Skeletal biology and medicine: [2] = B Disease mechanisms and therapeutic challenges
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boston, Mass.
Blackwell
2007
|
| Schriftenreihe: | Annals of the New York Academy of Science
1117 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 394 S. Ill., graph. Darst. |
| ISBN: | 9781573317283 1573317284 |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1117
November 2007
SKELETAL BIOLOGY AND
MEDICINE, PART B
Disease Mechanisms and Therapeutic
Challenges
Editor
MONE ZAIDI
This volume is the result of a conference entitled 2nd Conference on Skeletal Biology and
Medicine, held on April 25-28, 2007 in New York City, and sponsored by Mount Sinai
School of Medicine and the New York Academy of Sciences.
CONTENTS
The Second Conference on Skeletal Medicine and Biology: Special Features.
By Mone Zaidi xiii
Historical Reflections and the Future. By Iain MacIntyre xx
Part I. Bone and Blood Vessels
Oxygen Sensing and Osteogenesis. By Ying Wang, Chao Wan,
Shawn R. Gilbert, and Thomas L. Clemens 1
Perspective on the Osteoclast: An Angiogenic Cell?5V Frank C. Cackowski
and G. David Roodman 12
Fetal Growth Plate: A Developmental Model of Cellular Adaptation to Hypoxia.
Bv Sylvain Provot and Ernestina Schipani 26
Vascular Bmp~Msx2-Wnt Signaling and Oxidative Stress in Arterial Calcification.
By Jian-Su Shao, Ziyad Al Aly, Chung-Fang Lai, Su-Li Cheng, Jun Cai,
Emily Huang, Abe Behrmann, and Dwight A. Towler 40
Hypoxia-Mediated Mitochondrial Stress in RAW264.7 Cells Induces
Osteoclast-Like TRAP-Positive Cells. By Satish Srinivasan and
Narayan G. Avadhani 51
Stem Cell Therapy in Bone Repair and Regeneration. By Neeha Zaidi and
Alan J. Nixon 62
Fluid Shear Stress Upregulates Vascular Endothelial Growth Factor Gene
Expression in Osteoblasts. By Mia M. Thi, Dumitru A. Iacobas,
Sanda Iacobas, and David C. Spray 73
Part II. Skeletal Immunity and Inflammation
B Lymphocytes and the Skeleton. By Mark C. Horowitz and
Joseph A. Lorenzo 82
Vitamin D in Defense of the Human Immune Response. By John S. Adams,
Philip T. Liu, Rene Chun, Robert L. Modlin, and Martin Hewison ... 94
MRI and Quantification of Draining Lymph Node Function in Inflammatory
Arthritis. By Steven T. Proulx, Edmund Kwok, Zhigang You,
Christopher A. Beck, David J. Shealy, Christopher T. Ritchlin,
Brendan F. Boyce, Lianping Xing, and Edward M. Schwarz 106
Perfusion Abnormalities in Subchondral Bone Associated with Marrow Edema,
Osteoarthritis, and Avascular Necrosis. By Roy K. Aaron,
Jonathan P. Dyke, Deborah McK. Ciombor, Douglas Ballon,
Jonathan Lee, Edward Jung, and Glenn A. Tung 124
Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression
in Response to Mechanotransduction. By Ayse B. Celil Aydemir,
Stephenie Lee, Dae Won Kim, Thomas R. Gardner, Daniel Prince,
Jae Mok Ahn, and Francis Young-In Lee 138
Orthopedic Implant Particle-Induced Tumor Necrosis Factor-a Production in
Macrophage-Monocyte Lineage Cells Is Mediated by Nuclear Factor of
Activated T Cells. By Hiroshi Minematsu, Mike J. Shin, Ayse B. Celil
Aydemir, Sung Wook Seo, Dae Won Kim, Theodore A. Blaine,
Fernando Macian, Jay Yang, and Francis Young-In Lee 143
ERK Signaling Regulates Macrophage Colony-Stimulating Factor Expression
Induced by Titanium Particles in MC3T3.E1 Murine Calvarial
Preosteoblastic Cells. By Sung W. Seo, Daniel Lee, Samuel K. Cho,
Abraham D. Kim, Hiroshi Minematsu, Ayse B. Celil Aydemir,
Jeffrey A. Geller, William Macaulay, Jay Yang, and
Francis Young-In Lee, 151
Synovial Fluid Fibroblasts and Lymphocytes Support the Osteoclastogenesis in
Human Psoriatic Arthritis. By Giorgio Mori, Francesco P. Cantatore,
glacomina brunett1, angela oranger, graziana colaianni,
Laura Quarta, Addolorata Corrado, Silvia Colucci, and
Maria Grano 159
