Alternative splicing in the postgenomic era:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media [u.a.]
2007
|
| Schriftenreihe: | Advances in experimental medicine and biology
623 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXIII, 228 S. graph. Darst. |
| ISBN: | 9780387773735 |
Internformat
MARC
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| 020 | |a 9780387773735 |9 978-0-387-77373-5 | ||
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| 245 | 1 | 0 | |a Alternative splicing in the postgenomic era |c ed. by Benjamin J. Blencowe ... |
| 264 | 1 | |a New York, NY |b Springer Science + Business Media [u.a.] |c 2007 | |
| 300 | |a XXIII, 228 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 623 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a RNA editing | |
| 650 | 4 | |a Genetic transcription | |
| 650 | 4 | |a Exons (Genetics) | |
| 650 | 4 | |a Split genes | |
| 650 | 4 | |a Alternative Splicing | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Proteins / genetics | |
| 650 | 4 | |a Proteome / genetics | |
| 650 | 4 | |a RNA, Messenger / genetics | |
| 650 | 0 | 7 | |a RNS-Spleißen |0 (DE-588)4201877-8 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Blencowe, Benjamin J. |e Sonstige |4 oth | |
| 830 | 0 | |a Advances in experimental medicine and biology |v 623 |w (DE-604)BV000003102 |9 623 | |
| 856 | 4 | 2 | |m OEBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016456423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804137585435475968 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
FOREWORD V
PREFACE IX
ABOUT THE EDITORS XIII
PARTICIPANTS XV
1. NUCLEAR ORGANIZATIONAND SPLICING CONTROL 1
MARIA CARMO-FONSECAAND C61IA CARVALHO
ABSTRACT 1
SPLICING AND THE NUCLEUS 1
COMPARTMENTALIZATION OF SPLICING AND SPLICING FACTORS 3
COMPARTMENTALIZATION OF SPLICING FACTORS AND SPLICING REGULATION 8
PERSPECTIVES 9
2. SPLICEOSOMEASSEMBLY AND COMPOSITION 14
ARIANNE J. MATLIN AND MELISSA J. MOORE
ABSTRACT 14
INTRODUCTION 14
COMPOSITION AND STRUCTURE 14
IN VITRO SPLICEOSOME ASSEMBLY 15
PRODUCT RELEASE AND SNRNP RECYCLING 24
INTERACTIONS AT THE ENDS OFTRANSCRIPTS THAT PROMOTE SPLICEOSOMEASSEMBLY
24
THE HOLOSPLICEOSOME HYPOTHESIS 24
INSIGHTS FROM IN VIVO ANALYSIS OF SPLICEOSOME ASSEMBLY 25
COMMITMENT TO PARTICULAR SPLICE SITES 26
PROOFREADING 26
FINAL COMMENTS 28
XIX
IMAGE 2
XX
=-~- ~~--------...- F ** __ ~ _.::.. _
CONTENTS
3. RELATINGALTERNATIVESPLICINGTO PROTEOME COMPLEXITYAND GENOME EVOLUTION
36
YI XING AND CHRISTOPHER LEE
ABSTRACT 36
ALTERNATIVE SPLICING AND PROTEOMIC COMPLEXITY 36
ALTERNATIVE SPLICING OF PROTEIN DOMAINS AND FUNCTIONAL SITES 37
ALTERNATIVE SPLICING AND PROTEIN STRUCTURE 39
ALTERNATIVE SPLICING AND GENOME EVOLUTION 40
ALTERNATIVE SPLICING AND AMINO ACID MUTATION SELECTION PRESSURE 43
ALTERNATIVE SPLICING AND RNA SELECTION PRESSURE 43
CONNECTING RNA SELECTION PRESSURE TO REAL SPLICING REGULATION 44 FUTURE
CHALLENGES 45
4. COMPLEXALTERNATIVESPLICING 50
JUNG WOD PARK AND BRENTON R. GRAVELEY
ABSTRACT 50
INTRODUCTION 50
AN OVERVIEW OF ALTERNATIVE SPLICING-FROM SIMPLE TO COMPLEX 52
MECHANISMS USED FOR MUTUALLY EXCLUSIVE SPLICING IN DSCAM 54
CONCLUSIONS 61
5. TECHNOLOGIESFORTHE GLOBALDISCOVERY AND ANALYSIS OF
ALTERNATIVESPLICING 64
JOHN A. CALARCO, ARNEET L. SALTZMAN, JOANNA Y. IP AND BENJAMIN J.
