Drug targets in kinetoplastid parasites:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media [u.a.]
2008
|
| Schriftenreihe: | Advances in experimental medicine and biology
625 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 157 S. Ill., graph. Darst. |
| ISBN: | 9780387775692 |
Internformat
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| 245 | 1 | 0 | |a Drug targets in kinetoplastid parasites |c ed. by Hemanta K. Majumder |
| 264 | 1 | |a New York, NY |b Springer Science + Business Media [u.a.] |c 2008 | |
| 300 | |a XIX, 157 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 625 | |
| 650 | 2 | |a Leishmaniasis |a drug therapy | |
| 650 | 2 | |a Membrane Glycoproteins |a drug effects | |
| 650 | 2 | |a Protozoan Proteins |a drug effects | |
| 650 | 4 | |a Antiprotozoal agents | |
| 650 | 4 | |a Drug targeting | |
| 650 | 4 | |a Kinetoplastida | |
| 650 | 4 | |a Leishmaniasis |x Chemotherapy | |
| 650 | 4 | |a Leishmaniasis |x drug therapy | |
| 650 | 4 | |a Membrane Glycoproteins |x drug effects | |
| 650 | 4 | |a Protozoan Proteins |x drug effects | |
| 650 | 0 | 7 | |a Kinetoplastida |0 (DE-588)4772258-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Targeted drug delivery |0 (DE-588)4302415-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Parasitäre Krankheit |0 (DE-588)4044638-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antiparasitäres Mittel |0 (DE-588)4219802-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Kinetoplastida |0 (DE-588)4772258-7 |D s |
| 689 | 0 | 1 | |a Parasitäre Krankheit |0 (DE-588)4044638-4 |D s |
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| 700 | 1 | |a Majumder, Hemanta K. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804137585508876288 |
|---|---|
| adam_text | DRUG TARGETS IN KINETOPLASTID PARASITES EDITED BY HEMANTA K. MAJUMDER
MOLECULAR PARASITOLOGY LABORATORY, INDIAN INSTITUTE OF CHEMICAL BIOLOGY,
KOLKATA, INDIA SPRINGER SCIENCE+BUSINESS MEDIA, LLC LANDES BIOSCIENCE
CONTENTS 1. ARSENITE RESISTANCE IN LEISHMANIA AND POSSIBLE DRUG TARGETS
1 GAGANMEET SINGH, K.G. JAYANARAYAN AND CHINMOY S. DEY ABSTRACT 1
INTRODUCTION 1 ARSENITE RESISTANCE IN LEISHMANIA 2 POTENTIAL DRUG
TARGETS 3 CONCLUSION 5 2. UNIQUE CHARACTERISTICS OF THE KINETOPLAST DNA
REPLICATION MACHINERY PROVIDE POTENTIAL DRUG TARGETS IN TRYPANOSOMATIDS
9 DOTAN SELA, NETA MILMAN, IRIT KAPELLER, AVIAD ZICK, RACHEL BEZALEL,
