Membranes for the life sciences:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2008
|
| Schriftenreihe: | Membrane technology
1 |
| Schlagworte: | |
| Online-Zugang: | Beschreibung für Leser Inhaltsverzeichnis |
| Beschreibung: | XV, 327 S. zahlr. Ill. und graph. Darst. |
| ISBN: | 9783527314805 3527314806 |
Internformat
MARC
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| 245 | 1 | 0 | |a Membranes for the life sciences |c ed. by Klaus-Viktor Peinemann ... |
| 246 | 1 | 3 | |a Membranes for life sciences |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2008 | |
| 300 | |a XV, 327 S. |b zahlr. Ill. und graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Membrane technology |v 1 | |
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| 650 | 4 | |a Zarlar (Teknoloji) | |
| 650 | 4 | |a Zarlar, yapay | |
| 650 | 4 | |a Biowissenschaften | |
| 650 | 4 | |a Biomimetics |x methods | |
| 650 | 4 | |a Life sciences | |
| 650 | 4 | |a Membranes (Technology) | |
| 650 | 4 | |a Membranes, Artificial | |
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Datensatz im Suchindex
| _version_ | 1805090198598451200 |
|---|---|
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lv
Contents
Preface XI
Contributors XIII
1 Membranes in Hemodialysis 1
Jörg Vienken
1.1 Introduction 1
1.2 Historical Achievements 2
1.3 Membranes for Hemodialysis: Polymers and Nomendature 7
1.3.1 Membranes from Regenerated Cellulose 8
1.3.1.1 Modified Cellulosic Membranes 9
1.3.1.2 Cellulose Acetates 9
1.3.1.3 DEAE-Modified Cellulose, Hemophan 10
1.3.1.4 Benzyl-Modified Cellulose (Synthetically Modified Cellulose, SMC) 11
1.3.1.5 PEG-Grafted Cellulose 11
1.3.1.6 Vitamin E-Modified Cellulosic Membranes 12
1.3.2 Synthetic Membranes 12
1.3.2.1 Polyacrylonitrile (PAN) 13
1.3.2.2 Polymethylmethacrylate (PMMA) 14
1.3.2.3 Polysulfone (PSu) 15
1.3.2.4 Polyamide (PA) 17
1.4 Dialyzer Constructions 17
1.4.1 Hollow Fiber Dialyzers 17
1.4.2 Housing 18
1.4.3 Potting Material 18
IAA Fiber Bündle 19
1.5 Dialysis Membranes and Performance: Principles of
Membrane Transport 20
1.6 Dialysis Membranes and Biocompatibility 24
1.6.1 Some Basic Information on Membranes and
Biocompatibility Parameters 24
1.6.2 Thrombogenicity of Different Types of Dialyzers and Filters 26
Membranes for Ine Life Sciences. Edited by Klaus-Viktor Peinemann and Suzana Pereira Nunes
Copyright © 2008 WILEY-VCH Verlag GmbH Co. KGaA. All rights reserved
ISBN: 978-3-527-314*0-5
VI I Contents
1.6.3 Complement Activation by Different Dialyzers and Filters 29
1.6.4 Cell Activation by Different Types of Dialyzers and Hemofilters 31
1.6.4.1 Apoptosis 31
1.6.5 Oxygen Species Production - Induction of Oxidative Stress 32
1.6.5.1 Degranulation of Neutrophils 34
1.6.6 Stimulation of Cytokine Generation by Different Types of
Dialyzers and Hemofilters 35
1.6.6-1 The Impact of Membrane Types on LPS-Stimulated IL-lß
Secretion 36
1.6.7 The Impact of Large-Pore Dialysis Membranes on the
Infiammatory Response in HD Patients by Cytokine
Elimination 36
1.6.8 The Effect of Different Dialyzers on the Acute Phase Reaction 37
1.6.9 Activation of the Kinin System by Different Types of Dialyzers
and Hemofilters 37
1.7 Conclusion 39
2 Membranes for Artificial Lungs 49
Frank Wiese