BLENCOWE
ABSTRACT 64
INTRODUCTION 64
MICROARRAY-BASED METHODS FOR THE LARGE-SCALE DISCOVERY AND
CHARACTERIZATION OF ALTERNATIVE SPLICING EVENTS 65
APPLICATIONS OF ALTERNATIVE SPLICING MICROARRAYS 68
NON MICROARRAY-BASED METHODS FOR THE DISCOVERY AND CHARACTERIZATION OF
ALTERNATIVE SPIICING EVENTS 75
CONCLUSIONS 80
6. SEARCHINGFOR SPLICING MOTIFS 85
LAWRENCE A. CHASIN
ABSTRACT 85
SPLICE SITE SEQUENCES ARE NECESSARY BUT NOT SUFFICIENT ; 85
THE SPLICE SITES 85
THE BRANCH POINT 86
EXON DEFINITION 86
ADDITIONAL SEQUENCE INFORMATION LIES WITHIN EXONS AND INTRONS 88
GLOBAL APPROACHES FOR DEFINING SEQUENCE MOTIFS FOR SPLICING 88
EXONIC SPLICING ENHANCERS (ESES) PREDICTED BY COMPUTATION 88
EXONIC SPLICING SILENCERS (ESSS) PREDICTED BY COMPUTATION 93
IMAGE 3
NTS CONTENTS XXI
36
,36 ,36 .37 .39 .40 .43 .43 .44
.45
,50
..50 ..50 ..52 ..54
.. 61
.64
...64 ...64
... 65
... 68
... 75
... 80
.. 85
....85
.... 85
.... 85
.... 86
.... 86
.... 88
.... 88
.... 88
.... 93
EXONIC SPLICING REGULATORS (ESRS) PREDICTED BY COMPUTATION 93
MOLECULAR SELECTIONS 95
COMPARISON OF COMPUTATIONALLY PREDICTED AND FUNCTIONAL SELEX SELECTED
EXONIC MOTIFS 99
AN EMBARRASSMENT OF RIEBES? 99
TBE FUTURE 102
7. SR PROTEINSAND RELATED FACTORS IN ALTERNATIVE SPLICING 107
SHENGRONG LIN AND XIANG-DONG FU
ABSTRACT 107
INTRODUCTION 107
THE ROLE OF SR PROTEINS IN SPLICE SITE SELECTION 109
SR PROTEINS MODULATE ALTERNATIVE SPLICING IN BOTB WAYS 110
HOW DO SR-RELATED SPLICING FACTORS REGULATE ALTERNATIVE SPLICING? 112
FUNCTIONAL REQUIREMENT OF SR PROTEINS IN VIVO 112
SR PROTEINS AS SPLICING REGULATORS IN VIVO: WHY SO FEW TARGETS? 113
REGULATION OF SR SPLICING REGULATORS 114
SR PROTEIN-REGULATED SPLICING IN DEVELOPMENT AND DISEASE 116
CONCLUDING REMARKS 116
8. HNRNP PROTEINSAND SPLICING CONTROL 123
REBECA MARTINEZ-CONTRERAS, PHILIPPE CLOUTIER, LULZIM SHKRETA,
JEAN-FRANCCIS FISETTE, TIMOTHEE REVIL AND BENOIT CHABOT
ABSTRACT 123
INTRODUCTION 123
ABRIEFHISTORY OF HNRNP PROTEINS 125
BNRNP PROTEINS, SPLICING AND ALTERNATIVE SPLICING 125
SPLICING LESSONS FROM TBE STUDY OF BNRNP PRO TEINS 134
CONCLUDING REMARKS 137
9. FUNCTIONALANDMECHANISTICINSIGHTS FROM GENOME-WIDESTUDIES OF SPLICING
REGULATION IN THE BRAIN 148
JEMEJ ULE AND ROBERT B. DAMELL
