Harrison's principles of internal medicine:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
McGraw-Hill
2008
|
| Edition: | 17. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | Getr. Zählung Ill., graph. Darst., Kt. 1 DVD (12 cm) |
| ISBN: | 9780071466332 0071466339 9780071599917 9780071599900 9780071476911 |
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| 245 | 1 | 0 | |a Harrison's principles of internal medicine |c ed. Anthony S. Fauci ... |
| 246 | 1 | 3 | |a Principles of internal medicine |
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| 300 | |a Getr. Zählung |b Ill., graph. Darst., Kt. |e 1 DVD (12 cm) | ||
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Record in the Search Index
| _version_ | 1804137448852160512 |
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| adam_text | ALLERGY, IMMUNOLOGY, RHEUMATOLOGY
FIG. 311-3 The diagnosis and management of rhinitis 2070
FIG. 313-2 The diagnosis and initial therapy of SLE 2078
FIG. 314-3 The medical management of
rheumatoid arthritis 2091
FIG. 317-1 Treatment for Sjogren s syndrome 2109
FIG. 318-4 The diagnosis of the spondyloarthritides 2117
FIG. 319-1 Approach to the patient with suspected
diagnosis of vasculitis 2121
FIG. 322-8 Patient management for sarcoidosis 2140
FIG. 322-9 The management of acute sarcoidosis 2141
FIG. 322-10 Management of chronic sarcoidosis 2141
FIG. 324-1 The diagnosis of amyloidosis and
determination of type 2146
FIG. 325-1 The diagnosis of musculoskeletal complaints 2151
FIG. 325-2 The consideration of the most common
musculoskeletal conditions 2152
FIG. 325-6 Approach to synovia] fluid
aspiration and analysis 2156
CARDIOLOGY
FIG. 8-2 Cardiac risk assessment and stratification
in patients undergoing noncardiac surgery 51
FIG. 219-1 An alternative echocardiography first
approach to the evaluation of a heart murmur ... 1381
FIG. 222-11 Flow diagram showing selection of initial
stress test in a patient with chest pain 1404
FIG. 227-4 Treatment algorithm for chronic heart failure
patients with a depressed ejection fraction 1450
FIG. 230-1 Management strategy for patients with
mitral stenosis (MS) and mild symptoms 1468
FIG. 230-4 Management strategy for patients with
chronic severe mitral regurgitation 1471
FIG. 230-5 Management strategy for patients
with severe aortic stenosis 1475
FIG. 230-6 Management strategy for patients with
chronic severe aortic regurgitation 1477
FIG. 237-1 Evaluation of the patient with known
or suspected ischemic heart disease 1517
FIG. 237-2 The management of the patient with
ischemic heart disease 1525
FIG. 239-7 The assessment of need for implantation
of cardioverter/defibrillator 1542
CLINICAL GENETICS
FIG. 64-3 Genetic counseling 417
FIG. 79-6 Genetic testing in a family
with cancer predisposition 495
CLINICAL NUTRITION
FIG. 73-1 Decision-making for the implementation
of specialized nutrition support (SNS) 456
FIG. 76-1 Basic treatment decisions regarding patients
with anorexia or bulimia nervosa 476
EMERGENCY AND CRITICAL CARE
FIG. 216-1 Evacuation in a multicasualties radiologic event... 1361
FIG. 216 -3 General guidelines for treatment
of radiation casualties 1364
FIG. 261-2 Approach to the patient in shock 1675
FIG. 262-5 Algorithm for the initial management of ARDS ... 1683
FIG. 266-2 Emergency management of
patients with cardiogenic shock,
acute pulmonary edema, or both 1704
FIG. 267-3A Cardiac arrest management:
ventricular fibrillation 1712
FIG. 267-3B Cardiac arrest management:
bradyarrhythmia/asystole 1712
FIG. 269-4 Prognostication of outcome
in comatose survivors 1723
ENDOCRINOLOGY AND METABOLISM
FIG. 50-2 The evaluation and differential
diagnosis of hirsutism 303
FIG. 333-6 Management of prolactinoma 2206
FIG. 333-7 Management of adult growth
hormone (GH) deficiency 2209
FIG. 333-9 Management of acromegaly 2211
FIG. 333-10 Management of Cushing s syndrome 2214
FIG. 333-11 Management of a nonfunctioning
pituitary mass 2216
FIG. 336-7 Evaluating patients suspected of
having Cushing s syndrome 2256
FIG. 336-10 Diagnostic flowchart for evaluating patients
with possible mineralocorticoid excess states 2261
FIG. 336-12 Diagnostic flowchart for evaluating patients
with suspected adrenal insufficiency 2264
FIG. 338-11 Screening for microalbuminuria 2288
FIG. 338-12 Dyslipidemia management in diabetes 2291
FIG. 338-14 Essential elements in comprehensive
diabetes care of type 2 diabetes 2299
FIG. 338-15 Glycemic management of type 2 diabetes 2302
FIG. 339-2 Hypoglycemia-associated autonomic
failure in insulin-deficient diabetes 2307
FIG. 339-3 Diagnostic approach to a patient with
documented or suspected hypoglycemia 2309
FIG. 340-5 Evaluation of gynecomastia 2319
FIG. 340-6 Evaluation of hypogonadism 2320
FIG. 347-6 The evaluation of patients with hypercalcemia ... 2389
FIG. 351-3 Algorithm for screening for
HFE-associated hemochromatosis 2433
GASTROENTEROLOGY AND HEPATOLOGY
FIG. 38-1 Approach to the patient with dysphagia 240
FIG. 40-2 Management of acute diarrhea 249
FIG. 40-3 Management of chronic diarrhea 252
FIG. 40-4 Management of constipation 254
FIG. 42-1 Management of acute upper
gastrointestinal bleeding 259
FIG. 42-2 Management of acute lower
gastrointestinal bleeding 260
FIG. 43-1 Evaluation of the patient with jaundice 262
FIG. 287-12 Overview of new-onset dyspepsia 1865
FIG. 295-1 Algorithm for evaluation
of abnormal liver tests 1922
FIG. 296-1 Algorithm for the evaluation of
chronically abnormal liver tests 1924
FIG. 301-3 Treatment algorithm for alcoholic hepatitis 1971
FIG. 302-1 Management of recurrent variceal hemorrhage... 1977
FIG. 302-3 Treatment of refractory ascites 1979
FIG. 306-1 An approach to the patient with
suspected chronic pancreatitis 2004
HEMATOLOGY AND ONCOLOGY
FIG. 58-17 The physiologic classification of anemia 361
FIG. 58-18 An approach to diagnosing
patients with polycythemia 363
FIG. 82-2 The diagnosis and treatment of
febrile neutropenic patients 539
FIG. 84-1 Evaluation of a patient
with cervical adenopathy 549
FIG. 85-2 Algorithm for evaluation of
solitary pulmonary nodule (SPN) 558
FIG. 86-1 Approach to palpable breast mass 564
FIG. 86-2 The triple diagnosis technique
in suspected breast cancer 564
FIG. 86-3 Management of a breast cyst 564
FIG. 86-4 Approaches to abnormalities
detected by mammogram 565
FIG. 88-1 Treatment approach to patients
with hepatocellular carcinoma 583
FIG. 91-2 The diagnostic evaluation of
men with prostate disorders 595
FIG. 95-2 Treatment algorithm for adenocarcinoma and
poorly differentiated adenocarcinoma CUP 616
FIG. 95-3 Treatment algorithm for squamous cell CUP 616
FIG. 99-3 Pathophysiology of sickle cell crisis 637
FIG. 104-2 The therapy of newly diagnosed
chronic myeloid leukemia 681
FIG. 109-2 Evaluating the thrombocytopenic patient 720
FIG. 112-1 Classification of antithrombotic drugs 736
FIG. 270-2 Management of cancer patients with back pain... .1733
FIG. 270-4 Management of patients at high
risk for the tumor lysis syndrome 1737
INFECTIOUS DISEASES AND HIV/AIDS
FIG. 118-4 The diagnostic use of TEE and TTE
in infective endocarditis 793
FIG. 121-3 The management of patients
with intraabdominal abscesses
using percutaneous drainage 811
FIG. 122-1 The approach to patients with
community-acquired infectious
diarrhea or bacterial food poisoning 815
FIG. 144-1 Schematic of the relationships between
colonization with Helkobacter pylori
and diseases of the upper gastrointestinal
tract among persons in developed countries 947
FIG. 144-2 The management of Helkobacter pylori infection .. .948
FIG. 166-2 Algorithm for the treatment of the various acute
or chronic manifestations of Lyme borreliosis 1058
FIG. 182-30 The acute HIV infection 1169
FIG. 182-34 The evaluation of diarrhea in
patient with HIV infection 1176
FIG. 188-4 Rabies postexposure prophylaxis 1225
NEPHROLOGY
FIG. 46-1 The clinical approach to hyponatremia 278
FIG. 46-2 The clinical approach to hypernatremia 280
FIG. 46-3 The clinical approach to hypokalemia 282
FIG. 46-4 The clinical approach to hyperkalemia 284
FIG. 49-2 The evaluation and management
of patients with ED 298
FIG. 276-2 A typical algorithm for early
posttransplant care of the kidney recipient 1780
FIG. 283-1 Diagnostic approach for urinary tract
obstruction in unexplained renal failure 1829
NEUROLOGY AND PSYCHIATRY
FIG. 363-2 Evaluation of the adult patient with a seizure 2505
FIG. 363-3 Pharmacologic treatment of generalized
tonic-clonic status epilepticus in adults 2511
FIG. 364-1 Medical management of stroke and TIA 2514
FIG. 366-4 Treatment approach to newly diagnosed
idiopathic Parkinson s Disease 2554
FIG. 375-4 Therapeutic decision-making
for multiple sclerosis 2618
FIG. 376-1 The management of patients
with suspected CNS infections 2622
FIG. 376-2 The pathophysiology of the neurologic
complications of bacterial meningitis 2624
FIG. 379-1 Approach to the evaluation
of peripheral neuropathies 2652
FIG. 379-2 Diagnostic approach to
Charcot-Marie-Tooth disease (CMT) 2664
FIG. 381-2 The management of myasthenia gravis 2676
FIG. 386-1 Medical management of
major depressive disorder 2717
PULMONARY
FIG. 33-3 The evaluation of the patient with dyspnea 224
FIG. 34-1 Management of cough lasting
longer than 3 weeks 226
FIG. 34-2 The evaluation of nonmassive hemoptysis 228
FIG. 244-1 The workup of a patient with
unexplained pulmonary hypertension 1576
FIG. 244-2 The selection of optimal drug
treatment of a patient with
pulmonary arterial hypertension 1577
FIG. 246-5 A diagnostic approach to
the patient with hypoxemia 1591
FIG. 252-2 A diagnostic approach to bronchiectasis 1630
i
FIG. 256-1 How to decide whether diagnostic imaging
is needed in suspected PTE and DVT 1652
FIG. 256-4 Imaging tests to diagnose DVT and PE 1655
FIG. 256-5 Acute management of pulmonary
thromboembolism 1655
FIG. 257-1 Approach to the diagnosis of pleural effusions 1658
SYSTEMIC PRESENTATIONS
FIG. 16-6 Algorithms for management of acute
low back pain, age 18 years 114
FIG. 11-2 Common and uncommon clinical courses
in the last days of terminally ill patients 78
FIG. 19-1 Approach to the patient with
classic fever of unknown origins 133
FIG. 21-1 Approach to the patient with syncope 142
FIG. 23-3 The initial workup of a patient with weakness 149
FIG. 30-4 An algorithm for the approach to hearing loss 201
FIG. 57-1 An algorithm for the diagnosis
of a patient with photosensitivity 354
Summaries of Chapters e1 to e39 xvii
Contributors xxi
Preface xxxv
?^ PART 1 Introduction to
Clinical Medicine
1 The Practice of Medicine 1
The Editors
2 Global Issues in Medicine 6
Jim Yong Kim I Paul Farmer
3 Decision-Making in Clinical Medicine 16
Daniel B. Mark
4 Screening and Prevention of Disease 24
Gary J. Martin
5 Principles of Clinical Pharmacology 27
Dan M Roden
6 Women s Health 39
Andrea E. Dunaif
7 Medical Disorders during Pregnancy 44
Robert L Barbieri /John T. Repke
8 Medical Evaluation of the Surgical Patient 49
WeiC. Lau/KimA. Eagle
9 Geriatric Medicine 53
Lisa B. Caruso I Rebecca A. Silliman
10 Complementary and Alternative Medicine 62
Stephen E. Straus
11 Palliative and End-of-Life Care 66
Ezekiel J. Emanuel I Joshua Hauser I Linda L. Emanuel
0 e1 The Safety and Quality of Health Care el
David W. Bates
^0 e2 Economic Considerations
in the Practice of Medicine e7
David Meltzer
£ e3 Racial and Ethnic Disparities in Health Care el l
Joseph R. Betancourt I David Blumenthal
£p e4 Ethical Issues in Clinical Medicine el9
Bernard Lo
? PART 2 Cardinal Manifestations and
Presentation of Diseases
^^^^k PAIN
12 Pain: Pathophysiology and Management 81
Howard L Fields /Joseph B. Martin
13 Chest Discomfort 87
Thomas H. Lee
14 Abdominal Pain 91
William Silen
15 Headache 95
Peter J. Goadsby I Neil H. Raskin
16 Back and Neck Pain 107
John W. Engstrom
Rflffl^^ ALTERATIONS IN BODY TEMPERATURE
17 Fever and Hyperthermia 117
Charles A. Dinarello I Reuven Porat
18 Fever and Rash 121
Elaine T. Kaye I Kenneth M. Kaye
0jf e5 Atlas of Rashes Associated with Fever e23
Kenneth M. Kaye I Elaine T. Kaye
19 Fever of Unknown Origin 130
Jeffrey A. Gelfand / Michael V. Callahan
20 Hypothermia and Frostbite 135
Daniel F. Danzl
QQj^Q NERVOUS SYSTEM DYSFUNCTION
21 Syncope 139
Mark D. Carlson
22 Dizziness and Vertigo 144
Robert B. Daroff
23 Weakness and Paralysis 147
Michael J. Aminoff
24 Gait and Balance Disorders 151
Lewis Sudarsky
25 Numbness, Tingling, and Sensory Loss 154
Michael J. Aminoff I Arthur K. Asbury
26 Confusion and Delirium 158
S. Andrew Josephson I Bruce L Miller
£ e6 Memory Loss e33
Thomas D. Bird / Bruce L Miller
27 Aphasia, Memory Loss, and
Other Focal Cerebral Disorders 162
M. -Marsel Mesulam
28 Sleep Disorders 171
Charles A. Czeisler / John W. Winkelman /
Gary S. Richardson
m|Q| DISORDERS OF EYES, EARS, NOSE, ANO THROAT
29 Disorders of the Eye 180
Jonathan C. Horton
30 Disorders of Smell, Taste, and Hearing 196
Anil K. Lalwani
31 Pharyngitis, Sinusitis, Otitis, and
Other Upper Respiratory Tract Infections 205
Michael A. Rubin I Ralph Gonzales I Merle A. Sande
32 Oral Manifestations of Disease 214
Samuel C. Durso
^0 e7 Atlas of Oral Manifestations of Disease e37
Samuel C. Durso I Janet A. Yellowitz I Jane C. Atkinson
^^QQ| ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTIONS
33 Dyspnea and Pulmonary Edema 221
Richard M. Schwartzstein
34 Cough and Hemoptysis 225
Steven E. Weinberger I David A. Lipson
35 Hypoxia and Cyanosis 229
Eugene Braunwald
36 Edema 231
Eugene Braunwald /Joseph Loscalzo
0 e8 Approach to the Patient with a Heart Murmur .... e43
Patrick T. O Gara / Eugene Braunwald
37 Palpitations 236
Joseph Loscalzo
HRJQ^ ALTERATIONS IN GASTROINTESTINAL FUNCTION
38 Dysphagia 237
Raj K. Goyal
39 Nausea, Vomiting, and Indigestion 240
William L Hasler
40 Diarrhea and Constipation 245
Michael Camilleri /Joseph A. Murray
41 Weight Loss 255
Carol M. Reife
42 Gastrointestinal Bleeding 257
Loren Laine
43 Jaundice 261
DanielS. Pratt / Marshall M. Kaplan
44 Abdominal Swelling and Ascites 266
Robert M. Glickman I Roshini Rajapaksa
JJEfl^ ALTERATIONS IN RENAL AND URINARY TRACT FUNCTION
45 Azotemia and Urinary Abnormalities 268
Bradley M. Denker I Barry M. Brenner
(^ e9 Atlas of Urinary Sediments and Renal Biopsies ... e53
Agnes B. Fogo I Eric G. Neilson
46 Fluid and Electrolyte Disturbances 274
Gary G. Singer / Barry M. Brenner
47 Hypercalcemia and Hypocalcemia 285
Sundeep Khosla
48 Acidosis and Alkalosis 287
Thomas D. DuBose, Jr.
