Molecular mechanisms and models of aging:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boston, Mass.
Blackwell
2007
|
| Schriftenreihe: | Annals of the New York Academy of Sciences
1119 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 312 S. Ill., graph. Darst. |
| ISBN: | 9781573316866 1573316865 |
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| 650 | 4 | |a Aging |x Physiological aspects |v Congresses | |
| 650 | 4 | |a Aging |x physiology |v Congresses | |
| 650 | 4 | |a Geriatrics |v Congresses | |
| 650 | 4 | |a Geriatrics |x methods |v Congresses | |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1119
November 2007
MOLECULAR MECHANISMS AND
MODELS OF AGING
Editors
Efstathios S. Gonos, Ioannis P. Trougakos,
AND NlKI OlONDROGIANNI
This volume is the result of a meeting entitled 12th Congress of the International
Association of Biomedical Gerontology: Molecular Mechanisms and Models of Ageing,
held on Spetses Island, Greece, May 20-24, 2007.
CONTENTS
Preface. By Efstathios S. Gonos, Ioannis P. Trougakos. and
Niki Chondrogianni xi
Part I. Overview of Mammalian Aging and Senescence
Clonal Attenuation of Somatic Cells in Aging Mammals: A Review of Supportive
Evidence and Its Biomedical Significance. Si George M. Mar i in I
Part II. Cell Signaling and Replicative Senescence
Exposure of Human Diploid Fibroblasts to Hypoxia Extends Proliferative Life Span.
By Efthymios Poui.ios, Ioannis P. Trougakos. Niki ChondrcxiIanni. and
Efstathios S. Gonos 9
Cyclin Dl Overexpression Permits the Reproducible Detection of Senescent Human
Vascular Smooth Muscle Cells. Si Dominick G. A. Burton.
Angela N. Sheerin. Elizabeth L. Ostler. Kaye Smith. Peter J. Giles.
Jill Lowe, William Rhys-Williams, David G. Kipling, and
Richard G. A. Faragher 20
Part III. Biomarkers of Aging
Morphological Changes Associated with Aging: Age Spots and the
Microinflammatory Model of Skin Aging. By Earl Goyarts,
Neelam Muizzuddin, Daniel Maes, and Paolo U. Giacomoni 32
Molecular Mechanisms of Skin Aging: State of the Art. By E. Makrantonaki
AND C. C. ZOUBOULLS 40
Part IV. DNA Repair and Aging
Acquisition of Oxidative DNA Damage during Senescence: The First Step
toward Carcinogenesis? By Sebastien Martien and
CORINNE ABBAD1E 51
Effect of the Histone Deacetylase Inhibitor Trichostatin A in Human Peripheral
Blood Lymphocytes as a Function of Donor Age. By T. G. Sourlingas,
K. P. Kypreou, G. N. Topakas, I. N. Karchilakj,
C. Stavropoulos-Giokas, and K. E. Sekeri-Pataryas 64
Part V. Free Radicals, Oxidative Stress, Proteolysis, and Proteins Maintenance
Transient Increased Extracellular Release of H2O2 during Establishment of
UVB-Induced Premature Senescence. By Celine Borlon, Aline Chretien,
Florence Debacq-Chainiaux, and Olivier Toussaint 72
Importance of the Lon Protease in Mitochondrial Maintenance and the
Significance of Declining Lon in Aging. By Jenny K. Ngo and
Kelvin J. A. Davies 78
Protein Oxidative Modifications and Replicative Senescence of WI-38 Human
Embryonic Fibroblasts. By Emad Khairy Ahmed, Cedric R. Picot,
Anne-Laure Bulteau, and Bertrand Friguet 88
Lipofuscin: Formation, Distribution, and Metabolic Consequences. By
Tobias Jung, Nicolle Bader, and Tilman Grune 97
Part VI. Intervention
Stress-Mediated Hormetic Modulation of Aging, Wound Healing, and
Angiogenesis in Human Cells. By Suresh I. S. Rattan, Henrik Sejersen,
RlCARDO A. FERNANDES, AND WEIWEI LUO 112
Real Aging Retardation in Humans through Diminishing Risks to Health. By
Ulo Kristjuhan 122
Zinc, Metallothioneins, and Longevity—Effect of Zinc Supplementation: Zincage