ABSTRACT 148
INTRODUCTION 148
AT TBE INTERSECTION BETWEEN CANCER CELLS AND NEURONS 148
TBE THREE MAIN BENEFITS OF SPLICING REGULATION IN TBE DRAIN 149
UNDERSTANDING THE NATURE OF PROTEIN-RNAINTERACTIONS 150
AN RNA MAP FOR NOVA-DEPENDENT SPLICING REGULATION 152
RELATING TBE RNA MAP TO MECBANISMS OF SPLICING REGULATION 153
IS COMBINATORIAL SPLICING REGULATION COOPERATIVE OR ADDITIVE? 154
MODULAR STRUCTURE OF COREGULATED TRANSCRIPTS 154
EVOLUTIONARY CONSIDERATIONS 155
IMAGE 4
XXUE CONTENTS CONTE»
10. REGULATIONOF ALTERNATIVESPLICING BY SIGNAL TRANSDUCTIONPATHWAYS 161
KRISTEN W. LYNCH
ABSTRACT 161
INTRODUCTION 161
MOLECULAR HUBS HELP LINK THE EXTRACELLULAR WORLD TO THE SPLICING
MACHINERY 162
POSTTRANSLATIONAL MODUEICATIONS OF SPLICING MACHINERY 163
SIGNAL-INDUCED CHANGES IN LOCALIZATION OF SPLICING FACTORS 165
OTHER MECHANISMS: ALTERED PROTEIN-PROTEIN INTERACTIONS AND PROTEIN
EXPRESSION 167
REGULATION VIA CROSS-TALK WITH SIGNAL-RESPONSIVE CHANGES IN
TRANSCRIPTION 168 COORDINATED REGULATION 169
ACHIEVING SPECIFICITY IN SIGNAL-RESPONSIVENESS OF ALTERNATIVE SPLICING
170 FEED-BACK AND FEED-FORWARD 170
SUMMARY 171
11. COUPLINGTRANSCRIPTIONAND ALTERNATIVE SPLICING ... 175
ALBERTO R. KOMBLIHTT
ABSTRACT 175
INTRODUCTION 175
PROMOTERS AFFECT ALTERNATIVE SPLICING 177
RNAPII CTD AND COUPLING 178
FACTOR RECRUITMENT 179
RECRUITMENT OF SRP20, THE CTD AND ALTERNATIVE SPLICING 181
TRANSCRIPTION ELONGATION AND ALTERNATIVE SPLICING 182
SLOW POLYMERASES AND ALTERNATIVE SPLICING 183
CHROMATIN, ELONGATION ANDALTERNATIVE SPLICING 184
COORDINATION BETWEEN AND POLARITY IN MULTIPLE ALTERNATIVE SPLICING
EVENTS L84 CONCLUSLONS AND PERSPECTIVES 186
12. THE COUPLING OF ALTERNATIVESPLICING ANDNONSENSE-MEDIATEDMRNADECAY
190
LIANA F. LAREAU,ANGELAN. BROOKS,DAVIDA.W.SOERGEL, QI MENG AND STEVENE.
BRENNER
ABSTRACT 190
INTRODUCTION 190
MANY ALTERNATIVE SPLICE FORMS ARE TARGETS OF NMD 192
DO THE OBSERVED PTC+ MRNAISOFORMS EVADE NMD TO PRODUCE FUNCTIONAL
PROTEIN? 195
ARE THE OBSERVED PTC+ MRNAISOFORMS A SIDE EFFECT OF PRODUCTIVE
ALTERNATIVE SPLICING? 199
DO THE OBSERVED PTC+ MRNAISOFORMS REPRESENT MISSPLICING OR CELLULAR
NOISE? 199
ARE PTC+ MRNA ISOFORMS IMPORTANT FOR THE REGULATION OF GENEEXPRESSION?
