Investigation and optimisation of the presster: a linear compaction simulator for rotary tablet presses
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
[München]
Verl. Dr. Hut
2007
|
| Schriftenreihe: | Pharmazeutische Technologie
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Bonn, Univ., Diss., 2007 |
| Beschreibung: | 177 S. Ill., graph. Darst. 210 mm x 148 mm, 247 gr. |
| ISBN: | 9783899636666 389963666X |
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| 245 | 1 | 0 | |a Investigation and optimisation of the presster |b a linear compaction simulator for rotary tablet presses |c Thorsten Neuhaus |
| 264 | 1 | |a [München] |b Verl. Dr. Hut |c 2007 | |
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| adam_text | CONTENTS CONTENTS 1 INTRODUCTION AND OBJECTIVES 2 THEORETICAL ASPECTS
AND ANALYSIS OF POWDER COMPACTION BEHAVIOUR 5 2.1 COMPACTIBILITY 5 2.2
TENSILE STRENGTH 6 2.3 COMPRESSIBILITY 7 2.4 COMPACTION PRESSURE VS.
IN-DIE-TABLET-HEIGHT PLOT 8 2.5 POROSITY 9 2.6 HECKEL-PLOT 10 2.7 DWELL
TIME 12 3 THE PRESSTER - A LINEAR COMPACTION SIMULATOR 14 4 RESULTS AND
DISCUSSION 18 4.1 DATA ACQUISITION SYSTEM 19 4.1.1 ORIGINAL PRESSTER
DATA ACQUISITION SYSTEM 19 4.1.2 PRESSTER-INDEPENDENT DATA ACQUISITION
SYSTEM DAQ4 22 4.1.3 SUMMARY 26 GESCANNT DURCH BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/987371355 DIGITALISIERT DURCH 4.4.6
SUMMARY 81 CONTENTS 4.2 COMPACTION FORCE MEASUREMENT SYSTEMS 27 4.2.1
TECHNIQUES FOR FORCE MEASUREMENTS 27 4.2.2 INVESTIGATION OF THE ORIGINAL
PRESSTER PRE- AND MAIN COMPACTION FORCE MEASUREMENT SYSTEMS 29 4.2.3
DYNAMIC CALIBRATION OF THE ORIGINAL PRE- AND MAIN COMPACTION FORCE
MEASUREMENT SYSTEMS 32 4.2.4 COMPACTIBILITY STUDIES SIMULATING A FETTE
P1200 ROTARY TABLET PRESS 34 4.2.5 SUMMARY 38 4.3 EJECTION FORCE
MEASUREMENT SYSTEM 40 4.3.1 INVESTIGATION OF THE ORIGINAL PRESSTER
EJECTION FORCE MEASUREMENT SYSTEM 43 4.3.2 MODIFICATION OF THE EJECTION
FORCE MEASUREMENT SYSTEM 46 4.3.3 CALIBRATION OF THE MODIFIED EJECTION
FORCE MEASUREMENT SYSTEM 47 4.3.4 EVALUATION OF MEASUREMENTS PERFORMED
BY THE MODIFIED EJECTION FORCE MEASUREMENT SYSTEM 49 4.3.5 SUMMARY 63
4.4 TAKE-OFF FORCE MEASUREMENT SYSTEM 65 4.4.1 DIFFERENT TECHNIQUES FOR
TAKE-OFF FORCE MEASUREMENTS 66 4.4.2 INVESTIGATION OF THE ORIGINAL
PRESSTER TAKE-OFF FORCE MEASUREMENT SYSTEM 67 4.4.3 MODIFICATION OF THE