HSBfflft ALTERATIONS IN SEXUAL FUNCTION AND REPRODUCTION
49 Sexual Dysfunction 296
Kevin T. McVary
50 Hirsutism and Virilization 301
David A. Ehrmann
51 Menstrual Disorders and Pelvic Pain 304
Janet E. Hall
UQ2Q^ ALTERATIONS IN THE SKIN
52 Approach to the Patient with a Skin Disorder 308
Thomas J. Lawley/Kim B. Yancey
53 Eczema, Psoriasis, Cutaneous Infections,
Acne, and Other Common Skin Disorders 312
Calvin O. McCall I Thomas J. Lawley
54 Skin Manifestations of Internal Disease 321
Jean L. Bolognia I Irwin M. Braverman
55 Immunologkally Mediated Skin Diseases 336
Kim B. Yancey I Thomas J. Lawley
56 Cutaneous Drug Reactions 343
Jean-Claude Roujeau I Robert S. Stern/Bruce U. Wintroub
57 Photosensitivity and Other Reactions to Light 350
David R. Bickers
0fr e1O Atlas of Skin Manifestations
of Internal Disease e6l
Thomas ]. Lawley I Stephen F. Templeton
QQQQQ^ HEMAT010GIC ALTERATIONS
58 Anemia and Polycythemia 355
John W. Adamson I Dan L Longo
59 Bleeding and Thrombosis 363
Barbara A. Konkle
60 Enlargement of Lymph Nodes and Spleen 370
Patrick H. Henry I Dan L. Longo
61 Disorders of Granulocytes and Monocytes 375
Steven M. Holland I John J. Gallin
5 e11 Atlas of Hematology and Analysis
of Peripheral Blood Smears e77
Dan L Longo
~^ PART 3 Genetics and Disease
62 Principles of Human Genetics 385
/. Larry Jameson / Peter Kopp
63 Chromosome Disorders 407
Terry J. Hassold I Stuart Schwartz
64 The Practice of Genetics in Clinical Medicine 414
Susan Miesfeldt / J. Larry Jameson
65 Gene Therapy in Clinical Medicine 420
KatherineA. High
y^- PART 4 Regenerative Medicine
66 Stem Cell Biology 425
Minoru S. H. Ko
67 Applications of Stem Cell Biology
in Clinical Medicine 427
John A. Kessler
68 Hematopoietic Stem Cells 430
David T. Scadden I Dan L. Longo
69 Tissue Engineering 434
Jennifer Anderson /Joseph P. Vacanti
y^ PART 5 Nutrition
70 Nutritional Requirements and Dietary Assessment... 437
Johanna Dwyer
71 Vitamin and Trace Mineral
Deficiency and Excess 441
Robert M. Russell I Paolo M. Suter
72 Malnutrition and Nutritional Assessment 450
Douglas C. Heimburger
73 Enteral and Parenteral Nutrition Therapy 455
Bruce R. Bistrian I David F. Driscoll
74 Biology of Obesity 462
Jeffrey S. Flier I Eleftheria Maratos-Flier
75 Evaluation and Management of Obesity 468
Robert F. Kushner
76 Eating Disorders 473
B. Timothy Walsh
W PART 6 Oncology and Hematology
|^^^^k NEOPLASTIC DISORDERS
77 Approach to the Patient with Cancer 479
Dan L. Longo
78 Prevention and Early Detection of Cancer 486
Otis W. Brawley I Barnett S. Kramer
79 Cancer Genetics 492
Pat J. Morin I Jeffrey M. Trent I Francis S. Collins I
Bert Vogelstein
80 Cancer Cell Biology and Angiogenesis 498
Robert G. Fenton I Dan L. Longo
81 Principles of Cancer Treatment 514
Edward A. Sausville / Dan L Longo
82 Infections in Patients with Cancer 533
Robert Finberg
83 Cancer of the Skin 541
Arthur J. Sober I Hensin Tsao I Carl V. Washington
84 Head and Neck Cancer 548
Everett E. Vokes
85 Neoplasms of the Lung 551
John D. Minna I Joan H. Schiller
86 Breast Cancer 563
Marc E. Lippman
87 Gastrointestinal Tract Cancer 570
Robert J. Mayer
88 Tumors of the Liver and Biliary Tree 580
Brian I. Can
89 Pancreatic Cancer 586
Yu Jo Chua I David Cunningham
90 Bladder and Renal Cell Carcinomas 589
Howard I. Scher I Robert J. Motzer
91 Benign and Malignant Diseases of the Prostate 593
Howard I. Scher
92 Testicular Cancer 601
Robert J. Motzer I George J. Bosl
93 Gynecologic Malignancies 604
Robert C. Young
94 Soft Tissue and Bone Sarcomas
and Bone Metastases 610
Shreyaskumar R. Patel/Robert S. Benjamin
95 Carcinoma of Unknown Primary 614
Gauri R. Varadhachary /James L. Abbruzzese
96 Paraneoplastic Syndromes:
Endocrinologic/Hematologic 617
/. Larry Jameson / Bruce E. Johnson
97 Paraneoplastic Neurologic Syndromes 623
Josep Dalmau I Myrna R. Rosenfeld
0 e12 Thymoma e89
Dan L. Longo
0^ e13 Late Consequences of Cancer
and Its Treatment e9i
Michael C. Perry I Dan L. Longo
B^QA HEMATOPOIETIC DISORDERS
98 Iron Deficiency and Other
Hypoproliferative Anemias 628
John W. Adamson
99 Disorders of Hemoglobin 635
Edward J. Benz, Jr.
100 Megaloblastic Anemias 643
A. Victor Hoffbrand
101 Hemolytic Anemias and Anemia
Due to Acute Blood Loss 652
Lucio Luzzatto
102 Aplastic Anemia, Myelodysplasia, and Related
Bone Marrow Failure Syndromes 663
Neal S. Young
103 Polycythemia Vera and Other
Myeloproliferative Diseases 671
Jerry L. Spivak
104 Acute and Chronic Myeloid Leukemia 677
Meir Wetzler I John C. Byrd I Clara D. Bloomfield
105 Malignancies of Lymphoid Cells 687
Dan L. Longo
106 Plasma Cell Disorders 700
Nikhil C. Munshi I Dan L. Longo I Kenneth C. Anderson
107 Transfusion Biology and Therapy 707
Jeffery S. Dzieczkowski / Kenneth C. Anderson
108 Hematopoietic Cell Transplantation 713
Frederick R. Appelbaum
Q^ESEb DISORDERS OF HEMOSTASIS
109 Disorders of Platelets and Vessel Wall 718
Barbara A. Konkle
110 Coagulation Disorders 725
Voider Arruda I Katherine A. High
111 Venous Thrombosis 731
F.R. Rosendaal I H.R. Buller
112 Antiplatelet, Anticoagulant,
and Fibrinolytic Drugs 735
Jeffrey I. Weitz
y=- PART 7 Infectious Diseases
^^^Q^ BASIC CONSIDERATIONS IN INFECTIOUS DISEASES
113 Introduction to Infectious Diseases:
Host-Pathogen Interactions 749
Lawrence C. Madoff I Dennis L. Kasper
114 Molecular Mechanisms of Microbial Pathogenesis ... 753
Gerald B. Pier
115 Approach to the Acutely III
Infected Febrile Patient 761
Tamar F. Barlam I Dennis L. Kasper
116 Immunization Principles and Vaccine Use 767
Gerald T. Keusch I Kenneth J. Bart I Mark Miller
117 Health Advice for International Travel 782
Jay S. Keystone I Phyllis E. Kozarsky
£ ei4 Laboratory Diagnosis of Infectious Diseases e97
Alexander J. McAdam / Andrew B. Onderdonk
^^^^A CLINICAL SYNDROMES: COMMUNITY-ACQUIRED INFECTIONS
118 Infective Endocarditis 789
Adolf W. Karchmer
119 Infections of the Skin, Muscle, and Soft Tissues 798
Dennis L. Stevens
120 Osteomyelitis 803
Jeffrey Parsonnet
121 Intraabdominal Infections and Abscesses 807
Miriam J. Baron /Dennis L Kasper
122 Acute Infectious Diarrheal Diseases
and Bacterial Food Poisoning 813
Joan R. Butterton I Stephen B. Calderwood
123 Clostridium difficile-Associated Disease,
Including Pseudomembranous Colitis 818
DaleN. Gerding I Stuart Johnson
124 Sexually Transmitted Infections:
Overview and Clinical Approach 821
KingK. Holmes
(5 e15 Infectious Complications of Burns and Bites ... el07
Lawrence C. Madoff I Florencia Pereyra
IJ^Q^A CLINICAL SYNDROMES: HEALTH CARE-ASSOCIATED INFECTIONS
125 Health Care-Associated Infections 835
Robert A. Weinstein
126 Infections in Transplant Recipients 842
Robert Finberg I Joyce Fingeroth
Bffffljflll APPROACH TO THERAPY FOR BACTERIAL DISEASES
127 Treatment and Prophylaxis of Bacterial Infections ... 851
Gordon L. Archer I Ronald E. Polk
|QQ^ DISEASES CAUSED BY GRAM-POSITIVE BACTERIA
128 Pneumococcal Infections 865
Daniel M. Musher
129 Staphylococcal Infections 872
Franklin D. Lowy
130 Streptococcal and Enterococcal Infections 881
Michael R. Wessels
131 Diphtheria and Other Infections Caused
by Corynebacteria and Related Species 890
William R. Bishai I John R. Murphy
132 Infections Caused by Listeria monocytogenes 895
Elizabeth L. Hohmann I Daniel A. Portnoy
133 Tetanus 898
Elias Abrutyn
134 Botulism 901
Elias Abrutyn
135 Gas Gangrene and Other Clostridial Infections 903
Dennis L Kasper I Lawrence C. Madoff
m^Q^ DISEASES CAUSED BY GRAM-NEGATIVE BACTERIA
136 Meningococcal Infections 908
Lee M. Wetzler
137 Gonococcal Infections 914
Sanjay Ram I Peter A. Rice
138 Moraxella Infections 921
Daniel M. Musher
139 Haemophilus Infections 923
Timothy F. Murphy
140 Infections Due to the HACEK Group and
Miscellaneous Gram-Negative Bacteria 926
Tamar F. Barlam I Dennis L. Kasper
141 Legionella Infection 929
Miguel Sabria I Victor L. Yu
142 Pertussis and Other Bordetello Infections 933
Scott A. Halperin
143 Diseases Caused by Gram-Negative Enteric Bacilli... 937
Thomas A. Russo /James R. Johnson
144 Helicobacter pylori Infections 946
John C. Atherton I Martin J. Blaser
145 Infections Due to Pseudomonas Species
and Related Organisms 949
Reuben Ramphal
146 Salmonellosis 956
David A. Pegues I Samuel I. Miller
147 Shigellosis 962
Philippe Sansonetti I Jean Bergounioux
148 Infections Due to Campylobacter
and Related Species 965
Martin J. Blaser
149 Cholera and Other Vibrioses 968
Matthew K. Waldor / Gerald T. Keusch
150 Brucellosis 973
Michael J. Corbel I Nicholas J. Beeching
151 Tularemia 976
Richard F. Jacobs / Gordon E. Schutze
152 Plague and Other Yersinia Infections 980
David T. Dennis I Grant L. Campbell
153 Bortonella Infections, Including
Cat-Scratch Disease 987
David H. Spach I Emily Darby
154 Donovanosis 991
Gavin Hart
mQEQ^ MISCELLANEOUS BACTERIAL INFECTIONS
155 Nocardiosis 992
Gregory A. Filice
156 Actinomycosis 996
Thomas A. Russo
157 Infections Due to Mixed Anaerobic Organisms 999
Dennis L. Kasper/Ronit Cohen-Poradosu
¦Pffl^^ MYCOBACTERIAL OISEASES
158 Tuberculosis 1006
Mario C. Raviglione I Richard J. O Brien
159 Leprosy (Hansen s Disease) 1021
Robert H. Gelber
160 Nontuberculous Mycobacteria 1027
C. Fordham von Reyn
161 Antimycobacterial Agents 1032
Richard J. Wallace, Jr. /David E. Griffith
£££QQ^| SPIROCHETAL DISEASES
162 Syphilis 1038
Sheila A. Lukehart
163 Endemic Treponematoses 1046
Sheila A. Lukehart
164 Leptospirosis 1048
Peter Speelman I Rudy Hartskeerl
165 Relapsing Fever 1052
David T. Dennis
166 Lyme Borreliosis 1055
Allen C. Steere
RJ^JQ DISEASES CAUSED BY RICKETTSIAE,
1^^ MYCOPLASMAS, AND CHLAMYDIAE
167 Rickettsial Diseases 1059
David H. Walker / J. Stephen Dumler I Thomas Marrie
168 Infections Due to Mycoplasmas 1068
William M. McCormack
169 Chlamydial Infections 1070
Walter E. Stamm
|^^^A VIRAL DISEASES: GENERAL CONSIDERATIONS
170 Medical Virology 1079
Fred Wang I Elliott Kieff
171 Antiviral Chemotherapy,
Excluding Antiretroviral Drugs 1087
Lindsey R. Baden I Raphael Dolin
^^^^^ INFECTIONS DUE TO DNA VIRUSES
172 Herpes Simplex Viruses 1095
Lawrence Corey
173 Varicella-Zoster Virus Infections 1102
Richard]. Whitley
174 Epstein-Barr Virus Infections,
Including Infectious Mononucleosis 1106
Jeffrey I. Cohen
175 Cytomegalovirus and Human
Herpesvirus Types 6, 7, and 8 1109
Martin S. Hirsch
176 Molluscum Contagiosum, Monkeypox, and
Other Poxviruses, Excluding Smallpox Virus 1113
Fred Wang
177 Parvovirus Infections 1114
Kevin E. Brown
178 Human Papillomavirus Infections 1117
Richard C. Reichman
Q^Jj^^ INFECTIONS DUE TO DNA AND RNA RESPIRATORY VIRUSES
179 Common Viral Respiratory Infections and
Severe Acute Respiratory Syndrome (SARS) 1120
Raphael Dolin
180 Influenza 1127
Raphael Dolin
I^^^Q INFECTIONS DUE TO HUMAN IMMUNODEFICIENCY
^^^^P VIRUS AND OTHER HUMAN RETROVIRUSES
181 The Human Retroviruses 1132
Dan L. Longo /Anthony S. Fauci
182 Human Immunodeficiency Virus Disease:
AIDS and Related Disorders 1137
AnthonyS. Fauci IH. Clifford Lane
Q^^Q INFECTIONS DUE TO RNA VIRUSES
183 Viral Gastroenteritis 1204
Umesh D. Parashar I Roger I. Glass
184 Enteroviruses and Reoviruses 1208
Jeffrey I. Cohen
185 Measles (Rubeola) 1214
Anne Gershon
186 Rubella (German Measles) 1217
Anne Gershon
187 Mumps 1220
Anne Gershon
188 Rabies and Other Rhabdovirus Infections 1222
Alan C. Jackson/Eric C. Johannsen
189 Infections Caused by Arthropod-
and Rodent-Borne Viruses 1226
Clarence J. Peters
190 Ebola and Marburg Viruses 1240
Clarence J. Peters
^^^^^ FUNGAL ANO ALGAL INFECTIONS
191 Oiagnosis and Treatment of Fungal Infections 1242
John E. Edwards, Jr.