Molecular and Histological Analysis of a New Rat Model of Experimental Knee
Osteoarthritis. By C. Thomas G. Appleton, David D. McErlain,
James L. Henry, David W. Holdsworth, and Frank Beier 165
Expression of MIG-6, WNT-9A, and WNT-7B During Osteoarthritis. By
Cristina Velasquillo, David Garciadiego-Cazares, Maylin Almonte,
Marcia Bustamante, Clemente Ibarra, Juan B. Kouri, and
Jesus Chimal-Monroy, 175
Calcitonin Affects Both Bone and Cartilage: A Dual Action Treatment for
Osteoarthritis? By Morten A. Karsdal, Bodil C. Sondergaard,
Michel Arnold, and Claus Christiansen 181
Part HI. Clinical and Therapeutic Challenges in Bone and Joint Disease
Progress, Paradox, and Potential: Parathyroid Hormone Research over Five
Decades. By John T. Potts and Thomas J. Gardella 196
Bisphosphonates: An Update on Mechanisms of Action and How These Relate
to Clinical Efficacy. By R. Graham G. Russell, Zhidao Xia,
James E. Dunford, Udo Oppermann, Aaron Kwaasi, Philippa A. Hulley,
Kathryn L. Kavanagh, James T. Triffitt, Mark W. Lundy,
Roger J. Phipps, Bobby L. Barnett, Fraser P. Coxon,
Michael J. Rogers, Nelson B. Watts, and Frank H. Ebetino 209
Future Developments in Therapy. By Carlos M. Isales and
Jay M. McDonald 258
Selecting Patients for Osteoporosis Therapy. By Stuart L. Silverman 264
Progression of Efficacy with Ibandronate: A Paradigm for the Development
of New Bisphosphonates. By Mone Zaidi, Solomon Epstein,
Steven T. Harris, Joseph D. Kohles, and Charles H. Chesnut 273
Rationale for Using Nitric Oxide Donor Therapy for Prevention of Bone
Loss and Treatment of Osteoporosis in Humans. By
SUNIL J. WlMALAWANSA 283
Proteasome Inhibitors Stimulate Both Bone Formation and Hair Growth by
Similar Mechanisms. By Gregory Mundy, Gloria Gutierrez,
Ross Garrett, Wolfgang Gallwitz, Gianni Rossini,
Claus Christiansen, and Andria Langenberg 298
The Skeletal Dysplasias: Clinical-Molecular Correlations. By David L. Rimoin,
Daniel Cohn, Deborah Krakow, William Wilcox,
Ralph S. Lachman, and Yasemin Alanay 302
Gene Therapy in Musculoskeletal Repair. By Alan J. Nixon,
Laurie R. Goodrich, Michael S. Scimeca, Thomas H. Witte,
Lauren V Schnabel, Ashlee E. Watts, and Paul D. Robbins 310
Studies of Osteotropism on Both Sides of the Breast Cancer-Bone
Interaction. By Jodie Moreau, Kristen M. Anderson,
Joshua R. Mauney, David Kaplan, and Michael Rosenblatt 328
Effects of Adrenal Steroids on the Bone Metabolism of Children with
Congenital Adrenal Hyperplasia. By Karen Lin-Su and
Maria I. New 345
Quantitative Ultrasound Technology in Evaluating Bone Status and Osteoporosis
in Patients with Cushing s Syndrome. By Valentina Camozzi,
Giovanni Lutsetto, Monica Zangari, and Franco Lumachi 352
Bone Mineral Density Improvement After Successful Parathyroidectomy in
Pre- and Postmenopausal Women with Primary Hyperparathyroidism:
A Prospective Study. By Franco Lumachi, Valentina Camozzi,
Mario Ermani, Federi ca De Lotto, and Giovanni Luisetto 357
Lumbar Spine Bone Mineral Density Changes in Patients with Primary
Hyperparathyroidism According to Age and Gender. By Franco Lumachi,
Valentina Camozzi, Mario Ermani, Alfredo Nardi, and
Giovanni Luisetto 362
Osteogenic Differentiation of Human Mesenchymal Bone Marrow Cells in Silk
Scaffolds Is Regulated by Nitric Oxide. By Petros D. Dammoulis,
Dimitrious E. Drakos, Eleni Gagari, and David L. Kaplan 367
IL-7 Modulates Osteoclastogenesis in Patients Affected by Solid Tumors. By
Ilaria Roato, Eva Gorassini, Giacomina Brunetti, Maria Grano,
llbero cluffreda, antonio mussa, and rlccardo ferracini 377
PTHrP and Tumorigenesis: Is There a Role in Prognosis? By
Minoru Nishihara, Takashi Kanematsu,Takashi Taguchi, and
Mohammed S. Razzaque 385
Index of Contributors 393
Financial assistance was received from:
• Amgen, Inc.
