Tumor angiogenesis: basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin
Springer
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis Klappentext |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVIII, 845 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783540331766 354033176X |
Internformat
MARC
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| 245 | 1 | 0 | |a Tumor angiogenesis |b basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |c Dieter Marmé ... (ed.) |
| 264 | 1 | |a Berlin |b Springer |c 2008 | |
| 300 | |a XVIII, 845 S. |b Ill., graph. Darst. |c 25 cm | ||
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Datensatz im Suchindex
| _version_ | 1804137474791833600 |
|---|---|
| adam_text | Contents
Historical Overview
.................................
ι
1
Tumor Angiogenesis: from Bench to Bedside
JUDAH FOLKMAN
.................................... 3
Mechanisms
....................................... 29
2
Vasculogenesis and Angiogenesis in Development
Anne Eichmann,
Karine
Bouvrée,
and
Luc Pardanaud
.......... 31
3
Guidance of Vascular and
Neuronal
Network Formation
Carmen Ruiz
de Almodovar,
Serena Zacchigna, Monica Autiero,
and Peter Carmeliet
................................ 47
4
The Angiogenic Switch in Tumorigenesis
Andreas Wicki and Gerhard Christofori
.................. 67
5
Pathophysiology and Clinical Implications of
Vascular Endothelial Growth Factor
Napoleone Ferrara.................................
89
6
Regulation of Angiogenesis and Vascular Homeostasis Through
the Angiopoietin/Tie System
Hellmut
G. Augustin
and
Ulrike Fiedler...................109
7
Eph Receptors and Ephrins: Role in Vascular Development
and Tumor Angiogenesis
Dana M. Brantley-Sieders and Jin Chen
.................... 121
8
The Role of the Neuropilins and Their Associated
Plexin
Receptors in
Tumor Angiogenesis and Tumor Progression
Gera Neufeld
and
Opra
Kessler.........................135
VHI
Contents
9
Platelet-derived Growth Factor:
Impact on Physiological and Tumor Angiogenesis
Arne Östman
and
Christer Betsholtz
..................... 155
10
Hypoxia and Tumour Angiogenesis
M.
Christiane Brahimi-Horn,
Julie Laferrière,
Nathalie Mazure,
and Jacques Pouyssegur
.............................. 171
11
Hypoxia and Angiogenesis in Glioblastomas
Till Acker and Karl H. Plate
.......................... 195
12
Endogenous Inhibitors of Angiogenesis
Malin Sund
and Raghu Kalluri
.........................215
13
Thrombospondins and Angiogenesis
Nathan V. Lee and M.
Luisa Iruela-Arispe
..................233
14
Molecular and Cellular Aspects of Heparanase
Neta
Ilan,
Liât
Fux, Michael Elkin, and Israel Vlodavsky
.......247
15
Vessel Maturation and Perivascular Cells
Anne M. Goodwin and Patricia
A. D Amore
..................273
16
Adhesion Molecules in the Vascular Cell Cross-Talk
Ugo Cavallaro....................................
289
17
Homing and Differentiation of Endothelial Progenitor Cells
Carmen Urbich, Emmanouil Chavakis, and
Stefanie
Dimmeler
.....309
18
Molecular Players in Lymphangiogenesis
Marja
Lohela and
Kari
Alitalo.........................
325
19
The Relationship Between Tumors and the Lymphatics:
Consequences for Metastasis
Jonathan P. Sleeman
................................341
20
Inflammation and Angiogenesis:
Innate Immune Cells as Modulator of Tumor Vascularization
Margareta
M.
