Roitt's essential immunology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Malden, Mass. [u.a.]
Blackwell Publ.
2007
|
| Ausgabe: | 11. ed., thoroughly rev. and redrawn, [Nachdr.] |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Frühere Aufl. u.d.T.: Ivan M. Roitt: Essential immunology |
| Beschreibung: | XVI, 474 S. zahlr. Ill., graph. Darst. |
| ISBN: | 1405136030 9781405136037 |
Internformat
MARC
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| 245 | 1 | 0 | |a Roitt's essential immunology |c Peter J. Delves ... |
| 246 | 1 | 3 | |a Essential immunology |
| 250 | |a 11. ed., thoroughly rev. and redrawn, [Nachdr.] | ||
| 264 | 1 | |a Malden, Mass. [u.a.] |b Blackwell Publ. |c 2007 | |
| 300 | |a XVI, 474 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Frühere Aufl. u.d.T.: Ivan M. Roitt: Essential immunology | ||
| 650 | 0 | 7 | |a Immunologie |0 (DE-588)4026637-0 |2 gnd |9 rswk-swf |
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| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Roitt, Ivan M. |e Sonstige |4 oth | |
| 700 | 1 | |a Delves, Peter J. |e Sonstige |4 oth | |
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| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016301982&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |3 Klappentext |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016301982 | ||
Datensatz im Suchindex
| _version_ | 1804137356289114112 |
|---|---|
| adam_text | Contents
Acknowledgements, x
Preface,
xi
Abbreviations,
xii
User guide,
xvi
1
Innate immunity,
1
External barriers against infection,
1
Phagocytic cells kill microorganisms,
2
Complement facilitates phagocytosis,
10
Complement can mediate an acute inflammatory reaction,
13
Humoral mechanisms provide a second defensive strategy,
16
Extracellular killing,
18
2
Specific acquired immunity,
21
Antibody—the specific adaptor,
21
Cellular basis of antibody production,
23
Acquired memory,
28
Acquired immunity has antigen specificity,
29
Vaccination depends on acquired memory,
30
Cell-mediated immunity protects against intraceUular organisms,
31
Immunopathology,
32
3
Antibodies,
37
The division of labor,
37
Five classes of immunoglobulin,
37
The IgG molecule,
38
The structure and function of the immunoglobulin classes,
43
Genetics of antibody diversity and function,
52
4
Membrane
receptors for antigen,
61
The B-cell surface receptor for antigen
(BCR),
61
The
Т
-cell
surface receptor for antigen (TCR),
63
Vi
CONTENTS
The generation of diversity for antigen recognition,
67
NK receptors,
72
The major histocompatibility complex (MHC),
75
5
The primary interaction with antigen,
86
What antibodies see,
86
Identifying B-cell epitopes on a protein,
89
Thermodynamics of antibody-antigen interactions,
91
Specificity and cross-reactivity of antibodies,
92
What the
Т
-cell
sees,
95
Processing of intracellular antigen for presentation by Class IMHC,
95
Processing of antigen for Class II MHC presentation follows a different pathway,
97
Cross-presentation for activation of naive CD8+ T-cells,
100
The nature of the groovy
peptide,
101
The
αβ
Т
-cell
receptor forms a ternary complex with MHC and antigenic
peptide,
103
Т
-cells with a different outlook,
105
Superantigens
stimulate whole families of lymphocyte receptors,
106
The recognition of different forms of antigen by B- and
Т
-cells is advantageous to
the host,
107
6
Immunological methods and applications, 111
Making antibodies to order, 111
Purification of antigens and antibodies by affinity chromatography,
117
Modulation of biological activity by antibodies,
118
Immunodetection of antigen in cells and tissues,
119
Detection and quantitation of antigen by antibody,
125
Epitope mapping,
130
Estimation of antibody,
131
Detection of immune complex formation,
137
Isolation of leukocyte
subpopulations,
137
Gene expression analysis,
139
Assessment of functional activity,
140
Genetic engineering of cells,
147
7
The anatomy of the immune response,
155
The need for organized lymphoid tissue,
155
Lymphocytes traffic between lymphoid tissues,
156
Lymph nodes,
160
Spleen,
162
The skin immune system,
162
