Membrane structural biology: with biochemical and biophysical foundations
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge Univ. Press
2008
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 332 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9780521856553 |
Internformat
MARC
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| 100 | 1 | |a Luckey, Mary |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Membrane structural biology |b with biochemical and biophysical foundations |c Mary Luckey |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge [u.a.] |b Cambridge Univ. Press |c 2008 | |
| 300 | |a XI, 332 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cell Membrane |x physiology | |
| 650 | 4 | |a Membrane Lipids |x physiology | |
| 650 | 4 | |a Membrane Proteins |x physiology | |
| 650 | 4 | |a Membrane lipids | |
| 650 | 4 | |a Membrane proteins | |
| 650 | 4 | |a Membranes (Biology) | |
| 650 | 0 | 7 | |a Physiologie |0 (DE-588)4045981-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Membranproteine |0 (DE-588)4130026-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biochemie |0 (DE-588)4006777-4 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804137664492863488 |
|---|---|
| adam_text | Contents in Brief
Preface xi
1 Introduction 1
2 The Diversity of Membrane Lipids 13
3 Tools for Studying Membrane Components:
Detergents and Model Systems 42
4 Proteins in or at the Bilayer 68
5 Bundles and Barrels 102
6 Functions and Families 127
7 Protein Folding and Biogenesis 160
8 Diffraction and Simulation 191
9 Membrane Enzymes and Transducers 213
10 Transporters and Channels 241
11 Membrane Protein Assemblies 271
12 Themes and Future Directions 309
Appendix I: Abbreviations 315
Appendix II: Single-Letter Codes for Amino Acids 318
Index 319
Contents
Preface page xi
1 Introduction 1
General Features of Membranes 1
Paradigm 1: The Amphiphilic Molecules in
Membranes Assemble Spontaneously
due to the Hydrophobic Effect 4
Paradigm 2: The Fluid Mosaic Model
Describes the Membrane Structure 5
A Shift in the Paradigm: Biomembranes
Have Lateral Domains that Form
Rafts 8
A View for the Future: Dynamic Protein
Complexes Crowd the Membrane
Interior and Extend Its Borders 9
2 The Diversity of Membrane Lipids 13
The Acyl Chains 13
Complex Lipids 17
Phospholipids 17
Sphingolipids 20
Sterols and Linear Isoprenoids 20
The Lipid Bilayer Matrix 23
Structure of Bilayer Lipids 24
Diffusion of Bilayer Lipids 24
box 2.1 Fluorescence techniques 26
Lipid Asymmetry and Membrane
Thickness 26
Lipid Polymorphism 28
Lamellar Phase 28
Hexagonal Phase and the Amphiphile
Shape Hypothesis 29
Cubic Phase 31
Miscibility of Bilayer Lipids 31
box 2.2 Phase diagrams 31
Lateral Domains and Lipid Rafts 33
Detergent-Resistant Membranes 36
Diversity of Lipids 37
box 2.3 Nonlamellar phase lipids and
growth of E. coli 40
3 Tools for Studying Membrane Components:
Detergents and Model Systems 42
Detergents 43
Types of Detergents 43
box 3.1 Surfactants and surface
tension 43
Mechanism of Detergent Action 45
Membrane Solubilization 48
Lipid Removal 50
Model Membranes 50
Monday ers 50
Planar Bilayers 53
box 3.2 Electrophysiology 53
Patch Clamps 55
Supported Bilayers 57
Liposomes from SUVs to GUVs 60
Mixed Micelles and Bicelles 63
Blebs and Blisters 63
Nanodiscs 66
4 Proteins in or at the Bilayer 68
Classes of Proteins that Interact
with the Membrane 68
Proteins at the Bilayer Surface 69
Extrinsic/Peripheral Membrane
Proteins 69
Reversible Interactions of Peripheral
Proteins with the Lipid Bilayer 76
box 4.1 Binding of ligands to surfaces 79
Proteins and Peptides that Insert
into the Membrane 84
Toxins 84
Colicins 85
Peptides 87
SecA: Protein Acrobatics 88
Proteins Embedded in the Membrane 90
Monotopic Proteins 90
Integral Membrane Proteins 90
Protein-Lipid Interactions 94
box 4.2 Electron paramagnetic resonance 97
Hydrophobic Mismatch 98
5 Bundles and Barrels 102
Helical Bundles 102
Bacteriorhodopsin 102
Photosynthetic Reaction Center 107
(3-Barrels 113
box 5.1 NMR determination of membrane
protein structure 116
Porins 118
Specific Porins 120
Iron Receptors 123
6 Functions and Families 127
Membrane Enzymes 127
box 6.1 Surface dilution effects 128
Diacylglycerol Kinase 129
P450 Cytochromes 130
Transport Proteins 131
Transport Classification System 132