NURIT YAFFE AND JOSEPH SHLOMAI REEVALUATING THE KINETOPLAST AS A
POTENTIAL TARGET FOR ANTI-TRYPANOSOMAL DRUGS 9 THE KDNA NETWORK AND ITS
MONOMERIC COMPONENTS 10 UNIQUE CHARACTERISTICS OF THE KDNA REPLICATION
SYSTEM 10 REPLICATION OF FREE KDNA MINICIRCLES AND CATENATED MAXICIRCLES
13 REGULATION OF KDNA REPLICATION 14 CONCLUDING REMARKS 16 3. DRUGS AND
TRANSPORTERS IN KINETOPLASTID PROTOZOA 22 SCOTT M. LANDFEAR ABSTRACT 22
INTRODUCTION 22 ROLES OF MEMBRANE TRANSPORT PROTEINS AMONG THE
KINETOPLASTIDA 23 LEISHMANIA GLUCOSE TRANSPORTERS 26 LEISHMANIA PURINE
TRANSPORTERS 28 XVI CONTENTS 4. SELECTIVE LEAD COMPOUNDS AGAINST
KINETOPLASTID TUBULIN 33 R.E. MORGAN AND K.A. WERBOVETZ ABSTRACT 33
INTRODUCTION 33 ORYZALIN AS A LEAD COMPOUND AGAINST KINETOPLASTID
TUBULIN 36 AROMATIC THIOCYANATES AS LEAD COMPOUNDS 42 GENERATING NEW
LEADS 44 CONCLUSION . 44 5. FISHING FOR ANTI-LEISHMANIA DRUGS:
PRINCIPLES AND PROBLEMS 48 EMANUELA HANDMAN, LUKASZ KEDZIERSKI,
ALESSANDRO D. UBOLDI AND JAMES W. GODING
ABSTRACT............................... ....... ....... ............. 48
INTRODUCTION
...*........»*..***...**..**.**.**..***..***.*...*****.*...*.*..***..**.....*..*..**..*..***...*»»***»»*»»»*
48 THE DISEASE BURDEN OF LEISHMANIASIS 49 TRANSMISSION AND EPIDEMIOLOGY
49 DISEASE MANIFESTATIONS 50 MANAGEMENT AND CONTROL OF LEISHMANIASIS 51
THE IMPACT OF NEW TECHNOLOGIES ON DRUG DISCOVERY 52 HIGH THROUGHPUT
SCREENING 52 STRUCTURE-BASED DRUG DISCOVERY 53 PROTEOMICS 53 MONOCLONAL
ANTIBODIES 54 NATURAL PRODUCTS 54 TARGET SELECTION AND VALIDATION 55
PROTEINS AND METABOLIC PATHWAYS UNIQUE TO THE PARASITE 55 PROTEINS
ESSENTIAL FOR PARASITE SURVIVAL AND VIRULENCE FACTORS 56 TARGET
VALIDATION 56 CONCLUDING REMARKS 57 6. STEROL 14-DEMETHYLASE INHIBITORS
FOR TRYPANOSOMA CRUZI INFECTIONS 61 FREDERICK S. BUCKNER ABSTRACT 61
INTRODUCTION 61 CHAGAS
DISEASE...................................................................................................................
62 DRUG DEVELOPMENT FOR CHAGAS DISEASE . 62 STEROL BIOSYNTHESIS*OVERVIEW
63 STEROL 14-DEMETHYLASE (CYP51) AND AZOLE INHIBITORS 65 STEROLS OF T.
CRUZI 66 ACTIVITY OF AZOLE COMPOUNDS AGAINST T. CRUZI 67 THE DEVELOPMENT
STATUS OF STEROL 14-DEMETHYLASE INHIBITORS 76 CAN A BETTER STEROL
14-DEMETHYLASE INHIBITOR BE DEVELOPED AGAINST T. CRUZF! 76 SUMMARY 77
CONTENTS XV JJ 7. HISTONE DEACETYLASES 81 DAVID HORN ABSTRACT 81