Mueller
..............................351
21
Arteriovenous Malformation in Mice and Men
Nicole Revencu, Laurence Boon, Miikka Vikkula
.............363
Contents
IX
Animal
Models and Preclinical Anti-Angiogenic
Studies
........375
22
Vascular Endothelial Growth Factor Antibodies for
Anti-angiogenic Therapy
Hans-Peter
Gerber,
Megan E. Baldwin, and Farbod Shojaei
.......377
23
Vascular Endothelial Growth Factor Receptor Tyrosine Kinase
Inhibitors for the Treatment of Cancer
Stephen R. Wedge and
Juliane M. Jürgensmeier...............395
24
Vascular Endothelial Growth Factor Receptor Antibodies for
Anti-Angiogenic Therapy
Peter
Bohlen,
Zhenping Zhu, and Daniel J. Hicklin
............425
25
Angiopoietin^ Antagonists for Anti-Angiogenic Therapy
Paul E. Hughes, Anthony
Polverino,
Jonathan D. Oliner,
and Richard L. Kendall
..............................453
26
Anti-Angiogenic Therapy with Thrombospondins
Jack Lawler
......................................465
27
The Use of Orthotopic Models to Validate
Antivascular
Therapies for Cancer
Robert R. Langley, Sun-Jin Kim, and Isaiah J.
Fidler............477
28
Vascular Tumor Targeting
Dragan
Grabulovski and
Dario
Neri.....................
491
29
Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis
James P. B. O Connor,
Daniela D.
Rosa, Alan Jackson,
and Gordon
С
Jayson
................................511
30
Imaging of Tumor Angiogenesis and Antiangiogenesis
Fabian Kiessling and Martin Krix
.......................529
31
Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy
Marcus Czabanka and Peter Vajkoczy
....................545
32
Cellular Actions of Angiogenesis Inhibitors on Blood Vessels
Peter Baluk, Beverly L. Falcon, Hiroya Hashizume,
Barbara
Sennino,
and Donald M. McDonald
................557
33
Antiangiogenic Therapy for Normalization of Tumor Vasculature
and
Microenvironment
Rakesh K. Jain and Dan G.
Duda
.........................577
Contents
34
Metronomic Antiangiogenic Chemotherapy:
Questions and Answers
Robert S.
Kerbel,
Urban Emmenegger, Shan Man,
Raquel Muñoz,
Francesco Bertolini, and Yuval Shared
.........593
Anti-Angiogenic Tumor Therapy in Clinical Studies
...........609
35
The Development of Avastin
Robert Mass
.....................................611
36
Clinical Development of Sorafenib (BAY
43-9006),
a VEGFR and RAF Inhibitor
Dimitris Voliotis and J. Dumas
..........................655
37
Clinical Development of the VEGFR Signalling Inhibitor AZD2171
Joachim Drevs
and Clemens
Unger
.......................673
38
Clinical Development of Sunitinib
Malate
Isan
Chen, Carlo
Bello,
and Zuleima Aguilar
...............689
39
The EGF(R) and VEGF(R) Pathways as Combined Targets for
Anti-Angiogenesis Trials in Cancer Therapy
Klaas
Hoekman, Hester van Cruijsen, and Guiseppe
Giaccone
.....707
40
Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies
Bruno Morgan and Mark A. Horsfield
....................717
41
Vandetanib
(ZACTIMA™; ZD6474):
Preclinical and Clinical Development
Alan Barge and Anderson J. Ryan
........................741
42
Integrins:
Targets for Anti-Angiogenic Therapy
Oliver Kisker
....................................761
43
Thalidomide in Multiple Myeloma
Thomas M. Moehler, Jens Hillengass, Axel
Glasmacher,
Hartmut Goldschmidt..............................779
44
Surrogate Markers of Angiogenesis
Valentina Raia,
Patrizia
Mancuso, and Francesco Bertolini
.....795
45
Vascular Disrupting Agents in Cancer Therapy
Gillian M. Tozer, Chryso Kanthou, and David J. Chaplin
........809
Subject Index
........................................831
Tumor angiogenesis
is one of the most promi¬
nent mechanisms driving tumor development
and progression. Since its discovery more
than
30
years ago some of the most important
signaling pathways linking specific angiogenic
activities of the tumor cells to the fatal reac¬
tions of the patient s vascular system have been
elucidated. As a consequence crucial targets for
therapeutic intervention have been identified
and validated.