201 CONSTITUTIVE UNPRODUCTIVE SPLICING 201
REGUL AUTOR CONSE WHYL
13.AJ
JAMES
ABSTRL INTRO~
TAUOP MYOTCL FACIOS CANCE PRADEI
CONCH
INDE
IMAGE 5
&!L
13. ALTERNATIVESPLICING IN DISEASE 212
INDEX 225
XXUEI
JAMES P. ORENGO AND THOMAS A. COOPER
CONTENTS
REGULATED UNPRODUETIVE SPLICING 202
AUTOREGULATORY UNPRODUCTIVE SPLICING 203
CONSERVATION OFREGULATED UNPRODUETIVE SPLIEING AND TRANSLATION (RUST)
205 WHY REGULATED UNPRODUCTIVE SPLIEING AND TRANSLATION? 206
ABSTRACT 212
INTRODUCTION 212
TAUOPATHIES: MUTATIONS IN THE MAPT GENE 213
MYOTONIE DYSTROPHY 214
FACIOSEAPULOHUMERAL MUSEULAR DYSTROPHY (FSHD) 217
CANCER AND MIS-REGULATED SPLICING 218
PRAEDER-WILLI SYNDROME (PWS) 220
CONELUSIONS 220
.... 190
.NTENTS
....162 .... 163
.... 165
.... 167
.... 168
.... 169
.... 170
**** 170 .... 171
... 175
... 161 ....161
.. 161
.....175
..... 175
..... 177
***** 178 ..... 179
..... 181
..... 182
..... 183
..... 184
, 184
, 186
......190
...... 190
......192
...... 195
,......199
....... 199
....... 201
....... 201
|
| adam_txt |
IMAGE 1
CONTENTS
FOREWORD V
PREFACE IX
ABOUT THE EDITORS XIII
PARTICIPANTS XV
1. NUCLEAR ORGANIZATIONAND SPLICING CONTROL 1
MARIA CARMO-FONSECAAND C61IA CARVALHO
ABSTRACT 1
SPLICING AND THE NUCLEUS 1
COMPARTMENTALIZATION OF SPLICING AND SPLICING FACTORS 3
COMPARTMENTALIZATION OF SPLICING FACTORS AND SPLICING REGULATION 8
PERSPECTIVES 9
2. SPLICEOSOMEASSEMBLY AND COMPOSITION 14
ARIANNE J. MATLIN AND MELISSA J. MOORE
ABSTRACT 14
INTRODUCTION 14
COMPOSITION AND STRUCTURE 14
IN VITRO SPLICEOSOME ASSEMBLY 15
PRODUCT RELEASE AND SNRNP RECYCLING 24
INTERACTIONS AT THE ENDS OFTRANSCRIPTS THAT PROMOTE SPLICEOSOMEASSEMBLY
24
THE HOLOSPLICEOSOME HYPOTHESIS 24
INSIGHTS FROM IN VIVO ANALYSIS OF SPLICEOSOME ASSEMBLY 25
COMMITMENT TO PARTICULAR SPLICE SITES 26
PROOFREADING 26
FINAL COMMENTS 28
XIX
IMAGE 2
XX
=-~- ~~--------.- F ** _ ~ _.::. _
CONTENTS
3. RELATINGALTERNATIVESPLICINGTO PROTEOME COMPLEXITYAND GENOME EVOLUTION
36
YI XING AND CHRISTOPHER LEE
ABSTRACT 36
ALTERNATIVE SPLICING AND PROTEOMIC COMPLEXITY 36
ALTERNATIVE SPLICING OF PROTEIN DOMAINS AND FUNCTIONAL SITES 37
ALTERNATIVE SPLICING AND PROTEIN STRUCTURE 39
ALTERNATIVE SPLICING AND GENOME EVOLUTION 40
ALTERNATIVE SPLICING AND AMINO ACID MUTATION SELECTION PRESSURE 43
ALTERNATIVE SPLICING AND RNA SELECTION PRESSURE 43
CONNECTING RNA SELECTION PRESSURE TO REAL SPLICING REGULATION 44 FUTURE
CHALLENGES 45
4. COMPLEXALTERNATIVESPLICING 50
JUNG WOD PARK AND BRENTON R. GRAVELEY
ABSTRACT 50
INTRODUCTION 50
AN OVERVIEW OF ALTERNATIVE SPLICING-FROM SIMPLE TO COMPLEX 52
MECHANISMS USED FOR MUTUALLY EXCLUSIVE SPLICING IN DSCAM 54
CONCLUSIONS 61
5. TECHNOLOGIESFORTHE GLOBALDISCOVERY AND ANALYSIS OF
ALTERNATIVESPLICING 64
JOHN A. CALARCO, ARNEET L. SALTZMAN, JOANNA Y. IP AND BENJAMIN J.