INTRODUCTION 81 THE DEACETYLASES 81 THE INHIBITORS 83 CURRENT RESEARCH
83 SUMMARY ....... ............................ 85 8. TARGETING
GLYCOPROTEINS OR GLYCOLIPIDS AND THEIR METABOLIC PATHWAYS FOR
ANTIPARASITE THERAPY ... 87 SUMI MUKHOPADHYAY NEE BANDYOPADHYAY AND
CHITRA MANDAL ABSTRACT 87 AN INTRODUCTION TO THE KINETOPLASTID PARASITES
87 TRYPANOSOMIASIS 87 LEISHMANIASIS 88 WHY TARGET GLYCOPROTEINS AND
GLYCOLIPIDS? 89 GLYCOCONJUGATES OF TRYPANOSOMES 91 BIOLOGICAL RELEVANCE
OF GLYCOCONJUGATES IN TRYPANOSOMIASIS 91 TARGETING VSG EPITOPES 91
TARGETING MUCIN GLYCOPROTEINS 92 LACTOSE DERIVATIVES ARE INHIBITORS OF
TRANS-SIALIDASE PRESENT IN THE MUCINS 92 GLYCOCONJUGATE BIOSYNTHETIC
MACHINERY IN TRYPANOSOME 93 TARGETING ENZYMES OF THE BIOSYNTHETIC
PATHWAY 93 GLYCOCONJUGATES OF LEISHMANIA 93 BIOLOGICAL RELEVANCE 94
DEVELOPMENT OF ANTI-LEISHMANIALS BY TARGETING 96 GP63 PRODUCING ENZYMES
96 GALACTOFURANOSE ON LPG 96 SIALOGLYCANS 97 OTHER GLYCOCONJUGATES 97
PPG 98 GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) LIPIDS 98 ENZYMES PRODUCING
GLYCOPROTEINS 98 AS DRUG CARRIER 98 PERSPECTIVE 99 9. DNA TOPOISOMERASES
OF LEISHMANIA: THE POTENTIAL TARGETS FOR ANTI-LEISHMANIAL THERAPY 103
BENU BRATA DAS, AGNEYO GANGULY AND HEMANTA K.. MAJUMDER ABSTRACT 103
INTRODUCTION 103 DNA TOPOISOMERASES: THE WONDER ENZYME 104
CLASSIFICATION OF DNA TOPOISOMERASES 104 TOPOISOMERASES OF KINETOPLASTID
PARASITES 106 TOPOISOMERASES AS THERAPEUTIC TARGETS 110 CONCLUSION 113
XVIII CONTENTS 10. ANTIPARASITIC CHEMOTHERAPY: TINKERING WITH THE PURINE
SALVAGE PATHWAY 116 ALOK KUMAR DATTA, RUPAK DATTA AND BANIBRATA SEN
SUMMARY 116 GENERAL STRATEGIES FOR DEVELOPMENT AND CHARACTERISATION OF
DRUG TARGETS IN TRYPANOSOMATIDS 117 ACQUISITION AND ASSIMILATION OF
PURINES IN L. DONOVANI PROMASTIGOTES 118 PURINE METABOLISM IN L DONOVANI
AMASTIGOTES 119 PURINE SALVAGE ENZYMES AS TARGETS FOR STRUCTURE-BASED
INHIBITOR DESIGN 119 PROSPECTS OF ADENOSINE KINASE (ADK) AS THE DRUG
TARGET 120 GENERA] BIOCHEMICAL PROPERTIES OF THE I. DONOVANI ADK 121
STRUCTURE OF ADK FROM DIFFERENT SOURCES 121 SEQUENCE CHARACTERISTICS OF
LDADK GENE AND HOMOLOGY MODEL-BASED STRUCTURAL ANALYSIS OF THE PROTEIN
122 IDENTIFICATION OF POTENTIAL AMINO ACID RESIDUES INVOLVED IN
CATALYSIS 124 MECHANISM OF ADO BINDING 125 MECHANISM OF PHOSPHATE
TRANSFER 126 PRODUCT-MEDIATED ENZYME REGULATION 126 CONCLUSIONS AND
PERSPECTIVES 129 11. SEARCHING THE TRITRYP GENOMES FOR DRUG TARGETS ...
