How the immune system recognizes self and nonself: immunoreceptors and their signaling
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Tokyo [u.a.]
Springer Tokyo
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 251 S. Ill., graph. Darst. |
| ISBN: | 9784431738831 4431738835 |
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| 245 | 1 | 0 | |a How the immune system recognizes self and nonself |b immunoreceptors and their signaling |c Daisuke Kitamura, ed. |
| 264 | 1 | |a Tokyo [u.a.] |b Springer Tokyo |c 2008 | |
| 300 | |a XVIII, 251 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Herkenning |2 gtt | |
| 650 | 7 | |a Immunologie |2 gtt | |
| 650 | 4 | |a Cellular immunity | |
| 650 | 4 | |a Immune recognition | |
| 650 | 4 | |a Immune response | |
| 650 | 4 | |a Immune system | |
| 650 | 4 | |a Immunity, Cellular |x physiology | |
| 650 | 4 | |a Lymphocytes |x physiology | |
| 650 | 4 | |a Receptors, Immunologic |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804137392162996224 |
|---|---|
| adam_text | Contents
Preface V
List of Authors XI
Color Plates XV
1 Recognition of Pathogens: Toll-Like Receptors 1
Satoshi Uematsu and Shizuo Akira
1.1 Introduction 1
1.2 Innate Immunity 1
1.3 Pathogen Recognition by TLR 5
1.4 Toll-Like Receptor Signaling Pathways 9
1.5 Negative Regulation of TLR Signaling 17
1.6 Conclusion and Future Prospects 22
References 23
2 Strategies of Natural Killer (NK) Cell Recognition and
Their Roles in Tumor Immunosurveillance 37
C. Andrew Stewart and Eric Vivier
2.1 Introduction: An Interesting Epistemological Case 37
2.2 Natural Killer Cells in Innate Immunity 38
2.3 Natural Killer Cell Recognition of Missing-Self: An Array of
Inhibitory Cell Surface Receptors 40
2.4 Complexity of the NK Cell Zipper 44
2.5 Coordination of NK Cell Activating and Inhibitory Signals
in Cancer 53
2.6 Programming a Natural Killer: Steady-State and
Situation-Specific Regulation of NK Effector Functions 62
2.7 Conclusions and Perspectives: NK Cells, Self Versus Nonself,
and Cancer 67
References 67
VII
VIII Contents
3 Recent Progress on Paired Immunoglobulin-Like Receptors 83
Hiromi Kubagawa, Ching-Cheng Chen, Ikuko Torii, Max D. Cooper,
Kyoko Masuda, Yoshimoto Katsura, and Hiroshi Kawamoto
3.1 Introduction 83
3.2 PIR Expression by Early Hematopoietic Cells 85
3.3 PIR Expression by Thymocyte Progenitors 86
3.4 Differentiation Potential of PIR+ and PIR Lymphoid
Progenitors 87
3.5 PIR Expression by Dendritic Cell Precursors 89
3.6 PIR Ligands 90
3.7 Paired Immunoglobulin-Like Receptor Function 92
3.8 Conclusion 94
References 95
4 Self-nonself Recognition through B-Cell Antigen Receptor 99
Daisuke Kitamura
4.1 Introduction 99
4.2 Signal Transduction from BCR 101
4.3 BCR Signaling Pathways for Immune Response 112
4.4 BCR Signaling Pathways for Self Tolerance 116
4.5 Concluding Remarks: To Respond or Not to Respond, That is
the Question 120
References 122
5 How Do T Cells Discriminate Self from Nonself? 133
Catherine Mazza and Bernard Malissen
5.1 Introduction 133
5.2 Structure of the TCR Complex 135
5.3 How Does the ocp TCR Convey Signals Across the Membrane? ... 140
5.4 TCR Assembly During Intrathymic Development 147
5.5 How TCRs Bind pMHC 149
5.6 What Causes die Restriction in Orientation Imposed on
TCR-pMHC Interactions? 156
5.7 Rationalizing the Purpose of TCR ocp Positive Selection 159
5.8 Recessive and Dominant Tolerance 161
5.9 Evolutionary Perspectives 162
References 164
6 Fc Receptors 173
Falk Nimmerjahn and Jeffrey V. Ravetch