Study. By Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano,
Laura Costarelli, Elisa Muti, Silvia Tesei, Cinzia Giuli, Roberta Papa,
Fiorella Marcellini, Erminia Mariani, Lothar Rink, George Herbein,
Audrey Varin, Tamas Fulop, Daniela Monti, Jolanta Jajte,
George Dedoussis, Efstathios S. Gonos, Ioannis P. Trougakos, and
Marco Malavolta 129
Ghrelin Receptor (GHS-R1A) Agonists Show Potential as Interventive Agents
during Aging. By Roy G. Smith, Yuxiang Sun, Hong Jiang,
Rosie Albarran-Zeckler, and Nikolai Timchenko 147
Part VII. Molecular Links between Aging and Cancer
Functional Significance of Minor Structural and Expression Changes in Stress
Chaperone Mortalin. By Custer C. Dfocaris, Nashi Widodo,
Tetsuro Ishii, Sunil C. Kaul, and Renu Wadhwa 165
GRO-a: A Potential Marker for Cancer and Aging Silenced by RNA
Interference. By Sabine Fimmel, Lena Devf.rmann, Anke Herrmann,
and Christos Zouboulis 176
Caspase-3 and Bcl-2 Expression in Aging in Adrenal Zona Reticularis After
Dexamethasone Administration. By Henrique Almeida, Lii.iana Matos,
and Delminda Neves 190
Part VIII. Age-Related Diseases
Nutraceutical Strategy in Aging: Targeting Heat Shock Protein and Inflammatory
Profile through Understanding Interleukin-6 Polymorphism. By F. Marotta,
K. Koike, A. Lorenzetti, Y. Naito, F. Fayet, H. Shimizu, and
P. Marandola 196
Role of TLR4 Polymorphisms in Inflammatory Responses: Implications for
Unsuccessful Aging. By Carmela Rita Balistrf.ri, Giuseppina Candore,
Florinda List i, Teresa Fazio, Simona Gangi, Egle Inc alcaterra,
Marco Caruso, Maurizio Li Vecchi, Domenico Lio, and
Calogero Caruso 203
ProNGF, Sortilin, and Age-related Neurodegeneration. By Ray a Al-Shawi,
Angela Hafner, Soyon Chun, Saba Raza, Keith Crutcher,
Christopher Thrasivoulou, Paul Simons, and Timothy Cowen 208
Identification of Fasting-induced Genes in the Rat Hypothalamus: Relationship
with Neuroprotection. By Takuya Chiba, Satoshi Fujita,
Haruaki Kubota, Daisuke Inoue, Ay a Mizuno, Toshimitsu Komatsu,
Haruyoshi Yamaza, Yoshikazl Higami, and Isao Siiimokawa 216
Acute Myocardial Infarction and Proinflainmatory Gene Variants. By
Federico Licastro, Martina Chiapelli, Ci.audio Marc ello Caldarera,
Calogero Caruso, Domenico Lio, and Elizabeth H. Cordlr 227
Bone Mineral Density in Ukrainian Women of Different Age. By
V V POYOROZNYUK, N. I. DZEROYTCH, AND T. A. KARASEVSKAYA 243
Part IX. Model Organisms
Sex-specific Effects of the DAF-12 Steroid Receptor on Aging in Caenorluibclitis
elegans. By Diana McCulloch and David Gems 253
Modulating Longevity in Drosophila by Over- and Underexpression of
Glutamate-Cysteine Ligase. By James M. Luc hak, Leena Prabhudesai.
Rajindar S. Sohal, Svetlana N. Radyuk. and William C. Orr 260
Modeling Werner Syndrome in Drosophila melanogaster: Hyper-recombination in
Flies Lacking WRN-like Exonuclease. By Lynne S. Cox, David J. Clancy,
Ivan Boubriak, and Robert D. C. Saunders 274
Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis
elegans. By Popi Svntichaki, Kostoula Troulinaki, and
Nektarios Tavernarakjs 289
Part X. Evolutionary and Epidemiological Aspects of Aging
Calorie Restriction, Post-reproductive Life Span, and Programmed Aging:
A Plea for Rigor. By Aubrey D. N. J. De Grey 296
Nonpathological Senescence Arises from Unsuitable External Influences. By
Alexander V. Khalyavkin and Anatoli I. Yashin 306
Index of Contributors 311
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants
in the reported conferences are their own and not necessarily those of the Academy.
