Factors influencing mammalian kidney development: implications for health in adult life
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer Berlin
2008
|
| Schriftenreihe: | Advances in Anatomy, Embryology and Cell Biology
196 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VII, 78 S., [1] Bl. Ill., graph. Darst. |
| ISBN: | 3540777679 9783540777687 |
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| 245 | 1 | 0 | |a Factors influencing mammalian kidney development |b implications for health in adult life |c Karen M. Moritz ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer Berlin |c 2008 | |
| 300 | |a VII, 78 S., [1] Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Advances in Anatomy, Embryology and Cell Biology |v 196 | |
| 650 | 4 | |a Kidney |x growth & development | |
| 650 | 4 | |a Kidney |x metabolism | |
| 650 | 4 | |a Kidneys |x Growth | |
| 650 | 4 | |a Nephrology | |
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Datensatz im Suchindex
| _version_ | 1804137708139839488 |
|---|---|
| adam_text | List of
Contents
1
Introduction
........................................................ 1
2
Morphological Development of the Mammalian Kidney
................... 1
2.1
Pronephros
.......................................................... 3
2.2
Mesonephros
........................................................ 3
2.3
Metanephros
........................................................ 5
2.4
Renal Vascular Development
........................................... 7
2.5
Development of the Renal Nerves
....................................... 9
3
Genetic Regulation of Metanephric Development
......................... 9
3.1
Molecular Specification of the Metanephric Blastema
..................... 10
3.2
Molecular Regulation of Ureteric Budding and
Branching Morphogenesis
............................................. 10
3.3
Molecular Regulation of Nephrogenesis
................................. 12
3.4
Molecular Regulation of the
Stroma
..................................... 14
3.5
The Renin-Angiotensin System: An Important System
Regulating Renal Development and Function
............................ 14
3.6
Summary of Molecular Regulation of Metanephric Development
.............. 15
4
Abnormalities of Renal Development in the Human
...................... 16
4.1
Hydronephrosis
...................................................... 16
4.2
Congenital Anomalies of the Kidney and Urinary Tract
.................... 16
4.3
Bilateral Renal Agenesis (Potter s Syndrome)
............................. 17
4.4
Renal Abnormalities Caused by Maternal Drug Use
....................... 17
4.5
Polycystic Kidney Disease
............................................. 17
5
Methodology to Examine Kidney Development
.......................... 18
5.1
Organ Culture
....................................................... 18
5.2
Three-Dimensional and Four-Dimensional Imaging
...................... 20
5.3
Quantitation of Nephron Number
...................................... 21
5.3.1
Unbiased Counting of Nephrons
........................................ 21
5.3.2
Acid Maceration
..................................................... 24
5.4
Microarrays
......................................................... 24
5.5
Use of Knock-in/Reporter Mice to Analyse Gene Function
and Expression
....................................................... 25
6
Development of Function in the Fetus
................................... 27
6.1
Mesonephric Function
................................................ 27
List of Contents
6.2
Fetal Metanephric Renal Function
...................................... 27
6.3
Sodium Transporters
.................................................. 28
6.4
Water Channels
...................................................... 32
6.5
Renal Renin-Angiotensin System
....................................... 32
7
Nephron Endowment
................................................. 32
7.1
Nephron Endowment in the Human
.................................... 32
7.2
Effect of Prematurity
................................................. 35
7.3
Factors Important for Normal Kidney Development
....................... 36
7.3.1
Vitamin A
........................................................... 36
7.3.2
Iron
................................................................ 36
7.4
Timing of Nephrogenesis and Nephron Endowment in
Animal Models
....................................................... 37
8
Developmental Programming of the Kidney
............................. 39
8.1
Overview: The Developmental Origins of
Health and Disease Hypothesis
......................................... 39
8.2
Human Epidemiology
................................................. 40
8.2.1
Links of Disease Outcome to Birthweight
................................ 40
8.2.2
Importance of Early Postnatal Growth
.................................. 41
8.3
Common Animal Models Used to Test the DOHaD Hypothesis
............. 41
8.3.1
Maternal Undernutrition
.............................................. 41
8.3.2
Placental Insufficiency
................................................ 42
8.3.3
Maternal Glucocorticoid Exposure
...................................... 42
8.4
Reduced Nephron Endowment: A Common Denominator
in the DOHaD Hypothesis?