192 Histoplasmosis 1244
ChadiA. Hage/L. Joseph Wheat
193 Coccidioidomycosis 1247
Neil M. Ampel
194 Blastomycosis 1249
Stanley W. Chapman I Donna C. Sullivan
195 Cryptococcosis 1251
Arturo Casadevall
196 Candidiasis 1254
John E. Edwards, Jr.
197 Aspergillosis 1256
David W. Denning
198 Mucormycosis I26l
Alan M. Sugar
199 Miscellaneous Mycoses and Algal Infections 1263
Stanley W. Chapman I Donna C. Sullivan
200 Pneumocystis Infection 1267
A. George Smulian I Peter D. Walzer
Q9QQR1 PROTOZOAl AND HELMINTHIC INFECTIONS:
^^^^^ GENERAL CONSIDERATIONS
0^0 e16 Laboratory Diagnosis of Parasitic Infections el 13
Sharon L. Reed I Charles E. Davis
201 Agents Used to Treat Parasitic Infections 1270
Thomas A. Moore
£y e17 Pharmacology of Agents Used
to Treat Parasitic Infections el 19
Thomas A. Moore
^^^^^ PROTOZOAL INFECTIONS
202 Amebiasis and Infection with Free-Living Amebas ... 1275
Sharon L. Reed
203 Malaria 1280
Nicholas J. White/Joel G. Breman
204 Babesiosis 1294
Jeffrey A. Gelfand I Edouard Vannier
£) el8 Atlas of Blood Smears of Malaria and Babesiosis.. el27
Nicholas J. White I Joel G. Breman
205 Leishmaniasis 1296
Barbara L. Herwaldt
206 Trypanosomiasis 1300
Louis V. Kirchhoff
207 Toxoplasma Infections 1305
Lloyd H. Kasper
208 Protozoal Intestinal Infections and Trichomoniasis... 1311
Peter F. Weller
^^W^^ HELMINTHIC INFECTIONS
209 Trichinella and Other Tissue Nematodes 1316
Peter E Weller
210 Intestinal Nematodes 1319
Peter E Weller I Thomas B. Nutman
211 Filarial and Related Infections 1324
Thomas B. Nutman I Peter F. Weller
212 Schistosomiasis and Other Trematode Infections ... 1330
Adel A. F. Mahmoud
213 Cestodes 1336
A. Clinton White, Jr./PeterF. Weller
y^- PART 8 Bioterrorism and
Clinical Medicine
214 Microbial Bioterrorism 1343
H. Clifford Lane /Anthony S. Fauci
215 Chemical Bioterrorism 1352
Charles G. Hurst / Jonathan Newmark/
James A. Romano, Jr.
216 Radiation Bioterrorism 1358
ZeligA. Tochner I Eli Glatstein
^ PART 9 Disorders of the
Cardiovascular System
ES3A INTR0DUCTI0N TO CARDIOVASCULAR DISORDERS
217 Basic Biology of the Cardiovascular System 1365
Joseph Loscalzo I Peter Libby I Eugene Braunwald
218 Epidemiology of Cardiovascular Disease 1375
Thomas A. Gaziano IJ. Michael Gaziano
219 Approach to the Patient with
Possible Cardiovascular Disease 1379
Eugene Braunwald
EQEQ^ DIAGNOSIS OF CARDIOVASCULAR DISORDERS
220 Physical Examination of the
Cardiovascular System 1382
Robert A. O Rourke I Eugene Braunwald
221 Electrocardiography 1388
Ary L. Goldberger
^ e19 Atlas of Electrocardiography ei3l
Ary L. Goldberger
222 Noninvasive Cardiac Imaging: Echocardiography,
Nuclear Cardiology, and MRI/CT Imaging 1397
Rick A. Nishimura I Raymond J. Gibbons I
James F. Glockner I A. Jamil Tajik
£ e20 Atlas of Noninvasive Cardiac Imaging .. el49
Rick A. Nishimura I Raymond J. Gibbons I
James F. Glockner/A. Jamil Tajik
223 Diagnostic Cardiac Catheterization
and Angiography 1405
Donald S. Bairn
^^^^A DISORDERS OF RHYTHM
224 Principles of Electrophysiology 1410
Gordon F. Tomaselli
225 The Bradyarrhythmias 1416
Gordon F. Tomaselli
226 The Tachyarrhythmias 1425
Francis Marchlinski
0J0 e2i Atlas of Cardiac Arrhythmias el59
Ary L. Goldberger
¦fflffl^ DISORDERS OF THE HEART
227 Heart Failure and Cor Pulmonale 1443
Douglas L. Mann
228 Cardiac Transplantation and
Prolonged Assisted Circulation 1455
Sharon A. Hunt
229 Congenital Heart Disease in the Adult 1458
John S. Child
230 Valvular Heart Disease 1465
Patrick O Gara I Eugene Braunwald
231 Cardiomyopathy and Myocarditis 1481
Joshua Wynne I Eugene Braunwald
232 Pericardial Disease 1488
Eugene Braunwald
233 Tumors and Trauma of the Heart 1495
Eric H.Awtry/Wilson S.Colucci
234 Cardiac Manifestations of Systemic Disease 1498
Eric H. Awtry I Wilson S. Colucci
EQSQt vascular d|s£ase
235 The Pathogenesis, Prevention,
and Treatment of Atherosclerosis 1501
Peter Libby
(Q) e22 Atlas of Atherosclerosis el7l
Peter Libby
236 The Metabolic Syndrome 1509
Robert H.Eckel
237 Ischemic Heart Disease 1514
ElliottM. Antman /Andrew P. Selwyn I
Eugene Braunwald I Joseph Loscalzo
238 Unstable Angina and Non-ST-Elevation
Myocardial Infarction 1527
Christopher P. Cannon I Eugene Braunwald
239 ST-Segment Elevation Myocardial Infarction 1532
ElliottM. Antman /Eugene Braunwald
240 Percutaneous Coronary Intervention 1544
Donald S. Bairn
£) e23 Atlas of Percutaneous
Revascularization el73
Donald S. Bairn
241 Hypertensive Vascular Disease 1549
Theodore A. Kotchen
242 Diseases of the Aorta -.-... 1563
Mark A. Creager / Joseph Loscalzo
243 Vascular Diseases of the Extremities 1568
Mark A. Creager I Joseph Loscalzo
244 Pulmonary Hypertension ..../ 1576
Stuart Rich
?- PART 10 Disorders of the
Respiratory System
R^H DIAGNOSIS OF RESPIRATORY DISORDERS
245 Approach to the Patient with
Disease of the Respiratory System 1583
David A. Lipson I Steven E. Weinberger
246 Disturbances of Respiratory Function 1586
Steven E. Weinberger I Ilene M. Rosen
247 Diagnostic Procedures in
Respiratory Disease 1593
Scott Manaker / Steven E. Weinberger
0 e24 Atlas of Chest Imaging ei79
Patricia A. Kritek /John J. Reilly, Jr.
m|J^^ DISEASES OF THE RESPIRATORY SYSTEM
248 Asthma 1596
Peter J. Barnes
249 Hypersensitivity Pneumonitis and
Pulmonary Infiltrates with Eosinophilia 1607
Joel N. Kline I Gary W. Hunninghake
250 Environmental Lung Disease 1611
Frank E. Speizer / John R. Balmes
251 Pneumonia 1619
Lionel A. Mandell / Richard Wunderink
252 Bronchiectasis and Lung Abscess 1629
Gregory Tino I Steven E. Weinberger
253 Cystic Fibrosis 1632
Richard C. Boucher
254 Chronic Obstructive Pulmonary Disease 1635
John J. Reilly, Jr. I Edwin K. Silverman I
Steven D. Shapiro
255 Interstitial Lung Diseases 1643
Talmadge E. King, Jr.
256 Deep Venous Thrombosis and
Pulmonary Thromboembolism 1651
Samuel Z. Goldhaber
257 Disorders of the Pleura and Mediastinum 1658
Richard W. Light
258 Disorders of Ventilation 1661
Eliot A. Phillipson
259 Sleep Apnea 1665
Neil). Douglas
260 Lung Transplantation 1668
Elbert P. Trulock
? PART 11 Critical Care Medicine
£QJj^^ RESPIRATORY CRITICAL CARE
261 Principles of Critical Care Medicine 1673
John P. Kress /Jesse B. Hall
262 Acute Respiratory Distress Syndrome 1680
Bruce D. Levy I Steven D. Shapiro
263 Mechanical Ventilatory Support 1684
Edward P. Ingenito
¦^^^^ SHOCK AND CARDIAC ARREST
264 Approach to the Patient with Shock 1689
Ronald V. Maier
265 Severe Sepsis and Septic Shock 1695
Robert S. Munford
266 Cardiogenic Shock and Pulmonary Edema 1702
Judith S. Hochman / David H. Ingbar
267 Cardiovascular Collapse, Cardiac Arrest,
and Sudden Cardiac Death 1707
Robert J. Myerberg I Agustin Castellanos
^Jj^^ NEUROLOGIC CRITICAL CARE
268 Coma 1714
Allan H. Ropper
269 Neurologic Critical Care, Including
Hypoxic-lschemic Encephalopathy
and Subarachnoid Hemorrhage 1720
/. Claude Hemphill III I Wade S. Smith
jj^^QA ONCOLOGIC EMERGENCIES
270 Oncologic Emergencies 1730
Rasim Gucalp /Janice P. Dutcher
? PART 12 Disorders of the Kidney
and Urinary Tract
271 Cellular and Molecular Biology of the Kidney 1741
Alfred L. George, Jr. I Eric G. Neilson
272 Adaptation of the Kidney to Renal Injury 1748
Raymond C. Harris / Eric G. Neilson
273 Acute Renal Failure 1752
Kathleen D. Liu I Glenn M. Chertow
274 Chronic Kidney Disease 1761
Joanne M. Bargman I Karl Skorecki
275 Dialysis in the Treatment of Renal Failure 1772
Kathleen D. Liu I Glenn M. Chertow
276 Transplantation in the
Treatment of Renal Failure 1776
Charles B. Carpenter I Edgar L Milford I
Mohamed H. Sayegh
277 Glomerular Diseases 1782
Julia B. Lewis I Eric G. Neilson
278 Polycystic Kidney Disease and
Other Inherited Tubular Disorders 1797
David J. Salant I Parul S. Patel
279 Tubulointerstitial Diseases of the Kidney 1806
Alan S. L. Yu /Barry M. Brenner
280 Vascular Injury to the Kidney 1811
Kamal F. Badr I Barry M. Brenner
281 Nephrolithiasis 1815
John R. Asplin I Fredric L. Coe I Murray J. Favus
282 Urinary Tract Infections,
Pyelonephritis, and Prostatitis 1820
Walter E. Stamm
283 Urinary Tract Obstruction 1827
Julian L. Seifter I Barry M. Brenner
^ PART 13 Disorders of the
Gastrointestinal System
KRffl^^ DISORDERS OF THE ALIMENTARY TRACT
284 Approach to the Patient with
Gastrointestinal Disease 1831
William L. Hasler I Chung Owyang
285 Gastrointestinal Endoscopy 1836
Louis Michel Wong-Kee-Song I Mark Topazian
0^0 e25 video Atlas of Gastrointestinal Endoscopy el95
Louis Michel Wong-Kee-Song I Mark Topazian
286 Diseases of the Esophagus 1847
RajK. Goyal
287 Peptic Ulcer Disease and Related Disorders 1855
John Del Valle
288 Disorders of Absorption 1872
Henry J. Binder
289 inflammatory Bowel Disease 1886
Sonia Friedman I Richard S. Blumberg
290 Irritable Bowel Syndrome 1899
Chung Owyang
291 Diverticular Disease and
Common Anorectal Disorders 1903
Susan L. Gearhart
292 Mesenteric Vascular Insufficiency 1910
Susan L. Gearhart
293 Acute Intestinal Obstruction 1912
Susan L. Gearhart I William Silen
294 Acute Appendicitis and Peritonitis 1914
Susan L. Gearhart I William Silen
£Q2S llVER AND BIUARY TRACT DISEASE
295 Approach to the Patient with Liver Disease 1918
Marc Ghany /Jay H. Hoofnagle
296 Evaluation of Liver Function 1923
Daniel S. Pratt I Marshall M. Kaplan
297 The Hyperbilirubinemias 1927
Allan W. Wolkoff
298 Acute Viral Hepatitis 1932
Jules L. Dienstag
299 Toxic and Drug-Induced Hepatitis 1949
Jules L. Dienstag
300 Chronic Hepatitis 1955
Jules L. Dienstag
301 Alcoholic Liver Disease 1969
Mark E. Mailliard I Michael F. Sorrell
302 Cirrhosis and Its Complications 1971
Bruce R. Bacon
^0 e26 Atlas of Liver Biopsies e203
Jules L. Dienstag I Atul K. Bhan
303 Genetic, Metabolic, and Infiltrative
Diseases Affecting the Liver 1980
Bruce R. Bacon
304 Liver Transplantation 1983
Jules L. Dienstag / Raymond T. Chung
305 Diseases of the Gallbladder and Bile Ducts 1991
Norton J. Greenberger I Gustav Paumgartner
^^^^^ DISORDERS OF THE PANCREAS
306 Approach to the Patient
with Pancreatic Disease 2001
Phillip P. Toskes/ Norton J. Greenberger
307 Acute and Chronic Pancreatitis 2005
Norton J. Greenberger I Phillip P. Toskes
^ PART 14 Disorders of the Immune
System, Connective Tissue,
and Joints
£QJQ^ftTHE |MMUNE SYSTEM |N HEALTH AND D|SEASE
308 Introduction to the Immune System 2019
Barton F. Haynes I Kelly A. Soderberg /Anthony S. Fauci
309 The Major Histocompatibility Complex 2045
Gerald T. Nepom
310 Primary Immune Deficiency Diseases 2053
Max D. Cooper I Harry W. Schroeder, Jr.