Mucosal immunity,
163
Bone marrow can be a major site of antibody synthesis,
166
The enjoyment of privileged sites,
167
The handling of antigen,
167
8
Lymphocyte activation,
171
Clustering of membrane receptors leads to their activation,
171
T-lymphocy
tes
and antigen-presenting cells interact through several pairs of
accessory molecules,
172
The activation of
Т
-cells requires two signals,
173
Protein tyrosine phosphorylation is an early event in
Т
-cell
signaling,
173
Downstream events following TCR signaling,
174
____________________________CONTENTS____________________________________________
B-cells
respond to three different types of antigen,
178
The nature of B-cell activation,
180
9
The production of effectors,
185
Cytokines act as intercellular messengers,
185
Different
Т
-cell
subsets can make different cytokine patterns,
191
Activated
Т
-cells proliferate in response to cytokines,
194
T-cell effectors in cell-mediated immunity,
195
Proliferation and maturation of B-cell responses are mediated by cytokines,
200
What is going on in the germinal center?,
200
The synthesis of antibody,
202
Immunoglobulin class switching occurs in individual B-cells,
202
Factors affecting antibody affinity in the immune response,
204
Memory cells,
206
10
Control mechanisms,
211
Antigens can interfere with each other,
211
Complement and antibody also play a role,
211
Activation-induced cell death,
213
Т
-cell
regulation,
213
Idiotype networks,
218
The influence of genetic factors,
220
Regulatory immunoneuroendocrine networks,
223
Effects of diet, exercise, trauma and age on immunity,
226
11
Ontogeny and phylogeny,
229
Hematopoietic stem cells,
229
The
thymus
provides the environment for
Т
-cell
differentiation,
229
Т
-cell
ontogeny,
233
Т
-cell
tolerance,
237
B-cells differentiate in the fetal liver and then in bone marrow,
243
B-l and B-2 cells represent two distinct populations,
244
Development of B-cell specificity,
245
The induction of tolerance in B-lymphocy
tes,
247
Natural killer (NK) cell ontogeny,
249
The overall response in the
neonate,
250
The evolution of the immune response,
250
The evolution of distinct B- and
Т
-cell
lineages was accompanied by the development
of separate sites for differentiation,
252
Cellular recognition molecules exploit the immunoglobulin gene superfamily,
252
12
Adversarial strategies during infection,
256
Inflammation revisited,
256
Extracellular bacteria susceptible to killing by phagocytosis and complement,
260
Bacteria which grow in an intracellular habitat,
268
Immunity to viral infection,
272
Immunity to fungi,
277
Immunity to parasitic infections,
278
13
Vaccines,
287
Passively acquired immunity,
287
Vaccination,
290
Killed organisms as vaccines,
290
vili
_____________________________________________
CONTENTS
______________________
Live
attenuated organisms have many advantages as vaccines,
291
Subunit vaccines containing individual protective antigens,
294
Epitope-specific vaccines may be needed,
297
Current vaccines,
301
Vaccines under development,
301
Vaccines against parasitic diseases have proved particularly difficult to develop,
305
Vaccines for protection against bioterrorism,
307
Immunization against cancer,
307
Other applications for vaccines,
307
Adjuvants,
307
14
Immunodeficiency,
312
Deficiencies of innate immune mechanisms,
312
Primary B-cell deficiency,
315
Primary T-cell deficiency,
316
Combined immunodeficiency,
318
Recognition of immunodeficiencies,
320
Treatment of primary immunodeficiencies,
320
Secondary immunodeficiency,
320
Acquired immunodeficiency syndrome (AIDS),
321
15
Hypersensitivity,
336
Anaphylactic hypersensitivity (Type I),
336
Antibody-dependent cytotoxic hypersensitivity (Type
П),
347
Immune complex-mediated hypersensitivity (Type
Ш),
350
Cell-mediated (delayed-type) hypersensitivity (Type IV),
356
Stimulatory hypersensitivity (Type V),
359
Innate hypersensitivity reactions,
360
16
Transplantation,
364
Genetic control of transplantation antigens,
364
Some other consequences of MHC incompatibility,
366
Mechanisms of graft rejection,
367
The prevention of graft rejection,
369
