Biological inorganic chemistry: an introduction
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2008
|
| Ausgabe: | 1. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XII, 369 S. Ill., graph. Darst. |
| ISBN: | 9780444527400 0444527400 |
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| 245 | 1 | 0 | |a Biological inorganic chemistry |b an introduction |c Robert R. Crichton. With the collaboration of Fréderic Lallemand ... |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2008 | |
| 300 | |a XII, 369 S. |b Ill., graph. Darst. | ||
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Chimie bioinorganique |2 ram | |
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Datensatz im Suchindex
| _version_ | 1804137496033886209 |
|---|---|
| adam_text | Contents
1 An Overview of Metals in Biology 1
Introduction 1
Why Do We Need Anything Other Than C, H, N and O (Together with Some P and S)? ... 2
What are the Essential Metal Ions? 3
References 12
2 Basic Coordination Chemistry for Biologists 13
Introduction 13
Ionic bonding 14
Covalent bonding 14
Hard and Soft Ligands 15
The chelate effect 16
Coordination Geometry 18
Crystal Field Theory and Ligand Field Theory 19
References 26
3 Biological Ligands for Metal Ions 27
Introduction 27
Protein Amino Acid Residues (and Derivatives) as Ligands 27
An Example of a Non-Protein Ligand: Carbonate and Phosphate 29
Engineering Metal Insertion into Organic Cofactors 30
Chelatase: Terminal Step in Tetrapyrrole Metallation 30
Iron-Sulfur Cluster Containing Proteins 32
Iron-Sulfur Cluster Formation 33
Copper Insertion into Superoxide Dismutase 35
More Complex Cofactors: MoCo, FeMoCo, P-Clusters, H-Clusters and CuZ 36
Siderophores 39
References 42
4 Structural and Molecular Biology for Chemists 43
Introduction 43
The Structural Building Blocks of Proteins 43
Primary, Secondary, Tertiary and Quaternary Structures of Proteins 47
The structural building blocks of nucleic acids 55
Secondary and Tertiary Structures of Nucleic Acids 56
Carbohydrates 59
Lipids and biological membranes 64
A brief overview of molecular biology 66
Replication and transcription 67
Translation 71
PostScript 75
References 76
vii
5 An Overview of Intermediary Metabolism and Bioenergetics 77
Introduction 77
Redox Reactions in Metabolism 78
The Central Role of ATP in Metabolism 79
The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism 82
An Overview of Intermediary Metabolism: Catabolism 86
Selected Case Studies: Glycolysis and the Tricarboxylic Acid Cycle . . . 88
An Overview of Intermediary Metabolism: Anabolism . . . . . . 92
Bioenergetics: Generation of Phosphoryl Transfer Potential at the Expense
of Proton Gradients o7
References
6 Methods to Study Metals in Biological Systems 105
Introduction .„,
Magnetic Properties _ _ ° 107
Electron Paramagnetic Resonance (EPR) Spectroscopy 108
Mössbauer Spectroscopy m
NMR Spectroscopy „
Electronic and Vibrational Spectroscopies [[[ U2
Circular Dichroism and Magnetic Circular Dichroism 113
Resonance Raman Spectroscopy j 14
Extended X-Ray Absorption Fine Structure 11S
X-Ray Diffraction jj^
References . .
116
7 Metal Assimilation Pathways
Introduction
Metal Assimilation in Bacteria , ,-,
Iron 1I7
Copper and zinc
Metal Assimilation in Plants andFungi. . . 171
Iron
Copper and zinc
Metal Assimilation in Mammals ,~
Iron 126
Copper and zinc ....