2.1 Introduction 49
2.2 History of Blood Oxygenation 49
2.2.1 Membrane Oxygenators 50
2.3 Principleof Gas Transfer 53
2.4 Membranes and Membrane Properties 55
2-4.1 Microporous Membranes 55
2.4.2 Dense Membranes/"Diffusion Membranes" 57
2.5 Membrane Production 59
2.6 Operational Modes and Membrane Makeup in Oxygenators 61
2.6.1 Microporous Capillary Membranes, Blood Inside 62
2.6.2 Microporous Capillary Membranes, Blood Outside 62
2.7 Extracorporeal Circulation 65
2.7.1 Cardiodiapulmonary Bypass (CPB) 65
2.7.2 Lung Support Systems 65
3 Membranes for Blood Fractionation/Apheresis 69
Frank Wiese
3.1 Introduction 69
3.2 History of Plasmapheresis 70
3.3 Principles of Plasmapheresis 73
3.4 Membranes and Membrane Properties 76
3.4.1 Plasma Separation Membranes 76
3.4.2 Plasma Fractionation Membranes 79
3.5 Membrane Production 81
3.6 Operational Modes in Plasmapheresis Procedures 83
3.7 Medical Indications for Blood Plasma Treatment 88
Contents I
4 Membranes in the Biopharmaceutical Industry 91
Anthony Allegrezza, Todd Ireland, Willem Kools, Michael Phillips,
Bala Raghunath, Randy Wilkins, Alex Xenopoulos
4.1 Introduction 91
4.2 Microfiltration Membranes Used in the Biotech Industry 93
4.2.1 Introduction 93
4.2.2 Microfiltration Membranes: Development of Industrial
Membranes 94
4.2.3 Effect of Membrane Structure on Properties 95
4.2.4 Aspects of Cartridge Design 97
4.2.5 Membrane Surface Modifikation 98
4.2.6 Sterilizing Filters 99
4.2.6.1 Retention 99
4.2.6.2 Permeability 101
4.2.6.3 Capacity 102
4.3 Practical Membrane Considerations for Sterile Filtration by
Microporous Membranes 102
4.3.1 Sterile Filtration Process Considerations 103
4.3.1.1 Filter Selection 104
4.3.1.2 Device Selection 110
4.4 Ultrafiltration and Virus Filtration Membranes for
Biopharmaceutical Applications 113
4.4.1 Ultrafiltration Membranes 113
4.4.1.1 Membrane Suppliers 114
4.4.1.2 Membrane Selection 114
4.4.1.3 Membrane Structures 115
4.4.1.4 Characterization 115
4.4.1.5 Devices 116
4.4.2 Virus Filtration Membranes 117
4.4.2.1 Membrane Suppliers 117
4.4.2.2 Membrane Structures 118
4.4.2.3 Devices 118
4.4.2.4 Membrane Selection 229
4.4.2.5 Characterization 220
4.5 Applications of Ultrafiltration Membranes in Biopharmaceutical
Manufacturing 222
4.5.1 Ultrafiltration Theory 222
4.5.2 Typical Ultrafiltration Process 223
4.5.2.1 Process Development and Optimization 224
4.5.3 Processing Plan Optimization 228
4.5.3.1 Mode of Operation 228
4.5.3.2 Diafiltration Mode/Strategy 229
4.5.4 Scale-up Considerations 232
4.5.4.1 Process Implementation Considerations 132
4.5.4.2 Process Robustness 133
VIII Contents
4.5.5 System Considerations 134
4.5.5.1 Equipment Options 134
4.5.5.2 Process Control Options 134
4.6 Practical Aspects of Virus Filtration Process Design and
Implementation 135
4.6.1 Membrane Selection 135
4.6.2 Process Development and Optimization 138
4.6.3 Capacity 140
4.6.4 Small-Scale Simulation 141
4.6.5 Pilot-Scale Studies 141
4.6.6 Virus Validation Studies 142
4.6.7 Implementation 143
4.7 Membrane Adsorbers 145
4.7A Membrane Chemistries 146
47.2 Current Applications 147
4.7.2.1 Flow-Through Polishing 147
4.7.2.2 Flow-Through Precapture 148
4.7.2.3 Large Molecule Bind-Elute Purification 149
4.7.3 Future Trends 149