Is xenografting a practical proposition?,
375
Stem cell therapy,
376
Clinical experience in grafting,
377
The fetus is a potential allograft,
380
17
Tumor immunology,
384
Cellular transformation and immune surveillance,
384
Tumor antigens,
385
Spontaneous immune responses to tumors,
389
Tumor escape mechanisms,
391
Unregulated development gives rise to lymphoproliferative disorders,
392
Approaches to cancer immunotherapy,
398
Immunodiagnosis of solid tumors,
407
18
Autoimmune diseases,
410
The scope of autoimmune diseases,
410
Nature and nurture,
413
Autoreacti
vity
comes naturally,
420
Is autoimmunity driven by antigen?,
422
_________________________________________
CONTENTS
___________________
Control of the
Т
-helper
cell is pivotal,
423
Autoimmunity can arise through bypass of T-helpers,
424
Autoimmuni
ty
can arise through bypass of regulatory mechanisms,
428
Autoimmune disorders are multifactorial,
431
Pathogenic effects of humoral autoantibody,
432
Pathogenic effects of complexes with autoantigens,
435
T-cell-mediated
hypersensitívity
as a pathogenic factor in autoimmune disease,
440
Some other systemic vascular disorders with immunopathological components,
444
Diagnostic value of autoantibody tests,
445
Treatment of autoimmune disorders,
445
Appendix: Glossary,
456
Index,
467
Companion website: www.roitt.com
Essential Immunology
Roitťs
Essential Immunology has established itself as the book of choice for
students of immunology worldwide. This excellent textbook is commonly
regarded as the best of the immunology primers and the eleventh edition
remains at the cutting edge of this fascinating area of science.
The trademark of
Roitťs
Essential Immunologyls its highly readable content,
emphasis on core knowledge and excellent four-colour artwork; thoroughly
revised and redrawn for this new edition. The text covers key information
needed by students of medicine and immunology, including:
•
The basis of immunology
•
The recognition of antigen
•
Technology
•
The acquired immune response
•
Immunity to infection
•
Clinical immunology
Roitťs
Essential Immunology is also supported by a website at www.roitt.com
which includes:
•
Interactive MCQs for each chapter, with feedback on all answers selected
•
Animations showing key concepts
•
A database of figures, further reading and useful links
|
| adam_txt |
Contents
Acknowledgements, x
Preface,
xi
Abbreviations,
xii
User guide,
xvi
1
Innate immunity,
1
External barriers against infection,
1
Phagocytic cells kill microorganisms,
2
Complement facilitates phagocytosis,
10
Complement can mediate an acute inflammatory reaction,
13
Humoral mechanisms provide a second defensive strategy,
16
Extracellular killing,
18
2
Specific acquired immunity,
21
Antibody—the specific adaptor,
21
Cellular basis of antibody production,
23
Acquired memory,
28
Acquired immunity has antigen specificity,
29
Vaccination depends on acquired memory,
30
Cell-mediated immunity protects against intraceUular organisms,
31
Immunopathology,
32
3
Antibodies,
37
The division of labor,
37
Five classes of immunoglobulin,
37
The IgG molecule,
38
The structure and function of the immunoglobulin classes,
43
Genetics of antibody diversity and function,
52
4
Membrane
receptors for antigen,
61
The B-cell surface receptor for antigen
(BCR),
61
The
Т
-cell
surface receptor for antigen (TCR),
63
Vi
CONTENTS
The generation of diversity for antigen recognition,
67
NK receptors,
72
The major histocompatibility complex (MHC),
75
5
The primary interaction with antigen,
86
What antibodies see,
86
Identifying B-cell epitopes on a protein,
89
Thermodynamics of antibody-antigen interactions,
91
Specificity and cross-reactivity of antibodies,
92
What the
Т
-cell
sees,
95
Processing of intracellular antigen for presentation by Class IMHC,
95
Processing of antigen for Class II MHC presentation follows a different pathway,
97
Cross-presentation for activation of naive CD8+ T-cells,
100
The nature of the 'groovy'
peptide,
101
The
αβ
Т
-cell
receptor forms a ternary complex with MHC and antigenic
peptide,
103
Т
-cells with a different outlook,
105
Superantigens
