Telomeres and telomerase in ageing, disease, and cancer: molecular mechanisms of adult stem cell ageing
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIV, 311 S. Ill., graph. Darst. 24 cm |
| ISBN: | 3540737081 9783540737087 |
Internformat
MARC
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| 245 | 1 | 0 | |a Telomeres and telomerase in ageing, disease, and cancer |b molecular mechanisms of adult stem cell ageing |c K. Lenhard Rudolph, ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a XIV, 311 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Adult Stem Cells | |
| 650 | 4 | |a Aging |x Molecular aspects | |
| 650 | 4 | |a Aging |x genetics | |
| 650 | 4 | |a Cancer |x Molecular aspects | |
| 650 | 4 | |a Cell Aging |x genetics | |
| 650 | 4 | |a Neoplasms |x genetics | |
| 650 | 4 | |a Telomerase | |
| 650 | 4 | |a Telomerase |x physiology | |
| 650 | 4 | |a Telomere | |
| 650 | 4 | |a Telomere |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804137615771828224 |
|---|---|
| adam_text | Contents
Contributors
...................................................
vii
Introduction
................................................... xi
Part I Telomere Shortening and Ageing
1.
Cellular versus Organismal Aging
............................ 3
Andrew Dillin and
Jan Karlseder
2.
Telomere-Induced Senescence of Primary Cells
................. 23
Richard Allsopp
3.
Telomeres, Senescence, Oxidative Stress, and Heterogeneity
....... 43
João
F. Passos, Glyn
Nelson, and Thomas
von Zglinicki
4.
Initiation of Genomic Instability, Cellular Senescence, and
Organismal Aging by Dysfunctional Telomeres
.................. 57
Sandy Chang
5.
Telomerase Mutations and Premature Ageing in Humans
......... 77
Hong-Yan Du,
Monica Bessler, and Philip J. Mason
Part II Telomerase, Telomeres, and Stem Cell Aging
6.
Mechanisms of Stem Cell Ageing
.............................
Ill
Amanda Waterstrat, Erin Oakley, Alison Miller, Carol Swiderski,
Ying Liang, and Gary Van
Zant
7.
Senescence Signatures of Human Hematopoietic Stem Cells
....... 141
Stefan
Zimmermann
and
Uwe
M
Martens
vi
Contents
8.
Telomere
Shortening Induces Cell Intrinsic Checkpoints
and Environmental Alterations Limiting Adult
Stem Cell Function
......................................... 161
Luis Guachalla Gutierrez and Zhenyu Ju
9.
pl6INK4a and Stem Cell Ageing: A Telomere-Independent
Process?
.................................................. 181
Norman E.
Sharpless
10.
Telomerase as a Potential Regulator of Tissue
Progenitor Cells
............................................ 203
Steven E. Artandi
Part III Telomeres,
DNA
Damage and Cancer
11.
Telomere Shortening and Telomerase Activation during
Cancer Formation
.......................................... 213
K. Lenhard Rudolph
12.
Telomere Binding Proteins and Disease
........................ 229
Maria
A. Blasco
Part IV Therapeutic Targets
13.
Targeting Telomerase: Therapeutic Options for
Cancer Treatment
......................................... 247
W.
Nicol
Keith and Alan E.
Bilsland
14.
Werner Syndrome, Telomeres, and Stress Signaling:
Implications for Future Therapies?
........................... 285
Terence Davis and David Kipling
Index
......................................................... 309
The understanding of the molecular mechanisms underlying
the ageing process is essential to improve quality of life and
health span in the growing populations of the elderly.
Telomere shortening represents one of the basic aspects of age¬
ing and telomere dysfunction could contribute to the accumula¬
tion of
DNA
damage during ageing. This book summarizes
experimental evidence and clinical data indicating that telomere
dysfunction influences human ageing, diseases and cancer.
In addition, the book describes our current knowledge on
checkpoints that limit cellular lifespan (senescence) and survival
(apoptosis, crisis) in response to telomere dysfunction.
A special focus of the book is on adult stem cells. There is
emerging evidence that adult stem cell ageing impairs organis-
mal fitness and survival and contributes to cancer formation
(cancer stem cells). The book summarizes basic mechanisms of
adult stem cell ageing. Moreover, the authors describe evidence
that telomere dysfunction impairs stem cell function by inducing
cell intrinsic checkpoints as well as environmental alterations.
All of these subjects are of great interest for ageing researchers,
physicians and students and should provide a rational basis
for beginning to identify molecular targets for novel therapies
that aim to improve quality of life during ageing.
|
| adam_txt |
Contents
Contributors
.
vii
Introduction
. xi
Part I Telomere Shortening and Ageing
1.
Cellular versus Organismal Aging
. 3
Andrew Dillin and
Jan Karlseder
2.
Telomere-Induced Senescence of Primary Cells
. 23
Richard Allsopp
3.
Telomeres, Senescence, Oxidative Stress, and Heterogeneity
. 43
João
F. Passos, Glyn
Nelson, and Thomas
von Zglinicki
4.
Initiation of Genomic Instability, Cellular Senescence, and
Organismal Aging by Dysfunctional Telomeres
. 57
Sandy Chang
5.
Telomerase Mutations and Premature Ageing in Humans
. 77
Hong-Yan Du,
Monica Bessler, and Philip J. Mason
Part II Telomerase, Telomeres, and Stem Cell Aging
6.
Mechanisms of Stem Cell Ageing
.
Ill
Amanda Waterstrat, Erin Oakley, Alison Miller, Carol Swiderski,
Ying Liang, and Gary Van
Zant
7.