5 Membrane Applications in Red and White Biotechnology 155
Stephan Lutz, Nagaraj Rao
5.1 Introduction 155
5.2 Types of Membrane Processes in Red and White
Biotechnology 156
5.2.1 Bubble-Free Aeration 156
5.2.2 Filtration Processes 157
5.2.3 Dialysis and Electrodialysis 157
5.2.4 Adsorption of Microorganisms 158
5.3 Examples of Membrane Processes in Biotechnology 158
5.3.1 Bubble-Free Gassing 158
5.3.1.1 Hydrogen 158
5.3.1.2 Oxygen 159
5.3.2 Membranes for Cell Retention 161
5.3.2.1 Higher Cells/Red Biotechnology 161
5.3.2.2 Whole-Cell Biotransformation 162
5.3.3 Membranes for Enzyme Retention 162
5.3.4 Membranes for Cofactor Retention 166
5.3.5 Application of Dialysis and Electrodialysis in Biotransformations 167
5.3.6 Application of Pervaporation and Stripping in
Biotransformations 168
5.3.7 Nanofiltration and Ultrafiltration in Biotechnology 170
5.3.8 Bioelectrochemical Applications 170
5.4 Summary 172
5.5 Acknowledgment 172
Contents I
6 Membranes in Controlled Release 175
Nicholas A. Peppas, Kristy M. Wood, J. Brock Thomas
6.1 Introduction 175
6.2 Controlled Release Kinetics 176
6.2.1 Diffusion in Membrane-Controlled Release 176
6.2.2 Physical Parameters of Controlling Release 180
6.3 Membranes and Solute Transport 180
6.3.1 Characterization of Membranes 180
6.3.2 Solute Transport in Network Membranes 182
6.3.2.1 Structural Parameters of Membranes 182
6.3.2.2 Determination of Molecular Pore Sizes 183
6.4 Applications in Drug Delivery 184
7 Drug Delivery Through Skin: Overcoming the Ultimate
Biological Membrane 191
Dimitrios F. Stamatialis
7.1 Introduction 191
7.2 Human Skin - Fundamentals of Skin Permeation 192
7.2.1 Human Skin Structure 192
7.2.2 Stratum Corneum - Main Drug Barrier 193
7.2.3 Drug Transport Through the Skin 195
7.2.3.1 Passive Diffusion 195
7.2.3.2 Iontophoresis 198
7.2.3.3 Electroporation 204
7.2.3.4 Other Methods 207
7.3 Transdermal Drug Delivery System - Structure/Design 212
7.3.1 Passive TDD Systems 212
7.3.1.1 Types 212
7.3.1.2 Materials 213
7.3.1.3 Skin or Device-Controlled Delivery 214
7.3.1.4 Commercialization - Patents 215
7.3.2 Active TDD Systems 216
7.3.2.1 Types 216
7.3.2.2 Materials - Devices 226
7.3.2.3 Commercialization - Patents 218
7.4 Condusions and Outlook 221
8 Application of Membranes in Tissue Engineering
and Biohybrid Organ Technology 227
Thomas Croth, Zhen-Mei Liu
8.1 Introduction 227
8.1.1 Application of Membranes in Blood Detoxification 227
8.1.2 Requirements to Support Adhesion and Function of Cells 228
8.2 Application of Membranes in Tissue Engineering 231
X I Contents
8.2.1 Introduction to Tissue Engineering and Membrane
Applications 231
8.2.2 Tissue Engineering of Skin 232
8.2.3 Tissue Engineering of Bone 236
8.2.4 Further Tissue Engineering Applications of Membranes 240
8.3 Membranes in Biohybrid Organ Technology 242
8.3.1 Organ Failure and Biohybrid Organ Technology 242
8.3.2 Biohybrid liver 245
8.3.3 Biohybrid Kidney 249
8.4 Summary and Conclusions 253
8.5 Acknowledgments 254
9 Membranes in Bioartificial Pancreas - An Overview
of the Development of a Bioartificial Pancreas, as a Treatment
of Insulin-Dependent Diabetes Mellitus 263
Ana Isabel Silva, Antonio Norton de Matos, I. Cabrielle M. Brons,
Marilia Clemente Velez Mateus
9.1 Introduction 263