6.1 Introduction 173
6.2 Fc Receptors—Basic Facts 174
6.3 Fc Receptor Signaling 178
6.4 Fc Receptor Biology In Vivo 181
Contents IX
6.5 Summary 192
References 192
7 Self and Nonself Recognition by Coreceptors on B Lymphocytes:
Regulation of B lymphocytes by CD19, CD21, CD22, and CD72 ... 199
Kozo Watanabe and Takeshi Tsubata
7.1 Introduction 199
7.2 Regulation of B Cells by CD19/CD21 Complex 200
7.3 Regulation of B Cells by CD22 206
7.4 Regulation of B Cells by CD72 210
7.5 Self and Nonself Recognition by Coreceptors on B cells 212
References 213
8 Co-Receptors in the Positive and Negative Regulation of
T-Cell Immunity 221
Helga Schneider and Christopher E. Rudd
8.1 Introduction 221
8.2 Positive Co-stimulatory Molecules 224
8.3 Negative Co-stimulatory Molecules 229
8.4 Conclusion 236
References 237
Index 247
|
| adam_txt |
Contents
Preface V
List of Authors XI
Color Plates XV
1 Recognition of Pathogens: Toll-Like Receptors 1
Satoshi Uematsu and Shizuo Akira
1.1 Introduction 1
1.2 Innate Immunity 1
1.3 Pathogen Recognition by TLR 5
1.4 Toll-Like Receptor Signaling Pathways 9
1.5 Negative Regulation of TLR Signaling 17
1.6 Conclusion and Future Prospects 22
References 23
2 Strategies of Natural Killer (NK) Cell Recognition and
Their Roles in Tumor Immunosurveillance 37
C. Andrew Stewart and Eric Vivier
2.1 Introduction: An Interesting Epistemological Case 37
2.2 Natural Killer Cells in Innate Immunity 38
2.3 Natural Killer Cell Recognition of "Missing-Self: An Array of
Inhibitory Cell Surface Receptors 40
2.4 Complexity of the "NK Cell Zipper" 44
2.5 Coordination of NK Cell Activating and Inhibitory Signals
in Cancer 53
2.6 Programming a "Natural" Killer: Steady-State and
Situation-Specific Regulation of NK Effector Functions 62
2.7 Conclusions and Perspectives: NK Cells, "Self Versus Nonself,"
and Cancer 67
References 67
VII
VIII Contents
3 Recent Progress on Paired Immunoglobulin-Like Receptors 83
Hiromi Kubagawa, Ching-Cheng Chen, Ikuko Torii, Max D. Cooper,
Kyoko Masuda, Yoshimoto Katsura, and Hiroshi Kawamoto
3.1 Introduction 83
3.2 PIR Expression by Early Hematopoietic Cells 85
3.3 PIR Expression by Thymocyte Progenitors 86
3.4 Differentiation Potential of PIR+ and PIR' Lymphoid
Progenitors 87
3.5 PIR Expression by Dendritic Cell Precursors 89
3.6 PIR Ligands 90
3.7 Paired Immunoglobulin-Like Receptor Function 92
3.8 Conclusion 94
References 95
4 Self-nonself Recognition through B-Cell Antigen Receptor 99
Daisuke Kitamura
4.1 Introduction 99
4.2 Signal Transduction from BCR 101
4.3 BCR Signaling Pathways for Immune Response 112
4.4 BCR Signaling Pathways for Self Tolerance 116
4.5 Concluding Remarks: To Respond or Not to Respond, That is
the Question 120
References 122
5 How Do T Cells Discriminate Self from Nonself? 133
Catherine Mazza and Bernard Malissen
5.1 Introduction 133
5.2 Structure of the TCR Complex 135
5.3 How Does the ocp TCR Convey Signals Across the Membrane? . 140
5.4 TCR Assembly During Intrathymic Development 147
5.5 How TCRs Bind pMHC 149
5.6 What Causes die Restriction in Orientation Imposed on
TCR-pMHC Interactions? 156
5.7 Rationalizing the Purpose of TCR ocp Positive Selection 159
5.8 Recessive and Dominant Tolerance 161
5.9 Evolutionary Perspectives 162
References 164
6 Fc Receptors 173
Falk Nimmerjahn and Jeffrey V. Ravetch
6.1 Introduction 173
6.2 Fc Receptors—Basic Facts 174
6.3 Fc Receptor Signaling 178
6.4 Fc Receptor Biology In Vivo 181
Contents IX
6.5 Summary 192
References 192