^0 e27 Primary Immunodeficiencies Associated
with or Secondary to Other Diseases e207
Max D. Cooper I Harry W. Schroeder, Jr.
H^QQQI DISORDERS OF IMMUNE-MEDIATED INJURY
311 Allergies, Anaphylaxis, and
Systemic Mastocytosis 2061
K. Frank Austen
312 Autoimmunity and Autoimmune Diseases 2071
Peter E. Lipsky I Betty Diamond
313 Systemic Lupus Erythematosus 2075
Bevra Hannahs Hahn
314 Rheumatoid Arthritis 2083
Peter E. Lipsky
315 Acute Rheumatic Fever 2092
Jonathan R. Carapetis
316 Systemic Sclerosis (Scleroderma)
and Related Disorders 2096
John Varga
317 Sjogren s Syndrome 2107
Haralampos M. Moutsopoulos
318 The Spondyloarthritides 2109
Joel D. Taurog
319 The Vasculitis Syndromes 2119
Carol A. Langford /Anthony S. Fauci
^0 e28 Atlas of Clinical Imaging in
the Vasculitic Syndromes e209
Carol A. Langford /Anthony S. Fauci
320 Behget s Syndrome 2132
Haralampos M. Moutsopoulos
321 Relapsing Polychondritis 2133
Carol A. Langford I Bruce C. Gilliland
322 Sarcoidosis 2135
Robert P. Baughman I Elyse E. Lower
323 Familial Mediterranean Fever 2142
Daniel L. Kastner
324 Amyloidosis 2145
David C. Seldin / Martha Skinner
0^^^ DISORDERS OF THE JOINTS AND ADJACENT TISSUES
325 Approach to Articular and
Musculoskeletal Disorders 2149
John J. Cush I Peter E. Lipsky
326 Osteoarthritis 2158
David T. Felson
327 Gout and Other Crystal-Associated
Arthropathies 2165
H. Ralph Schumacher / Lan X. Chen
328 Infectious Arthritis 2169
Lawrence C. Madoff
329 Fibromyalgia 2175
Carol A. Langford / Bruce C. Gilliland
330 Arthritis Associated with Systemic Disease
and Other Arthritides 2177
Carol A. Langford / Bruce C. Gilliland
331 Periarticular Disorders of the Extremities 2184
Carol A. Langford / Bruce C. Gilliland
^ PART 15 Endocrinology
and Metabolism
MffiPA ENDOCRINOLOGY
332 Principles of Endocrinology 2187
/. Larry Jameson
333 Disorders of the Anterior Pituitary
and Hypothalamus 2195
Shlomo Melmed IJ. Larry Jameson
334 Disorders of the Neurohypophysis 2217
Gary L. Robertson
335 Disorders of the Thyroid Gland 2224
/. Larry Jameson I Anthony P. Weetman
336 Disorders of the Adrenal Cortex 2247
Gordon H. Williams / Robert G. Dluhy
337 Pheochromocytoma 2269
HartmutP. H. Neumann
338 Diabetes Mellitus 2275
Alvin C. Powers
339 Hypoglycemia 2305
Philip E. Cryer
340 Disorders of the Testes and
Male Reproductive System 2310
Shalender Bhasin /J. Larry Jameson
341 The Female Reproductive System:
Infertility and Contraception 2324
Janet E. Hall
342 The Menopause Transition and
Postmenopausal Hormone Therapy 2334
JoAnn E. Manson I Shari S. Bassuk
343 Disorders of Sex Development 2339
John C. Achermann /J. Larry Jameson
344 Endocrine Tumors of the
Gastrointestinal Tract and Pancreas 2347
Robert T. Jensen
345 Disorders Affecting Multiple
Endocrine Systems 2358
Camilo Jimenez I Robert F. Gagel
¦ftfflj^^ DISORDERS OF BONE AND MINERAL METABOLISM
346 Bone and Mineral Metabolism
in Health and Disease 2365
F. Richard Bringhurst I Marie B. Demay I
Stephen M. Krane I Henry M. Kronenberg
347 Diseases of the Parathyroid Gland and
Other Hyper- and Hypocakemic Disorders 2377
John T. Potts, Jr.
348 Osteoporosis 2397
Robert Lindsay I Felicia Cosman
349 Paget Disease and Other Dysplasias of Bone 2408
Murray]. Favus / Tamara }. Yokes
J^^^ DISORDERS OF INTERMEDIARY METABOLISM
350 Disorders of Lipoprotein Metabolism 2416
Daniel ]. Rader I Helen H. Hobbs
351 Hemochromatosis 2429
Lawrie W. Powell
352 The Porphyrias 2434
Robert J. Desnick I Kenneth H. Astrin
353 Disorders of Purine and Pyrimidine Metabolism 2444
Robert L. Wortmann
354 Wilson Disease 2449
George J. Brewer
355 Lysosomal Storage Disease 2452
Robert J. Hopkin / Gregory A. Grabowski
356 Glycogen Storage Diseases and Other
Inherited Disorders of Carbohydrate Metabolism ... 2457
Yuan-Tsong Chen
357 Heritable Disorders of Connective Tissue 2461
Darwin J. Prockop I Malwina Czarny-Ratajczak
358 Inherited Disorders of Amino Acid
Metabolism in Adults 2470
Nicola Longo
359 Inherited Defects of Membrane Transport 2474
Nicola Longo
^ e29 Atlas of Clinical Manifestations
of Metabolic Diseases e2l5
/. Larry Jameson
? PART 16 Neurologic Disorders
B3^| DIAGNOSIS OF NEUROLOGIC DISORDERS
360 Mechanisms of Neurologic Diseases 2477
Stephen L. Hauser/M. Flint Beal
361 Approach to the Patient with Neurologic Disease ... 2484
Daniel H. Lowenstein /Joseph B. Martin I
Stephen L. Hauser
362 Neuroimaging in Neurologic Disorders 2489
William P. Dillon
( e30 Atlas of Neuroimaging e225
Andre Furtado I William P. Dillon
^ e31 Electrodiagnostic Studies of Nervous System
Disorders: EEG, Evoked Potentials, and EMG e26l
Michael J. Aminoff
^ e32 Technique of Lumbar Puncture e267
Elizabeth Robbins I Stephen L. Hauser
¦^^^ DISEASES OF THE CENTRAL NERVOUS SYSTEM
363 Seizures and Epilepsy 2498
Daniel H. Lowenstein
364 Cerebrovascular Diseases 2513
Wade S. Smith /Joey D. English IS. Claiborne Johnston
365 Dementia 2536
Thomas D. Bird I Bruce L. Miller
366 Parkinson s Disease and Other
Extrapyramidal Movement Disorders 2549
Mahlon R. DeLong/Jorge L. Juncos
367 Hyperkinetic Movement Disorders 2560
C. Warren Olanow
368 Ataxic Disorders 2565
Roger N. Rosenberg
369 Amyotrophic Lateral Sclerosis and
Other Motor Neuron Diseases 2572
Robert H. Brown, Jr.
370 Disorders of the Autonomic Nervous System 2576
Phillip A. Low/ John W. Engstrom
371 Trigeminal Neuralgia, Bell s Palsy, and
Other Cranial Nerve Disorders 2583
M. Flint Beal I Stephen L Hauser
372 Diseases of the Spinal Cord 2588
Stephen L. Hauser/Allan H. Ropper
373 Concussion and Other Head Injuries 2596
Allan H. Ropper
374 Primary and Metastatic Tumors
of the Nervous System 2601
Stephen M. Sagar/MarkA. Israel
375 Multiple Sclerosis and Other
Demyelinating Diseases 2611
Stephen L. Hauser I Douglas S. Goodin
376 Meningitis, Encephalitis,
Brain Abscess, and Empyema 2621
Karen L. Roos I Kenneth L. Tyler
377 Chronic and Recurrent Meningitis 2641
Walter J. Koroshetz I Morton N. Swartz
378 Prion Diseases 2646
Stanley B. Prusiner I Bruce L. Miller
BSQ NERVE ANO MUSCLE DISORDERS
379 Peripheral Neuropathy 2651
Vinay Chaudhry
380 Guillain-Barre Syndrome and Other
Immune-Mediated Neuropathies 2667
Stephen L. Hauser I Arthur K. Asbury
381 Myasthenia Gravis and Other Diseases
of the Neuromuscular Junction 2672
Daniel B. Drachman
382 Muscular Dystrophies and
Other Muscle Diseases 2678
Robert H. Brown, Jr. /AnthonyA. Amato I
Jerry R. Mendell
383 Polymyositis, Dermatomyositis,
and Inclusion Body Myositis 2696
Marinos C. Dalakas
0 e33 Special Issues in Inpatient
Neurologic Consultation e27l
S. Andrew Josephson /Martin A. Samuels
^^^^^ CHRONIC FATIGUE SYNDROME
384 Chronic Fatigue Syndrome 2703
Stephen E. Straus
K^^ffl|| PSYCHIATRIC DISORDERS
385 Biology of Psychiatric Disorders 2705
Steven E. Hyman I EricKandel
386 Mental Disorders 2710
Victor I. Reus
¦TOffll^ ALCOHOLISM AND DRUG DEPENDENCY
387 Alcohol and Alcoholism 2724
Marc A. Schuckit
388 Opioid Drug Abuse and Dependence 2729
Marc A. Schuckit
389 Cocaine and Other Commonly Abused Drugs 2733
Jack H. Mendelson I Nancy K. Mello
390 Nicotine Addiction 2736
David M. Burns
y^- PART 17 Poisoning, Drug Overdose,
and Envenomation
(tf) e34 Heavy Metal Poisoning e277
Howard Hu
Q) e35 Poisoning and Drug Overdosage e28i
Christopher H. Linden / Michael J. Burns I
Mark B. Mycyk
391 Disorders Caused by Reptile Bites
and Marine Animal Exposures 2741
Paul S. Auerbach I Robert L. Norris
392 Ectoparasite Infestations and
Arthropod Bites and Stings 2748
Richard J. Pollack /James H. Maguire
^ PART 18 e-Chaptersfrom
International
Advisory Editors
^ e36 Pulmonary Biomarkers in COPD e297
Peter J. Barnes
ty e37 Chagas Disease: Advances
in Diagnosis and Management e303
Andrei C. Sposito /JoseA. F. Ramires
% e38 The Polypill e307
K. Srinath Reddy/Nitish Naik /Ambuj Roy
0 e39 Mitochondrial DNA and
Heritable Traits and Diseases e3ll
Karl Skorecki I Hanna Mandel
APPENDIX
Laboratory Values of Clinical Importance A-l
Alexander Kratz I Michael A. Pesce I Daniel J. Fink
INDEX 1-1
|
| adam_txt |
ALLERGY, IMMUNOLOGY, RHEUMATOLOGY
FIG. 311-3 The diagnosis and management of rhinitis 2070
FIG. 313-2 The diagnosis and initial therapy of SLE 2078
FIG. 314-3 The medical management of
rheumatoid arthritis 2091
FIG. 317-1 Treatment for Sjogren's syndrome 2109
FIG. 318-4 The diagnosis of the spondyloarthritides 2117
FIG. 319-1 Approach to the patient with suspected
diagnosis of vasculitis 2121
FIG. 322-8 Patient management for sarcoidosis 2140
FIG. 322-9 The management of acute sarcoidosis 2141
FIG. 322-10 Management of chronic sarcoidosis 2141
FIG. 324-1 The diagnosis of amyloidosis and
determination of type 2146
FIG. 325-1 The diagnosis of musculoskeletal complaints 2151
FIG. 325-2 The consideration of the most common
musculoskeletal conditions 2152
FIG. 325-6 Approach to synovia] fluid
aspiration and analysis 2156
CARDIOLOGY
FIG. 8-2 Cardiac risk assessment and stratification
in patients undergoing noncardiac surgery 51
FIG. 219-1 An alternative "echocardiography first"
approach to the evaluation of a heart murmur . 1381
FIG. 222-11 Flow diagram showing selection of initial
stress test in a patient with chest pain 1404
FIG. 227-4 Treatment algorithm for chronic heart failure
patients with a depressed ejection fraction 1450
FIG. 230-1 Management strategy for patients with
mitral stenosis (MS) and mild symptoms 1468
FIG. 230-4 Management strategy for patients with
chronic severe mitral regurgitation 1471
FIG. 230-5 Management strategy for patients
with severe aortic stenosis 1475
FIG. 230-6 Management strategy for patients with
chronic severe aortic regurgitation 1477
FIG. 237-1 Evaluation of the patient with known
or suspected ischemic heart disease 1517
FIG. 237-2 The management of the patient with
ischemic heart disease 1525
FIG. 239-7 The assessment of need for implantation
of cardioverter/defibrillator 1542
CLINICAL GENETICS
FIG. 64-3 Genetic counseling 417
FIG. 79-6 Genetic testing in a family
with cancer predisposition 495
CLINICAL NUTRITION
FIG. 73-1 Decision-making for the implementation
of specialized nutrition support (SNS) 456
FIG. 76-1 Basic treatment decisions regarding patients
with anorexia or bulimia nervosa 476
EMERGENCY AND CRITICAL CARE
FIG. 216-1 Evacuation in a multicasualties radiologic event. 1361
FIG. 216 -3 General guidelines for treatment
of radiation casualties 1364
FIG. 261-2 Approach to the patient in shock 1675
FIG. 262-5 Algorithm for the initial management of ARDS . 1683
FIG. 266-2 Emergency management of
patients with cardiogenic shock,
acute pulmonary edema, or both 1704
FIG. 267-3A Cardiac arrest management:
ventricular fibrillation 1712
FIG. 267-3B Cardiac arrest management:
bradyarrhythmia/asystole 1712
FIG. 269-4 Prognostication of outcome
in comatose survivors 1723
ENDOCRINOLOGY AND METABOLISM