9.1.1 Diabetes and Its Treatment 263
9.1.2 The Bioartificial Organ Concept 265
9.2 Bioartificial Pancreas 266
9.2.1 Immunoprotection and Biocompatibility of Implanted Devices 267
9.2.2 Vascular Devices 268
9.2.2.1 Biocompatible Materials in Vascular Devices 269
9.2.3 Extravascular Devices 272
9.2.3.1 Implantation Sites 272
9.2.3.2 Macrocapsules 273
9.2.3.3 Microcapsular Devices 280
9.2.4 Influence of Recipients Sensitization to Donor Antigens in
Graft Survival 308
9.2.5 Islet Oxygenation Studies 308
9.2.5.1 Oxygenation of Ba-Alginate Microencapsulated Islets 311
9.3 Final Comments 312
9.4 Acknowledgment 313
Index 321 |
| adam_txt |
lv
Contents
Preface XI
Contributors XIII
1 Membranes in Hemodialysis 1
Jörg Vienken
1.1 Introduction 1
1.2 Historical Achievements 2
1.3 Membranes for Hemodialysis: Polymers and Nomendature 7
1.3.1 Membranes from Regenerated Cellulose 8
1.3.1.1 Modified Cellulosic Membranes 9
1.3.1.2 Cellulose Acetates 9
1.3.1.3 DEAE-Modified Cellulose, Hemophan 10
1.3.1.4 Benzyl-Modified Cellulose (Synthetically Modified Cellulose, SMC) 11
1.3.1.5 PEG-Grafted Cellulose 11
1.3.1.6 Vitamin E-Modified Cellulosic Membranes 12
1.3.2 Synthetic Membranes 12
1.3.2.1 Polyacrylonitrile (PAN) 13
1.3.2.2 Polymethylmethacrylate (PMMA) 14
1.3.2.3 Polysulfone (PSu) 15
1.3.2.4 Polyamide (PA) 17
1.4 Dialyzer Constructions 17
1.4.1 Hollow Fiber Dialyzers 17
1.4.2 Housing 18
1.4.3 Potting Material 18
IAA Fiber Bündle 19
1.5 Dialysis Membranes and Performance: Principles of
Membrane Transport 20
1.6 Dialysis Membranes and Biocompatibility 24
1.6.1 Some Basic Information on Membranes and
Biocompatibility Parameters 24
1.6.2 Thrombogenicity of Different Types of Dialyzers and Filters 26
Membranes for Ine Life Sciences. Edited by Klaus-Viktor Peinemann and Suzana Pereira Nunes
Copyright © 2008 WILEY-VCH Verlag GmbH Co. KGaA. All rights reserved
ISBN: 978-3-527-314*0-5
VI I Contents
1.6.3 Complement Activation by Different Dialyzers and Filters 29
1.6.4 Cell Activation by Different Types of Dialyzers and Hemofilters 31
1.6.4.1 Apoptosis 31
1.6.5 Oxygen Species Production - Induction of Oxidative Stress 32
1.6.5.1 Degranulation of Neutrophils 34
1.6.6 Stimulation of Cytokine Generation by Different Types of
Dialyzers and Hemofilters 35
1.6.6-1 The Impact of Membrane Types on LPS-Stimulated IL-lß
Secretion 36
1.6.7 The Impact of Large-Pore Dialysis Membranes on the
Infiammatory Response in HD Patients by Cytokine
Elimination 36
1.6.8 The Effect of Different Dialyzers on the Acute Phase Reaction 37
1.6.9 Activation of the Kinin System by Different Types of Dialyzers
and Hemofilters 37
1.7 Conclusion 39
2 Membranes for Artificial Lungs 49
Frank Wiese
2.1 Introduction 49
2.2 History of Blood Oxygenation 49
2.2.1 Membrane Oxygenators 50
2.3 Principleof Gas Transfer 53
2.4 Membranes and Membrane Properties 55
2-4.1 Microporous Membranes 55
2.4.2 Dense Membranes/"Diffusion Membranes" 57
2.5 Membrane Production 59
2.6 Operational Modes and Membrane Makeup in Oxygenators 61
2.6.1 Microporous Capillary Membranes, Blood Inside 62
2.6.2 Microporous Capillary Membranes, Blood Outside 62
2.7 Extracorporeal Circulation 65
2.7.1 Cardiodiapulmonary Bypass (CPB) 65
2.7.2 Lung Support Systems 65
3 Membranes for Blood Fractionation/Apheresis 69