7 Self and Nonself Recognition by Coreceptors on B Lymphocytes:
Regulation of B lymphocytes by CD19, CD21, CD22, and CD72 . 199
Kozo Watanabe and Takeshi Tsubata
7.1 Introduction 199
7.2 Regulation of B Cells by CD19/CD21 Complex 200
7.3 Regulation of B Cells by CD22 206
7.4 Regulation of B Cells by CD72 210
7.5 Self and Nonself Recognition by Coreceptors on B cells 212
References 213
8 Co-Receptors in the Positive and Negative Regulation of
T-Cell Immunity 221
Helga Schneider and Christopher E. Rudd
8.1 Introduction 221
8.2 Positive Co-stimulatory Molecules 224
8.3 Negative Co-stimulatory Molecules 229
8.4 Conclusion 236
References 237
Index 247 |
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| spelling | How the immune system recognizes self and nonself immunoreceptors and their signaling Daisuke Kitamura, ed. Tokyo [u.a.] Springer Tokyo 2008 XVIII, 251 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Herkenning gtt Immunologie gtt Cellular immunity Immune recognition Immune response Immune system Immunity, Cellular physiology Lymphocytes physiology Receptors, Immunologic physiology Immunologische Erkennung (DE-588)4256574-1 gnd rswk-swf Immunsystem (DE-588)4026643-6 gnd rswk-swf (DE-588)4148875-1 Datensammlung gnd-content Immunsystem (DE-588)4026643-6 s Immunologische Erkennung (DE-588)4256574-1 s b DE-604 Kitamura, Daisuke Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016324984&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | How the immune system recognizes self and nonself immunoreceptors and their signaling Herkenning gtt Immunologie gtt Cellular immunity Immune recognition Immune response Immune system Immunity, Cellular physiology Lymphocytes physiology Receptors, Immunologic physiology Immunologische Erkennung (DE-588)4256574-1 gnd Immunsystem (DE-588)4026643-6 gnd |
| subject_GND | (DE-588)4256574-1 (DE-588)4026643-6 (DE-588)4148875-1 |
| title | How the immune system recognizes self and nonself immunoreceptors and their signaling |
| title_auth | How the immune system recognizes self and nonself immunoreceptors and their signaling |
| title_exact_search | How the immune system recognizes self and nonself immunoreceptors and their signaling |
| title_exact_search_txtP | How the immune system recognizes self and nonself immunoreceptors and their signaling |
| title_full | How the immune system recognizes self and nonself immunoreceptors and their signaling Daisuke Kitamura, ed. |
| title_fullStr | How the immune system recognizes self and nonself immunoreceptors and their signaling Daisuke Kitamura, ed. |
| title_full_unstemmed | How the immune system recognizes self and nonself immunoreceptors and their signaling Daisuke Kitamura, ed. |
| title_short | How the immune system recognizes self and nonself |
| title_sort | how the immune system recognizes self and nonself immunoreceptors and their signaling |
| title_sub | immunoreceptors and their signaling |
| topic | Herkenning gtt Immunologie gtt Cellular immunity Immune recognition Immune response Immune system Immunity, Cellular physiology Lymphocytes physiology Receptors, Immunologic physiology Immunologische Erkennung (DE-588)4256574-1 gnd Immunsystem (DE-588)4026643-6 gnd |
| topic_facet | Herkenning Immunologie Cellular immunity Immune recognition Immune response Immune system Immunity, Cellular physiology Lymphocytes physiology Receptors, Immunologic physiology Immunologische Erkennung Immunsystem Datensammlung |
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