stimulate whole families of lymphocyte receptors,
106
The recognition of different forms of antigen by B- and
Т
-cells is advantageous to
the host,
107
6
Immunological methods and applications, 111
Making antibodies to order, 111
Purification of antigens and antibodies by affinity chromatography,
117
Modulation of biological activity by antibodies,
118
Immunodetection of antigen in cells and tissues,
119
Detection and quantitation of antigen by antibody,
125
Epitope mapping,
130
Estimation of antibody,
131
Detection of immune complex formation,
137
Isolation of leukocyte
subpopulations,
137
Gene expression analysis,
139
Assessment of functional activity,
140
Genetic engineering of cells,
147
7
The anatomy of the immune response,
155
The need for organized lymphoid tissue,
155
Lymphocytes traffic between lymphoid tissues,
156
Lymph nodes,
160
Spleen,
162
The skin immune system,
162
Mucosal immunity,
163
Bone marrow can be a major site of antibody synthesis,
166
The enjoyment of privileged sites,
167
The handling of antigen,
167
8
Lymphocyte activation,
171
Clustering of membrane receptors leads to their activation,
171
T-lymphocy
tes
and antigen-presenting cells interact through several pairs of
accessory molecules,
172
The activation of
Т
-cells requires two signals,
173
Protein tyrosine phosphorylation is an early event in
Т
-cell
signaling,
173
Downstream events following TCR signaling,
174
_CONTENTS_
B-cells
respond to three different types of antigen,
178
The nature of B-cell activation,
180
9
The production of effectors,
185
Cytokines act as intercellular messengers,
185
Different
Т
-cell
subsets can make different cytokine patterns,
191
Activated
Т
-cells proliferate in response to cytokines,
194
T-cell effectors in cell-mediated immunity,
195
Proliferation and maturation of B-cell responses are mediated by cytokines,
200
What is going on in the germinal center?,
200
The synthesis of antibody,
202
Immunoglobulin class switching occurs in individual B-cells,
202
Factors affecting antibody affinity in the immune response,
204
Memory cells,
206
10
Control mechanisms,
211
Antigens can interfere with each other,
211
Complement and antibody also play a role,
211
Activation-induced cell death,
213
Т
-cell
regulation,
213
Idiotype networks,
218
The influence of genetic factors,
220
Regulatory immunoneuroendocrine networks,
223
Effects of diet, exercise, trauma and age on immunity,
226
11
Ontogeny and phylogeny,
229
Hematopoietic stem cells,
229
The
thymus
provides the environment for
Т
-cell
differentiation,
229
Т
-cell
ontogeny,
233
Т
-cell
tolerance,
237
B-cells differentiate in the fetal liver and then in bone marrow,
243
B-l and B-2 cells represent two distinct populations,
244
Development of B-cell specificity,
245
The induction of tolerance in B-lymphocy
tes,
247
Natural killer (NK) cell ontogeny,
249
The overall response in the
neonate,
250
The evolution of the immune response,
250
The evolution of distinct B- and
Т
-cell
lineages was accompanied by the development
of separate sites for differentiation,
252
Cellular recognition molecules exploit the immunoglobulin gene superfamily,
252
12
Adversarial strategies during infection,
256
Inflammation revisited,
256
Extracellular bacteria susceptible to killing by phagocytosis and complement,
260
Bacteria which grow in an intracellular habitat,
268
Immunity to viral infection,
272
Immunity to fungi,
277
Immunity to parasitic infections,
278
13
Vaccines,
287
Passively acquired immunity,
287
Vaccination,
290
Killed organisms as vaccines,
290
vili
_
CONTENTS
_
Live
attenuated organisms have many advantages as vaccines,
291
Subunit vaccines containing individual protective antigens,
294
Epitope-specific vaccines may be needed,
297
Current vaccines,
301
Vaccines under development,
301
Vaccines against parasitic diseases have proved particularly difficult to develop,
305
Vaccines for protection against bioterrorism,
307
Immunization against cancer,
307
Other applications for vaccines,
307
Adjuvants,
307
14
Immunodeficiency,
312
Deficiencies of innate immune mechanisms,
312
Primary B-cell deficiency,
315
Primary T-cell deficiency,