Frank Wiese
3.1 Introduction 69
3.2 History of Plasmapheresis 70
3.3 Principles of Plasmapheresis 73
3.4 Membranes and Membrane Properties 76
3.4.1 Plasma Separation Membranes 76
3.4.2 Plasma Fractionation Membranes 79
3.5 Membrane Production 81
3.6 Operational Modes in Plasmapheresis Procedures 83
3.7 Medical Indications for Blood Plasma Treatment 88
Contents I
4 Membranes in the Biopharmaceutical Industry 91
Anthony Allegrezza, Todd Ireland, Willem Kools, Michael Phillips,
Bala Raghunath, Randy Wilkins, Alex Xenopoulos
4.1 Introduction 91
4.2 Microfiltration Membranes Used in the Biotech Industry 93
4.2.1 Introduction 93
4.2.2 Microfiltration Membranes: Development of Industrial
Membranes 94
4.2.3 Effect of Membrane Structure on Properties 95
4.2.4 Aspects of Cartridge Design 97
4.2.5 Membrane Surface Modifikation 98
4.2.6 Sterilizing Filters 99
4.2.6.1 Retention 99
4.2.6.2 Permeability 101
4.2.6.3 Capacity 102
4.3 Practical Membrane Considerations for Sterile Filtration by
Microporous Membranes 102
4.3.1 Sterile Filtration Process Considerations 103
4.3.1.1 Filter Selection 104
4.3.1.2 Device Selection 110
4.4 Ultrafiltration and Virus Filtration Membranes for
Biopharmaceutical Applications 113
4.4.1 Ultrafiltration Membranes 113
4.4.1.1 Membrane Suppliers 114
4.4.1.2 Membrane Selection 114
4.4.1.3 Membrane Structures 115
4.4.1.4 Characterization 115
4.4.1.5 Devices 116
4.4.2 Virus Filtration Membranes 117
4.4.2.1 Membrane Suppliers 117
4.4.2.2 Membrane Structures 118
4.4.2.3 Devices 118
4.4.2.4 Membrane Selection 229
4.4.2.5 Characterization 220
4.5 Applications of Ultrafiltration Membranes in Biopharmaceutical
Manufacturing 222
4.5.1 Ultrafiltration Theory 222
4.5.2 Typical Ultrafiltration Process 223
4.5.2.1 Process Development and Optimization 224
4.5.3 Processing Plan Optimization 228
4.5.3.1 Mode of Operation 228
4.5.3.2 Diafiltration Mode/Strategy 229
4.5.4 Scale-up Considerations 232
4.5.4.1 Process Implementation Considerations 132
4.5.4.2 Process Robustness 133
VIII Contents
4.5.5 System Considerations 134
4.5.5.1 Equipment Options 134
4.5.5.2 Process Control Options 134
4.6 Practical Aspects of Virus Filtration Process Design and
Implementation 135
4.6.1 Membrane Selection 135
4.6.2 Process Development and Optimization 138
4.6.3 Capacity 140
4.6.4 Small-Scale Simulation 141
4.6.5 Pilot-Scale Studies 141
4.6.6 Virus Validation Studies 142
4.6.7 Implementation 143
4.7 Membrane Adsorbers 145
4.7A Membrane Chemistries 146
47.2 Current Applications 147
4.7.2.1 Flow-Through Polishing 147
4.7.2.2 Flow-Through Precapture 148
4.7.2.3 Large Molecule Bind-Elute Purification 149
4.7.3 Future Trends 149
5 Membrane Applications in Red and White Biotechnology 155
Stephan Lutz, Nagaraj Rao
5.1 Introduction 155
5.2 Types of Membrane Processes in Red and White
Biotechnology 156
5.2.1 Bubble-Free Aeration 156
5.2.2 Filtration Processes 157
5.2.3 Dialysis and Electrodialysis 157
5.2.4 Adsorption of Microorganisms 158
5.3 Examples of Membrane Processes in Biotechnology 158
5.3.1 Bubble-Free Gassing 158
5.3.1.1 Hydrogen 158
5.3.1.2 Oxygen 159
5.3.2 Membranes for Cell Retention 161
5.3.2.1 Higher Cells/Red Biotechnology 161
5.3.2.2 Whole-Cell Biotransformation 162
5.3.3 Membranes for Enzyme Retention 162