FIG. 50-2 The evaluation and differential
diagnosis of hirsutism 303
FIG. 333-6 Management of prolactinoma 2206
FIG. 333-7 Management of adult growth
hormone (GH) deficiency 2209
FIG. 333-9 Management of acromegaly 2211
FIG. 333-10 Management of Cushing's syndrome 2214
FIG. 333-11 Management of a nonfunctioning
pituitary mass 2216
FIG. 336-7 Evaluating patients suspected of
having Cushing's syndrome 2256
FIG. 336-10 Diagnostic flowchart for evaluating patients
with possible mineralocorticoid excess states 2261
FIG. 336-12 Diagnostic flowchart for evaluating patients
with suspected adrenal insufficiency 2264
FIG. 338-11 Screening for microalbuminuria 2288
FIG. 338-12 Dyslipidemia management in diabetes 2291
FIG. 338-14 Essential elements in comprehensive
diabetes care of type 2 diabetes 2299
FIG. 338-15 Glycemic management of type 2 diabetes 2302
FIG. 339-2 Hypoglycemia-associated autonomic
failure in insulin-deficient diabetes 2307
FIG. 339-3 Diagnostic approach to a patient with
documented or suspected hypoglycemia 2309
FIG. 340-5 Evaluation of gynecomastia 2319
FIG. 340-6 Evaluation of hypogonadism 2320
FIG. 347-6 The evaluation of patients with hypercalcemia . 2389
FIG. 351-3 Algorithm for screening for
HFE-associated hemochromatosis 2433
GASTROENTEROLOGY AND HEPATOLOGY
FIG. 38-1 Approach to the patient with dysphagia 240
FIG. 40-2 Management of acute diarrhea 249
FIG. 40-3 Management of chronic diarrhea 252
FIG. 40-4 Management of constipation 254
FIG. 42-1 Management of acute upper
gastrointestinal bleeding 259
FIG. 42-2 Management of acute lower
gastrointestinal bleeding 260
FIG. 43-1 Evaluation of the patient with jaundice 262
FIG. 287-12 Overview of new-onset dyspepsia 1865
FIG. 295-1 Algorithm for evaluation
of abnormal liver tests 1922
FIG. 296-1 Algorithm for the evaluation of
chronically abnormal liver tests 1924
FIG. 301-3 Treatment algorithm for alcoholic hepatitis 1971
FIG. 302-1 Management of recurrent variceal hemorrhage. 1977
FIG. 302-3 Treatment of refractory ascites 1979
FIG. 306-1 An approach to the patient with
suspected chronic pancreatitis 2004
HEMATOLOGY AND ONCOLOGY
FIG. 58-17 The physiologic classification of anemia 361
FIG. 58-18 An approach to diagnosing
patients with polycythemia 363
FIG. 82-2 The diagnosis and treatment of
febrile neutropenic patients 539
FIG. 84-1 Evaluation of a patient
with cervical adenopathy 549
FIG. 85-2 Algorithm for evaluation of
solitary pulmonary nodule (SPN) 558
FIG. 86-1 Approach to palpable breast mass 564
FIG. 86-2 The "triple diagnosis" technique
in suspected breast cancer 564
FIG. 86-3 Management of a breast cyst 564
FIG. 86-4 Approaches to abnormalities
detected by mammogram 565
FIG. 88-1 Treatment approach to patients
with hepatocellular carcinoma 583
FIG. 91-2 The diagnostic evaluation of
men with prostate disorders 595
FIG. 95-2 Treatment algorithm for adenocarcinoma and
poorly differentiated adenocarcinoma CUP 616
FIG. 95-3 Treatment algorithm for squamous cell CUP 616
FIG. 99-3 Pathophysiology of sickle cell crisis 637
FIG. 104-2 The therapy of newly diagnosed
chronic myeloid leukemia 681
FIG. 109-2 Evaluating the thrombocytopenic patient 720
FIG. 112-1 Classification of antithrombotic drugs 736
FIG. 270-2 Management of cancer patients with back pain. .1733
FIG. 270-4 Management of patients at high
risk for the tumor lysis syndrome 1737
INFECTIOUS DISEASES AND HIV/AIDS
FIG. 118-4 The diagnostic use of TEE and TTE
in infective endocarditis 793
FIG. 121-3 The management of patients
with intraabdominal abscesses
using percutaneous drainage 811
FIG. 122-1 The approach to patients with
community-acquired infectious
diarrhea or bacterial food poisoning 815
FIG. 144-1 Schematic of the relationships between
colonization with Helkobacter pylori
and diseases of the upper gastrointestinal
tract among persons in developed countries 947
FIG. 144-2 The management of Helkobacter pylori infection . .948
FIG. 166-2 Algorithm for the treatment of the various acute
or chronic manifestations of Lyme borreliosis 1058
FIG. 182-30 The acute HIV infection 1169
FIG. 182-34 The evaluation of diarrhea in
patient with HIV infection 1176
FIG. 188-4 Rabies postexposure prophylaxis 1225
NEPHROLOGY
FIG. 46-1 The clinical approach to hyponatremia 278
FIG. 46-2 The clinical approach to hypernatremia 280
FIG. 46-3 The clinical approach to hypokalemia 282
FIG. 46-4 The clinical approach to hyperkalemia 284
FIG. 49-2 The evaluation and management
of patients with ED 298
FIG. 276-2 A typical algorithm for early
posttransplant care of the kidney recipient 1780
FIG. 283-1 Diagnostic approach for urinary tract
obstruction in unexplained renal failure 1829
NEUROLOGY AND PSYCHIATRY
FIG. 363-2 Evaluation of the adult patient with a seizure 2505
FIG. 363-3 Pharmacologic treatment of generalized
tonic-clonic status epilepticus in adults 2511
FIG. 364-1 Medical management of stroke and TIA 2514
FIG. 366-4 Treatment approach to newly diagnosed
idiopathic Parkinson's Disease 2554
FIG. 375-4 Therapeutic decision-making
for multiple sclerosis 2618
FIG. 376-1 The management of patients
with suspected CNS infections 2622
FIG. 376-2 The pathophysiology of the neurologic
complications of bacterial meningitis 2624
FIG. 379-1 Approach to the evaluation
of peripheral neuropathies 2652
FIG. 379-2 Diagnostic approach to
Charcot-Marie-Tooth disease (CMT) 2664
FIG. 381-2 The management of myasthenia gravis 2676
FIG. 386-1 Medical management of
major depressive disorder 2717
PULMONARY
FIG. 33-3 The evaluation of the patient with dyspnea 224
FIG. 34-1 Management of cough lasting
longer than 3 weeks 226
FIG. 34-2 The evaluation of nonmassive hemoptysis 228
FIG. 244-1 The workup of a patient with
unexplained pulmonary hypertension 1576
FIG. 244-2 The selection of optimal drug
treatment of a patient with
pulmonary arterial hypertension 1577
FIG. 246-5 A diagnostic approach to
the patient with hypoxemia 1591
FIG. 252-2 A diagnostic approach to bronchiectasis 1630
'i
FIG. 256-1 How to decide whether diagnostic imaging
is needed in suspected PTE and DVT 1652
FIG. 256-4 Imaging tests to diagnose DVT and PE 1655
FIG. 256-5 Acute management of pulmonary
thromboembolism 1655
FIG. 257-1 Approach to the diagnosis of pleural effusions 1658
SYSTEMIC PRESENTATIONS
FIG. 16-6 Algorithms for management of acute
low back pain, age 18 years 114
FIG. 11-2 Common and uncommon clinical courses
in the last days of terminally ill patients 78
FIG. 19-1 Approach to the patient with
classic fever of unknown origins 133
FIG. 21-1 Approach to the patient with syncope 142
FIG. 23-3 The initial workup of a patient with weakness 149
FIG. 30-4 An algorithm for the approach to hearing loss 201
FIG. 57-1 An algorithm for the diagnosis
of a patient with photosensitivity 354
Summaries of Chapters e1 to e39 xvii
Contributors xxi
Preface xxxv
?^ PART 1 Introduction to
Clinical Medicine
1 The Practice of Medicine 1
The Editors
2 Global Issues in Medicine 6
Jim Yong Kim I Paul Farmer
3 Decision-Making in Clinical Medicine 16
Daniel B. Mark
4 Screening and Prevention of Disease 24
Gary J. Martin
5 Principles of Clinical Pharmacology 27
Dan M Roden
6 Women's Health 39
Andrea E. Dunaif
7 Medical Disorders during Pregnancy 44
Robert L Barbieri /John T. Repke
8 Medical Evaluation of the Surgical Patient 49
WeiC. Lau/KimA. Eagle
9 Geriatric Medicine 53
Lisa B. Caruso I Rebecca A. Silliman
10 Complementary and Alternative Medicine 62
Stephen E. Straus
11 Palliative and End-of-Life Care 66
Ezekiel J. Emanuel I Joshua Hauser I Linda L. Emanuel
0 e1 The Safety and Quality of Health Care el
David W. Bates
^0 e2 Economic Considerations
in the Practice of Medicine e7
David Meltzer
£ e3 Racial and Ethnic Disparities in Health Care el l
Joseph R. Betancourt I David Blumenthal
£p e4 Ethical Issues in Clinical Medicine el9
Bernard Lo
? PART 2 Cardinal Manifestations and
Presentation of Diseases
^^^^k PAIN
12 Pain: Pathophysiology and Management 81
Howard L Fields /Joseph B. Martin
13 Chest Discomfort 87
Thomas H. Lee
14 Abdominal Pain 91
William Silen
15 Headache 95
Peter J. Goadsby I Neil H. Raskin
16 Back and Neck Pain 107
John W. Engstrom
Rflffl^^ ALTERATIONS IN BODY TEMPERATURE
17 Fever and Hyperthermia 117
Charles A. Dinarello I Reuven Porat
18 Fever and Rash 121
Elaine T. Kaye I Kenneth M. Kaye
0jf e5 Atlas of Rashes Associated with Fever e23
Kenneth M. Kaye I Elaine T. Kaye
19 Fever of Unknown Origin 130
Jeffrey A. Gelfand / Michael V. Callahan
20 Hypothermia and Frostbite 135
Daniel F. Danzl
QQj^Q NERVOUS SYSTEM DYSFUNCTION
21 Syncope 139
Mark D. Carlson
22 Dizziness and Vertigo 144
Robert B. Daroff
23 Weakness and Paralysis 147
Michael J. Aminoff
24 Gait and Balance Disorders 151
Lewis Sudarsky
25 Numbness, Tingling, and Sensory Loss 154
Michael J. Aminoff I Arthur K. Asbury
26 Confusion and Delirium 158
S. Andrew Josephson I Bruce L Miller
£ e6 Memory Loss e33
Thomas D. Bird / Bruce L Miller
27 Aphasia, Memory Loss, and
Other Focal Cerebral Disorders 162
M. -Marsel Mesulam
28 Sleep Disorders 171
Charles A. Czeisler / John W. Winkelman /
Gary S. Richardson
m|Q| DISORDERS OF EYES, EARS, NOSE, ANO THROAT
29 Disorders of the Eye 180
Jonathan C. Horton
30 Disorders of Smell, Taste, and Hearing 196
Anil K. Lalwani
31 Pharyngitis, Sinusitis, Otitis, and
Other Upper Respiratory Tract Infections 205
Michael A. Rubin I Ralph Gonzales I Merle A. Sande
32 Oral Manifestations of Disease 214
Samuel C. Durso
^0 e7 Atlas of Oral Manifestations of Disease e37
Samuel C. Durso I Janet A. Yellowitz I Jane C. Atkinson
^^QQ| ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTIONS
33 Dyspnea and Pulmonary Edema 221
Richard M. Schwartzstein
34 Cough and Hemoptysis 225
Steven E. Weinberger I David A. Lipson
35 Hypoxia and Cyanosis 229
Eugene Braunwald
36 Edema 231
Eugene Braunwald /Joseph Loscalzo
0 e8 Approach to the Patient with a Heart Murmur . e43
Patrick T. O'Gara / Eugene Braunwald
37 Palpitations 236
Joseph Loscalzo
HRJQ^ ALTERATIONS IN GASTROINTESTINAL FUNCTION
38 Dysphagia 237
Raj K. Goyal
39 Nausea, Vomiting, and Indigestion 240
William L Hasler
40 Diarrhea and Constipation 245
Michael Camilleri /Joseph A. Murray
41 Weight Loss 255
Carol M. Reife
42 Gastrointestinal Bleeding 257
Loren Laine
43 Jaundice 261
DanielS. Pratt / Marshall M. Kaplan
44 Abdominal Swelling and Ascites 266
Robert M. Glickman I Roshini Rajapaksa
JJEfl^ ALTERATIONS IN RENAL AND URINARY TRACT FUNCTION
45 Azotemia and Urinary Abnormalities 268
Bradley M. Denker I Barry M. Brenner
(^ e9 Atlas of Urinary Sediments and Renal Biopsies . e53
Agnes B. Fogo I Eric G. Neilson
46 Fluid and Electrolyte Disturbances 274
Gary G. Singer / Barry M. Brenner
47 Hypercalcemia and Hypocalcemia 285
Sundeep Khosla
48 Acidosis and Alkalosis 287
Thomas D. DuBose, Jr.