TAKE-OFF FORCE MEASUREMENT SYSTEM 69 4.4.4 CALIBRATION OF THE MODIFIED
TAKE-OFF FORCE MEASUREMENT SYSTEM 71 4.4.5 EVALUATION OF MEASUREMENTS
PERFORMED BY THE MODIFIED TAKE-OFF FORCE MEASUREMENT SYSTEM 73 4.7.9
PRESS CHAMBER LUBRICATION 141 CONTENTS 4.5 PUNCH DISPLACEMENT
MEASUREMENT SYSTEM 83 4.5.1 TECHNOLOGIES FOR PUNCH DISPLACEMENT
MEASUREMENTS 84 4.5.2 CORRECTION FOR DEFORMATION OF MACHINE PARTS AND
PUNCHES 85 4.5.3 CORRECTION FOR PUNCH TILTING 90 4.5.4 INVESTIGATION OF
THE ORIGINAL PRESSTER PUNCH DISPLACEMENT MEASUREMENT SYSTEM 93 4.5.5
MODIFICATION OF THE PUNCH DISPLACEMENT MEASUREMENT SYSTEM 96 4.5.6
CALIBRATION OF THE MODIFIED PUNCH DISPLACEMENT MEASUREMENT SYSTEM 100
4.5.7 EVALUATION OF MEASUREMENTS PERFORMED BY THE MODIFIED PUNCH
DISPLACEMENT MEASUREMENT SYSTEM 103 4.5.7.1 PUNCH TIITING 103 4.5.7.2
COMPACTION PRESSURE VS. IN-DIE TABLET HEIGHT PLOT 109 4.5.7.3
HECKEL-PLOT 111 4.5.8 SUMMARY 119 4.6 SPEED OF THE TURRET AND RESULTING
DWELL TIME 121 4.6.1 SUMMARY 123 4.7 GENERAL ASPECTS 124 4.7.1 VERTICAL
ADJUSTMENT OF COMPACTION ROLLERS 124 4.7.2 VERTICAL PUNCH MOVEMENTS
UNRELATED TO ANY COMPACTION EVENT 126 4.7.3 LAG TIME BETWEEN PRE- AND
MAIN COMPACTION STATION 128 4.7.4 DIE FEEDING PROCESS 129 4.7.5 INERTIAL
FORCES 134 4.7.6 TABLET HANDLING AFTER THE TAKE-OFF EVENT 138 4.7.7
COMPACTION ROLLERS 139 4.7.8 STICKING PUNCHES 140 6.7.5 SORBITOL 161
CONTENTS 4.7.10 MULTILAYER AND LAMINATED TABLETS 141 4.7.11 SPECIAL
ASPECTS OF THE PRESSTER 142 4.7.12 SUMMARY 143 5 SUMMARY AND CONCLUSIONS
148 6 MATERIALS AND METHODS 154 6.1 PRESSTER 154 6.2 FETTE P1200 154 6.3
MULTICHECK TURBO III 155 6.4 DATA ACQUISITION SYSTEM DAQ4 155 6.5 HIGH
SPEED IMAGING SYSTEM 155 6.6 DIGIPUNCH 156 6.7 PHARMACEUTICAL EXCIPIENTS
157 6.7.1 LACTOSE 157 6.7.1.1 FLOWTAC 100 158 6.7.2 DIBASIC CALCIUM
PHOSPHATE 158 6.7.2.1 DI-CAFOS . 158 6.7.2.2 EMCOMPRESS 159 6.7.3
MICROCRYSTALLINE CELLULOSE 159 6.7.3.1 VIVAPUR 102 159 6.7.4
PREGELATINISED STARCH 159 6.7.4.1 STARCH 1500 160 CONTENTS 6.7.5.1
NEOSORBP60W 161 6.7.6 MAGNESIUM STEARATE 161 6.7.6.1 MAGNESIUM STEARATE
PHARMA VEG 162 6.8 PREPARATION OF TABLETING BLENDS 163 7 REFERENCES 164
8 SYMBOLS AND ABBREVIATIONS 175 9 SPECIAL NOTES 177
|
| adam_txt |
CONTENTS CONTENTS 1 INTRODUCTION AND OBJECTIVES 2 THEORETICAL ASPECTS
AND ANALYSIS OF POWDER COMPACTION BEHAVIOUR 5 2.1 COMPACTIBILITY 5 2.2
TENSILE STRENGTH 6 2.3 COMPRESSIBILITY 7 2.4 COMPACTION PRESSURE VS.