133 PETER J. MYLER ABSTRACT 133 TRITRYP GENOME CONTENT 133 COMPUTATIONAL
APPROACHES FOR DRUG TARGET SELECTION 135 DATABASES OF TRITRYP METABOLISM
136 IDENTIFICATION OF METABOLIC CHOKE-POINTS 137 SEARCHING FOR
PARASITE ORTHOLOGUES OF KNOWN DRUG TARGETS 137 MATCHING DRUG-LIKE
CHEMICALS TO PARASITE PROTEINS 138 CONCLUSION 138 12. PURINE AND
PYRIMIDINE METABOLISM IN LEISHMANIA 141 NICOLA S. CARTER, PHILLIP YATES,
CASSANDRA S. ARENDT, JAN M. BOITZ AND BUDDY ULLMAN ABSTRACT 141
NOMENCLATURE 141 PURINE METABOLISM 142 PURINE TRANSPORT IN LEISHMANIA
142 PURINE TRANSPORTERS AS DRUG TARGETS IN LEISHMANIA 143
STRUCTURE-FUNCTION STUDIES ON PURINE TRANSPORTERS 144 PURINE SALVAGE
ENZYMES OF LEISHMANIA 146 PURINE SALVAGE ENZYMES AS DRUG TARGETS IN
LEISHMANIA 146 THE COMPARTMENTALIZATION OF PURINE SALVAGE IN LEISHMANIA
148 PYRIMIDINE METABOLISM 148 PYRIMIDINE BIOSYNTHESIS IN LEISHMANIA 149
PYRIMIDINE SALVAGE AND NUCLEOTIDE SYNTHESIS IN LEISHMANIA 150 THE
PYRIMIDINE PATHWAY AS A DRUG TARGET IN LEISHMANIA 150 SUMMARY 151 INDEX
155
|
| adam_txt |
DRUG TARGETS IN KINETOPLASTID PARASITES EDITED BY HEMANTA K. MAJUMDER
MOLECULAR PARASITOLOGY LABORATORY, INDIAN INSTITUTE OF CHEMICAL BIOLOGY,
KOLKATA, INDIA SPRINGER SCIENCE+BUSINESS MEDIA, LLC LANDES BIOSCIENCE
CONTENTS 1. ARSENITE RESISTANCE IN LEISHMANIA AND POSSIBLE DRUG TARGETS
1 GAGANMEET SINGH, K.G. JAYANARAYAN AND CHINMOY S. DEY ABSTRACT 1
INTRODUCTION 1 ARSENITE RESISTANCE IN LEISHMANIA 2 POTENTIAL DRUG
TARGETS 3 CONCLUSION 5 2. UNIQUE CHARACTERISTICS OF THE KINETOPLAST DNA
REPLICATION MACHINERY PROVIDE POTENTIAL DRUG TARGETS IN TRYPANOSOMATIDS
9 DOTAN SELA, NETA MILMAN, IRIT KAPELLER, AVIAD ZICK, RACHEL BEZALEL,
NURIT YAFFE AND JOSEPH SHLOMAI REEVALUATING THE KINETOPLAST AS A
POTENTIAL TARGET FOR ANTI-TRYPANOSOMAL DRUGS 9 THE KDNA NETWORK AND ITS
MONOMERIC COMPONENTS 10 UNIQUE CHARACTERISTICS OF THE KDNA REPLICATION
SYSTEM 10 REPLICATION OF FREE KDNA MINICIRCLES AND CATENATED MAXICIRCLES
13 REGULATION OF KDNA REPLICATION 14 CONCLUDING REMARKS 16 3. DRUGS AND
TRANSPORTERS IN KINETOPLASTID PROTOZOA 22 SCOTT M. LANDFEAR ABSTRACT 22
INTRODUCTION 22 ROLES OF MEMBRANE TRANSPORT PROTEINS AMONG THE
KINETOPLASTIDA 23 LEISHMANIA GLUCOSE TRANSPORTERS 26 LEISHMANIA PURINE
TRANSPORTERS 28 XVI CONTENTS 4. SELECTIVE LEAD COMPOUNDS AGAINST
KINETOPLASTID TUBULIN 33 R.E. MORGAN AND K.A. WERBOVETZ ABSTRACT 33
INTRODUCTION 33 ORYZALIN AS A LEAD COMPOUND AGAINST KINETOPLASTID
TUBULIN 36 AROMATIC THIOCYANATES AS LEAD COMPOUNDS 42 GENERATING NEW
LEADS 44 CONCLUSION . 44 5. FISHING FOR ANTI-LEISHMANIA DRUGS:
PRINCIPLES AND PROBLEMS 48 EMANUELA HANDMAN, LUKASZ KEDZIERSKI,
ALESSANDRO D. UBOLDI AND JAMES W. GODING