• Genzyme Corporation
• Eli Lilly Company
• Merck Research Laboratories
• Mitzy and Warren Eisenberg Family Foundation
• National Institute of Arthritis and Musculoskeletal and Skin Diseases - NIH
• Novartis Pharmaceuticals
• NPS Pharmaceuticals
• Procter Gamble Alliance for Better Bone Health
• Roche Pharmaceuticals
• Sanofi-Aventis
• Diane Wolf Foundation
• Erving Joyce Wolf Foundation
• Wyeth Pharmaceuticals
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants
in the reported conferences are their own and not necessarily those of the Academy.
The Academy has no intent to influence legislation by providing such forums.
|
| adam_txt |
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1117
November 2007
SKELETAL BIOLOGY AND
MEDICINE, PART B
Disease Mechanisms and Therapeutic
Challenges
Editor
MONE ZAIDI
This volume is the result of a conference entitled 2nd Conference on Skeletal Biology and
Medicine, held on April 25-28, 2007 in New York City, and sponsored by Mount Sinai
School of Medicine and the New York Academy of Sciences.
CONTENTS
The Second Conference on Skeletal Medicine and Biology: Special Features.
By Mone Zaidi xiii
Historical Reflections and the Future. By Iain MacIntyre xx
Part I. Bone and Blood Vessels
Oxygen Sensing and Osteogenesis. By Ying Wang, Chao Wan,
Shawn R. Gilbert, and Thomas L. Clemens 1
Perspective on the Osteoclast: An Angiogenic Cell?5V Frank C. Cackowski
and G. David Roodman 12
Fetal Growth Plate: A Developmental Model of Cellular Adaptation to Hypoxia.
Bv Sylvain Provot and Ernestina Schipani 26
Vascular Bmp~Msx2-Wnt Signaling and Oxidative Stress in Arterial Calcification.
By Jian-Su Shao, Ziyad Al Aly, Chung-Fang Lai, Su-Li Cheng, Jun Cai,
Emily Huang, Abe Behrmann, and Dwight A. Towler 40
Hypoxia-Mediated Mitochondrial Stress in RAW264.7 Cells Induces
Osteoclast-Like TRAP-Positive Cells. By Satish Srinivasan and
Narayan G. Avadhani 51
Stem Cell Therapy in Bone Repair and Regeneration. By Neeha Zaidi and
Alan J. Nixon 62
Fluid Shear Stress Upregulates Vascular Endothelial Growth Factor Gene
Expression in Osteoblasts. By Mia M. Thi, Dumitru A. Iacobas,
Sanda Iacobas, and David C. Spray 73
Part II. Skeletal Immunity and Inflammation
B Lymphocytes and the Skeleton. By Mark C. Horowitz and
Joseph A. Lorenzo 82
Vitamin D in Defense of the Human Immune Response. By John S. Adams,
Philip T. Liu, Rene Chun, Robert L. Modlin, and Martin Hewison . 94
MRI and Quantification of Draining Lymph Node Function in Inflammatory
Arthritis. By Steven T. Proulx, Edmund Kwok, Zhigang You,
Christopher A. Beck, David J. Shealy, Christopher T. Ritchlin,
Brendan F. Boyce, Lianping Xing, and Edward M. Schwarz 106
Perfusion Abnormalities in Subchondral Bone Associated with Marrow Edema,
Osteoarthritis, and Avascular Necrosis. By Roy K. Aaron,
Jonathan P. Dyke, Deborah McK. Ciombor, Douglas Ballon,
Jonathan Lee, Edward Jung, and Glenn A. Tung 124
Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression
in Response to Mechanotransduction. By Ayse B. Celil Aydemir,
Stephenie Lee, Dae Won Kim, Thomas R. Gardner, Daniel Prince,
Jae Mok Ahn, and Francis Young-In Lee 138
Orthopedic Implant Particle-Induced Tumor Necrosis Factor-a Production in
Macrophage-Monocyte Lineage Cells Is Mediated by Nuclear Factor of
Activated T Cells. By Hiroshi Minematsu, Mike J. Shin, Ayse B. Celil
Aydemir, Sung Wook Seo, Dae Won Kim, Theodore A. Blaine,
Fernando Macian, Jay Yang, and Francis Young-In Lee 143
ERK Signaling Regulates Macrophage Colony-Stimulating Factor Expression
Induced by Titanium Particles in MC3T3.E1 Murine Calvarial
Preosteoblastic Cells. By Sung W. Seo, Daniel Lee, Samuel K. Cho,