Superfamilies of ATPases 134
ABC Transporter Superfamily 134
Group Translocation 135
Symporters 137
Antiporters 138
Ion Channels 138
Membrane Receptors 139
Nicotinic Acetylcholine Receptor 139
G-Protein Coupled Receptors 140
Bioinformatics Tools for Membrane
Protein Families 141
Predicting TM Segments 141
box 6.2 Bioinformatics basics 142
Hydrophobicity Plots 143
Orientation of Membrane Proteins 143
The Positive-Inside Rule 144
box 6.3 Making and testing hydrophobicity
plots 144
Genomic Analysis of Membrane
Proteins 145
box 6.4 Statistical methods for TM
prediction 148
Helix-Helix Interactions 154
Proteomics of Membrane Proteins 156
3-Barrels 157
7 Protein Folding and Biogenesis 160
Protein Folding 161
Folding a-Helical Membrane Proteins 162
box 7.1 Energetics of folding and insertion
a hydrophobic a-helix into the
bilayer 164
Folding Studies of (3-Barrel Membrane
Proteins 167
Other Folding Studies 169
Biogenesis of Membrane Proteins 170
Export from the Cytoplasm 170
box 7.2 Evidence for cleavable signal
sequences involved in protein
translocation 171
box 7.3 Import of mitochondrial proteins 177
Integration of Nascent Proteins into
the Membrane 178
box 7.4 Cross-linking traces nascent
peptides through the translocon into
thebilayer 179
Topogenisis in Membrane Proteins 184
Misfolding Diseases 187
8 Diffraction and Simulation 191
Back to the Bilayer 191
Liquid Crystallography 192
box 8.1 X-ray and neutron scattering 193
Liquid Crystal Theory 193
Joint Refinement of X-Ray and Neutron
Diffraction Data 194
Modeling the Bilayer 196
Simulations of Lipid Bilayers 196
Molecular Dynamics 197
box 8.2 Molecular dynamics calculations 198
Monte Carlo 202
Lipids Observed in X-Ray Structures
of Membrane Proteins 203
The Crystallographer s Art 207
Membrane Simulations 210
9 Membrane Enzymes and Transducers 213
Enzymes 214
OMPLA 214
Prostaglandin H2 Synthase 216
box 9.1 Mechanism of action of
prostaglandin H2 synthase 218
Formate Dehydrogenase 222
Transducers 226
Rhodopsin, a GPCR 227
box 9.2 Efficiency of light-induced signal
transduction 229
box 9.3 Numbering TM helices 231
Mechanosensitive Ion Channels 235
10 Transporters and Channels 241
Transporters 241
LacY and GlpT 242
Mitochondrial ADP/ATP Carrier 249
Channels 253
Aquaporins and Glyceroaquaporins 253
Potassium Channels 258
Calcium ATPase 264
11 Membrane Protein Assemblies 271
FiFo-ATPase/ATPSynthase 272
Subunit Structure and Function 273
Regulation of the F, F0-ATPase 276
Catalytic Mechanism of a Rotary Motor 277
Complexes of the Respiratory Chain 279
Cytochrome be 279
Cytochrome-c Oxidase 284
The Translocon 286
The M. jannaschii Translocon
Structure 286
The Translocon-Ribosome Complex 288
ABC Transporters and Beyond 290
The Vitamin Bu Uptake System 291
Transport across the Inner Membrane 291
Transport across the Outer Membrane 294
Drug Efflux Systems 296
Savl866, an ABC Multidrug Transporter 297
EmrE, Small but Powerful 299
Tripartite Drug Efflux via a Membrane
Vacuum Cleaner 300
AcrB, a Peristaltic Pump 300
AcrA, a Membrane Fusion Protein 302
TolC, the Channel-Tunnel 304
12 Themes and Future Directions 309
Oligomerization 309
Conformational Changes 310
Motifs and Patterns 311
Conclusions 312
Appendix I: Abbreviations 315
Appendix II: Single Letter Codes for Amino
Acids 318
Index 319
|
| adam_txt |
Contents in Brief
Preface xi
1 Introduction 1
2 The Diversity of Membrane Lipids 13
3 Tools for Studying Membrane Components:
Detergents and Model Systems 42
4 Proteins in or at the Bilayer 68
5 Bundles and Barrels 102
6 Functions and Families 127
7 Protein Folding and Biogenesis 160
8 Diffraction and Simulation 191
9 Membrane Enzymes and Transducers 213
10 Transporters and Channels 241
11 Membrane Protein Assemblies 271
12 Themes and Future Directions 309
Appendix I: Abbreviations 315
Appendix II: Single-Letter Codes for Amino Acids 318
Index 319
Contents
Preface page xi
1 Introduction 1
General Features of Membranes 1
Paradigm 1: The Amphiphilic Molecules in
Membranes Assemble Spontaneously
due to the Hydrophobic Effect 4
Paradigm 2: The Fluid Mosaic Model
Describes the Membrane Structure 5
A Shift in the Paradigm: Biomembranes
Have Lateral Domains that Form
"Rafts" 8
A View for the Future: Dynamic Protein
Complexes Crowd the Membrane
Interior and Extend Its Borders 9
2 The Diversity of Membrane Lipids 13
