Applied bioinformatics: an introduction ; with ... 6 tables ; [including exercises and solutions]
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2008
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Frühere Ausg. u.d.T.: Selzer, Paul M.: Angewandte Bioinformatik |
| Physical Description: | XIV, 287 S. Ill., graph. Darst. |
| ISBN: | 9783540727996 9783540728009 |
Staff View
MARC
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| 100 | 1 | |a Selzer, Paul M. |e Verfasser |4 aut | |
| 240 | 1 | 0 | |a Angewandte Bioinformatik |
| 245 | 1 | 0 | |a Applied bioinformatics |b an introduction ; with ... 6 tables ; [including exercises and solutions] |c P. M. Selzer ; R. J. Marhöfer ; A. Rohwer |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a XIV, 287 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
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| adam_text | Contents
1 Computers,
Operating
Systems
and the
Internet___ 1
1.1 Computers
and Operating
Systems............. 1
1.2 Internet and WWW.......................... 5
1.3
The Physical Connection to the Internet
......... 6
1.4
The Logical Connection to the Internet
......... 8
1.5
Internet Services
............................. 8
1.5.1
E-mail
...................................... 8
1.5.2
FTP
........................................ 11
1.5.3
World Wide Web
............................. 16
1.6
Using UNIX
................................. 18
1.7
The History of Bioinformatics
................. 23
WWW Links
................................ 29
2
The Biological Foundations of Bioinformatics
...... 31
2.1
Nucleic Acids and Proteins
.................... 31
2.2
Structure of the Nucleic Acids
DNA
and
RNA
___ 31
2.3
The Storage of Genetic Information
............ 33
2.4
The Structure of Proteins
..................... 36
2.4.1
Primary Structure
............................ 36
2.4.2
Secondary Structure
.......................... 39
2.5
Tertiary and Quaternary Structure
............. 41
WWW Links
................................ 43
xii Contents
3
Biological Databases
............................ 45
3.1
Biological Knowledge is Stored in Global
Databases
................................... 45
3.2
Primary Databases
........................... 46
3.2.1
Nucleotide Sequence Databases
................ 46
3.2.2
Protein Sequence Databases
................... 53
3.3
Secondary Databases
......................... 58
3.3.1 PROSITE................................... 58
3.3.2
PRINTS
..................................... 60
3.3.3
Pfam
....................................... 61
3.3.4
Interpro
.................................... 61
3.4
Genotype-Phenotype Databases
............... 62
3.4.1
PhenomicDB
................................ 63
3.5
Molecular Structure Databases
................. 64
3.5.1
Protein Data Bank (PDB)
...................... 64
3.5.2
SCOP
....................................... 65
3.5.3
CATH
...................................... 67
3.5.4
PubChem
................................... 67
WWW Links
................................ 72
4
Sequence Comparisons and Sequence-Based
Database Searches
.............................. 75
4.1
Pairwise and Multiple Sequence Comparisons
... 75
4.2
Database Searches with Nucleotide and Protein
Sequences
................................... 83
4.2.1
Important Algorithms for Database
Searching
................................... 87
4.3
Software for Sequence Analysis
................ 87
WWW Links
............ 92
5
The Decoding of Eukaryotic Genomes
............. 95
5.1
The Sequencing of Complete Genomes
.......... 95
5.2
The Characterization of Genomes using
STS
and
EST
Sequences
....................... 96
Contents xiii
5.2.1
Sequence Tagged Sites are Landmarks
in the Human Genome
........................ 96
5.2.2
Expressed Sequence Tags
...................... 97
5.3
The Implementation of an
EST
Project
.......... 99
5.4
The Identification of Unknown Genes
........... 103
5.5
The Discovery of Splice Variants
............... 105
5.6
Genetic Causes for Individual Differences
....... 108
5.6.1
Pharmacogenetics and Individual
Medicine
.................................... 110
WWW Links
................................ 115
6
Protein Structures and Structure-Based Rational
Drug Design
................................... 117
6.1
Protein Structure
............................ 117
6.2
Signal Peptides
.............................. 118
6.3
Transmembrane
Proteins
..................... 122
6.4
Analyses of Protein Structures
................. 123
6.4.1
Protein Modeling
............................ 124
6.4.2
The Determination of Protein Structures
by High Throughput Methods
................. 125
6.5
Structure-Based Rational Drug Design
.......... 126
6.5.1
A Docking Example
.......................... 128
6.5.2
Pharmacophore Modeling
..................... 131
6.5.3
Successes of Structure-Based Rational
Drug Design
................................ 133
WWW Links
................................ 136
7
Systems Biology: The Functional Analysis
of Genomes
.................................... 139
7.1
The Identification of the Cellular Functions
of Gene Products
............................. 139
7.1.1
Transcriptomics
............................. 140
7.1.2
Proteomics
.................................. 153
7.1.3
Metabolomics
............................... 163
7.1.4
Phenomics
.................................. 166
xiv Contents
7.2 Systems
Biology.............................