IN-DIE-TABLET-HEIGHT PLOT 8 2.5 POROSITY 9 2.6 HECKEL-PLOT 10 2.7 DWELL
TIME 12 3 THE PRESSTER - A LINEAR COMPACTION SIMULATOR 14 4 RESULTS AND
DISCUSSION 18 4.1 DATA ACQUISITION SYSTEM 19 4.1.1 ORIGINAL PRESSTER
DATA ACQUISITION SYSTEM 19 4.1.2 PRESSTER-INDEPENDENT DATA ACQUISITION
SYSTEM DAQ4 22 4.1.3 SUMMARY 26 GESCANNT DURCH BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/987371355 DIGITALISIERT DURCH 4.4.6
SUMMARY 81 CONTENTS 4.2 COMPACTION FORCE MEASUREMENT SYSTEMS 27 4.2.1
TECHNIQUES FOR FORCE MEASUREMENTS 27 4.2.2 INVESTIGATION OF THE ORIGINAL
PRESSTER PRE- AND MAIN COMPACTION FORCE MEASUREMENT SYSTEMS 29 4.2.3
DYNAMIC CALIBRATION OF THE ORIGINAL PRE- AND MAIN COMPACTION FORCE
MEASUREMENT SYSTEMS 32 4.2.4 COMPACTIBILITY STUDIES SIMULATING A FETTE
P1200 ROTARY TABLET PRESS 34 4.2.5 SUMMARY 38 4.3 EJECTION FORCE
MEASUREMENT SYSTEM 40 4.3.1 INVESTIGATION OF THE ORIGINAL PRESSTER
EJECTION FORCE MEASUREMENT SYSTEM 43 4.3.2 MODIFICATION OF THE EJECTION
FORCE MEASUREMENT SYSTEM 46 4.3.3 CALIBRATION OF THE MODIFIED EJECTION
FORCE MEASUREMENT SYSTEM 47 4.3.4 EVALUATION OF MEASUREMENTS PERFORMED
BY THE MODIFIED EJECTION FORCE MEASUREMENT SYSTEM 49 4.3.5 SUMMARY 63
4.4 TAKE-OFF FORCE MEASUREMENT SYSTEM 65 4.4.1 DIFFERENT TECHNIQUES FOR
TAKE-OFF FORCE MEASUREMENTS 66 4.4.2 INVESTIGATION OF THE ORIGINAL
PRESSTER TAKE-OFF FORCE MEASUREMENT SYSTEM 67 4.4.3 MODIFICATION OF THE
TAKE-OFF FORCE MEASUREMENT SYSTEM 69 4.4.4 CALIBRATION OF THE MODIFIED
TAKE-OFF FORCE MEASUREMENT SYSTEM 71 4.4.5 EVALUATION OF MEASUREMENTS
PERFORMED BY THE MODIFIED TAKE-OFF FORCE MEASUREMENT SYSTEM 73 4.7.9
PRESS CHAMBER LUBRICATION 141 CONTENTS 4.5 PUNCH DISPLACEMENT
MEASUREMENT SYSTEM 83 4.5.1 TECHNOLOGIES FOR PUNCH DISPLACEMENT
MEASUREMENTS 84 4.5.2 CORRECTION FOR DEFORMATION OF MACHINE PARTS AND
PUNCHES 85 4.5.3 CORRECTION FOR PUNCH TILTING 90 4.5.4 INVESTIGATION OF
THE ORIGINAL PRESSTER PUNCH DISPLACEMENT MEASUREMENT SYSTEM 93 4.5.5
MODIFICATION OF THE PUNCH DISPLACEMENT MEASUREMENT SYSTEM 96 4.5.6
CALIBRATION OF THE MODIFIED PUNCH DISPLACEMENT MEASUREMENT SYSTEM 100
4.5.7 EVALUATION OF MEASUREMENTS PERFORMED BY THE MODIFIED PUNCH
DISPLACEMENT MEASUREMENT SYSTEM 103 4.5.7.1 PUNCH TIITING 103 4.5.7.2
COMPACTION PRESSURE VS. IN-DIE TABLET HEIGHT PLOT 109 4.5.7.3
HECKEL-PLOT 111 4.5.8 SUMMARY 119 4.6 SPEED OF THE TURRET AND RESULTING
DWELL TIME 121 4.6.1 SUMMARY 123 4.7 GENERAL ASPECTS 124 4.7.1 VERTICAL
ADJUSTMENT OF COMPACTION ROLLERS 124 4.7.2 VERTICAL PUNCH MOVEMENTS
UNRELATED TO ANY COMPACTION EVENT 126 4.7.3 LAG TIME BETWEEN PRE- AND
MAIN COMPACTION STATION 128 4.7.4 DIE FEEDING PROCESS 129 4.7.5 INERTIAL
FORCES 134 4.7.6 TABLET HANDLING AFTER THE TAKE-OFF EVENT 138 4.7.7
COMPACTION ROLLERS 139 4.7.8 STICKING PUNCHES 140 6.7.5 SORBITOL 161
CONTENTS 4.7.10 MULTILAYER AND LAMINATED TABLETS 141 4.7.11 SPECIAL
ASPECTS OF THE PRESSTER 142 4.7.12 SUMMARY 143 5 SUMMARY AND CONCLUSIONS
148 6 MATERIALS AND METHODS 154 6.1 PRESSTER 154 6.2 FETTE P1200 154 6.3
MULTICHECK TURBO III 155 6.4 DATA ACQUISITION SYSTEM DAQ4 155 6.5 HIGH
SPEED IMAGING SYSTEM 155 6.6 DIGIPUNCH 156 6.7 PHARMACEUTICAL EXCIPIENTS