The Academy has no intent to influence legislation by providing such forums.
|
| adam_txt |
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1119
November 2007
MOLECULAR MECHANISMS AND
MODELS OF AGING
Editors
Efstathios S. Gonos, Ioannis P. Trougakos,
AND NlKI OlONDROGIANNI
This volume is the result of a meeting entitled 12th Congress of the International
Association of Biomedical Gerontology: Molecular Mechanisms and Models of Ageing,
held on Spetses Island, Greece, May 20-24, 2007.
CONTENTS "
Preface. By Efstathios S. Gonos, Ioannis P. Trougakos. and
Niki Chondrogianni xi
Part I. Overview of Mammalian Aging and Senescence
Clonal Attenuation of Somatic Cells in Aging Mammals: A Review of Supportive
Evidence and Its Biomedical Significance. Si George M. Mar i in I
Part II. Cell Signaling and Replicative Senescence
Exposure of Human Diploid Fibroblasts to Hypoxia Extends Proliferative Life Span.
By Efthymios Poui.ios, Ioannis P. Trougakos. Niki ChondrcxiIanni. and
Efstathios S. Gonos 9
Cyclin Dl Overexpression Permits the Reproducible Detection of Senescent Human
Vascular Smooth Muscle Cells. Si Dominick G. A. Burton.
Angela N. Sheerin. Elizabeth L. Ostler. Kaye Smith. Peter J. Giles.
Jill Lowe, William Rhys-Williams, David G. Kipling, and
Richard G. A. Faragher 20
Part III. Biomarkers of Aging
Morphological Changes Associated with Aging: Age Spots and the
Microinflammatory Model of Skin Aging. By Earl Goyarts,
Neelam Muizzuddin, Daniel Maes, and Paolo U. Giacomoni 32
Molecular Mechanisms of Skin Aging: State of the Art. By E. Makrantonaki
AND C. C. ZOUBOULLS 40
Part IV. DNA Repair and Aging
Acquisition of Oxidative DNA Damage during Senescence: The First Step
toward Carcinogenesis? By Sebastien Martien and
CORINNE ABBAD1E 51
Effect of the Histone Deacetylase Inhibitor Trichostatin A in Human Peripheral
Blood Lymphocytes as a Function of Donor Age. By T. G. Sourlingas,
K. P. Kypreou, G. N. Topakas, I. N. Karchilakj,
C. Stavropoulos-Giokas, and K. E. Sekeri-Pataryas 64
Part V. Free Radicals, Oxidative Stress, Proteolysis, and Proteins Maintenance
Transient Increased Extracellular Release of H2O2 during Establishment of
UVB-Induced Premature Senescence. By Celine Borlon, Aline Chretien,
Florence Debacq-Chainiaux, and Olivier Toussaint 72
Importance of the Lon Protease in Mitochondrial Maintenance and the
Significance of Declining Lon in Aging. By Jenny K. Ngo and
Kelvin J. A. Davies 78
Protein Oxidative Modifications and Replicative Senescence of WI-38 Human
Embryonic Fibroblasts. By Emad Khairy Ahmed, Cedric R. Picot,
Anne-Laure Bulteau, and Bertrand Friguet 88
Lipofuscin: Formation, Distribution, and Metabolic Consequences. By
Tobias Jung, Nicolle Bader, and Tilman Grune 97
Part VI. Intervention
Stress-Mediated Hormetic Modulation of Aging, Wound Healing, and
Angiogenesis in Human Cells. By Suresh I. S. Rattan, Henrik Sejersen,
RlCARDO A. FERNANDES, AND WEIWEI LUO 112
Real Aging Retardation in Humans through Diminishing Risks to Health. By
Ulo Kristjuhan 122
Zinc, Metallothioneins, and Longevity—Effect of Zinc Supplementation: Zincage
Study. By Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano,
Laura Costarelli, Elisa Muti, Silvia Tesei, Cinzia Giuli, Roberta Papa,
Fiorella Marcellini, Erminia Mariani, Lothar Rink, George Herbein,