170
WWW Links................................ 178
8
Comparative
Genome
Analyses
................... 181
8.1
The Era of
Genome
Sequencing................
181
8.2
Drug
Research
at the Target Protein
............ 182
8.3
Comparative Genome Analyses Provide
Information about the Biology of Organisms
----- 185
8.3.1
Genome Structure
........................... 185
8.3.2
Coding Regions
.............................. 186
8.3.3
Noncoding Regions
.......................... 188
8.4
Comparative Metabolic Analyses
............... 188
8.4.1
Kyoto Encyclopedia of Genes and Genomes
...... 191
8.5
Groups of Orthologous Proteins
............... 195
WWW Links
................................ 199
9
Solutions to the Exercises
........................ 201
Glossary
.......................................... 247
Index
............................. ___ 277
|
| adam_txt |
Contents
1 Computers,
Operating
Systems
and the
Internet_ 1
1.1 Computers
and Operating
Systems. 1
1.2 Internet and WWW. 5
1.3
The Physical Connection to the Internet
. 6
1.4
The Logical Connection to the Internet
. 8
1.5
Internet Services
. 8
1.5.1
E-mail
. 8
1.5.2
FTP
. 11
1.5.3
World Wide Web
. 16
1.6
Using UNIX
. 18
1.7
The History of Bioinformatics
. 23
WWW Links
. 29
2
The Biological Foundations of Bioinformatics
. 31
2.1
Nucleic Acids and Proteins
. 31
2.2
Structure of the Nucleic Acids
DNA
and
RNA
_ 31
2.3
The Storage of Genetic Information
. 33
2.4
The Structure of Proteins
. 36
2.4.1
Primary Structure
. 36
2.4.2
Secondary Structure
. 39
2.5
Tertiary and Quaternary Structure
. 41
WWW Links
. 43
xii Contents
3
Biological Databases
. 45
3.1
Biological Knowledge is Stored in Global
Databases
. 45
3.2
Primary Databases
. 46
3.2.1
Nucleotide Sequence Databases
. 46
3.2.2
Protein Sequence Databases
. 53
3.3
Secondary Databases
. 58
3.3.1 PROSITE. 58
3.3.2
PRINTS
. 60
3.3.3
Pfam
. 61
3.3.4
Interpro
. 61
3.4
Genotype-Phenotype Databases
. 62
3.4.1
PhenomicDB
. 63
3.5
Molecular Structure Databases
. 64
3.5.1
Protein Data Bank (PDB)
. 64
3.5.2
SCOP
. 65
3.5.3
CATH
. 67
3.5.4
PubChem
. 67
WWW Links
. 72
4
Sequence Comparisons and Sequence-Based
Database Searches
. 75
4.1
Pairwise and Multiple Sequence Comparisons
. 75
4.2
Database Searches with Nucleotide and Protein
Sequences
. 83
4.2.1
Important Algorithms for Database
Searching
. 87
4.3
Software for Sequence Analysis
. 87
WWW Links
. 92
5
The Decoding of Eukaryotic Genomes
. 95
5.1
The Sequencing of Complete Genomes
. 95
5.2
The Characterization of Genomes using
STS
and
EST
Sequences
. 96
Contents xiii
5.2.1
Sequence Tagged Sites are Landmarks
in the Human Genome
. 96
5.2.2
Expressed Sequence Tags
. 97
5.3
The Implementation of an
EST
Project
. 99
5.4
The Identification of Unknown Genes
. 103
5.5
The Discovery of Splice Variants
. 105
5.6
Genetic Causes for Individual Differences
. 108
5.6.1
Pharmacogenetics and Individual
Medicine
. 110
WWW Links
. 115
6
Protein Structures and Structure-Based Rational
Drug Design
. 117
6.1
Protein Structure
. 117
6.2
Signal Peptides
. 118
6.3
Transmembrane
Proteins
. 122
6.4
Analyses of Protein Structures
. 123
6.4.1
Protein Modeling
. 124
6.4.2
The Determination of Protein Structures
by High Throughput Methods
. 125
6.5
Structure-Based Rational Drug Design
. 126
6.5.1
A Docking Example
. 128
6.5.2
Pharmacophore Modeling
. 131
6.5.3
Successes of Structure-Based Rational
Drug Design
. 133
WWW Links
. 136
7
Systems Biology: The Functional Analysis
of Genomes
. 139
7.1
The Identification of the Cellular Functions
of Gene Products
. 139
7.1.1
Transcriptomics
. 140
7.1.2
Proteomics
. 153
7.1.3
Metabolomics
. 163
7.1.4
Phenomics
. 166
xiv Contents
7.2 Systems
Biology.