5.3.4 Membranes for Cofactor Retention 166
5.3.5 Application of Dialysis and Electrodialysis in Biotransformations 167
5.3.6 Application of Pervaporation and Stripping in
Biotransformations 168
5.3.7 Nanofiltration and Ultrafiltration in Biotechnology 170
5.3.8 Bioelectrochemical Applications 170
5.4 Summary 172
5.5 Acknowledgment 172
Contents I
6 Membranes in Controlled Release 175
Nicholas A. Peppas, Kristy M. Wood, J. Brock Thomas
6.1 Introduction 175
6.2 Controlled Release Kinetics 176
6.2.1 Diffusion in Membrane-Controlled Release 176
6.2.2 Physical Parameters of Controlling Release 180
6.3 Membranes and Solute Transport 180
6.3.1 Characterization of Membranes 180
6.3.2 Solute Transport in Network Membranes 182
6.3.2.1 Structural Parameters of Membranes 182
6.3.2.2 Determination of Molecular Pore Sizes 183
6.4 Applications in Drug Delivery 184
7 Drug Delivery Through Skin: Overcoming the Ultimate
Biological Membrane 191
Dimitrios F. Stamatialis
7.1 Introduction 191
7.2 Human Skin - Fundamentals of Skin Permeation 192
7.2.1 Human Skin Structure 192
7.2.2 Stratum Corneum - Main Drug Barrier 193
7.2.3 Drug Transport Through the Skin 195
7.2.3.1 Passive Diffusion 195
7.2.3.2 Iontophoresis 198
7.2.3.3 Electroporation 204
7.2.3.4 Other Methods 207
7.3 Transdermal Drug Delivery System - Structure/Design 212
7.3.1 Passive TDD Systems 212
7.3.1.1 Types 212
7.3.1.2 Materials 213
7.3.1.3 Skin or Device-Controlled Delivery 214
7.3.1.4 Commercialization - Patents 215
7.3.2 Active TDD Systems 216
7.3.2.1 Types 216
7.3.2.2 Materials - Devices 226
7.3.2.3 Commercialization - Patents 218
7.4 Condusions and Outlook 221
8 Application of Membranes in Tissue Engineering
and Biohybrid Organ Technology 227
Thomas Croth, Zhen-Mei Liu
8.1 Introduction 227
8.1.1 Application of Membranes in Blood Detoxification 227
8.1.2 Requirements to Support Adhesion and Function of Cells 228
8.2 Application of Membranes in Tissue Engineering 231
X I Contents
8.2.1 Introduction to Tissue Engineering and Membrane
Applications 231
8.2.2 Tissue Engineering of Skin 232
8.2.3 Tissue Engineering of Bone 236
8.2.4 Further Tissue Engineering Applications of Membranes 240
8.3 Membranes in Biohybrid Organ Technology 242
8.3.1 Organ Failure and Biohybrid Organ Technology 242
8.3.2 Biohybrid liver 245
8.3.3 Biohybrid Kidney 249
8.4 Summary and Conclusions 253
8.5 Acknowledgments 254
9 Membranes in Bioartificial Pancreas - An Overview
of the Development of a Bioartificial Pancreas, as a Treatment
of Insulin-Dependent Diabetes Mellitus 263
Ana Isabel Silva, Antonio Norton de Matos, I. Cabrielle M. Brons,
Marilia Clemente Velez Mateus
9.1 Introduction 263
9.1.1 Diabetes and Its Treatment 263
9.1.2 The Bioartificial Organ Concept 265
9.2 Bioartificial Pancreas 266
9.2.1 Immunoprotection and Biocompatibility of Implanted Devices 267
9.2.2 Vascular Devices 268
9.2.2.1 Biocompatible Materials in Vascular Devices 269
9.2.3 Extravascular Devices 272
9.2.3.1 Implantation Sites 272
9.2.3.2 Macrocapsules 273
9.2.3.3 Microcapsular Devices 280
9.2.4 Influence of Recipients Sensitization to Donor Antigens in
Graft Survival 308
9.2.5 Islet Oxygenation Studies 308
9.2.5.1 Oxygenation of Ba-Alginate Microencapsulated Islets 311
9.3 Final Comments 312