Based on these efforts and achievements, tar¬
geted drug development programs have been
implemented to interfere with tumor angiogen-
esis as an attractive strategy in cancer treatment.
As a promising result the first targeted
anti-
angio¬
genic drugs have been approved for a variety of
solid metastasizing cancers. The first generation
of these molecules targets the two most promi¬
nent regulatory components of tumor angio-
genesis: the vascular endothelial growth factor
(VEGF), produced by tumor cells, and the VEGF
receptor tyrosine kinase, which is expressed on
vascular endothelial cells.
Part
1
of this volume describes the basic
mechanisms of tumor angiogenesis. Beyond
the VEGF/VEGF receptor system, additional
tumor-angiogenic systems are presented as new
potential targets for anti-angiogenic therapy.
Part
2.
reviews the efforts made in preclinical
research to validate new targets and to show
efficacy in animals. Part
3
is entirely devoted
to the clinical development of the novel anti-
angiogenic drugs and their current use in
clinical practice.
Marmé
Fusenig
Editors
Tumor
Angiogenesis
Basic Mechanisms
and Cancer Therapy
|
| adam_txt |
Contents
Historical Overview
.
ι
1
Tumor Angiogenesis: from Bench to Bedside
JUDAH FOLKMAN
. 3
Mechanisms
. 29
2
Vasculogenesis and Angiogenesis in Development
Anne Eichmann,
Karine
Bouvrée,
and
Luc Pardanaud
. 31
3
Guidance of Vascular and
Neuronal
Network Formation
Carmen Ruiz
de Almodovar,
Serena Zacchigna, Monica Autiero,
and Peter Carmeliet
. 47
4
The Angiogenic Switch in Tumorigenesis
Andreas Wicki and Gerhard Christofori
. 67
5
Pathophysiology and Clinical Implications of
Vascular Endothelial Growth Factor
Napoleone Ferrara.
89
6
Regulation of Angiogenesis and Vascular Homeostasis Through
the Angiopoietin/Tie System
Hellmut
G. Augustin
and
Ulrike Fiedler.109
7
Eph Receptors and Ephrins: Role in Vascular Development
and Tumor Angiogenesis
Dana M. Brantley-Sieders and Jin Chen
. 121
8
The Role of the Neuropilins and Their Associated
Plexin
Receptors in
Tumor Angiogenesis and Tumor Progression
Gera Neufeld
and
Opra
Kessler.135
VHI
Contents
9
Platelet-derived Growth Factor:
Impact on Physiological and Tumor Angiogenesis
Arne Östman
and
Christer Betsholtz
. 155
10
Hypoxia and Tumour Angiogenesis
M.
Christiane Brahimi-Horn,
Julie Laferrière,
Nathalie Mazure,
and Jacques Pouyssegur
. 171
11
Hypoxia and Angiogenesis in Glioblastomas
Till Acker and Karl H. Plate
. 195
12
Endogenous Inhibitors of Angiogenesis
Malin Sund
and Raghu Kalluri
.215
13
Thrombospondins and Angiogenesis
Nathan V. Lee and M.
Luisa Iruela-Arispe
.233
14
Molecular and Cellular Aspects of Heparanase
Neta
Ilan,
Liât
Fux, Michael Elkin, and Israel Vlodavsky
.247
15
Vessel Maturation and Perivascular Cells
Anne M. Goodwin and Patricia
A. D'Amore
.273
16
Adhesion Molecules in the Vascular Cell Cross-Talk
Ugo Cavallaro.
289
17
Homing and Differentiation of Endothelial Progenitor Cells
Carmen Urbich, Emmanouil Chavakis, and
Stefanie
Dimmeler
.309
18
Molecular Players in Lymphangiogenesis
Marja
Lohela and
Kari
Alitalo.