Abraham D. Kim, Hiroshi Minematsu, Ayse B. Celil Aydemir,
Jeffrey A. Geller, William Macaulay, Jay Yang, and
Francis Young-In Lee, 151
Synovial Fluid Fibroblasts and Lymphocytes Support the Osteoclastogenesis in
Human Psoriatic Arthritis. By Giorgio Mori, Francesco P. Cantatore,
glacomina brunett1, angela oranger, graziana colaianni,
Laura Quarta, Addolorata Corrado, Silvia Colucci, and
Maria Grano 159
Molecular and Histological Analysis of a New Rat Model of Experimental Knee
Osteoarthritis. By C. Thomas G. Appleton, David D. McErlain,
James L. Henry, David W. Holdsworth, and Frank Beier 165
Expression of MIG-6, WNT-9A, and WNT-7B During Osteoarthritis. By
Cristina Velasquillo, David Garciadiego-Cazares, Maylin Almonte,
Marcia Bustamante, Clemente Ibarra, Juan B. Kouri, and
Jesus Chimal-Monroy, 175
Calcitonin Affects Both Bone and Cartilage: A Dual Action Treatment for
Osteoarthritis? By Morten A. Karsdal, Bodil C. Sondergaard,
Michel Arnold, and Claus Christiansen 181
Part HI. Clinical and Therapeutic Challenges in Bone and Joint Disease
Progress, Paradox, and Potential: Parathyroid Hormone Research over Five
Decades. By John T. Potts and Thomas J. Gardella 196
Bisphosphonates: An Update on Mechanisms of Action and How These Relate
to Clinical Efficacy. By R. Graham G. Russell, Zhidao Xia,
James E. Dunford, Udo Oppermann, Aaron Kwaasi, Philippa A. Hulley,
Kathryn L. Kavanagh, James T. Triffitt, Mark W. Lundy,
Roger J. Phipps, Bobby L. Barnett, Fraser P. Coxon,
Michael J. Rogers, Nelson B. Watts, and Frank H. Ebetino 209
Future Developments in Therapy. By Carlos M. Isales and
Jay M. McDonald 258
Selecting Patients for Osteoporosis Therapy. By Stuart L. Silverman 264
Progression of Efficacy with Ibandronate: A Paradigm for the Development
of New Bisphosphonates. By Mone Zaidi, Solomon Epstein,
Steven T. Harris, Joseph D. Kohles, and Charles H. Chesnut 273
Rationale for Using Nitric Oxide Donor Therapy for Prevention of Bone
Loss and Treatment of Osteoporosis in Humans. By
SUNIL J. WlMALAWANSA 283
Proteasome Inhibitors Stimulate Both Bone Formation and Hair Growth by
Similar Mechanisms. By Gregory Mundy, Gloria Gutierrez,
Ross Garrett, Wolfgang Gallwitz, Gianni Rossini,
Claus Christiansen, and Andria Langenberg 298
The Skeletal Dysplasias: Clinical-Molecular Correlations. By David L. Rimoin,
Daniel Cohn, Deborah Krakow, William Wilcox,
Ralph S. Lachman, and Yasemin Alanay 302
Gene Therapy in Musculoskeletal Repair. By Alan J. Nixon,
Laurie R. Goodrich, Michael S. Scimeca, Thomas H. Witte,
Lauren V Schnabel, Ashlee E. Watts, and Paul D. Robbins 310
Studies of Osteotropism on Both Sides of the Breast Cancer-Bone
Interaction. By Jodie Moreau, Kristen M. Anderson,
Joshua R. Mauney, David Kaplan, and Michael Rosenblatt 328
Effects of Adrenal Steroids on the Bone Metabolism of Children with
Congenital Adrenal Hyperplasia. By Karen Lin-Su and
Maria I. New 345
Quantitative Ultrasound Technology in Evaluating Bone Status and Osteoporosis
in Patients with Cushing's Syndrome. By Valentina Camozzi,
Giovanni Lutsetto, Monica Zangari, and Franco Lumachi 352
Bone Mineral Density Improvement After Successful Parathyroidectomy in
Pre- and Postmenopausal Women with Primary Hyperparathyroidism:
A Prospective Study. By Franco Lumachi, Valentina Camozzi,
Mario Ermani, Federi'ca De Lotto, and Giovanni Luisetto 357
Lumbar Spine Bone Mineral Density Changes in Patients with Primary
Hyperparathyroidism According to Age and Gender. By Franco Lumachi,
Valentina Camozzi, Mario Ermani, Alfredo Nardi, and
Giovanni Luisetto 362
Osteogenic Differentiation of Human Mesenchymal Bone Marrow Cells in Silk