HSBfflft ALTERATIONS IN SEXUAL FUNCTION AND REPRODUCTION
49 Sexual Dysfunction 296
Kevin T. McVary
50 Hirsutism and Virilization 301
David A. Ehrmann
51 Menstrual Disorders and Pelvic Pain 304
Janet E. Hall
UQ2Q^ ALTERATIONS IN THE SKIN
52 Approach to the Patient with a Skin Disorder 308
Thomas J. Lawley/Kim B. Yancey
53 Eczema, Psoriasis, Cutaneous Infections,
Acne, and Other Common Skin Disorders 312
Calvin O. McCall I Thomas J. Lawley
54 Skin Manifestations of Internal Disease 321
Jean L. Bolognia I Irwin M. Braverman
55 Immunologkally Mediated Skin Diseases 336
Kim B. Yancey I Thomas J. Lawley
56 Cutaneous Drug Reactions 343
Jean-Claude Roujeau I Robert S. Stern/Bruce U. Wintroub
57 Photosensitivity and Other Reactions to Light 350
David R. Bickers
0fr e1O Atlas of Skin Manifestations
of Internal Disease e6l
Thomas ]. Lawley I Stephen F. Templeton
QQQQQ^ HEMAT010GIC ALTERATIONS
58 Anemia and Polycythemia 355
John W. Adamson I Dan L Longo
59 Bleeding and Thrombosis 363
Barbara A. Konkle
60 Enlargement of Lymph Nodes and Spleen 370
Patrick H. Henry I Dan L. Longo
61 Disorders of Granulocytes and Monocytes 375
Steven M. Holland I John J. Gallin
5 e11 Atlas of Hematology and Analysis
of Peripheral Blood Smears e77
Dan L Longo
~^ PART 3 Genetics and Disease
62 Principles of Human Genetics 385
/. Larry Jameson / Peter Kopp
63 Chromosome Disorders 407
Terry J. Hassold I Stuart Schwartz
64 The Practice of Genetics in Clinical Medicine 414
Susan Miesfeldt / J. Larry Jameson
65 Gene Therapy in Clinical Medicine 420
KatherineA. High
y^- PART 4 Regenerative Medicine
66 Stem Cell Biology 425
Minoru S. H. Ko
67 Applications of Stem Cell Biology
in Clinical Medicine 427
John A. Kessler
68 Hematopoietic Stem Cells 430
David T. Scadden I Dan L. Longo
69 Tissue Engineering 434
Jennifer Anderson /Joseph P. Vacanti
y^ PART 5 Nutrition
70 Nutritional Requirements and Dietary Assessment. 437
Johanna Dwyer
71 Vitamin and Trace Mineral
Deficiency and Excess 441
Robert M. Russell I Paolo M. Suter
72 Malnutrition and Nutritional Assessment 450
Douglas C. Heimburger
73 Enteral and Parenteral Nutrition Therapy 455
Bruce R. Bistrian I David F. Driscoll
74 Biology of Obesity 462
Jeffrey S. Flier I Eleftheria Maratos-Flier
75 Evaluation and Management of Obesity 468
Robert F. Kushner
76 Eating Disorders 473
B. Timothy Walsh
W PART 6 Oncology and Hematology
|^^^^k NEOPLASTIC DISORDERS
77 Approach to the Patient with Cancer 479
Dan L. Longo
78 Prevention and Early Detection of Cancer 486
Otis W. Brawley I Barnett S. Kramer
79 Cancer Genetics 492
Pat J. Morin I Jeffrey M. Trent I Francis S. Collins I
Bert Vogelstein
80 Cancer Cell Biology and Angiogenesis 498
Robert G. Fenton I Dan L. Longo
81 Principles of Cancer Treatment 514
Edward A. Sausville / Dan L Longo
82 Infections in Patients with Cancer 533
Robert Finberg
83 Cancer of the Skin 541
Arthur J. Sober I Hensin Tsao I Carl V. Washington
84 Head and Neck Cancer 548
Everett E. Vokes
85 Neoplasms of the Lung 551
John D. Minna I Joan H. Schiller
86 Breast Cancer 563
Marc E. Lippman
87 Gastrointestinal Tract Cancer 570
Robert J. Mayer
88 Tumors of the Liver and Biliary Tree 580
Brian I. Can
89 Pancreatic Cancer 586
Yu Jo Chua I David Cunningham
90 Bladder and Renal Cell Carcinomas 589
Howard I. Scher I Robert J. Motzer
91 Benign and Malignant Diseases of the Prostate 593
Howard I. Scher
92 Testicular Cancer 601
Robert J. Motzer I George J. Bosl
93 Gynecologic Malignancies 604
Robert C. Young
94 Soft Tissue and Bone Sarcomas
and Bone Metastases 610
Shreyaskumar R. Patel/Robert S. Benjamin
95 Carcinoma of Unknown Primary 614
Gauri R. Varadhachary /James L. Abbruzzese
96 Paraneoplastic Syndromes:
Endocrinologic/Hematologic 617
/. Larry Jameson / Bruce E. Johnson
97 Paraneoplastic Neurologic Syndromes 623
Josep Dalmau I Myrna R. Rosenfeld
0 e12 Thymoma e89
Dan L. Longo
0^ e13 Late Consequences of Cancer
and Its Treatment e9i
Michael C. Perry I Dan L. Longo
B^QA HEMATOPOIETIC DISORDERS
98 Iron Deficiency and Other
Hypoproliferative Anemias 628
John W. Adamson
99 Disorders of Hemoglobin 635
Edward J. Benz, Jr.
100 Megaloblastic Anemias 643
A. Victor Hoffbrand
101 Hemolytic Anemias and Anemia
Due to Acute Blood Loss 652
Lucio Luzzatto
102 Aplastic Anemia, Myelodysplasia, and Related
Bone Marrow Failure Syndromes 663
Neal S. Young
103 Polycythemia Vera and Other
Myeloproliferative Diseases 671
Jerry L. Spivak
104 Acute and Chronic Myeloid Leukemia 677
Meir Wetzler I John C. Byrd I Clara D. Bloomfield
105 Malignancies of Lymphoid Cells 687
Dan L. Longo
106 Plasma Cell Disorders 700
Nikhil C. Munshi I Dan L. Longo I Kenneth C. Anderson
107 Transfusion Biology and Therapy 707
Jeffery S. Dzieczkowski / Kenneth C. Anderson
108 Hematopoietic Cell Transplantation 713
Frederick R. Appelbaum
Q^ESEb DISORDERS OF HEMOSTASIS
109 Disorders of Platelets and Vessel Wall 718
Barbara A. Konkle
110 Coagulation Disorders 725
Voider Arruda I Katherine A. High
111 Venous Thrombosis 731
F.R. Rosendaal I H.R. Buller
112 Antiplatelet, Anticoagulant,
and Fibrinolytic Drugs 735
Jeffrey I. Weitz
y=- PART 7 Infectious Diseases
^^^Q^ BASIC CONSIDERATIONS IN INFECTIOUS DISEASES
113 Introduction to Infectious Diseases:
Host-Pathogen Interactions 749
Lawrence C. Madoff I Dennis L. Kasper
114 Molecular Mechanisms of Microbial Pathogenesis . 753
Gerald B. Pier
115 Approach to the Acutely III
Infected Febrile Patient 761
Tamar F. Barlam I Dennis L. Kasper
116 Immunization Principles and Vaccine Use 767
Gerald T. Keusch I Kenneth J. Bart I Mark Miller
117 Health Advice for International Travel 782
Jay S. Keystone I Phyllis E. Kozarsky
£ ei4 Laboratory Diagnosis of Infectious Diseases e97
Alexander J. McAdam / Andrew B. Onderdonk
^^^^A CLINICAL SYNDROMES: COMMUNITY-ACQUIRED INFECTIONS
118 Infective Endocarditis 789
Adolf W. Karchmer
119 Infections of the Skin, Muscle, and Soft Tissues 798
Dennis L. Stevens
120 Osteomyelitis 803
Jeffrey Parsonnet
121 Intraabdominal Infections and Abscesses 807
Miriam J. Baron /Dennis L Kasper
122 Acute Infectious Diarrheal Diseases
and Bacterial Food Poisoning 813
Joan R. Butterton I Stephen B. Calderwood
123 Clostridium difficile-Associated Disease,
Including Pseudomembranous Colitis 818
DaleN. Gerding I Stuart Johnson
124 Sexually Transmitted Infections:
Overview and Clinical Approach 821
KingK. Holmes
(5 e15 Infectious Complications of Burns and Bites . el07
Lawrence C. Madoff I Florencia Pereyra
IJ^Q^A CLINICAL SYNDROMES: HEALTH CARE-ASSOCIATED INFECTIONS
125 Health Care-Associated Infections 835
Robert A. Weinstein
126 Infections in Transplant Recipients 842
Robert Finberg I Joyce Fingeroth
Bffffljflll APPROACH TO THERAPY FOR BACTERIAL DISEASES
127 Treatment and Prophylaxis of Bacterial Infections . 851
Gordon L. Archer I Ronald E. Polk
|QQ^ DISEASES CAUSED BY GRAM-POSITIVE BACTERIA
128 Pneumococcal Infections 865
Daniel M. Musher
129 Staphylococcal Infections 872
Franklin D. Lowy
130 Streptococcal and Enterococcal Infections 881
Michael R. Wessels
131 Diphtheria and Other Infections Caused
by Corynebacteria and Related Species 890
William R. Bishai I John R. Murphy
132 Infections Caused by Listeria monocytogenes 895
Elizabeth L. Hohmann I Daniel A. Portnoy
133 Tetanus 898
Elias Abrutyn
134 Botulism 901
Elias Abrutyn
135 Gas Gangrene and Other Clostridial Infections 903
Dennis L Kasper I Lawrence C. Madoff
m^Q^ DISEASES CAUSED BY GRAM-NEGATIVE BACTERIA
136 Meningococcal Infections 908
Lee M. Wetzler
137 Gonococcal Infections 914
Sanjay Ram I Peter A. Rice
138 Moraxella Infections 921
Daniel M. Musher
139 Haemophilus Infections 923
Timothy F. Murphy
140 Infections Due to the HACEK Group and
Miscellaneous Gram-Negative Bacteria 926
Tamar F. Barlam I Dennis L. Kasper
141 Legionella Infection 929
Miguel Sabria I Victor L. Yu
142 Pertussis and Other Bordetello Infections 933
Scott A. Halperin
143 Diseases Caused by Gram-Negative Enteric Bacilli. 937
Thomas A. Russo /James R. Johnson
144 Helicobacter pylori Infections 946
John C. Atherton I Martin J. Blaser
145 Infections Due to Pseudomonas Species
and Related Organisms 949
Reuben Ramphal
146 Salmonellosis 956
David A. Pegues I Samuel I. Miller
147 Shigellosis 962
Philippe Sansonetti I Jean Bergounioux
148 Infections Due to Campylobacter
and Related Species 965
Martin J. Blaser
149 Cholera and Other Vibrioses 968
Matthew K. Waldor / Gerald T. Keusch
150 Brucellosis 973
Michael J. Corbel I Nicholas J. Beeching
151 Tularemia 976
Richard F. Jacobs / Gordon E. Schutze
152 Plague and Other Yersinia Infections 980
David T. Dennis I Grant L. Campbell
153 Bortonella Infections, Including
Cat-Scratch Disease 987
David H. Spach I Emily Darby
154 Donovanosis 991
Gavin Hart
mQEQ^ MISCELLANEOUS BACTERIAL INFECTIONS
155 Nocardiosis 992
Gregory A. Filice
156 Actinomycosis 996
Thomas A. Russo
157 Infections Due to Mixed Anaerobic Organisms 999
Dennis L. Kasper/Ronit Cohen-Poradosu
¦Pffl^^ MYCOBACTERIAL OISEASES
158 Tuberculosis 1006
Mario C. Raviglione I Richard J. O'Brien
159 Leprosy (Hansen's Disease) 1021
Robert H. Gelber
160 Nontuberculous Mycobacteria 1027
C. Fordham von Reyn
161 Antimycobacterial Agents 1032
Richard J. Wallace, Jr. /David E. Griffith
£££QQ^| SPIROCHETAL DISEASES
162 Syphilis 1038
Sheila A. Lukehart
163 Endemic Treponematoses 1046
Sheila A. Lukehart
164 Leptospirosis 1048
Peter Speelman I Rudy Hartskeerl
165 Relapsing Fever 1052
David T. Dennis
166 Lyme Borreliosis 1055
Allen C. Steere
RJ^JQ DISEASES CAUSED BY RICKETTSIAE,
1^^ MYCOPLASMAS, AND CHLAMYDIAE
167 Rickettsial Diseases 1059
David H. Walker / J. Stephen Dumler I Thomas Marrie
168 Infections Due to Mycoplasmas 1068
William M. McCormack
169 Chlamydial Infections 1070
Walter E. Stamm
|^^^A VIRAL DISEASES: GENERAL CONSIDERATIONS
170 Medical Virology 1079
Fred Wang I Elliott Kieff
171 Antiviral Chemotherapy,
Excluding Antiretroviral Drugs 1087
Lindsey R. Baden I Raphael Dolin
^^^^^ INFECTIONS DUE TO DNA VIRUSES
172 Herpes Simplex Viruses 1095
Lawrence Corey
173 Varicella-Zoster Virus Infections 1102
Richard]. Whitley
174 Epstein-Barr Virus Infections,
Including Infectious Mononucleosis 1106
Jeffrey I. Cohen
175 Cytomegalovirus and Human
Herpesvirus Types 6, 7, and 8 1109
Martin S. Hirsch
176 Molluscum Contagiosum, Monkeypox, and
Other Poxviruses, Excluding Smallpox Virus 1113
Fred Wang
177 Parvovirus Infections 1114
Kevin E. Brown
178 Human Papillomavirus Infections 1117
Richard C. Reichman
Q^Jj^^ INFECTIONS DUE TO DNA AND RNA RESPIRATORY VIRUSES
179 Common Viral Respiratory Infections and
Severe Acute Respiratory Syndrome (SARS) 1120
Raphael Dolin
180 Influenza 1127
Raphael Dolin
I^^^Q INFECTIONS DUE TO HUMAN IMMUNODEFICIENCY
^^^^P VIRUS AND OTHER HUMAN RETROVIRUSES
181 The Human Retroviruses 1132
Dan L. Longo /Anthony S. Fauci
182 Human Immunodeficiency Virus Disease:
AIDS and Related Disorders 1137
AnthonyS. Fauci IH. Clifford Lane
Q^^Q INFECTIONS DUE TO RNA VIRUSES
183 Viral Gastroenteritis 1204
Umesh D. Parashar I Roger I. Glass
184 Enteroviruses and Reoviruses 1208
Jeffrey I. Cohen
185 Measles (Rubeola) 1214
Anne Gershon
186 Rubella (German Measles) 1217
Anne Gershon
187 Mumps 1220
Anne Gershon
188 Rabies and Other Rhabdovirus Infections 1222
Alan C. Jackson/Eric C. Johannsen
189 Infections Caused by Arthropod-
and Rodent-Borne Viruses 1226
Clarence J. Peters
190 Ebola and Marburg Viruses 1240
Clarence J. Peters
^^^^^ FUNGAL ANO ALGAL INFECTIONS
191 Oiagnosis and Treatment of Fungal Infections 1242
John E. Edwards, Jr.
