Metabolites as Biomarkers for Drug
and Alcohol Abuse 224
8.4.1 Sampling and Extraction 225
8.4.2 Sample Handling and Derivatisation 226
8.4.3 Analytical Methods 226
8.5 Conclusions 230
References 231
Chapter 9 Matrix Assisted Laser Desorption Ionisation Mass
Spectrometric Imaging - Principles and Applications
Caroline J. Earnshaw, Sally J. Atkinson, Michael Burrell and
Malcolm R. Clench
9.1 Introduction 234
9.2 Practical Aspects of MALDI Mass Spectrometric
Imaging (MALDI-MSI) 235
9.2.1 Instrumentation for MALDI-MSI 235
9.2.2 Sample Preparation Procedures 238
9.3 Applications of MALDI-MSI 240
9.3.1 MALDI-MSI in the Study of Proteins in
Diseased and Healthy Tissue 240
9.3.2 MALDI-MSI in the Study of Drug/Xenobiotic
Distribution 240
9.3.3 MALDI-MSI and Phospholipids 244
9.3.4 MALDI-MSI and Metabonomics 246
9.4 Data Handling and Data Interpretation Issues 249
9.5 Conclusions 251
Acknowledgements 251
References 251
Chapter 10 Plant Metabolomics
Thomas Moritz and Annika I. Johansson
10.1 Introduction 254
10.2 Analytical Technology 255
10.2.1 General Considerations 255
10.2.2 Sample Preparation 256
10.2.3 GC/MS 257
10.2.4 LC/MS 259
Contents xj
10.3 Applications of Plant Metabolomics 261
10.3.1 Phenotyping Plants Using Metabolomics 261
10.3.2 Genetic Metabolomics: Identification of
Metabolic QTLs 264
10.3.3 Plant Metabolomics and Gene Identification 265
10.3.4 Other Applications of Plant Metabolomics 268
10.4 Conclusions and Future Directions 268
References 269
Chapter 11 Data Mining for Metabolomics
Anders Nordstrom
11.1 Introduction 273
11.1.1 Data Extraction - Generating Variables 274
11.1.2 Data Pre-treatment 278
11.2 Data Mining 279
11.2.1 Multivariate Data Mining 280
11.2.2 Exploratory Data Mining 283
11.2.3 Databases 284
11.3 Conclusions 288
Acknowledgement 288
References 288
Chapter 12 Metabonomics and Global Systems Biology
Ian D Wilson and Jeremy K. Nicholson
12.1 Introduction 295
12.2 Biological Fluids as a Window on the Global
"System" 297
12.3 Examples of the Use of Metabonomics in Normal
and Disease Models 298
12.4 The Microbiome - an Integral Part of the Global
System 303
12.5 Pharmaco-metabonomics 306
12.6 Combining Omics 307
12.7 Conclusions 314
References 314
Subject Index 317 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
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| discipline_str_mv | Biologie Chemie |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)4006432-3 Bibliografie gnd-content |
| genre_facet | Aufsatzsammlung Bibliografie |
| id | DE-604.BV023354472 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:06:27Z |
| indexdate | 2024-07-09T21:16:40Z |
| institution | BVB |
| isbn | 0854042997 9780854042999 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016538033 |
| oclc_num | 124025892 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-20 |
| owner_facet | DE-M49 DE-BY-TUM DE-20 |
| physical | XI, 323 S. Ill. 25cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | RSC Publishing |
| record_format | marc |
| series2 | RSC biomolecular sciences |
| spelling | Metabolomics, metabonomics and metabolite profiling edited by William J. Griffiths Cambridge RSC Publishing 2008 XI, 323 S. Ill. 25cm txt rdacontent n rdamedia nc rdacarrier RSC biomolecular sciences Diagnostics moléculaires Métabolites Protéomique Metabolites Proteomics Molecular diagnosis Metabolom (DE-588)4807318-0 gnd rswk-swf Chemische Analyse (DE-588)4009840-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)4006432-3 Bibliografie gnd-content Metabolom (DE-588)4807318-0 s Chemische Analyse (DE-588)4009840-0 s DE-604 Griffiths, William J. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538033&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metabolomics, metabonomics and metabolite profiling Diagnostics moléculaires Métabolites Protéomique Metabolites Proteomics Molecular diagnosis Metabolom (DE-588)4807318-0 gnd Chemische Analyse (DE-588)4009840-0 gnd |
| subject_GND | (DE-588)4807318-0 (DE-588)4009840-0 (DE-588)4143413-4 (DE-588)4006432-3 |
| title | Metabolomics, metabonomics and metabolite profiling |
| title_auth | Metabolomics, metabonomics and metabolite profiling |
| title_exact_search | Metabolomics, metabonomics and metabolite profiling |
| title_exact_search_txtP | Metabolomics, metabonomics and metabolite profiling |
| title_full | Metabolomics, metabonomics and metabolite profiling edited by William J. Griffiths |
| title_fullStr | Metabolomics, metabonomics and metabolite profiling edited by William J. Griffiths |
| title_full_unstemmed | Metabolomics, metabonomics and metabolite profiling edited by William J. Griffiths |
| title_short | Metabolomics, metabonomics and metabolite profiling |
| title_sort | metabolomics metabonomics and metabolite profiling |
| topic | Diagnostics moléculaires Métabolites Protéomique Metabolites Proteomics Molecular diagnosis Metabolom (DE-588)4807318-0 gnd Chemische Analyse (DE-588)4009840-0 gnd |
| topic_facet | Diagnostics moléculaires Métabolites Protéomique Metabolites Proteomics Molecular diagnosis Metabolom Chemische Analyse Aufsatzsammlung Bibliografie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016538033&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT griffithswilliamj metabolomicsmetabonomicsandmetaboliteprofiling |