Scaffolds Is Regulated by Nitric Oxide. By Petros D. Dammoulis,
Dimitrious E. Drakos, Eleni Gagari, and David L. Kaplan 367
IL-7 Modulates Osteoclastogenesis in Patients Affected by Solid Tumors. By
Ilaria Roato, Eva Gorassini, Giacomina Brunetti, Maria Grano,
llbero cluffreda, antonio mussa, and rlccardo ferracini 377
PTHrP and Tumorigenesis: Is There a Role in Prognosis? By
Minoru Nishihara, Takashi Kanematsu,Takashi Taguchi, and
Mohammed S. Razzaque 385
Index of Contributors 393
Financial assistance was received from:
• Amgen, Inc.
• Genzyme Corporation
• Eli Lilly Company
• Merck Research Laboratories
• Mitzy and Warren Eisenberg Family Foundation
• National Institute of Arthritis and Musculoskeletal and Skin Diseases - NIH
• Novartis Pharmaceuticals
• NPS Pharmaceuticals
• Procter Gamble Alliance for Better Bone Health
• Roche Pharmaceuticals
• Sanofi-Aventis
• Diane Wolf Foundation
• Erving Joyce Wolf Foundation
• Wyeth Pharmaceuticals
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants
in the reported conferences are their own and not necessarily those of the Academy.
The Academy has no intent to influence legislation by providing such forums. |
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| index_date | 2024-07-02T19:49:29Z |
| indexdate | 2024-07-09T21:11:21Z |
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| isbn | 9781573317283 1573317284 |
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| series | Annals of the New York Academy of Science |
| series2 | Annals of the New York Academy of Science |
| spelling | Skeletal biology and medicine [2] = B Disease mechanisms and therapeutic challenges ed. by Mone Zaidi Boston, Mass. Blackwell 2007 XXI, 394 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Science 1117 Annals of the New York Academy of Science ... Therapie (DE-588)4059798-2 gnd rswk-swf Skelettkrankheit (DE-588)4127495-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2007 New York, NY gnd-content Skelettkrankheit (DE-588)4127495-7 s Therapie (DE-588)4059798-2 s DE-604 Zaidi, Mone Sonstige oth (DE-604)BV023114336 2 Annals of the New York Academy of Science 1117 (DE-604)BV002532608 1117 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016316921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Skeletal biology and medicine Annals of the New York Academy of Science Therapie (DE-588)4059798-2 gnd Skelettkrankheit (DE-588)4127495-7 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4127495-7 (DE-588)1071861417 |
| title | Skeletal biology and medicine |
| title_auth | Skeletal biology and medicine |
| title_exact_search | Skeletal biology and medicine |
| title_exact_search_txtP | Skeletal biology and medicine |
| title_full | Skeletal biology and medicine [2] = B Disease mechanisms and therapeutic challenges ed. by Mone Zaidi |
| title_fullStr | Skeletal biology and medicine [2] = B Disease mechanisms and therapeutic challenges ed. by Mone Zaidi |
| title_full_unstemmed | Skeletal biology and medicine [2] = B Disease mechanisms and therapeutic challenges ed. by Mone Zaidi |
| title_short | Skeletal biology and medicine |
| title_sort | skeletal biology and medicine disease mechanisms and therapeutic challenges |
| topic | Therapie (DE-588)4059798-2 gnd Skelettkrankheit (DE-588)4127495-7 gnd |
| topic_facet | Therapie Skelettkrankheit Konferenzschrift 2007 New York, NY |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016316921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV023114336 (DE-604)BV002532608 |
| work_keys_str_mv | AT zaidimone skeletalbiologyandmedicine2b |