BLENCOWE
ABSTRACT 64
INTRODUCTION 64
MICROARRAY-BASED METHODS FOR THE LARGE-SCALE DISCOVERY AND
CHARACTERIZATION OF ALTERNATIVE SPLICING EVENTS 65
APPLICATIONS OF ALTERNATIVE SPLICING MICROARRAYS 68
NON MICROARRAY-BASED METHODS FOR THE DISCOVERY AND CHARACTERIZATION OF
ALTERNATIVE SPIICING EVENTS 75
CONCLUSIONS 80
6. SEARCHINGFOR SPLICING MOTIFS 85
LAWRENCE A. CHASIN
ABSTRACT 85
SPLICE SITE SEQUENCES ARE NECESSARY BUT NOT SUFFICIENT ; 85
THE SPLICE SITES 85
THE BRANCH POINT 86
EXON DEFINITION 86
ADDITIONAL SEQUENCE INFORMATION LIES WITHIN EXONS AND INTRONS 88
GLOBAL APPROACHES FOR DEFINING SEQUENCE MOTIFS FOR SPLICING 88
EXONIC SPLICING ENHANCERS (ESES) PREDICTED BY COMPUTATION 88
EXONIC SPLICING SILENCERS (ESSS) PREDICTED BY COMPUTATION 93
IMAGE 3
NTS CONTENTS XXI
36
,36 ,36 .37 .39 .40 .43 .43 .44
.45
,50
.50 .50 .52 .54
. 61
.64
.64 .64
. 65
. 68
. 75
. 80
. 85
.85
. 85
. 85
. 86
. 86
. 88
. 88
. 88
. 93
EXONIC SPLICING REGULATORS (ESRS) PREDICTED BY COMPUTATION 93
MOLECULAR SELECTIONS 95
COMPARISON OF COMPUTATIONALLY PREDICTED AND FUNCTIONAL SELEX SELECTED
EXONIC MOTIFS 99
AN EMBARRASSMENT OF RIEBES? 99
TBE FUTURE 102
7. SR PROTEINSAND RELATED FACTORS IN ALTERNATIVE SPLICING 107
SHENGRONG LIN AND XIANG-DONG FU
ABSTRACT 107
INTRODUCTION 107
THE ROLE OF SR PROTEINS IN SPLICE SITE SELECTION 109
SR PROTEINS MODULATE ALTERNATIVE SPLICING IN BOTB WAYS 110
HOW DO SR-RELATED SPLICING FACTORS REGULATE ALTERNATIVE SPLICING? 112
FUNCTIONAL REQUIREMENT OF SR PROTEINS IN VIVO 112
SR PROTEINS AS SPLICING REGULATORS IN VIVO: WHY SO FEW TARGETS? 113
REGULATION OF SR SPLICING REGULATORS 114
SR PROTEIN-REGULATED SPLICING IN DEVELOPMENT AND DISEASE 116
CONCLUDING REMARKS 116
8. HNRNP PROTEINSAND SPLICING CONTROL 123
REBECA MARTINEZ-CONTRERAS, PHILIPPE CLOUTIER, LULZIM SHKRETA,
JEAN-FRANCCIS FISETTE, TIMOTHEE REVIL AND BENOIT CHABOT
ABSTRACT 123
INTRODUCTION 123
ABRIEFHISTORY OF HNRNP PROTEINS 125
BNRNP PROTEINS, SPLICING AND ALTERNATIVE SPLICING 125
SPLICING LESSONS FROM TBE STUDY OF BNRNP PRO TEINS 134
CONCLUDING REMARKS 137
9. FUNCTIONALANDMECHANISTICINSIGHTS FROM GENOME-WIDESTUDIES OF SPLICING
REGULATION IN THE BRAIN 148
JEMEJ ULE AND ROBERT B. DAMELL
ABSTRACT 148