ABSTRACT. . . . 48
INTRODUCTION
.*.»*.***.**.**.**.**.***.***.*.*****.*.*.*.***.**.*.*.**.*.***.*»»***»»*»»»*
48 THE DISEASE BURDEN OF LEISHMANIASIS 49 TRANSMISSION AND EPIDEMIOLOGY
49 DISEASE MANIFESTATIONS 50 MANAGEMENT AND CONTROL OF LEISHMANIASIS 51
THE IMPACT OF NEW TECHNOLOGIES ON DRUG DISCOVERY 52 HIGH THROUGHPUT
SCREENING 52 STRUCTURE-BASED DRUG DISCOVERY 53 PROTEOMICS 53 MONOCLONAL
ANTIBODIES 54 NATURAL PRODUCTS 54 TARGET SELECTION AND VALIDATION 55
PROTEINS AND METABOLIC PATHWAYS UNIQUE TO THE PARASITE 55 PROTEINS
ESSENTIAL FOR PARASITE SURVIVAL AND VIRULENCE FACTORS 56 TARGET
VALIDATION 56 CONCLUDING REMARKS 57 6. STEROL 14-DEMETHYLASE INHIBITORS
FOR TRYPANOSOMA CRUZI INFECTIONS 61 FREDERICK S. BUCKNER ABSTRACT 61
INTRODUCTION 61 CHAGAS
DISEASE.
62 DRUG DEVELOPMENT FOR CHAGAS DISEASE . 62 STEROL BIOSYNTHESIS*OVERVIEW
63 STEROL 14-DEMETHYLASE (CYP51) AND AZOLE INHIBITORS 65 STEROLS OF T.
CRUZI 66 ACTIVITY OF AZOLE COMPOUNDS AGAINST T. CRUZI 67 THE DEVELOPMENT
STATUS OF STEROL 14-DEMETHYLASE INHIBITORS 76 CAN A BETTER STEROL
14-DEMETHYLASE INHIBITOR BE DEVELOPED AGAINST T. CRUZF! 76 SUMMARY 77
CONTENTS XV JJ 7. HISTONE DEACETYLASES 81 DAVID HORN ABSTRACT 81
INTRODUCTION 81 THE DEACETYLASES 81 THE INHIBITORS 83 CURRENT RESEARCH
83 SUMMARY . . 85 8. TARGETING
GLYCOPROTEINS OR GLYCOLIPIDS AND THEIR METABOLIC PATHWAYS FOR
ANTIPARASITE THERAPY . 87 SUMI MUKHOPADHYAY NEE BANDYOPADHYAY AND
CHITRA MANDAL ABSTRACT 87 AN INTRODUCTION TO THE KINETOPLASTID PARASITES
87 TRYPANOSOMIASIS 87 LEISHMANIASIS 88 WHY TARGET GLYCOPROTEINS AND
GLYCOLIPIDS? 89 GLYCOCONJUGATES OF TRYPANOSOMES 91 BIOLOGICAL RELEVANCE
OF GLYCOCONJUGATES IN TRYPANOSOMIASIS 91 TARGETING VSG EPITOPES 91
TARGETING MUCIN GLYCOPROTEINS 92 LACTOSE DERIVATIVES ARE INHIBITORS OF
TRANS-SIALIDASE PRESENT IN THE MUCINS 92 GLYCOCONJUGATE BIOSYNTHETIC
MACHINERY IN TRYPANOSOME 93 TARGETING ENZYMES OF THE BIOSYNTHETIC
PATHWAY 93 GLYCOCONJUGATES OF LEISHMANIA 93 BIOLOGICAL RELEVANCE 94
DEVELOPMENT OF ANTI-LEISHMANIALS BY TARGETING 96 GP63 PRODUCING ENZYMES
96 GALACTOFURANOSE ON LPG 96 SIALOGLYCANS 97 OTHER GLYCOCONJUGATES 97
PPG 98 GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) LIPIDS 98 ENZYMES PRODUCING
GLYCOPROTEINS 98 AS DRUG CARRIER 98 PERSPECTIVE 99 9. DNA TOPOISOMERASES
OF LEISHMANIA: THE POTENTIAL TARGETS FOR ANTI-LEISHMANIAL THERAPY 103
BENU BRATA DAS, AGNEYO GANGULY AND HEMANTA K. MAJUMDER ABSTRACT 103
INTRODUCTION 103 DNA TOPOISOMERASES: THE WONDER ENZYME 104
CLASSIFICATION OF DNA TOPOISOMERASES 104 TOPOISOMERASES OF KINETOPLASTID
PARASITES 106 TOPOISOMERASES AS THERAPEUTIC TARGETS 110 CONCLUSION 113
XVIII CONTENTS 10. ANTIPARASITIC CHEMOTHERAPY: TINKERING WITH THE PURINE