References 127
129
8 Transport, Storage and Homeostasis of Metal Ions 131
Introduction
Metal Storage and Homeostasis in Bacteria {
Iron 1J
Copper and zinc
Metal Transport, Storage and Homeostasis in Plants and Fungi B6
ron storage and transport in fungi and plants 136
Iron homeostasis in fungi and plants 137
Copper transport and storage in fungi and plants 139
Copper homeostasis in fungi and plants 142
Zinc transport and storage in fungi and plants 142
Zinc homeostasis in fungi and plants ] 43
Metal Transport, Storage and Homeostasis in Mammals 144
Iron transport and storage in mammals 144
Iron homeostasis in mammals 146
Copper and zinc transport and storage in mammals 148
Copper and zinc homeostasis in mammals 148
References 150
9 Sodium and Potassium—Channels and Pumps 151
Introduction: —Transport Across Membranes 151
Sodium Versus Potassium 152
Potassium Channels 153
Sodium Channels 155
The sodium-potassium ATPase 157
Active transport driven by Na+ gradients 158
Sodium/proton exchangers 159
Other roles of intracellular K+ 161
References 163
10 Magnesium-Phosphate Metabolism and Photoreceptors 165
Introduction 165
Magnesium-Dependent Enzymes 166
Phosphoryl Group Transfer: Kinases 167
Phosphoryl Group Transfer: Phosphatases 170
Stabilization of Enolate Anions: The Enolase Super Family 173
Enzymes of Nucleic Acid Metabolism 175
Magnesium and Photoreception 178
References 81
11 Calcium: Cellular Signalling 1H3
Introduction: —Comparison of Ca2+ and Mg2 + 183
The Discovery of a Role for Ca2+ Other Than as a Structural Component 183
Plasma Membrane Uptake Pathways 185
Calcium Export from Cells 85
Ca2+ Transport Across Intracellular Membranes 188
Ca2+ and Cell Signalling 91
References 95
12 Zinc: Lewis Acid and Gene Regulator 197
Introduction
Mononuclear Zinc Enzymes 198
Carbonic Anhydrase 99
Carboxypeptidases and Thermolysins 200
Alcohol Dehydrogenases 202
Other Mononuclear Zinc Enzymes 203
Multinuclear and Cocatalytic Zinc Enzymes 205
Zinc Fingers - DNA- and RNA-Binding Motifs 208
References 210
13 Iron: Essential for Almost All Life 211
Introduction 211
Iron and Oxygen 212
The Biological Importance of Iron 214
Biological Functions of Iron-Containing Proteins 216
Haemoproteins 217
Oxygen transport 217
Activators of molecular oxygen 220
Electron transport proteins 222
Iron-Sulfur Proteins 226
Other Iron-Containing Proteins 231
Mononuclear non-haem iron enzymes 231
Dinuclear non-haem iron enzymes 235
References 239
14 Copper: Coping with Dioxygen 241
Introduction 241
Blue Copper Proteins Involved in Electron Transport 242
Copper-Containing Enzymes in Oxygen Activation and Reduction 244
Type 2 Copper Oxidases and Oxygenases 244
Dinuclear Type 3 Copper Proteins 245
Multi-Copper Oxidases 247
Cytochrome c Oxidases 248
Superoxide Dismutation in Health and Diseases 250
Copper Enzymes Involved with Other Low-Molecular Weight Substrates 251
Mars and Venus: The Role of Copper in Iron Metabolism 253
References 254
15 Nickel and Cobalt: Evolutionär} Relics 257
Introduction: Comparison of Nickel and Cobalt 257
Nickel Enzymes 258
Urease 258
Ni-Fe-S Proteins 259
Methyl-Coenzyme M Reductase 263
Cobalamine and Cobalt Proteins 263
B]2-Dependent Isomerases 264
Bl2-Dependent Methyltransferases 266
Non-Corrin Co-Containing Enzymes 268
References 269
16 Manganese: Water Splitting, Oxygen Atom Donor 271
Introduction: Manganese Chemistry 271
Mn2+ and Detoxification of Oxygen Free Radicals 272
Non-Redox di-Mn Enzymes: Arginase 274
Photosynthetic Oxidation of Water: Oxygen Evolution 276
References 278
17 Molybdenum, Tungsten, Vanadium and Chromium 279
Introduction 279
Molybdenum and Tungsten 279
Molybdenum Enzyme Families 282