INTRODUCTION 148
AT TBE INTERSECTION BETWEEN CANCER CELLS AND NEURONS 148
TBE THREE MAIN BENEFITS OF SPLICING REGULATION IN TBE DRAIN 149
UNDERSTANDING THE NATURE OF PROTEIN-RNAINTERACTIONS 150
AN RNA MAP FOR NOVA-DEPENDENT SPLICING REGULATION 152
RELATING TBE RNA MAP TO MECBANISMS OF SPLICING REGULATION 153
IS COMBINATORIAL SPLICING REGULATION COOPERATIVE OR ADDITIVE? 154
MODULAR STRUCTURE OF COREGULATED TRANSCRIPTS 154
EVOLUTIONARY CONSIDERATIONS 155
IMAGE 4
XXUE CONTENTS CONTE»
10. REGULATIONOF ALTERNATIVESPLICING BY SIGNAL TRANSDUCTIONPATHWAYS 161
KRISTEN W. LYNCH
ABSTRACT 161
INTRODUCTION 161
MOLECULAR "HUBS" HELP LINK THE EXTRACELLULAR WORLD TO THE SPLICING
MACHINERY 162
POSTTRANSLATIONAL MODUEICATIONS OF SPLICING MACHINERY 163
SIGNAL-INDUCED CHANGES IN LOCALIZATION OF SPLICING FACTORS 165
OTHER MECHANISMS: ALTERED PROTEIN-PROTEIN INTERACTIONS AND PROTEIN
EXPRESSION 167
REGULATION VIA CROSS-TALK WITH SIGNAL-RESPONSIVE CHANGES IN
TRANSCRIPTION 168 COORDINATED REGULATION 169
ACHIEVING SPECIFICITY IN SIGNAL-RESPONSIVENESS OF ALTERNATIVE SPLICING
170 FEED-BACK AND FEED-FORWARD 170
SUMMARY 171
11. COUPLINGTRANSCRIPTIONAND ALTERNATIVE SPLICING . 175
ALBERTO R. KOMBLIHTT
ABSTRACT 175
INTRODUCTION 175
PROMOTERS AFFECT ALTERNATIVE SPLICING 177
RNAPII CTD AND COUPLING 178
FACTOR RECRUITMENT 179
RECRUITMENT OF SRP20, THE CTD AND ALTERNATIVE SPLICING 181
TRANSCRIPTION ELONGATION AND ALTERNATIVE SPLICING 182
SLOW POLYMERASES AND ALTERNATIVE SPLICING 183
CHROMATIN, ELONGATION ANDALTERNATIVE SPLICING 184
COORDINATION BETWEEN AND POLARITY IN MULTIPLE ALTERNATIVE SPLICING
EVENTS L84 CONCLUSLONS AND PERSPECTIVES 186
12. THE COUPLING OF ALTERNATIVESPLICING ANDNONSENSE-MEDIATEDMRNADECAY
190
LIANA F. LAREAU,ANGELAN. BROOKS,DAVIDA.W.SOERGEL, QI MENG AND STEVENE.
BRENNER
ABSTRACT 190
INTRODUCTION 190
MANY ALTERNATIVE SPLICE FORMS ARE TARGETS OF NMD 192
DO THE OBSERVED PTC+ MRNAISOFORMS EVADE NMD TO PRODUCE FUNCTIONAL
PROTEIN? 195
ARE THE OBSERVED PTC+ MRNAISOFORMS A SIDE EFFECT OF PRODUCTIVE
ALTERNATIVE SPLICING? 199
DO THE OBSERVED PTC+ MRNAISOFORMS REPRESENT MISSPLICING OR CELLULAR
NOISE? 199
ARE PTC+ MRNA ISOFORMS IMPORTANT FOR THE REGULATION OF GENEEXPRESSION?
