Checkpoint responses in cancer therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2008
|
| Schriftenreihe: | Cancer drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Klappentext Inhaltsverzeichnis |
| Beschreibung: | XIII, 314 S. Ill., graph. Darst. |
| ISBN: | 9781588299307 |
Internformat
MARC
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|---|---|---|---|
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| 007 | t | ||
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| 020 | |a 9781588299307 |9 978-1-58829-930-7 | ||
| 035 | |a (OCoLC)255918049 | ||
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| 245 | 1 | 0 | |a Checkpoint responses in cancer therapy |c ed. by Wei Dai |
| 264 | 1 | |a Totowa, NJ |b Humana Press |c 2008 | |
| 300 | |a XIII, 314 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Cancer drug discovery and development | |
| 650 | 0 | 7 | |a Pharmakotherapie |0 (DE-588)4076066-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-016528532 | ||
Datensatz im Suchindex
| _version_ | 1804137699568779264 |
|---|---|
| adam_text | Contents
Preface
.......................................................................................
v
Contributors
............................................................................... xi
1
RB-Pathway: Cell Cycle Control and Cancer Therapy
..... 1
Erik S. Knudsen and Wesley A.
Braden
2
Targeting the P53/MDM2 Pathway for Cancer Therapy
... 19
Christian Klein and Lyubomir T. Vassilev
3 DNA Topoisomerases
as Targets for the
Chemotherapeutic Treatment of Cancer
.......................... 57
Ryan P. Bender and Neil Osheroff
4
Targeting ATM/ATR in the
DNA
Damage Checkpoint....
93
Joseph M.
Ackermann
and Wafik S. El-Deiry
5
Compounds that Abrogate the G2 Checkpoint
................... 117
Takumi Kawabe
6
CDK Inhibitors as
Anticancer
Agents
................................ 135
Timothy A. Yap, L· Rhoda Molife,
and
Johann S. de
Bono
7
CHFR
as a
Potential
Anticancer Target
............................. 163
Minoru
Toyota,
Lisa Kashima,
and Takashi Tokino
8
Antimicrotubule Agents
...................................................... 177
Miguel A. Villalona-Calero,
Larry
Schaaf,
and Robert Turowski
9
Kinesin Motor
Inhibitors as
Effective
Anticancer
Drugs
..............................................................207
Vasiliki Sarli and Athanassios Giannis
10
Targeting the Spindle Checkpoint in Cancer
Chemotherapy
...................................................................227
Jungseog Rang and Hongtao Yu
Contents
11 Antiproliferation Inhibitors Targeting Aurora Kinases......243
Kishore Shakalya and Daruka Mahadevan
12 Piks
as Novel
Targets
for Cancer Drug Design
.................271
Wei Dai, Yali Yang, and
Ning
Jiang
13
Do Histone Deacetylase Inhibitors Target Cell Cycle
Checkpoints that Monitor Heterochromatin Structure?...
291
Brian
Gabrielli,
Frankié
Stevens,
and Heather Beamish
Index
..........................................................................................311
Checkpoint Responses in Cancer Therapy
Edited by
Wei Dai, PhD
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY
Extensive research has uncovered a set of molecular surveillance mechanisms
—
commonly called
checkpoints
—
that tightly monitor cell-cycle processes. Today s
anticancer
drug development has
identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to
uncover a new generation of
anticancer
drugs with improved therapeutic indices based on their ability
to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the
advances made since the 1980s, identifying components of cell-cycle checkpoints and their molecular
regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the
development of
anticancer
drugs. This book s distinguished panel of authors takes a close look at topics
ranging from the major molecular players affecting
DNA
synthesis and the response to
DNA
damage
to advances made in the identification of chemical compounds capable of inhibiting individual mitotic
kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary
of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource
for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction,
and apoptosis.
■
Offers a critical summary of findings for researchers in
the pharmaceutical and biotechnology industries
■
Provides a valuable resource for academic scientists in
cancer research and the study of cell-cycle regulation,
signal transduction, and apoptosis
Contents
RB Pathway: Cell Cycle Control and CancerTherapy. Targeting the P53/MDM2 Pathway for Cancer Therapy.
DNA
Topoisomerases as Targets forthe Chemotherapeutic Treatment of Cancer. Targeting ATM/ATR
in the
DNA
Damage Checkpoint. Compounds that Abrogate the G2 Checkpoint. CDK Inhibitors as
Anticancer
Agents. CHFRas a Potential
Anticancer
Target. Antimicrotubule Agents. Kinesin Motor
Inhibitors as Effective
Anticancer
Drugs. Targeting the Spindle Checkpoint in Cancer Chemotherapy.
Antiproliferation Inhibitors Targeting Aurora Kinases. Plks as Novel Targets for Cancer Drug Design.
Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin
Structure? Index.
|
| adam_txt |
Contents
Preface
.
v
Contributors
. xi
1
RB-Pathway: Cell Cycle Control and Cancer Therapy
. 1
Erik S. Knudsen and Wesley A.
Braden
2
Targeting the P53/MDM2 Pathway for Cancer Therapy
. 19
Christian Klein and Lyubomir T. Vassilev
3 DNA Topoisomerases
as Targets for the
Chemotherapeutic Treatment of Cancer
. 57
Ryan P. Bender and Neil Osheroff
4
Targeting ATM/ATR in the
DNA
Damage Checkpoint.
93
Joseph M.
Ackermann
and Wafik S. El-Deiry
5
Compounds that Abrogate the G2 Checkpoint
. 117
Takumi Kawabe
6
CDK Inhibitors as
Anticancer
Agents
. 135
Timothy A. Yap, L· Rhoda Molife,
and
Johann S. de
Bono
7
CHFR
as a
Potential
Anticancer Target
. 163
Minoru
Toyota,
Lisa Kashima,
and Takashi Tokino
8
Antimicrotubule Agents
. 177
Miguel A. Villalona-Calero,
Larry
Schaaf,
and Robert Turowski
9
Kinesin Motor
Inhibitors as
Effective
Anticancer
Drugs
.207
Vasiliki Sarli and Athanassios Giannis
10
Targeting the Spindle Checkpoint in Cancer
Chemotherapy
.227
Jungseog Rang and Hongtao Yu
Contents
11 Antiproliferation Inhibitors Targeting Aurora Kinases.243
Kishore Shakalya and Daruka Mahadevan
12 Piks
as Novel
Targets
for Cancer Drug Design
.271
Wei Dai, Yali Yang, and
Ning
Jiang
13
Do Histone Deacetylase Inhibitors Target Cell Cycle
Checkpoints that Monitor Heterochromatin Structure?.
291
Brian
Gabrielli,
Frankié
Stevens,
and Heather Beamish
Index
.311
Checkpoint Responses in Cancer Therapy
Edited by
Wei Dai, PhD
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY
Extensive research has uncovered a set of molecular surveillance mechanisms
—
commonly called
"checkpoints"
—
that tightly monitor cell-cycle processes. Today's
anticancer
drug development has
identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to
uncover a new generation of
anticancer
drugs with improved therapeutic indices based on their ability
to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the
advances made since the 1980s, identifying components of cell-cycle checkpoints and their molecular
regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the
development of
anticancer
drugs. This book's distinguished panel of authors takes a close look at topics
ranging from the major molecular players affecting
DNA
synthesis and the response to
DNA
damage
to advances made in the identification of chemical compounds capable of inhibiting individual mitotic
kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary
of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource
for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction,
and apoptosis.
■
Offers a critical summary of findings for researchers in
the pharmaceutical and biotechnology industries
■
Provides a valuable resource for academic scientists in
cancer research and the study of cell-cycle regulation,
signal transduction, and apoptosis
Contents
RB Pathway: Cell Cycle Control and CancerTherapy. Targeting the P53/MDM2 Pathway for Cancer Therapy.
DNA
Topoisomerases as Targets forthe Chemotherapeutic Treatment of Cancer. Targeting ATM/ATR
in the
DNA
Damage Checkpoint. Compounds that Abrogate the G2 Checkpoint. CDK Inhibitors as
Anticancer
Agents. CHFRas a Potential
Anticancer
Target. Antimicrotubule Agents. Kinesin Motor
Inhibitors as Effective
Anticancer
Drugs. Targeting the Spindle Checkpoint in Cancer Chemotherapy.
Antiproliferation Inhibitors Targeting Aurora Kinases. Plks as Novel Targets for Cancer Drug Design.
Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin
Structure? Index. |
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| spelling | Checkpoint responses in cancer therapy ed. by Wei Dai Totowa, NJ Humana Press 2008 XIII, 314 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer drug discovery and development Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Dai, Wei Sonstige oth Erscheint auch als Online-Ausgabe 978-1-59745-274-8 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016528532&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016528532&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Checkpoint responses in cancer therapy Pharmakotherapie (DE-588)4076066-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4076066-2 (DE-588)4073781-0 |
| title | Checkpoint responses in cancer therapy |
| title_auth | Checkpoint responses in cancer therapy |
| title_exact_search | Checkpoint responses in cancer therapy |
| title_exact_search_txtP | Checkpoint responses in cancer therapy |
| title_full | Checkpoint responses in cancer therapy ed. by Wei Dai |
| title_fullStr | Checkpoint responses in cancer therapy ed. by Wei Dai |
| title_full_unstemmed | Checkpoint responses in cancer therapy ed. by Wei Dai |
| title_short | Checkpoint responses in cancer therapy |
| title_sort | checkpoint responses in cancer therapy |
| topic | Pharmakotherapie (DE-588)4076066-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Pharmakotherapie Krebs Medizin |
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