Tungsten Enzymes 285
Nitrogenases 286
Vanadium Biochemistry 291
Vanadium Biology 292
Chromium in Biology 294
References 295
18 Metals in Brain and Their Role in Various Neurodegenerative Diseases 297
Introduction: Metals in Brain 297
Calcium 297
Zinc 300
Copper 301
Disorders of Copper Metabolism: Wilson s and Menkes Diseases 301
Aceruloplasminaemia 303
Creutzfeldt-Jakob and Other Prion Diseases 303
Iron 306
Redox Metal Ions, Oxidative Stress and
Neurodegenerative Diseases 308
Parkinson s Disease, PD 311
Alzheimer s Disease, AD 313
Huntington^ Disease 317
Friedreich s Ataxia 319
References 320
19 Biomineralization 321
Introduction
Iron Deposition in Ferritin 322
Iron pathways into ferritin 323
Iron oxidation at dinuclear centres 324
Ferrihydrite nucleation sites 326
Biomineralization JZ/
Calcium-Based Biominerals: Calcium Carbonates
in Ascidians and Molluscs 330
Biomineralization in Bone and Enamel Formation 333
The Organic Matrix, Mineral Phase and Bone Mineralization 334
References 336
20 Metals in Medicine and the Environment 339
Introduction 339
Metallotherapeutics with Lithium 340
Cisplatin: An Anti-Cancer Drug 341
Contrast Agents for Magnetic Resonance Imaging 344
Metals in the Environment 346
Cadmium 346
Aluminium 350
References 352
Index 353
|
| adam_txt |
Contents
1 An Overview of Metals in Biology 1
Introduction 1
Why Do We Need Anything Other Than C, H, N and O (Together with Some P and S)? . 2
What are the Essential Metal Ions? 3
References 12
2 Basic Coordination Chemistry for Biologists 13
Introduction 13
Ionic bonding 14
Covalent bonding 14
Hard and Soft Ligands 15
The chelate effect 16
Coordination Geometry 18
Crystal Field Theory and Ligand Field Theory 19
References 26
3 Biological Ligands for Metal Ions 27
Introduction 27
Protein Amino Acid Residues (and Derivatives) as Ligands 27
An Example of a Non-Protein Ligand: Carbonate and Phosphate 29
Engineering Metal Insertion into Organic Cofactors 30
Chelatase: Terminal Step in Tetrapyrrole Metallation 30
Iron-Sulfur Cluster Containing Proteins 32
Iron-Sulfur Cluster Formation 33
Copper Insertion into Superoxide Dismutase 35
More Complex Cofactors: MoCo, FeMoCo, P-Clusters, H-Clusters and CuZ 36
Siderophores 39
References 42
4 Structural and Molecular Biology for Chemists 43
Introduction 43
The Structural Building Blocks of Proteins 43
Primary, Secondary, Tertiary and Quaternary Structures of Proteins 47
The structural building blocks of nucleic acids 55
Secondary and Tertiary Structures of Nucleic Acids 56
Carbohydrates 59
Lipids and biological membranes 64
A brief overview of molecular biology 66
Replication and transcription 67
Translation 71
PostScript 75
References 76
vii
5 An Overview of Intermediary Metabolism and Bioenergetics 77
Introduction 77
Redox Reactions in Metabolism 78
The Central Role of ATP in Metabolism ' 79
The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism 82
An Overview of Intermediary Metabolism: Catabolism 86
Selected Case Studies: Glycolysis and the Tricarboxylic Acid Cycle . . '. 88
An Overview of Intermediary Metabolism: Anabolism '.'.'.'.'.'.'" 92
Bioenergetics: Generation of Phosphoryl Transfer Potential at the Expense
of Proton Gradients o7
References '
6 Methods to Study Metals in Biological Systems 105
Introduction .„,
Magnetic Properties _' _' ° 107
Electron Paramagnetic Resonance (EPR) Spectroscopy 108
Mössbauer Spectroscopy m
NMR Spectroscopy „
Electronic and Vibrational Spectroscopies [[[ U2
Circular Dichroism and Magnetic Circular Dichroism 113
Resonance Raman Spectroscopy j 14
Extended X-Ray Absorption Fine Structure 11S
X-Ray Diffraction jj^
References . .