SALVAGE PATHWAY 116 ALOK KUMAR DATTA, RUPAK DATTA AND BANIBRATA SEN
SUMMARY 116 GENERAL STRATEGIES FOR DEVELOPMENT AND CHARACTERISATION OF
DRUG TARGETS IN TRYPANOSOMATIDS 117 ACQUISITION AND ASSIMILATION OF
PURINES IN L. DONOVANI PROMASTIGOTES 118 PURINE METABOLISM IN L DONOVANI
AMASTIGOTES 119 PURINE SALVAGE ENZYMES AS TARGETS FOR STRUCTURE-BASED
INHIBITOR DESIGN 119 PROSPECTS OF ADENOSINE KINASE (ADK) AS THE DRUG
TARGET 120 GENERA] BIOCHEMICAL PROPERTIES OF THE I. DONOVANI ADK 121
STRUCTURE OF ADK FROM DIFFERENT SOURCES 121 SEQUENCE CHARACTERISTICS OF
LDADK GENE AND HOMOLOGY MODEL-BASED STRUCTURAL ANALYSIS OF THE PROTEIN
122 IDENTIFICATION OF POTENTIAL AMINO ACID RESIDUES INVOLVED IN
CATALYSIS 124 MECHANISM OF ADO BINDING 125 MECHANISM OF PHOSPHATE
TRANSFER 126 PRODUCT-MEDIATED ENZYME REGULATION 126 CONCLUSIONS AND
PERSPECTIVES 129 11. SEARCHING THE TRITRYP GENOMES FOR DRUG TARGETS .
133 PETER J. MYLER ABSTRACT 133 TRITRYP GENOME CONTENT 133 COMPUTATIONAL
APPROACHES FOR DRUG TARGET SELECTION 135 DATABASES OF TRITRYP METABOLISM
136 IDENTIFICATION OF METABOLIC "CHOKE-POINTS" 137 SEARCHING FOR
PARASITE ORTHOLOGUES OF KNOWN DRUG TARGETS 137 MATCHING DRUG-LIKE
CHEMICALS TO PARASITE PROTEINS 138 CONCLUSION 138 12. PURINE AND
PYRIMIDINE METABOLISM IN LEISHMANIA 141 NICOLA S. CARTER, PHILLIP YATES,
CASSANDRA S. ARENDT, JAN M. BOITZ AND BUDDY ULLMAN ABSTRACT 141
NOMENCLATURE 141 PURINE METABOLISM 142 PURINE TRANSPORT IN LEISHMANIA
142 PURINE TRANSPORTERS AS DRUG TARGETS IN LEISHMANIA 143
STRUCTURE-FUNCTION STUDIES ON PURINE TRANSPORTERS 144 PURINE SALVAGE
ENZYMES OF LEISHMANIA 146 PURINE SALVAGE ENZYMES AS DRUG TARGETS IN
LEISHMANIA 146 THE COMPARTMENTALIZATION OF PURINE SALVAGE IN LEISHMANIA
148 PYRIMIDINE METABOLISM 148 PYRIMIDINE BIOSYNTHESIS IN LEISHMANIA 149
PYRIMIDINE SALVAGE AND NUCLEOTIDE SYNTHESIS IN LEISHMANIA 150 THE
PYRIMIDINE PATHWAY AS A DRUG TARGET IN LEISHMANIA 150 SUMMARY 151 INDEX
155 |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV023271477 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:36:07Z |
| indexdate | 2024-07-09T21:14:38Z |
| institution | BVB |
| isbn | 9780387775692 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016456475 |
| oclc_num | 182857059 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XIX, 157 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer Science + Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Drug targets in kinetoplastid parasites ed. by Hemanta K. Majumder New York, NY Springer Science + Business Media [u.a.] 2008 XIX, 157 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 625 Leishmaniasis drug therapy Membrane Glycoproteins drug effects