Senescence Signatures of Human Hematopoietic Stem Cells
. 141
Stefan
Zimmermann
and
Uwe
M
Martens
vi
Contents
8.
Telomere
Shortening Induces Cell Intrinsic Checkpoints
and Environmental Alterations Limiting Adult
Stem Cell Function
. 161
Luis Guachalla Gutierrez and Zhenyu Ju
9.
pl6INK4a and Stem Cell Ageing: A Telomere-Independent
Process?
. 181
Norman E.
Sharpless
10.
Telomerase as a Potential Regulator of Tissue
Progenitor Cells
. 203
Steven E. Artandi
Part III Telomeres,
DNA
Damage and Cancer
11.
Telomere Shortening and Telomerase Activation during
Cancer Formation
. 213
K. Lenhard Rudolph
12.
Telomere Binding Proteins and Disease
. 229
Maria
A. Blasco
Part IV Therapeutic Targets
13.
Targeting Telomerase: Therapeutic Options for
Cancer Treatment
. 247
W.
Nicol
Keith and Alan E.
Bilsland
14.
Werner Syndrome, Telomeres, and Stress Signaling:
Implications for Future Therapies?
. 285
Terence Davis and David Kipling
Index
. 309
The understanding of the molecular mechanisms underlying
the ageing process is essential to improve quality of life and
'health span' in the growing populations of the elderly.
Telomere shortening represents one of the basic aspects of age¬
ing and telomere dysfunction could contribute to the accumula¬
tion of
DNA
damage during ageing. This book summarizes
experimental evidence and clinical data indicating that telomere
dysfunction influences human ageing, diseases and cancer.
In addition, the book describes our current knowledge on
checkpoints that limit cellular lifespan (senescence) and survival
(apoptosis, crisis) in response to telomere dysfunction.
A special focus of the book is on adult stem cells. There is
emerging evidence that adult stem cell ageing impairs organis-
mal fitness and survival and contributes to cancer formation
(cancer stem cells). The book summarizes basic mechanisms of
adult stem cell ageing. Moreover, the authors describe evidence
that telomere dysfunction impairs stem cell function by inducing
cell intrinsic checkpoints as well as environmental alterations.
All of these subjects are of great interest for ageing researchers,
physicians and students and should provide a rational basis
for beginning to identify molecular targets for novel therapies
that aim to improve quality of life during ageing. |
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| index_date | 2024-07-02T20:43:31Z |
| indexdate | 2024-07-09T21:15:07Z |
| institution | BVB |
| isbn | 3540737081 9783540737087 |
| language | English |
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| publisher | Springer |
| record_format | marc |
| spelling | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing K. Lenhard Rudolph, ed. Berlin [u.a.] Springer 2008 XIV, 311 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Adult Stem Cells Aging Molecular aspects Aging genetics Cancer Molecular aspects Cell Aging genetics Neoplasms genetics Telomerase Telomerase physiology Telomere Telomere physiology Adulte Stammzelle (DE-588)4699649-7 gnd rswk-swf Telomer Molekulargenetik (DE-588)4310952-4 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Telomerase (DE-588)4513124-7 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Altern (DE-588)4068596-2 s Telomer Molekulargenetik (DE-588)4310952-4 s DE-604 Krebs Medizin (DE-588)4073781-0 s Adulte Stammzelle (DE-588)4699649-7 s Telomerase (DE-588)4513124-7 s Rudolph, Karl Lenhard 1969- Sonstige (DE-588)121126102 oth Erscheint auch als Online-Ausgabe 978-3-540-73709-4 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016476556&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016476556&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing Adult Stem Cells Aging Molecular aspects Aging genetics Cancer Molecular aspects Cell Aging genetics Neoplasms genetics Telomerase Telomerase physiology Telomere Telomere physiology Adulte Stammzelle (DE-588)4699649-7 gnd Telomer Molekulargenetik (DE-588)4310952-4 gnd Altern (DE-588)4068596-2 gnd Telomerase (DE-588)4513124-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4699649-7 (DE-588)4310952-4 (DE-588)4068596-2 (DE-588)4513124-7 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing |
| title_auth | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing |
| title_exact_search | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing |
| title_exact_search_txtP | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing |
| title_full | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing K. Lenhard Rudolph, ed. |
| title_fullStr | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing K. Lenhard Rudolph, ed. |
| title_full_unstemmed | Telomeres and telomerase in ageing, disease, and cancer molecular mechanisms of adult stem cell ageing K. Lenhard Rudolph, ed. |
| title_short | Telomeres and telomerase in ageing, disease, and cancer |
| title_sort | telomeres and telomerase in ageing disease and cancer molecular mechanisms of adult stem cell ageing |
| title_sub | molecular mechanisms of adult stem cell ageing |
| topic | Adult Stem Cells Aging Molecular aspects Aging genetics Cancer Molecular aspects Cell Aging genetics Neoplasms genetics Telomerase Telomerase physiology Telomere Telomere physiology Adulte Stammzelle (DE-588)4699649-7 gnd Telomer Molekulargenetik (DE-588)4310952-4 gnd Altern (DE-588)4068596-2 gnd Telomerase (DE-588)4513124-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Adult Stem Cells Aging Molecular aspects Aging genetics Cancer Molecular aspects Cell Aging genetics Neoplasms genetics Telomerase Telomerase physiology Telomere Telomere physiology Adulte Stammzelle Telomer Molekulargenetik Altern Krebs Medizin Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016476556&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016476556&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT rudolphkarllenhard telomeresandtelomeraseinageingdiseaseandcancermolecularmechanismsofadultstemcellageing |