116
7 Metal Assimilation Pathways
Introduction
Metal Assimilation in Bacteria , ,-,
Iron 1I7
Copper and zinc
Metal Assimilation in Plants andFungi. .'. 171
Iron
Copper and zinc
Metal Assimilation in Mammals ,~
Iron 126
Copper and zinc .
References 127
129
8 Transport, Storage and Homeostasis of Metal Ions 131
Introduction
Metal Storage and Homeostasis in Bacteria \{\
Iron 1J
Copper and zinc
Metal Transport, Storage and Homeostasis in Plants and Fungi B6
ron storage and transport in fungi and plants 136
Iron homeostasis in fungi and plants 137
Copper transport and storage in fungi and plants 139
Copper homeostasis in fungi and plants 142
Zinc transport and storage in fungi and plants 142
Zinc homeostasis in fungi and plants ] 43
Metal Transport, Storage and Homeostasis in Mammals 144
Iron transport and storage in mammals 144
Iron homeostasis in mammals 146
Copper and zinc transport and storage in mammals 148
Copper and zinc homeostasis in mammals 148
References 150
9 Sodium and Potassium—Channels and Pumps 151
Introduction: —Transport Across Membranes 151
Sodium Versus Potassium 152
Potassium Channels 153
Sodium Channels 155
The sodium-potassium ATPase 157
Active transport driven by Na+ gradients 158
Sodium/proton exchangers 159
Other roles of intracellular K+ 161
References 163
10 Magnesium-Phosphate Metabolism and Photoreceptors 165
Introduction 165
Magnesium-Dependent Enzymes 166
Phosphoryl Group Transfer: Kinases 167
Phosphoryl Group Transfer: Phosphatases 170
Stabilization of Enolate Anions: The Enolase Super Family 173
Enzymes of Nucleic Acid Metabolism 175
Magnesium and Photoreception 178
References '81
11 Calcium: Cellular Signalling 1H3
Introduction: —Comparison of Ca2+ and Mg2 + 183
The Discovery of a Role for Ca2+ Other Than as a Structural Component 183
Plasma Membrane Uptake Pathways 185
Calcium Export from Cells '85
Ca2+ Transport Across Intracellular Membranes 188
Ca2+ and Cell Signalling '91
References '95
12 Zinc: Lewis Acid and Gene Regulator 197
Introduction
Mononuclear Zinc Enzymes 198
Carbonic Anhydrase '99
Carboxypeptidases and Thermolysins 200
Alcohol Dehydrogenases 202
Other Mononuclear Zinc Enzymes 203
Multinuclear and Cocatalytic Zinc Enzymes 205
Zinc Fingers - DNA- and RNA-Binding Motifs 208
References 210
13 Iron: Essential for Almost All Life 211
Introduction 211
Iron and Oxygen 212
The Biological Importance of Iron 214
Biological Functions of Iron-Containing Proteins 216
Haemoproteins 217
Oxygen transport 217
Activators of molecular oxygen 220
Electron transport proteins 222
Iron-Sulfur Proteins 226
Other Iron-Containing Proteins 231
Mononuclear non-haem iron enzymes 231
Dinuclear non-haem iron enzymes 235
References 239
14 Copper: Coping with Dioxygen 241
Introduction 241
Blue Copper Proteins Involved in Electron Transport 242
Copper-Containing Enzymes in Oxygen Activation and Reduction 244
Type 2 Copper Oxidases and Oxygenases 244
Dinuclear Type 3 Copper Proteins 245
Multi-Copper Oxidases 247
Cytochrome c Oxidases 248
Superoxide Dismutation in Health and Diseases 250
Copper Enzymes Involved with Other Low-Molecular Weight Substrates 251
Mars and Venus: The Role of Copper in Iron Metabolism 253
References 254
15 Nickel and Cobalt: Evolutionär} Relics 257
Introduction: Comparison of Nickel and Cobalt 257
Nickel Enzymes 258
Urease 258
Ni-Fe-S Proteins 259
Methyl-Coenzyme M Reductase 263
Cobalamine and Cobalt Proteins 263
B]2-Dependent Isomerases 264
Bl2-Dependent Methyltransferases 266