325
19
The Relationship Between Tumors and the Lymphatics:
Consequences for Metastasis
Jonathan P. Sleeman
.341
20
Inflammation and Angiogenesis:
Innate Immune Cells as Modulator of Tumor Vascularization
Margareta
M.
Mueller
.351
21
Arteriovenous Malformation in Mice and Men
Nicole Revencu, Laurence Boon, Miikka Vikkula
.363
Contents
IX
Animal
Models and Preclinical Anti-Angiogenic
Studies
.375
22
Vascular Endothelial Growth Factor Antibodies for
Anti-angiogenic Therapy
Hans-Peter
Gerber,
Megan E. Baldwin, and Farbod Shojaei
.377
23
Vascular Endothelial Growth Factor Receptor Tyrosine Kinase
Inhibitors for the Treatment of Cancer
Stephen R. Wedge and
Juliane M. Jürgensmeier.395
24
Vascular Endothelial Growth Factor Receptor Antibodies for
Anti-Angiogenic Therapy
Peter
Bohlen,
Zhenping Zhu, and Daniel J. Hicklin
.425
25
Angiopoietin^ Antagonists for Anti-Angiogenic Therapy
Paul E. Hughes, Anthony
Polverino,
Jonathan D. Oliner,
and Richard L. Kendall
.453
26
Anti-Angiogenic Therapy with Thrombospondins
Jack Lawler
.465
27
The Use of Orthotopic Models to Validate
Antivascular
Therapies for Cancer
Robert R. Langley, Sun-Jin Kim, and Isaiah J.
Fidler.477
28
Vascular Tumor Targeting
Dragan
Grabulovski and
Dario
Neri.
491
29
Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis
James P. B. O'Connor,
Daniela D.
Rosa, Alan Jackson,
and Gordon
С
Jayson
.511
30
Imaging of Tumor Angiogenesis and Antiangiogenesis
Fabian Kiessling and Martin Krix
.529
31
Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy
Marcus Czabanka and Peter Vajkoczy
.545
32
Cellular Actions of Angiogenesis Inhibitors on Blood Vessels
Peter Baluk, Beverly L. Falcon, Hiroya Hashizume,
Barbara
Sennino,
and Donald M. McDonald
.557
33
Antiangiogenic Therapy for Normalization of Tumor Vasculature
and
Microenvironment
Rakesh K. Jain and Dan G.
Duda
.577
Contents
34
Metronomic Antiangiogenic Chemotherapy:
Questions and Answers
Robert S.
Kerbel,
Urban Emmenegger, Shan Man,
Raquel Muñoz,
Francesco Bertolini, and Yuval Shared
.593
Anti-Angiogenic Tumor Therapy in Clinical Studies
.609
35
The Development of Avastin
Robert Mass
.611
36
Clinical Development of Sorafenib (BAY
43-9006),
a VEGFR and RAF Inhibitor
Dimitris Voliotis and J. Dumas
.655
37
Clinical Development of the VEGFR Signalling Inhibitor AZD2171
Joachim Drevs
and Clemens
Unger
.673
38
Clinical Development of Sunitinib
Malate
Isan
Chen, Carlo
Bello,
and Zuleima Aguilar
.689
39
The EGF(R) and VEGF(R) Pathways as Combined Targets for
Anti-Angiogenesis Trials in Cancer Therapy
Klaas
Hoekman, Hester van Cruijsen, and Guiseppe
Giaccone
.707
40
Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies
Bruno Morgan and Mark A. Horsfield
.717
41
Vandetanib
(ZACTIMA™; ZD6474):
Preclinical and Clinical Development
Alan Barge and Anderson J. Ryan
.741
42
Integrins:
Targets for Anti-Angiogenic Therapy
Oliver Kisker
.761
43
Thalidomide in Multiple Myeloma
Thomas M. Moehler, Jens Hillengass, Axel
Glasmacher,
Hartmut Goldschmidt.779
44
Surrogate Markers of Angiogenesis
Valentina Raia,
Patrizia
Mancuso, and Francesco Bertolini
.795
45
Vascular Disrupting Agents in Cancer Therapy
Gillian M. Tozer, Chryso Kanthou, and David J. Chaplin
.809
Subject Index
.831
Tumor angiogenesis
is one of the most promi¬
nent mechanisms driving tumor development
and progression. Since its discovery more
than
30
years ago some of the most important
signaling pathways linking specific angiogenic
activities of the tumor cells to the fatal reac¬
tions of the patient's vascular system have been
elucidated. As a consequence crucial targets for
therapeutic intervention have been identified
and validated.