192 Histoplasmosis 1244
ChadiA. Hage/L. Joseph Wheat
193 Coccidioidomycosis 1247
Neil M. Ampel
194 Blastomycosis 1249
Stanley W. Chapman I Donna C. Sullivan
195 Cryptococcosis 1251
Arturo Casadevall
196 Candidiasis 1254
John E. Edwards, Jr.
197 Aspergillosis 1256
David W. Denning
198 Mucormycosis I26l
Alan M. Sugar
199 Miscellaneous Mycoses and Algal Infections 1263
Stanley W. Chapman I Donna C. Sullivan
200 Pneumocystis Infection 1267
A. George Smulian I Peter D. Walzer
Q9QQR1 PROTOZOAl AND HELMINTHIC INFECTIONS:
^^^^^ GENERAL CONSIDERATIONS
0^0 e16 Laboratory Diagnosis of Parasitic Infections el 13
Sharon L. Reed I Charles E. Davis
201 Agents Used to Treat Parasitic Infections 1270
Thomas A. Moore
£y e17 Pharmacology of Agents Used
to Treat Parasitic Infections el 19
Thomas A. Moore
^^^^^ PROTOZOAL INFECTIONS
202 Amebiasis and Infection with Free-Living Amebas . 1275
Sharon L. Reed
203 Malaria 1280
Nicholas J. White/Joel G. Breman
204 Babesiosis 1294
Jeffrey A. Gelfand I Edouard Vannier
£) el8 Atlas of Blood Smears of Malaria and Babesiosis. el27
Nicholas J. White I Joel G. Breman
205 Leishmaniasis 1296
Barbara L. Herwaldt
206 Trypanosomiasis 1300
Louis V. Kirchhoff
207 Toxoplasma Infections 1305
Lloyd H. Kasper
208 Protozoal Intestinal Infections and Trichomoniasis. 1311
Peter F. Weller
^^W^^ HELMINTHIC INFECTIONS
209 Trichinella and Other Tissue Nematodes 1316
Peter E Weller
210 Intestinal Nematodes 1319
Peter E Weller I Thomas B. Nutman
211 Filarial and Related Infections 1324
Thomas B. Nutman I Peter F. Weller
212 Schistosomiasis and Other Trematode Infections . 1330
Adel A. F. Mahmoud
213 Cestodes 1336
A. Clinton White, Jr./PeterF. Weller
y^- PART 8 Bioterrorism and
Clinical Medicine
214 Microbial Bioterrorism 1343
H. Clifford Lane /Anthony S. Fauci
215 Chemical Bioterrorism 1352
Charles G. Hurst / Jonathan Newmark/
James A. Romano, Jr.
216 Radiation Bioterrorism 1358
ZeligA. Tochner I Eli Glatstein
^ PART 9 Disorders of the
Cardiovascular System
ES3A INTR0DUCTI0N TO CARDIOVASCULAR DISORDERS
217 Basic Biology of the Cardiovascular System 1365
Joseph Loscalzo I Peter Libby I Eugene Braunwald
218 Epidemiology of Cardiovascular Disease 1375
Thomas A. Gaziano IJ. Michael Gaziano
219 Approach to the Patient with
Possible Cardiovascular Disease 1379
Eugene Braunwald
EQEQ^ DIAGNOSIS OF CARDIOVASCULAR DISORDERS
220 Physical Examination of the
Cardiovascular System 1382
Robert A. O'Rourke I Eugene Braunwald
221 Electrocardiography 1388
Ary L. Goldberger
^ e19 Atlas of Electrocardiography ei3l
Ary L. Goldberger
222 Noninvasive Cardiac Imaging: Echocardiography,
Nuclear Cardiology, and MRI/CT Imaging 1397
Rick A. Nishimura I Raymond J. Gibbons I
James F. Glockner I A. Jamil Tajik
£ e20 Atlas of Noninvasive Cardiac Imaging .' el49
Rick A. Nishimura I Raymond J. Gibbons I
James F. Glockner/A. Jamil Tajik
223 Diagnostic Cardiac Catheterization
and Angiography 1405
Donald S. Bairn
^^^^A DISORDERS OF RHYTHM
224 Principles of Electrophysiology 1410
Gordon F. Tomaselli
225 The Bradyarrhythmias 1416
Gordon F. Tomaselli
226 The Tachyarrhythmias 1425
Francis Marchlinski
0J0 e2i Atlas of Cardiac Arrhythmias el59
Ary L. Goldberger
¦fflffl^ DISORDERS OF THE HEART
227 Heart Failure and Cor Pulmonale 1443
Douglas L. Mann
228 Cardiac Transplantation and
Prolonged Assisted Circulation 1455
Sharon A. Hunt
229 Congenital Heart Disease in the Adult 1458
John S. Child
230 Valvular Heart Disease 1465
Patrick O'Gara I Eugene Braunwald
231 Cardiomyopathy and Myocarditis 1481
Joshua Wynne I Eugene Braunwald
232 Pericardial Disease 1488
Eugene Braunwald
233 Tumors and Trauma of the Heart 1495
Eric H.Awtry/Wilson S.Colucci
234 Cardiac Manifestations of Systemic Disease 1498
Eric H. Awtry I Wilson S. Colucci
EQSQt vascular d|s£ase
235 The Pathogenesis, Prevention,
and Treatment of Atherosclerosis 1501
Peter Libby
(Q) e22 Atlas of Atherosclerosis el7l
Peter Libby
236 The Metabolic Syndrome 1509
Robert H.Eckel
237 Ischemic Heart Disease 1514
ElliottM. Antman /Andrew P. Selwyn I
Eugene Braunwald I Joseph Loscalzo
238 Unstable Angina and Non-ST-Elevation
Myocardial Infarction 1527
Christopher P. Cannon I Eugene Braunwald
239 ST-Segment Elevation Myocardial Infarction 1532
ElliottM. Antman /Eugene Braunwald
240 Percutaneous Coronary Intervention 1544
Donald S. Bairn
£) e23 Atlas of Percutaneous
Revascularization el73
Donald S. Bairn
241 Hypertensive Vascular Disease 1549
Theodore A. Kotchen
242 Diseases of the Aorta -.-. 1563
Mark A. Creager / Joseph Loscalzo
243 Vascular Diseases of the Extremities 1568
Mark A. Creager I Joseph Loscalzo
244 Pulmonary Hypertension ./ 1576
Stuart Rich
?- PART 10 Disorders of the
Respiratory System
R^H DIAGNOSIS OF RESPIRATORY DISORDERS
245 Approach to the Patient with
Disease of the Respiratory System 1583
David A. Lipson I Steven E. Weinberger
246 Disturbances of Respiratory Function 1586
Steven E. Weinberger I Ilene M. Rosen
247 Diagnostic Procedures in
Respiratory Disease 1593
Scott Manaker / Steven E. Weinberger
0 e24 Atlas of Chest Imaging ei79
Patricia A. Kritek /John J. Reilly, Jr.
m|J^^ DISEASES OF THE RESPIRATORY SYSTEM
248 Asthma 1596
Peter J. Barnes
249 Hypersensitivity Pneumonitis and
Pulmonary Infiltrates with Eosinophilia 1607
Joel N. Kline I Gary W. Hunninghake
250 Environmental Lung Disease 1611
Frank E. Speizer / John R. Balmes
251 Pneumonia 1619
Lionel A. Mandell / Richard Wunderink
252 Bronchiectasis and Lung Abscess 1629
Gregory Tino I Steven E. Weinberger
253 Cystic Fibrosis 1632
Richard C. Boucher
254 Chronic Obstructive Pulmonary Disease 1635
John J. Reilly, Jr. I Edwin K. Silverman I
Steven D. Shapiro
255 Interstitial Lung Diseases 1643
Talmadge E. King, Jr.
256 Deep Venous Thrombosis and
Pulmonary Thromboembolism 1651
Samuel Z. Goldhaber
257 Disorders of the Pleura and Mediastinum 1658
Richard W. Light
258 Disorders of Ventilation 1661
Eliot A. Phillipson
259 Sleep Apnea 1665
Neil). Douglas
260 Lung Transplantation 1668
Elbert P. Trulock
? PART 11 Critical Care Medicine
£QJj^^ RESPIRATORY CRITICAL CARE
261 Principles of Critical Care Medicine 1673
John P. Kress /Jesse B. Hall
262 Acute Respiratory Distress Syndrome 1680
Bruce D. Levy I Steven D. Shapiro
263 Mechanical Ventilatory Support 1684
Edward P. Ingenito
¦^^^^ SHOCK AND CARDIAC ARREST
264 Approach to the Patient with Shock 1689
Ronald V. Maier
265 Severe Sepsis and Septic Shock 1695
Robert S. Munford
266 Cardiogenic Shock and Pulmonary Edema 1702
Judith S. Hochman / David H. Ingbar
267 Cardiovascular Collapse, Cardiac Arrest,
and Sudden Cardiac Death 1707
Robert J. Myerberg I Agustin Castellanos
^Jj^^ NEUROLOGIC CRITICAL CARE
268 Coma 1714
Allan H. Ropper
269 Neurologic Critical Care, Including
Hypoxic-lschemic Encephalopathy
and Subarachnoid Hemorrhage 1720
/. Claude Hemphill III I Wade S. Smith
jj^^QA ONCOLOGIC EMERGENCIES
270 Oncologic Emergencies 1730
Rasim Gucalp /Janice P. Dutcher
? PART 12 Disorders of the Kidney
and Urinary Tract
271 Cellular and Molecular Biology of the Kidney 1741
Alfred L. George, Jr. I Eric G. Neilson
272 Adaptation of the Kidney to Renal Injury 1748
Raymond C. Harris / Eric G. Neilson
273 Acute Renal Failure 1752
Kathleen D. Liu I Glenn M. Chertow
274 Chronic Kidney Disease 1761
Joanne M. Bargman I Karl Skorecki
275 Dialysis in the Treatment of Renal Failure 1772
Kathleen D. Liu I Glenn M. Chertow
276 Transplantation in the
Treatment of Renal Failure 1776
Charles B. Carpenter I Edgar L Milford I
Mohamed H. Sayegh
277 Glomerular Diseases 1782
Julia B. Lewis I Eric G. Neilson
278 Polycystic Kidney Disease and
Other Inherited Tubular Disorders 1797
David J. Salant I Parul S. Patel
279 Tubulointerstitial Diseases of the Kidney 1806
Alan S. L. Yu /Barry M. Brenner
280 Vascular Injury to the Kidney 1811
Kamal F. Badr I Barry M. Brenner
281 Nephrolithiasis 1815
John R. Asplin I Fredric L. Coe I Murray J. Favus
282 Urinary Tract Infections,
Pyelonephritis, and Prostatitis 1820
Walter E. Stamm
283 Urinary Tract Obstruction 1827
Julian L. Seifter I Barry M. Brenner
^ PART 13 Disorders of the
Gastrointestinal System
KRffl^^ DISORDERS OF THE ALIMENTARY TRACT
284 Approach to the Patient with
Gastrointestinal Disease 1831
William L. Hasler I Chung Owyang
285 Gastrointestinal Endoscopy 1836
Louis Michel Wong-Kee-Song I Mark Topazian
0^0 e25 video Atlas of Gastrointestinal Endoscopy el95
Louis Michel Wong-Kee-Song I Mark Topazian
286 Diseases of the Esophagus 1847
RajK. Goyal
287 Peptic Ulcer Disease and Related Disorders 1855
John Del Valle
288 Disorders of Absorption 1872
Henry J. Binder
289 inflammatory Bowel Disease 1886
Sonia Friedman I Richard S. Blumberg
290 Irritable Bowel Syndrome 1899
Chung Owyang
291 Diverticular Disease and
Common Anorectal Disorders 1903
Susan L. Gearhart
292 Mesenteric Vascular Insufficiency 1910
Susan L. Gearhart
293 Acute Intestinal Obstruction 1912
Susan L. Gearhart I William Silen
294 Acute Appendicitis and Peritonitis 1914
Susan L. Gearhart I William Silen
£Q2S llVER AND BIUARY TRACT DISEASE
295 Approach to the Patient with Liver Disease 1918
Marc Ghany /Jay H. Hoofnagle
296 Evaluation of Liver Function 1923
Daniel S. Pratt I Marshall M. Kaplan
297 The Hyperbilirubinemias 1927
Allan W. Wolkoff
298 Acute Viral Hepatitis 1932
Jules L. Dienstag
299 Toxic and Drug-Induced Hepatitis 1949
Jules L. Dienstag
300 Chronic Hepatitis 1955
Jules L. Dienstag
301 Alcoholic Liver Disease 1969
Mark E. Mailliard I Michael F. Sorrell
302 Cirrhosis and Its Complications 1971
Bruce R. Bacon
^0 e26 Atlas of Liver Biopsies e203
Jules L. Dienstag I Atul K. Bhan
303 Genetic, Metabolic, and Infiltrative
Diseases Affecting the Liver 1980
Bruce R. Bacon
304 Liver Transplantation 1983
Jules L. Dienstag / Raymond T. Chung
305 Diseases of the Gallbladder and Bile Ducts 1991
Norton J. Greenberger I Gustav Paumgartner
^^^^^ DISORDERS OF THE PANCREAS
306 Approach to the Patient
with Pancreatic Disease 2001
Phillip P. Toskes/ Norton J. Greenberger
307 Acute and Chronic Pancreatitis 2005
Norton J. Greenberger I Phillip P. Toskes
^ PART 14 Disorders of the Immune
System, Connective Tissue,
and Joints
£QJQ^ftTHE |MMUNE SYSTEM |N HEALTH AND D|SEASE
308 Introduction to the Immune System 2019
Barton F. Haynes I Kelly A. Soderberg /Anthony S. Fauci
309 The Major Histocompatibility Complex 2045
Gerald T. Nepom
310 Primary Immune Deficiency Diseases 2053
Max D. Cooper I Harry W. Schroeder, Jr.