Non-Corrin Co-Containing Enzymes 268
References 269
16 Manganese: Water Splitting, Oxygen Atom Donor 271
Introduction: Manganese Chemistry 271
Mn2+ and Detoxification of Oxygen Free Radicals 272
Non-Redox di-Mn Enzymes: Arginase 274
Photosynthetic Oxidation of Water: Oxygen Evolution 276
References 278
17 Molybdenum, Tungsten, Vanadium and Chromium 279
Introduction 279
Molybdenum and Tungsten 279
Molybdenum Enzyme Families 282
Tungsten Enzymes 285
Nitrogenases 286
Vanadium Biochemistry 291
Vanadium Biology 292
Chromium in Biology 294
References 295
18 Metals in Brain and Their Role in Various Neurodegenerative Diseases 297
Introduction: Metals in Brain 297
Calcium 297
Zinc 300
Copper 301
Disorders of Copper Metabolism: Wilson's and Menkes Diseases 301
Aceruloplasminaemia 303
Creutzfeldt-Jakob and Other Prion Diseases 303
Iron 306
Redox Metal Ions, Oxidative Stress and
Neurodegenerative Diseases 308
Parkinson's Disease, PD 311
Alzheimer's Disease, AD 313
Huntington^ Disease 317
Friedreich's Ataxia 319
References 320
19 Biomineralization 321
Introduction "'
Iron Deposition in Ferritin 322
Iron pathways into ferritin 323
Iron oxidation at dinuclear centres 324
Ferrihydrite nucleation sites 326
Biomineralization JZ/
Calcium-Based Biominerals: Calcium Carbonates
in Ascidians and Molluscs 330
Biomineralization in Bone and Enamel Formation 333
The Organic Matrix, Mineral Phase and Bone Mineralization 334
References 336
20 Metals in Medicine and the Environment 339
Introduction 339
Metallotherapeutics with Lithium 340
Cisplatin: An Anti-Cancer Drug 341
Contrast Agents for Magnetic Resonance Imaging 344
Metals in the Environment 346
Cadmium 346
Aluminium 350
References 352
Index 353 |
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| spelling | Crichton, Robert R. Verfasser aut Biological inorganic chemistry an introduction Robert R. Crichton. With the collaboration of Fréderic Lallemand ... 1. ed. Amsterdam [u.a.] Elsevier 2008 XII, 369 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Chimie bioinorganique ram Bioinorganic chemistry Bioanorganische Chemie (DE-588)4126727-8 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Bioanorganische Chemie (DE-588)4126727-8 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016399044&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Biological inorganic chemistry an introduction |
| title_auth | Biological inorganic chemistry an introduction |
| title_exact_search | Biological inorganic chemistry an introduction |
| title_exact_search_txtP | Biological inorganic chemistry an introduction |
| title_full | Biological inorganic chemistry an introduction Robert R. Crichton. With the collaboration of Fréderic Lallemand ... |
| title_fullStr | Biological inorganic chemistry an introduction Robert R. Crichton. With the collaboration of Fréderic Lallemand ... |
| title_full_unstemmed | Biological inorganic chemistry an introduction Robert R. Crichton. With the collaboration of Fréderic Lallemand ... |
| title_short | Biological inorganic chemistry |
| title_sort | biological inorganic chemistry an introduction |
| title_sub | an introduction |
| topic | Chimie bioinorganique ram Bioinorganic chemistry Bioanorganische Chemie (DE-588)4126727-8 gnd |
| topic_facet | Chimie bioinorganique Bioinorganic chemistry Bioanorganische Chemie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016399044&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT crichtonrobertr biologicalinorganicchemistryanintroduction |