Based on these efforts and achievements, tar¬
geted drug development programs have been
implemented to interfere with tumor angiogen-
esis as an attractive strategy in cancer treatment.
As a promising result the first targeted
anti-
angio¬
genic drugs have been approved for a variety of
solid metastasizing cancers. The first generation
of these molecules targets the two most promi¬
nent regulatory components of tumor angio-
genesis: the vascular endothelial growth factor
(VEGF), produced by tumor cells, and the VEGF
receptor tyrosine kinase, which is expressed on
vascular endothelial cells.
Part
1
of this volume describes the basic
mechanisms of tumor angiogenesis. Beyond
the VEGF/VEGF receptor system, additional
tumor-angiogenic systems are presented as new
potential targets for anti-angiogenic therapy.
Part
2.
reviews the efforts made in preclinical
research to validate new targets and to show
efficacy in animals. Part
3
is entirely devoted
to the clinical development of the novel anti-
angiogenic drugs and their current use in
clinical practice.
Marmé
Fusenig
Editors
Tumor
Angiogenesis
Basic Mechanisms
and Cancer Therapy |
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| any_adam_object_boolean | 1 |
| building | Verbundindex |
| bvnumber | BV023199063 |
| classification_rvk | XH 1800 |
| ctrlnum | (OCoLC)635031985 (DE-599)DNB979112397 |
| dewey-full | 616.994071 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994071 |
| dewey-search | 616.994071 |
| dewey-sort | 3616.994071 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV023199063 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:07:33Z |
| indexdate | 2024-07-09T21:12:52Z |
| institution | BVB |
| isbn | 9783540331766 354033176X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016385325 |
| oclc_num | 635031985 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XVIII, 845 S. Ill., graph. Darst. 25 cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer |
| record_format | marc |
| spelling | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables Dieter Marmé ... (ed.) Berlin Springer 2008 XVIII, 845 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Angiogenese (DE-588)4142449-9 gnd rswk-swf Tumorwachstum (DE-588)4186432-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Tumorwachstum (DE-588)4186432-3 s Angiogenese (DE-588)4142449-9 s DE-604 Marmé, Dieter Sonstige oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2789670&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016385325&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016385325&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables Angiogenese (DE-588)4142449-9 gnd Tumorwachstum (DE-588)4186432-3 gnd |
| subject_GND | (DE-588)4142449-9 (DE-588)4186432-3 (DE-588)4143413-4 |
| title | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |
| title_auth | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |
| title_exact_search | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |
| title_exact_search_txtP | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |
| title_full | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables Dieter Marmé ... (ed.) |
| title_fullStr | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables Dieter Marmé ... (ed.) |
| title_full_unstemmed | Tumor angiogenesis basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables Dieter Marmé ... (ed.) |
| title_short | Tumor angiogenesis |
| title_sort | tumor angiogenesis basic mechanisms and cancer therapy with contributions by numerous experts with 72 tables |
| title_sub | basic mechanisms and cancer therapy ; with contributions by numerous experts ; with 72 tables |
| topic | Angiogenese (DE-588)4142449-9 gnd Tumorwachstum (DE-588)4186432-3 gnd |
| topic_facet | Angiogenese Tumorwachstum Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2789670&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016385325&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016385325&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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