170
WWW Links. 178
8
Comparative
Genome
Analyses
. 181
8.1
The Era of
Genome
Sequencing.
181
8.2
Drug
Research
at the Target Protein
. 182
8.3
Comparative Genome Analyses Provide
Information about the Biology of Organisms
----- 185
8.3.1
Genome Structure
. 185
8.3.2
Coding Regions
. 186
8.3.3
Noncoding Regions
. 188
8.4
Comparative Metabolic Analyses
. 188
8.4.1
Kyoto Encyclopedia of Genes and Genomes
. 191
8.5
Groups of Orthologous Proteins
. 195
WWW Links
. 199
9
Solutions to the Exercises
. 201
Glossary
. 247
Index
. _ 277 |
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| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie Informatik Chemie-Ingenieurwesen Biotechnologie |
| discipline_str_mv | Biologie Chemie Informatik Chemie-Ingenieurwesen Biotechnologie |
| format | Book |
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| id | DE-604.BV023100686 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:44:36Z |
| indexdate | 2024-07-09T21:11:02Z |
| institution | BVB |
| isbn | 9783540727996 9783540728009 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016303415 |
| oclc_num | 613414015 |
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| spelling | Selzer, Paul M. Verfasser aut Angewandte Bioinformatik Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] P. M. Selzer ; R. J. Marhöfer ; A. Rohwer Berlin [u.a.] Springer 2008 XIV, 287 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frühere Ausg. u.d.T.: Selzer, Paul M.: Angewandte Bioinformatik Bioinformatik (DE-588)4611085-9 gnd rswk-swf (DE-588)4143389-0 Aufgabensammlung gnd-content (DE-588)4123623-3 Lehrbuch gnd-content Bioinformatik (DE-588)4611085-9 s DE-604 Marhöfer, Richard J. 1967- Verfasser (DE-588)128383828 aut Rohwer, Andreas Verfasser aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016303415&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Selzer, Paul M. Marhöfer, Richard J. 1967- Rohwer, Andreas Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] Bioinformatik (DE-588)4611085-9 gnd |
| subject_GND | (DE-588)4611085-9 (DE-588)4143389-0 (DE-588)4123623-3 |
| title | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] |
| title_alt | Angewandte Bioinformatik |
| title_auth | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] |
| title_exact_search | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] |
| title_exact_search_txtP | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] |
| title_full | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] P. M. Selzer ; R. J. Marhöfer ; A. Rohwer |
| title_fullStr | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] P. M. Selzer ; R. J. Marhöfer ; A. Rohwer |
| title_full_unstemmed | Applied bioinformatics an introduction ; with ... 6 tables ; [including exercises and solutions] P. M. Selzer ; R. J. Marhöfer ; A. Rohwer |
| title_short | Applied bioinformatics |
| title_sort | applied bioinformatics an introduction with 6 tables including exercises and solutions |
| title_sub | an introduction ; with ... 6 tables ; [including exercises and solutions] |
| topic | Bioinformatik (DE-588)4611085-9 gnd |
| topic_facet | Bioinformatik Aufgabensammlung Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016303415&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT selzerpaulm angewandtebioinformatik AT marhoferrichardj angewandtebioinformatik AT rohwerandreas angewandtebioinformatik AT selzerpaulm appliedbioinformaticsanintroductionwith6tablesincludingexercisesandsolutions AT marhoferrichardj appliedbioinformaticsanintroductionwith6tablesincludingexercisesandsolutions AT rohwerandreas appliedbioinformaticsanintroductionwith6tablesincludingexercisesandsolutions |