9.4 Acknowledgment 313
Index 321 |
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| id | DE-604.BV023228880 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:19:12Z |
| indexdate | 2024-07-20T09:36:00Z |
| institution | BVB |
| isbn | 9783527314805 3527314806 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016414629 |
| oclc_num | 183145527 |
| open_access_boolean | |
| owner | DE-703 DE-355 DE-BY-UBR DE-1102 DE-29T DE-634 DE-526 DE-M49 DE-BY-TUM |
| owner_facet | DE-703 DE-355 DE-BY-UBR DE-1102 DE-29T DE-634 DE-526 DE-M49 DE-BY-TUM |
| physical | XV, 327 S. zahlr. Ill. und graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Membrane technology |
| series2 | Membrane technology |
| spelling | Membranes for the life sciences ed. by Klaus-Viktor Peinemann ... Membranes for life sciences Weinheim Wiley-VCH 2008 XV, 327 S. zahlr. Ill. und graph. Darst. txt rdacontent n rdamedia nc rdacarrier Membrane technology 1 Yaşam bilimi Zarlar (Teknoloji) Zarlar, yapay Biowissenschaften Biomimetics methods Life sciences Membranes (Technology) Membranes, Artificial Technische Membran (DE-588)4296416-7 gnd rswk-swf Biowissenschaften (DE-588)4129772-6 gnd rswk-swf Biowissenschaften (DE-588)4129772-6 s Technische Membran (DE-588)4296416-7 s DE-604 Peinemann, Klaus-Viktor Sonstige (DE-588)110446577 oth Membrane technology 1 (DE-604)BV023234102 1 http://deposit.dnb.de/cgi-bin/dokserv?id=2909585&prov=M&dok_var=1&dok_ext=htm Beschreibung für Leser HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016414629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Membranes for the life sciences Membrane technology Yaşam bilimi Zarlar (Teknoloji) Zarlar, yapay Biowissenschaften Biomimetics methods Life sciences Membranes (Technology) Membranes, Artificial Technische Membran (DE-588)4296416-7 gnd Biowissenschaften (DE-588)4129772-6 gnd |
| subject_GND | (DE-588)4296416-7 (DE-588)4129772-6 |
| title | Membranes for the life sciences |
| title_alt | Membranes for life sciences |
| title_auth | Membranes for the life sciences |
| title_exact_search | Membranes for the life sciences |
| title_exact_search_txtP | Membranes for the life sciences |
| title_full | Membranes for the life sciences ed. by Klaus-Viktor Peinemann ... |
| title_fullStr | Membranes for the life sciences ed. by Klaus-Viktor Peinemann ... |
| title_full_unstemmed | Membranes for the life sciences ed. by Klaus-Viktor Peinemann ... |
| title_short | Membranes for the life sciences |
| title_sort | membranes for the life sciences |
| topic | Yaşam bilimi Zarlar (Teknoloji) Zarlar, yapay Biowissenschaften Biomimetics methods Life sciences Membranes (Technology) Membranes, Artificial Technische Membran (DE-588)4296416-7 gnd Biowissenschaften (DE-588)4129772-6 gnd |
| topic_facet | Yaşam bilimi Zarlar (Teknoloji) Zarlar, yapay Biowissenschaften Biomimetics methods Life sciences Membranes (Technology) Membranes, Artificial Technische Membran |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2909585&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016414629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV023234102 |
| work_keys_str_mv | AT peinemannklausviktor membranesforthelifesciences AT peinemannklausviktor membranesforlifesciences |