201 CONSTITUTIVE UNPRODUCTIVE SPLICING 201
REGUL AUTOR CONSE WHYL
13.AJ
JAMES
ABSTRL INTRO~
TAUOP MYOTCL FACIOS CANCE PRADEI
CONCH
INDE
IMAGE 5
&!L
13. ALTERNATIVESPLICING IN DISEASE 212
INDEX 225
XXUEI
JAMES P. ORENGO AND THOMAS A. COOPER
CONTENTS
REGULATED UNPRODUETIVE SPLICING 202
AUTOREGULATORY UNPRODUCTIVE SPLICING 203
CONSERVATION OFREGULATED UNPRODUETIVE SPLIEING AND TRANSLATION (RUST)
205 WHY REGULATED UNPRODUCTIVE SPLIEING AND TRANSLATION? 206
ABSTRACT 212
INTRODUCTION 212
TAUOPATHIES: MUTATIONS IN THE MAPT GENE 213
MYOTONIE DYSTROPHY 214
FACIOSEAPULOHUMERAL MUSEULAR DYSTROPHY (FSHD) 217
CANCER AND MIS-REGULATED SPLICING 218
PRAEDER-WILLI SYNDROME (PWS) 220
CONELUSIONS 220
. 190
.NTENTS
.162 . 163
. 165
. 167
. 168
. 169
. 170
**** 170 . 171
. 175
. 161 .161
. 161
.175
. 175
. 177
***** 178 . 179
. 181
. 182
. 183
. 184
, 184
, 186
.190
. 190
.192
. 195
,.199
. 199
. 201
. 201 |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV023271419 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:36:06Z |
| indexdate | 2024-07-09T21:14:38Z |
| institution | BVB |
| isbn | 9780387773735 |
| language | English |
| lccn | 2007048348 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016456423 |
| oclc_num | 182613569 |
| open_access_boolean | |
| owner | DE-12 DE-20 |
| owner_facet | DE-12 DE-20 |
| physical | XXIII, 228 S. graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer Science + Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Alternative splicing in the postgenomic era ed. by Benjamin J. Blencowe ... New York, NY Springer Science + Business Media [u.a.] 2007 XXIII, 228 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 623 Includes bibliographical references and index RNA editing Genetic transcription Exons (Genetics) Split genes Alternative Splicing Gene Expression Regulation Proteins / genetics Proteome / genetics RNA, Messenger / genetics RNS-Spleißen (DE-588)4201877-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content RNS-Spleißen (DE-588)4201877-8 s b DE-604 Blencowe, Benjamin J. Sonstige oth Advances in experimental medicine and biology 623 (DE-604)BV000003102 623 OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016456423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Alternative splicing in the postgenomic era Advances in experimental medicine and biology RNA editing Genetic transcription Exons (Genetics) Split genes Alternative Splicing Gene Expression Regulation Proteins / genetics Proteome / genetics RNA, Messenger / genetics RNS-Spleißen (DE-588)4201877-8 gnd |
| subject_GND | (DE-588)4201877-8 (DE-588)4143413-4 |
| title | Alternative splicing in the postgenomic era |
| title_auth | Alternative splicing in the postgenomic era |
| title_exact_search | Alternative splicing in the postgenomic era |
| title_exact_search_txtP | Alternative splicing in the postgenomic era |
| title_full | Alternative splicing in the postgenomic era ed. by Benjamin J. Blencowe ... |
| title_fullStr | Alternative splicing in the postgenomic era ed. by Benjamin J. Blencowe ... |
| title_full_unstemmed | Alternative splicing in the postgenomic era ed. by Benjamin J. Blencowe ... |
| title_short | Alternative splicing in the postgenomic era |
| title_sort | alternative splicing in the postgenomic era |
| topic | RNA editing Genetic transcription Exons (Genetics) Split genes Alternative Splicing Gene Expression Regulation Proteins / genetics Proteome / genetics RNA, Messenger / genetics RNS-Spleißen (DE-588)4201877-8 gnd |
| topic_facet | RNA editing Genetic transcription Exons (Genetics) Split genes Alternative Splicing Gene Expression Regulation Proteins / genetics Proteome / genetics RNA, Messenger / genetics RNS-Spleißen Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016456423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT blencowebenjaminj alternativesplicinginthepostgenomicera |