Protozoan Proteins drug effects Antiprotozoal agents Drug targeting Kinetoplastida Leishmaniasis Chemotherapy Kinetoplastida (DE-588)4772258-7 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Parasitäre Krankheit (DE-588)4044638-4 gnd rswk-swf Antiparasitäres Mittel (DE-588)4219802-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kinetoplastida (DE-588)4772258-7 s Parasitäre Krankheit (DE-588)4044638-4 s Antiparasitäres Mittel (DE-588)4219802-1 s Targeted drug delivery (DE-588)4302415-4 s b DE-604 Majumder, Hemanta K. Sonstige oth Advances in experimental medicine and biology 625 (DE-604)BV000003102 625 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016456475&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Drug targets in kinetoplastid parasites Advances in experimental medicine and biology Leishmaniasis drug therapy Membrane Glycoproteins drug effects Protozoan Proteins drug effects Antiprotozoal agents Drug targeting Kinetoplastida Leishmaniasis Chemotherapy Kinetoplastida (DE-588)4772258-7 gnd Targeted drug delivery (DE-588)4302415-4 gnd Parasitäre Krankheit (DE-588)4044638-4 gnd Antiparasitäres Mittel (DE-588)4219802-1 gnd |
| subject_GND | (DE-588)4772258-7 (DE-588)4302415-4 (DE-588)4044638-4 (DE-588)4219802-1 (DE-588)4143413-4 |
| title | Drug targets in kinetoplastid parasites |
| title_auth | Drug targets in kinetoplastid parasites |
| title_exact_search | Drug targets in kinetoplastid parasites |
| title_exact_search_txtP | Drug targets in kinetoplastid parasites |
| title_full | Drug targets in kinetoplastid parasites ed. by Hemanta K. Majumder |
| title_fullStr | Drug targets in kinetoplastid parasites ed. by Hemanta K. Majumder |
| title_full_unstemmed | Drug targets in kinetoplastid parasites ed. by Hemanta K. Majumder |
| title_short | Drug targets in kinetoplastid parasites |
| title_sort | drug targets in kinetoplastid parasites |
| topic | Leishmaniasis drug therapy Membrane Glycoproteins drug effects Protozoan Proteins drug effects Antiprotozoal agents Drug targeting Kinetoplastida Leishmaniasis Chemotherapy Kinetoplastida (DE-588)4772258-7 gnd Targeted drug delivery (DE-588)4302415-4 gnd Parasitäre Krankheit (DE-588)4044638-4 gnd Antiparasitäres Mittel (DE-588)4219802-1 gnd |
| topic_facet | Leishmaniasis drug therapy Membrane Glycoproteins drug effects Protozoan Proteins drug effects Antiprotozoal agents Drug targeting Kinetoplastida Leishmaniasis Chemotherapy Targeted drug delivery Parasitäre Krankheit Antiparasitäres Mittel Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016456475&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT majumderhemantak drugtargetsinkinetoplastidparasites |