............................................ 43
8.4.1
Experimental Manipulations Resulting in a
Reduced Nephron Endowment
......................................... 43
8.5
Link Between Nephron Endowment and Hypertension
.................... 46
8.5.1
The Brenner Hypothesis
............................................... 46
8.5.2
The Link Between Low Nephron Number and
Hypertension in Humans
.............................................. 46
8.6
Mechanisms Leading to a Reduced Nephron Endowment
.................. 47
8.7
Programmed Changes in Renal Gene Expression
......................... 48
8.7.1
Renal Renin-Angiotensin System
....................................... 48
8.7.2
Sodium Channels
.................................................... 48
8.8
Why a Low Nephron Endowment Does Not Always
Lead to Hypertension
................................................. 49
8.8.1
Effect of Gender/Sex
.................................................. 49
8.8.2
Lifestyle Factors: A Congenital Nephron Deficit Renders the
Kidney Susceptible to Secondary Insults
................................. 50
8.8.3
Models and Methodologies: Problems and Pitfalls
........................ 52
8.9
Unilateral Nephrectomy as a Model of Low Nephron
Endowment
......................................................... 53
8.10
Potential Underlying Mechanisms of Developmental
Programming
........................................................ 53
8.10.1
Epigenetic Regulation
................................................. 53
8.10.2
Mitochondrial Dysfunction
............................................ 54
List of Contents
9
Future Directions
.................................................... 54
9.1
Clock Genes
......................................................... 55
9.2
Renal Stem Cells and Renal Regeneration
................................ 56
9.3
New Renal Factors
.................................................... 56
References
................................................................. 58
Subjectindex
............................................................... 79
|
| adam_txt |
List of
Contents
1
Introduction
. 1
2
Morphological Development of the Mammalian Kidney
. 1
2.1
Pronephros
. 3
2.2
Mesonephros
. 3
2.3
Metanephros
. 5
2.4
Renal Vascular Development
. 7
2.5
Development of the Renal Nerves
. 9
3
Genetic Regulation of Metanephric Development
. 9
3.1
Molecular Specification of the Metanephric Blastema
. 10
3.2
Molecular Regulation of Ureteric Budding and
Branching Morphogenesis
. 10
3.3
Molecular Regulation of Nephrogenesis
. 12
3.4
Molecular Regulation of the
Stroma
. 14
3.5
The Renin-Angiotensin System: An Important System
Regulating Renal Development and Function
. 14
3.6
Summary of Molecular Regulation of Metanephric Development
. 15
4
Abnormalities of Renal Development in the Human
. 16
4.1
Hydronephrosis
. 16
4.2
Congenital Anomalies of the Kidney and Urinary Tract
. 16
4.3
Bilateral Renal Agenesis (Potter's Syndrome)
. 17
4.4
Renal Abnormalities Caused by Maternal Drug Use
. 17
4.5
Polycystic Kidney Disease
. 17
5
Methodology to Examine Kidney Development
. 18
5.1
Organ Culture
. 18
5.2
Three-Dimensional and Four-Dimensional Imaging
. 20
5.3
Quantitation of Nephron Number
. 21
5.3.1
Unbiased Counting of Nephrons
. 21
5.3.2
Acid Maceration
. 24
5.4
Microarrays
. 24
5.5
Use of Knock-in/Reporter Mice to Analyse Gene Function
and Expression
. 25
6
Development of Function in the Fetus
. 27
6.1
Mesonephric Function
. 27
List of Contents
6.2
Fetal Metanephric Renal Function
. 27
6.3
Sodium Transporters
. 28
6.4
Water Channels
. 32
6.5
Renal Renin-Angiotensin System
. 32
7
Nephron Endowment
. 32
7.1
Nephron Endowment in the Human
. 32
7.2
Effect of Prematurity
. 35
7.3
Factors Important for Normal Kidney Development
. 36
7.3.1
Vitamin A
. 36
7.3.2
Iron
. 36
7.4
Timing of Nephrogenesis and Nephron Endowment in
Animal Models
. 37
8
Developmental Programming of the Kidney
. 39
8.1
Overview: The Developmental Origins of
Health and Disease Hypothesis
. 39
8.2
Human Epidemiology
. 40
8.2.1
Links of Disease Outcome to Birthweight
. 40
8.2.2
Importance of Early Postnatal Growth
. 41
8.3
Common Animal Models Used to Test the DOHaD Hypothesis
. 41
8.3.1
Maternal Undernutrition
. 41
8.3.2
Placental Insufficiency
. 42
8.3.3
Maternal Glucocorticoid Exposure
. 42
8.4
Reduced Nephron Endowment: A Common Denominator
in the DOHaD Hypothesis?