157 6.7.1 LACTOSE 157 6.7.1.1 FLOWTAC 100 158 6.7.2 DIBASIC CALCIUM
PHOSPHATE 158 6.7.2.1 DI-CAFOS '. 158 6.7.2.2 EMCOMPRESS 159 6.7.3
MICROCRYSTALLINE CELLULOSE 159 6.7.3.1 VIVAPUR 102 159 6.7.4
PREGELATINISED STARCH 159 6.7.4.1 STARCH 1500 160 CONTENTS 6.7.5.1
NEOSORBP60W 161 6.7.6 MAGNESIUM STEARATE 161 6.7.6.1 MAGNESIUM STEARATE
PHARMA VEG 162 6.8 PREPARATION OF TABLETING BLENDS 163 7 REFERENCES 164
8 SYMBOLS AND ABBREVIATIONS 175 9 SPECIAL NOTES 177 |
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| illustrated | Illustrated |
| index_date | 2024-07-02T19:50:20Z |
| indexdate | 2024-07-09T21:11:25Z |
| institution | BVB |
| isbn | 9783899636666 389963666X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016319498 |
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| owner_facet | DE-19 DE-BY-UBM DE-12 DE-91 DE-BY-TUM |
| physical | 177 S. Ill., graph. Darst. 210 mm x 148 mm, 247 gr. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Verl. Dr. Hut |
| record_format | marc |
| series2 | Pharmazeutische Technologie |
| spelling | Neuhaus, Thorsten 1975- Verfasser (DE-588)133381293 aut Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses Thorsten Neuhaus [München] Verl. Dr. Hut 2007 177 S. Ill., graph. Darst. 210 mm x 148 mm, 247 gr. txt rdacontent n rdamedia nc rdacarrier Pharmazeutische Technologie Zugl.: Bonn, Univ., Diss., 2007 Tablettierung - Simulation Tablettierung (DE-588)4184312-5 gnd rswk-swf Simulation (DE-588)4055072-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Tablettierung (DE-588)4184312-5 s Simulation (DE-588)4055072-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016319498&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neuhaus, Thorsten 1975- Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses Tablettierung - Simulation Tablettierung (DE-588)4184312-5 gnd Simulation (DE-588)4055072-2 gnd |
| subject_GND | (DE-588)4184312-5 (DE-588)4055072-2 (DE-588)4113937-9 |
| title | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses |
| title_auth | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses |
| title_exact_search | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses |
| title_exact_search_txtP | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses |
| title_full | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses Thorsten Neuhaus |
| title_fullStr | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses Thorsten Neuhaus |
| title_full_unstemmed | Investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses Thorsten Neuhaus |
| title_short | Investigation and optimisation of the presster |
| title_sort | investigation and optimisation of the presster a linear compaction simulator for rotary tablet presses |
| title_sub | a linear compaction simulator for rotary tablet presses |
| topic | Tablettierung - Simulation Tablettierung (DE-588)4184312-5 gnd Simulation (DE-588)4055072-2 gnd |
| topic_facet | Tablettierung - Simulation Tablettierung Simulation Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016319498&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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