^0 e27 Primary Immunodeficiencies Associated
with or Secondary to Other Diseases e207
Max D. Cooper I Harry W. Schroeder, Jr.
H^QQQI DISORDERS OF IMMUNE-MEDIATED INJURY
311 Allergies, Anaphylaxis, and
Systemic Mastocytosis 2061
K. Frank Austen
312 Autoimmunity and Autoimmune Diseases 2071
Peter E. Lipsky I Betty Diamond
313 Systemic Lupus Erythematosus 2075
Bevra Hannahs Hahn
314 Rheumatoid Arthritis 2083
Peter E. Lipsky
315 Acute Rheumatic Fever 2092
Jonathan R. Carapetis
316 Systemic Sclerosis (Scleroderma)
and Related Disorders 2096
John Varga
317 Sjogren's Syndrome 2107
Haralampos M. Moutsopoulos
318 The Spondyloarthritides 2109
Joel D. Taurog
319 The Vasculitis Syndromes 2119
Carol A. Langford /Anthony S. Fauci
^0 e28 Atlas of Clinical Imaging in
the Vasculitic Syndromes e209
Carol A. Langford /Anthony S. Fauci
320 Behget's Syndrome 2132
Haralampos M. Moutsopoulos
321 Relapsing Polychondritis 2133
Carol A. Langford I Bruce C. Gilliland
322 Sarcoidosis 2135
Robert P. Baughman I Elyse E. Lower
323 Familial Mediterranean Fever 2142
Daniel L. Kastner
324 Amyloidosis 2145
David C. Seldin / Martha Skinner
0^^^ DISORDERS OF THE JOINTS AND ADJACENT TISSUES
325 Approach to Articular and
Musculoskeletal Disorders 2149
John J. Cush I Peter E. Lipsky
326 Osteoarthritis 2158
David T. Felson
327 Gout and Other Crystal-Associated
Arthropathies 2165
H. Ralph Schumacher / Lan X. Chen
328 Infectious Arthritis 2169
Lawrence C. Madoff
329 Fibromyalgia 2175
Carol A. Langford / Bruce C. Gilliland
330 Arthritis Associated with Systemic Disease
and Other Arthritides 2177
Carol A. Langford / Bruce C. Gilliland
331 Periarticular Disorders of the Extremities 2184
Carol A. Langford / Bruce C. Gilliland
^ PART 15 Endocrinology
and Metabolism
MffiPA ENDOCRINOLOGY
332 Principles of Endocrinology 2187
/. Larry Jameson
333 Disorders of the Anterior Pituitary
and Hypothalamus 2195
Shlomo Melmed IJ. Larry Jameson
334 Disorders of the Neurohypophysis 2217
Gary L. Robertson
335 Disorders of the Thyroid Gland 2224
/. Larry Jameson I Anthony P. Weetman
336 Disorders of the Adrenal Cortex 2247
Gordon H. Williams / Robert G. Dluhy
337 Pheochromocytoma 2269
HartmutP. H. Neumann
338 Diabetes Mellitus 2275
Alvin C. Powers
339 Hypoglycemia 2305
Philip E. Cryer
340 Disorders of the Testes and
Male Reproductive System 2310
Shalender Bhasin /J. Larry Jameson
341 The Female Reproductive System:
Infertility and Contraception 2324
Janet E. Hall
342 The Menopause Transition and
Postmenopausal Hormone Therapy 2334
JoAnn E. Manson I Shari S. Bassuk
343 Disorders of Sex Development 2339
John C. Achermann /J. Larry Jameson
344 Endocrine Tumors of the
Gastrointestinal Tract and Pancreas 2347
Robert T. Jensen
345 Disorders Affecting Multiple
Endocrine Systems 2358
Camilo Jimenez I Robert F. Gagel
¦ftfflj^^ DISORDERS OF BONE AND MINERAL METABOLISM
346 Bone and Mineral Metabolism
in Health and Disease 2365
F. Richard Bringhurst I Marie B. Demay I
Stephen M. Krane I Henry M. Kronenberg
347 Diseases of the Parathyroid Gland and
Other Hyper- and Hypocakemic Disorders 2377
John T. Potts, Jr.
348 Osteoporosis 2397
Robert Lindsay I Felicia Cosman
349 Paget Disease and Other Dysplasias of Bone 2408
Murray]. Favus / Tamara }. Yokes
J^^^ DISORDERS OF INTERMEDIARY METABOLISM
350 Disorders of Lipoprotein Metabolism 2416
Daniel ]. Rader I Helen H. Hobbs
351 Hemochromatosis 2429
Lawrie W. Powell
352 The Porphyrias 2434
Robert J. Desnick I Kenneth H. Astrin
353 Disorders of Purine and Pyrimidine Metabolism 2444
Robert L. Wortmann
354 Wilson Disease 2449
George J. Brewer
355 Lysosomal Storage Disease 2452
Robert J. Hopkin / Gregory A. Grabowski
356 Glycogen Storage Diseases and Other
Inherited Disorders of Carbohydrate Metabolism . 2457
Yuan-Tsong Chen
357 Heritable Disorders of Connective Tissue 2461
Darwin J. Prockop I Malwina Czarny-Ratajczak
358 Inherited Disorders of Amino Acid
Metabolism in Adults 2470
Nicola Longo
359 Inherited Defects of Membrane Transport 2474
Nicola Longo
^ e29 Atlas of Clinical Manifestations
of Metabolic Diseases e2l5
/. Larry Jameson
? PART 16 Neurologic Disorders
B3^| DIAGNOSIS OF NEUROLOGIC DISORDERS
360 Mechanisms of Neurologic Diseases 2477
Stephen L. Hauser/M. Flint Beal
361 Approach to the Patient with Neurologic Disease . 2484
Daniel H. Lowenstein /Joseph B. Martin I
Stephen L. Hauser
362 Neuroimaging in Neurologic Disorders 2489
William P. Dillon
( e30 Atlas of Neuroimaging e225
Andre Furtado I William P. Dillon
^ e31 Electrodiagnostic Studies of Nervous System
Disorders: EEG, Evoked Potentials, and EMG e26l
Michael J. Aminoff
^ e32 Technique of Lumbar Puncture e267
Elizabeth Robbins I Stephen L. Hauser
¦^^^ DISEASES OF THE CENTRAL NERVOUS SYSTEM
363 Seizures and Epilepsy 2498
Daniel H. Lowenstein
364 Cerebrovascular Diseases 2513
Wade S. Smith /Joey D. English IS. Claiborne Johnston
365 Dementia 2536
Thomas D. Bird I Bruce L. Miller
366 Parkinson's Disease and Other
Extrapyramidal Movement Disorders 2549
Mahlon R. DeLong/Jorge L. Juncos
367 Hyperkinetic Movement Disorders 2560
C. Warren Olanow
368 Ataxic Disorders 2565
Roger N. Rosenberg
369 Amyotrophic Lateral Sclerosis and
Other Motor Neuron Diseases 2572
Robert H. Brown, Jr.
370 Disorders of the Autonomic Nervous System 2576
Phillip A. Low/ John W. Engstrom
371 Trigeminal Neuralgia, Bell's Palsy, and
Other Cranial Nerve Disorders 2583
M. Flint Beal I Stephen L Hauser
372 Diseases of the Spinal Cord 2588
Stephen L. Hauser/Allan H. Ropper
373 Concussion and Other Head Injuries 2596
Allan H. Ropper
374 Primary and Metastatic Tumors
of the Nervous System 2601
Stephen M. Sagar/MarkA. Israel
375 Multiple Sclerosis and Other
Demyelinating Diseases 2611
Stephen L. Hauser I Douglas S. Goodin
376 Meningitis, Encephalitis,
Brain Abscess, and Empyema 2621
Karen L. Roos I Kenneth L. Tyler
377 Chronic and Recurrent Meningitis 2641
Walter J. Koroshetz I Morton N. Swartz
378 Prion Diseases 2646
Stanley B. Prusiner I Bruce L. Miller
BSQ NERVE ANO MUSCLE DISORDERS
379 Peripheral Neuropathy 2651
Vinay Chaudhry
380 Guillain-Barre Syndrome and Other
Immune-Mediated Neuropathies 2667
Stephen L. Hauser I Arthur K. Asbury
381 Myasthenia Gravis and Other Diseases
of the Neuromuscular Junction 2672
Daniel B. Drachman
382 Muscular Dystrophies and
Other Muscle Diseases 2678
Robert H. Brown, Jr. /AnthonyA. Amato I
Jerry R. Mendell
383 Polymyositis, Dermatomyositis,
and Inclusion Body Myositis 2696
Marinos C. Dalakas
0 e33 Special Issues in Inpatient
Neurologic Consultation e27l
S. Andrew Josephson /Martin A. Samuels
^^^^^ CHRONIC FATIGUE SYNDROME
384 Chronic Fatigue Syndrome 2703
Stephen E. Straus
K^^ffl|| PSYCHIATRIC DISORDERS
385 Biology of Psychiatric Disorders 2705
Steven E. Hyman I EricKandel
386 Mental Disorders 2710
Victor I. Reus
¦TOffll^ ALCOHOLISM AND DRUG DEPENDENCY
387 Alcohol and Alcoholism 2724
Marc A. Schuckit
388 Opioid Drug Abuse and Dependence 2729
Marc A. Schuckit
389 Cocaine and Other Commonly Abused Drugs 2733
Jack H. Mendelson I Nancy K. Mello
390 Nicotine Addiction 2736
David M. Burns
y^- PART 17 Poisoning, Drug Overdose,
and Envenomation
(tf) e34 Heavy Metal Poisoning e277
Howard Hu
Q) e35 Poisoning and Drug Overdosage e28i
Christopher H. Linden / Michael J. Burns I
Mark B. Mycyk
391 Disorders Caused by Reptile Bites
and Marine Animal Exposures 2741
Paul S. Auerbach I Robert L. Norris
392 Ectoparasite Infestations and
Arthropod Bites and Stings 2748
Richard J. Pollack /James H. Maguire
^ PART 18 e-Chaptersfrom
International
Advisory Editors
^ e36 Pulmonary Biomarkers in COPD e297
Peter J. Barnes
ty e37 Chagas' Disease: Advances
in Diagnosis and Management e303
Andrei C. Sposito /JoseA. F. Ramires
% e38 The Polypill e307
K. Srinath Reddy/Nitish Naik /Ambuj Roy
0 e39 Mitochondrial DNA and
Heritable Traits and Diseases e3ll
Karl Skorecki I Hanna Mandel
APPENDIX
Laboratory Values of Clinical Importance A-l
Alexander Kratz I Michael A. Pesce I Daniel J. Fink
INDEX 1-1 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)1102147176 (DE-588)172126681 |
| building | Verbundindex |
| bvnumber | BV023181397 |
| callnumber-first | R - Medicine |
| callnumber-label | RC46 |
| callnumber-raw | RC46 |
| callnumber-search | RC46 |
| callnumber-sort | RC 246 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | YB 1300 |
| ctrlnum | (OCoLC)254506410 (DE-599)BVBBV023181397 |
| dewey-full | 616 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616 |
| dewey-search | 616 |
| dewey-sort | 3616 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 17. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV023181397 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:01:36Z |
| indexdate | 2024-07-09T21:12:28Z |
| institution | BVB |
| isbn | 9780071466332 0071466339 9780071599917 9780071599900 9780071476911 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016367922 |
| oclc_num | 254506410 |
| open_access_boolean | |
| owner | DE-20 DE-19 DE-BY-UBM |
| owner_facet | DE-20 DE-19 DE-BY-UBM |
| physical | Getr. Zählung Ill., graph. Darst., Kt. 1 DVD (12 cm) |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | McGraw-Hill |
| record_format | marc |
| spelling | Harrison's principles of internal medicine ed. Anthony S. Fauci ... Principles of internal medicine 17. ed. New York [u.a.] McGraw-Hill 2008 Getr. Zählung Ill., graph. Darst., Kt. 1 DVD (12 cm) txt rdacontent n rdamedia nc rdacarrier Internal Medicine Internal medicine Innere Krankheit (DE-588)4072828-6 gnd rswk-swf CD-ROM (DE-588)4139307-7 gnd rswk-swf Innere Medizin (DE-588)4027074-9 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Innere Medizin (DE-588)4027074-9 s CD-ROM (DE-588)4139307-7 s 1\p DE-604 Innere Krankheit (DE-588)4072828-6 s 2\p DE-604 Fauci, Anthony S. 1940- Sonstige (DE-588)1102147176 oth Harrison, Tinsley Randolph 1900-1978 Sonstige (DE-588)172126681 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016367922&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Harrison's principles of internal medicine Internal Medicine Internal medicine Innere Krankheit (DE-588)4072828-6 gnd CD-ROM (DE-588)4139307-7 gnd Innere Medizin (DE-588)4027074-9 gnd |
| subject_GND | (DE-588)4072828-6 (DE-588)4139307-7 (DE-588)4027074-9 (DE-588)4123623-3 |
| title | Harrison's principles of internal medicine |
| title_alt | Principles of internal medicine |
| title_auth | Harrison's principles of internal medicine |
| title_exact_search | Harrison's principles of internal medicine |
| title_exact_search_txtP | Harrison's principles of internal medicine |
| title_full | Harrison's principles of internal medicine ed. Anthony S. Fauci ... |
| title_fullStr | Harrison's principles of internal medicine ed. Anthony S. Fauci ... |
| title_full_unstemmed | Harrison's principles of internal medicine ed. Anthony S. Fauci ... |
| title_short | Harrison's principles of internal medicine |
| title_sort | harrison s principles of internal medicine |
| topic | Internal Medicine Internal medicine Innere Krankheit (DE-588)4072828-6 gnd CD-ROM (DE-588)4139307-7 gnd Innere Medizin (DE-588)4027074-9 gnd |
| topic_facet | Internal Medicine Internal medicine Innere Krankheit CD-ROM Innere Medizin Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016367922&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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