. 43
8.4.1
Experimental Manipulations Resulting in a
Reduced Nephron Endowment
. 43
8.5
Link Between Nephron Endowment and Hypertension
. 46
8.5.1
The Brenner Hypothesis
. 46
8.5.2
The Link Between Low Nephron Number and
Hypertension in Humans
. 46
8.6
Mechanisms Leading to a Reduced Nephron Endowment
. 47
8.7
Programmed Changes in Renal Gene Expression
. 48
8.7.1
Renal Renin-Angiotensin System
. 48
8.7.2
Sodium Channels
. 48
8.8
Why a Low Nephron Endowment Does Not Always
Lead to Hypertension
. 49
8.8.1
Effect of Gender/Sex
. 49
8.8.2
Lifestyle Factors: A Congenital Nephron Deficit Renders the
Kidney Susceptible to Secondary Insults
. 50
8.8.3
Models and Methodologies: Problems and Pitfalls
. 52
8.9
Unilateral Nephrectomy as a Model of Low Nephron
Endowment
. 53
8.10
Potential Underlying Mechanisms of Developmental
Programming
. 53
8.10.1
Epigenetic Regulation
. 53
8.10.2
Mitochondrial Dysfunction
. 54
List of Contents
9
Future Directions
. 54
9.1
Clock Genes
. 55
9.2
Renal Stem Cells and Renal Regeneration
. 56
9.3
New Renal Factors
. 56
References
. 58
Subjectindex
. 79 |
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| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Factors influencing mammalian kidney development implications for health in adult life Karen M. Moritz ... Berlin [u.a.] Springer Berlin 2008 VII, 78 S., [1] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in Anatomy, Embryology and Cell Biology 196 Kidney growth & development Kidney metabolism Kidneys Growth Nephrology Embryonalentwicklung (DE-588)4070792-1 gnd rswk-swf Niere (DE-588)4042270-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Niere (DE-588)4042270-7 s Embryonalentwicklung (DE-588)4070792-1 s DE-604 Moritz, Karen M. Sonstige oth Erscheint auch als Online-Ausgabe 978-3-540-77767-0 Advances in Anatomy, Embryology and Cell Biology 196 (DE-604)BV002528506 196 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016534210&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Factors influencing mammalian kidney development implications for health in adult life Advances in Anatomy, Embryology and Cell Biology Kidney growth & development Kidney metabolism Kidneys Growth Nephrology Embryonalentwicklung (DE-588)4070792-1 gnd Niere (DE-588)4042270-7 gnd |
| subject_GND | (DE-588)4070792-1 (DE-588)4042270-7 (DE-588)4143413-4 |
| title | Factors influencing mammalian kidney development implications for health in adult life |
| title_auth | Factors influencing mammalian kidney development implications for health in adult life |
| title_exact_search | Factors influencing mammalian kidney development implications for health in adult life |
| title_exact_search_txtP | Factors influencing mammalian kidney development implications for health in adult life |
| title_full | Factors influencing mammalian kidney development implications for health in adult life Karen M. Moritz ... |
| title_fullStr | Factors influencing mammalian kidney development implications for health in adult life Karen M. Moritz ... |
| title_full_unstemmed | Factors influencing mammalian kidney development implications for health in adult life Karen M. Moritz ... |
| title_short | Factors influencing mammalian kidney development |
| title_sort | factors influencing mammalian kidney development implications for health in adult life |
| title_sub | implications for health in adult life |
| topic | Kidney growth & development Kidney metabolism Kidneys Growth Nephrology Embryonalentwicklung (DE-588)4070792-1 gnd Niere (DE-588)4042270-7 gnd |
| topic_facet | Kidney growth & development Kidney metabolism Kidneys Growth Nephrology Embryonalentwicklung Niere Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016534210&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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