Audrey Varin, Tamas Fulop, Daniela Monti, Jolanta Jajte,
George Dedoussis, Efstathios S. Gonos, Ioannis P. Trougakos, and
Marco Malavolta 129
Ghrelin Receptor (GHS-R1A) Agonists Show Potential as Interventive Agents
during Aging. By Roy G. Smith, Yuxiang Sun, Hong Jiang,
Rosie Albarran-Zeckler, and Nikolai Timchenko 147
Part VII. Molecular Links between Aging and Cancer
Functional Significance of Minor Structural and Expression Changes in Stress
Chaperone Mortalin. By Custer C. Dfocaris, Nashi Widodo,
Tetsuro Ishii, Sunil C. Kaul, and Renu Wadhwa 165
GRO-a: A Potential Marker for Cancer and Aging Silenced by RNA
Interference. By Sabine Fimmel, Lena Devf.rmann, Anke Herrmann,
and Christos Zouboulis 176
Caspase-3 and Bcl-2 Expression in Aging in Adrenal Zona Reticularis After
Dexamethasone Administration. By Henrique Almeida, Lii.iana Matos,
and Delminda Neves 190
Part VIII. Age-Related Diseases
Nutraceutical Strategy in Aging: Targeting Heat Shock Protein and Inflammatory
Profile through Understanding Interleukin-6 Polymorphism. By F. Marotta,
K. Koike, A. Lorenzetti, Y. Naito, F. Fayet, H. Shimizu, and
P. Marandola 196
Role of TLR4 Polymorphisms in Inflammatory Responses: Implications for
Unsuccessful Aging. By Carmela Rita Balistrf.ri, Giuseppina Candore,
Florinda List'i, Teresa Fazio, Simona Gangi, Egle Inc alcaterra,
Marco Caruso, Maurizio Li Vecchi, Domenico Lio, and
Calogero Caruso 203
ProNGF, Sortilin, and Age-related Neurodegeneration. By Ray a Al-Shawi,
Angela Hafner, Soyon Chun, Saba Raza, Keith Crutcher,
Christopher Thrasivoulou, Paul Simons, and Timothy Cowen 208
Identification of Fasting-induced Genes in the Rat Hypothalamus: Relationship
with Neuroprotection. By Takuya Chiba, Satoshi Fujita,
Haruaki Kubota, Daisuke Inoue, Ay a Mizuno, Toshimitsu Komatsu,
Haruyoshi Yamaza, Yoshikazl Higami, and Isao Siiimokawa 216
Acute Myocardial Infarction and Proinflainmatory Gene Variants. By
Federico Licastro, Martina Chiapelli, Ci.audio Marc ello Caldarera,
Calogero Caruso, Domenico Lio, and Elizabeth H. Cordlr 227
Bone Mineral Density in Ukrainian Women of Different Age. By
V V POYOROZNYUK, N. I. DZEROYTCH, AND T. A. KARASEVSKAYA 243
Part IX. Model Organisms
Sex-specific Effects of the DAF-12 Steroid Receptor on Aging in Caenorluibclitis
elegans. By Diana McCulloch and David Gems 253
Modulating Longevity in Drosophila by Over- and Underexpression of
Glutamate-Cysteine Ligase. By James M. Luc hak, Leena Prabhudesai.
Rajindar S. Sohal, Svetlana N. Radyuk. and William C. Orr 260
Modeling Werner Syndrome in Drosophila melanogaster: Hyper-recombination in
Flies Lacking WRN-like Exonuclease. By Lynne S. Cox, David J. Clancy,
Ivan Boubriak, and Robert D. C. Saunders 274
Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis
elegans. By Popi Svntichaki, Kostoula Troulinaki, and
Nektarios Tavernarakjs 289
Part X. Evolutionary and Epidemiological Aspects of Aging
Calorie Restriction, Post-reproductive Life Span, and Programmed Aging:
A Plea for Rigor. By Aubrey D. N. J. De Grey 296
Nonpathological Senescence Arises from Unsuitable External Influences. By
Alexander V. Khalyavkin and Anatoli I. Yashin 306
Index of Contributors 311
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants
in the reported conferences are their own and not necessarily those of the Academy.