The Acyl Chains 13
Complex Lipids 17
Phospholipids 17
Sphingolipids 20
Sterols and Linear Isoprenoids 20
The Lipid Bilayer Matrix 23
Structure of Bilayer Lipids 24
Diffusion of Bilayer Lipids 24
box 2.1 Fluorescence techniques 26
Lipid Asymmetry and Membrane
Thickness 26
Lipid Polymorphism 28
Lamellar Phase 28
Hexagonal Phase and the Amphiphile
Shape Hypothesis 29
Cubic Phase 31
Miscibility of Bilayer Lipids 31
box 2.2 Phase diagrams 31
Lateral Domains and Lipid Rafts 33
Detergent-Resistant Membranes 36
Diversity of Lipids 37
box 2.3 Nonlamellar phase lipids and
growth of E. coli 40
3 Tools for Studying Membrane Components:
Detergents and Model Systems 42
Detergents 43
Types of Detergents 43
box 3.1 Surfactants and surface
tension 43
Mechanism of Detergent Action 45
Membrane Solubilization 48
Lipid Removal 50
Model Membranes 50
Monday ers 50
Planar Bilayers 53
box 3.2 Electrophysiology 53
Patch Clamps 55
Supported Bilayers 57
Liposomes from SUVs to GUVs 60
Mixed Micelles and Bicelles 63
Blebs and Blisters 63
Nanodiscs 66
4 Proteins in or at the Bilayer 68
Classes of Proteins that Interact
with the Membrane 68
Proteins at the Bilayer Surface 69
Extrinsic/Peripheral Membrane
Proteins 69
Reversible Interactions of Peripheral
Proteins with the Lipid Bilayer 76
box 4.1 Binding of ligands to surfaces 79
Proteins and Peptides that Insert
into the Membrane 84
Toxins 84
Colicins 85
Peptides 87
SecA: Protein Acrobatics 88
Proteins Embedded in the Membrane 90
Monotopic Proteins 90
Integral Membrane Proteins 90
Protein-Lipid Interactions 94
box 4.2 Electron paramagnetic resonance 97
Hydrophobic Mismatch 98
5 Bundles and Barrels 102
Helical Bundles 102
Bacteriorhodopsin 102
Photosynthetic Reaction Center 107
(3-Barrels 113
box 5.1 NMR determination of membrane
protein structure 116
Porins 118
Specific Porins 120
Iron Receptors 123
6 Functions and Families 127
Membrane Enzymes 127
box 6.1 Surface dilution effects 128
Diacylglycerol Kinase 129
P450 Cytochromes 130
Transport Proteins 131
Transport Classification System 132
Superfamilies of ATPases 134
ABC Transporter Superfamily 134
Group Translocation 135
Symporters 137
Antiporters 138
Ion Channels 138
Membrane Receptors 139
Nicotinic Acetylcholine Receptor 139
G-Protein Coupled Receptors 140
Bioinformatics Tools for Membrane
Protein Families 141
Predicting TM Segments 141
box 6.2 Bioinformatics basics 142
Hydrophobicity Plots 143
Orientation of Membrane Proteins 143
The Positive-Inside Rule 144
box 6.3 Making and testing hydrophobicity
plots 144
Genomic Analysis of Membrane
Proteins 145
box 6.4 Statistical methods for TM
prediction 148
Helix-Helix Interactions 154
Proteomics of Membrane Proteins 156
3-Barrels 157
7 Protein Folding and Biogenesis 160
Protein Folding 161
Folding a-Helical Membrane Proteins 162
box 7.1 Energetics of folding and insertion
a hydrophobic a-helix into the
bilayer 164
Folding Studies of (3-Barrel Membrane
Proteins 167
Other Folding Studies 169
Biogenesis of Membrane Proteins 170
Export from the Cytoplasm 170
box 7.2 Evidence for cleavable signal
sequences involved in protein
translocation 171
box 7.3 Import of mitochondrial proteins 177
Integration of Nascent Proteins into
the Membrane 178
box 7.4 Cross-linking traces nascent
peptides through the translocon into
thebilayer 179
Topogenisis in Membrane Proteins 184
Misfolding Diseases 187
8 Diffraction and Simulation 191
Back to the Bilayer 191
Liquid Crystallography 192
box 8.1 X-ray and neutron scattering 193
Liquid Crystal Theory 193
Joint Refinement of X-Ray and Neutron
Diffraction Data 194
Modeling the Bilayer 196
Simulations of Lipid Bilayers 196
Molecular Dynamics 197
box 8.2 Molecular dynamics calculations 198
Monte Carlo 202
Lipids Observed in X-Ray Structures
of Membrane Proteins 203
The Crystallographer's Art 207
Membrane Simulations 210
9 Membrane Enzymes and Transducers 213
Enzymes 214
OMPLA 214
Prostaglandin H2 Synthase 216
box 9.1 Mechanism of action of
prostaglandin H2 synthase 218
Formate Dehydrogenase 222
Transducers 226
Rhodopsin, a GPCR 227
box 9.2 Efficiency of light-induced signal
transduction 229
box 9.3 Numbering TM helices 231
Mechanosensitive Ion Channels 235
10 Transporters and Channels 241
Transporters 241
LacY and GlpT 242
Mitochondrial ADP/ATP Carrier 249
Channels 253