The Academy has no intent to influence legislation by providing such forums. |
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| genre | (DE-588)1071861417 Konferenzschrift 2007 Spetsä Stadt gnd-content |
| genre_facet | Konferenzschrift 2007 Spetsä Stadt |
| id | DE-604.BV023114592 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:49:34Z |
| indexdate | 2024-07-09T21:11:21Z |
| institution | BVB |
| isbn | 9781573316866 1573316865 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016317128 |
| oclc_num | 162143268 |
| open_access_boolean | |
| owner | DE-20 DE-12 |
| owner_facet | DE-20 DE-12 |
| physical | XII, 312 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Blackwell |
| record_format | marc |
| series | Annals of the New York Academy of Sciences |
| series2 | Annals of the New York Academy of Sciences |
| spelling | Molecular mechanisms and models of aging ed. by Efstathios S. Gonos ... Boston, Mass. Blackwell 2007 XII, 312 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 1119 Moleculaire biologie gtt Veroudering (biologie, psychologie) gtt Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Geriatrics Congresses Geriatrics methods Congresses Life Expectancy Congresses Models, Biological Congresses Alterskrankheit (DE-588)4132293-9 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2007 Spetsä Stadt gnd-content Altern (DE-588)4068596-2 s Molekularbiologie (DE-588)4039983-7 s DE-604 Alterskrankheit (DE-588)4132293-9 s Molekularpathologie (DE-588)4170396-0 s b DE-604 Gonos, Efstathios S. Sonstige oth Annals of the New York Academy of Sciences 1119 (DE-604)BV002532608 1119 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016317128&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular mechanisms and models of aging Annals of the New York Academy of Sciences Moleculaire biologie gtt Veroudering (biologie, psychologie) gtt Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Geriatrics Congresses Geriatrics methods Congresses Life Expectancy Congresses Models, Biological Congresses Alterskrankheit (DE-588)4132293-9 gnd Molekularbiologie (DE-588)4039983-7 gnd Molekularpathologie (DE-588)4170396-0 gnd Altern (DE-588)4068596-2 gnd |
| subject_GND | (DE-588)4132293-9 (DE-588)4039983-7 (DE-588)4170396-0 (DE-588)4068596-2 (DE-588)1071861417 |
| title | Molecular mechanisms and models of aging |
| title_auth | Molecular mechanisms and models of aging |
| title_exact_search | Molecular mechanisms and models of aging |
| title_exact_search_txtP | Molecular mechanisms and models of aging |
| title_full | Molecular mechanisms and models of aging ed. by Efstathios S. Gonos ... |
| title_fullStr | Molecular mechanisms and models of aging ed. by Efstathios S. Gonos ... |
| title_full_unstemmed | Molecular mechanisms and models of aging ed. by Efstathios S. Gonos ... |
| title_short | Molecular mechanisms and models of aging |
| title_sort | molecular mechanisms and models of aging |
| topic | Moleculaire biologie gtt Veroudering (biologie, psychologie) gtt Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Geriatrics Congresses Geriatrics methods Congresses Life Expectancy Congresses Models, Biological Congresses Alterskrankheit (DE-588)4132293-9 gnd Molekularbiologie (DE-588)4039983-7 gnd Molekularpathologie (DE-588)4170396-0 gnd Altern (DE-588)4068596-2 gnd |
| topic_facet | Moleculaire biologie Veroudering (biologie, psychologie) Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Geriatrics Congresses Geriatrics methods Congresses Life Expectancy Congresses Models, Biological Congresses Alterskrankheit Molekularbiologie Molekularpathologie Altern Konferenzschrift 2007 Spetsä Stadt |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016317128&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT gonosefstathioss molecularmechanismsandmodelsofaging |