Aquaporins and Glyceroaquaporins 253
Potassium Channels 258
Calcium ATPase 264
11 Membrane Protein Assemblies 271
FiFo-ATPase/ATPSynthase 272
Subunit Structure and Function 273
Regulation of the F, F0-ATPase 276
Catalytic Mechanism of a Rotary Motor 277
Complexes of the Respiratory Chain 279
Cytochrome be \ 279
Cytochrome-c Oxidase 284
The Translocon 286
The M. jannaschii Translocon
Structure 286
The Translocon-Ribosome Complex 288
ABC Transporters and Beyond 290
The Vitamin Bu Uptake System 291
Transport across the Inner Membrane 291
Transport across the Outer Membrane 294
Drug Efflux Systems 296
Savl866, an ABC Multidrug Transporter 297
EmrE, Small but Powerful 299
Tripartite Drug Efflux via a Membrane
Vacuum Cleaner 300
AcrB, a Peristaltic Pump 300
AcrA, a Membrane Fusion Protein 302
TolC, the Channel-Tunnel 304
12 Themes and Future Directions 309
Oligomerization 309
Conformational Changes 310
Motifs and Patterns 311
Conclusions 312
Appendix I: Abbreviations 315
Appendix II: Single Letter Codes for Amino
Acids 318
Index 319 |
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| author | Luckey, Mary |
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| discipline | Biologie Chemie |
| discipline_str_mv | Biologie Chemie |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV023324264 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:54:56Z |
| indexdate | 2024-07-09T21:15:53Z |
| institution | BVB |
| isbn | 9780521856553 |
| language | English |
| lccn | 2007031145 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016508307 |
| oclc_num | 162126895 |
| open_access_boolean | |
| owner | DE-703 DE-29T DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-11 |
| owner_facet | DE-703 DE-29T DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-11 |
| physical | XI, 332 S. zahlr. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Cambridge Univ. Press |
| record_format | marc |
| spelling | Luckey, Mary Verfasser aut Membrane structural biology with biochemical and biophysical foundations Mary Luckey 1. publ. Cambridge [u.a.] Cambridge Univ. Press 2008 XI, 332 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Physiologie (DE-588)4045981-0 gnd rswk-swf Membranproteine (DE-588)4130026-9 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf Membranproteine (DE-588)4130026-9 s DE-604 Biomembran (DE-588)4006884-5 s Biochemie (DE-588)4006777-4 s Physiologie (DE-588)4045981-0 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016508307&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Luckey, Mary Membrane structural biology with biochemical and biophysical foundations Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Physiologie (DE-588)4045981-0 gnd Membranproteine (DE-588)4130026-9 gnd Biochemie (DE-588)4006777-4 gnd Biomembran (DE-588)4006884-5 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4130026-9 (DE-588)4006777-4 (DE-588)4006884-5 |
| title | Membrane structural biology with biochemical and biophysical foundations |
| title_auth | Membrane structural biology with biochemical and biophysical foundations |
| title_exact_search | Membrane structural biology with biochemical and biophysical foundations |
| title_exact_search_txtP | Membrane structural biology with biochemical and biophysical foundations |
| title_full | Membrane structural biology with biochemical and biophysical foundations Mary Luckey |
| title_fullStr | Membrane structural biology with biochemical and biophysical foundations Mary Luckey |
| title_full_unstemmed | Membrane structural biology with biochemical and biophysical foundations Mary Luckey |
| title_short | Membrane structural biology |
| title_sort | membrane structural biology with biochemical and biophysical foundations |
| title_sub | with biochemical and biophysical foundations |
| topic | Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Physiologie (DE-588)4045981-0 gnd Membranproteine (DE-588)4130026-9 gnd Biochemie (DE-588)4006777-4 gnd Biomembran (DE-588)4006884-5 gnd |
| topic_facet | Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Physiologie Membranproteine Biochemie Biomembran |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016508307&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT luckeymary membranestructuralbiologywithbiochemicalandbiophysicalfoundations |