316
Combined immunodeficiency,
318
Recognition of immunodeficiencies,
320
Treatment of primary immunodeficiencies,
320
Secondary immunodeficiency,
320
Acquired immunodeficiency syndrome (AIDS),
321
15
Hypersensitivity,
336
Anaphylactic hypersensitivity (Type I),
336
Antibody-dependent cytotoxic hypersensitivity (Type
П),
347
Immune complex-mediated hypersensitivity (Type
Ш),
350
Cell-mediated (delayed-type) hypersensitivity (Type IV),
356
Stimulatory hypersensitivity (Type V),
359
'Innate' hypersensitivity reactions,
360
16
Transplantation,
364
Genetic control of transplantation antigens,
364
Some other consequences of MHC incompatibility,
366
Mechanisms of graft rejection,
367
The prevention of graft rejection,
369
Is xenografting a practical proposition?,
375
Stem cell therapy,
376
Clinical experience in grafting,
377
The fetus is a potential allograft,
380
17
Tumor immunology,
384
Cellular transformation and immune surveillance,
384
Tumor antigens,
385
Spontaneous immune responses to tumors,
389
Tumor escape mechanisms,
391
Unregulated development gives rise to lymphoproliferative disorders,
392
Approaches to cancer immunotherapy,
398
Immunodiagnosis of solid tumors,
407
18
Autoimmune diseases,
410
The scope of autoimmune diseases,
410
Nature and nurture,
413
Autoreacti
vity
comes naturally,
420
Is autoimmunity driven by antigen?,
422
_
CONTENTS
_
Control of the
Т
-helper
cell is pivotal,
423
Autoimmunity can arise through bypass of T-helpers,
424
Autoimmuni
ty
can arise through bypass of regulatory mechanisms,
428
Autoimmune disorders are multifactorial,
431
Pathogenic effects of humoral autoantibody,
432
Pathogenic effects of complexes with autoantigens,
435
T-cell-mediated
hypersensitívity
as a pathogenic factor in autoimmune disease,
440
Some other systemic vascular disorders with immunopathological components,
444
Diagnostic value of autoantibody tests,
445
Treatment of autoimmune disorders,
445
Appendix: Glossary,
456
Index,
467
Companion website: www.roitt.com
Essential Immunology
Roitťs
Essential Immunology has established itself as the book of choice for
students of immunology worldwide. This excellent textbook is commonly
regarded as 'the best of the immunology primers' and the eleventh edition
remains at the cutting edge of this fascinating area of science.
The trademark of
Roitťs
Essential Immunologyls its highly readable content,
emphasis on core knowledge and excellent four-colour artwork; thoroughly
revised and redrawn for this new edition. The text covers key information
needed by students of medicine and immunology, including:
•
The basis of immunology
•
The recognition of antigen
•
Technology
•
The acquired immune response
•
Immunity to infection
•
Clinical immunology
Roitťs
Essential Immunology is also supported by a website at www.roitt.com
which includes:
•
Interactive MCQs for each chapter, with feedback on all answers selected
•
Animations showing key concepts
•
A database of figures, further reading and useful links |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| building | Verbundindex |
| bvnumber | BV023099217 |
| classification_rvk | XD 2700 |
| ctrlnum | (OCoLC)263658855 (DE-599)BVBBV023099217 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 11. ed., thoroughly rev. and redrawn, [Nachdr.] |
| format | Book |
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| id | DE-604.BV023099217 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:44:03Z |
| indexdate | 2024-07-09T21:10:59Z |
| institution | BVB |
| isbn | 1405136030 9781405136037 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016301982 |
| oclc_num | 263658855 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XVI, 474 S. zahlr. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Blackwell Publ. |
| record_format | marc |
| spelling | Roitt's essential immunology Peter J. Delves ... Essential immunology 11. ed., thoroughly rev. and redrawn, [Nachdr.] Malden, Mass. [u.a.] Blackwell Publ. 2007 XVI, 474 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frühere Aufl. u.d.T.: Ivan M. Roitt: Essential immunology Immunologie (DE-588)4026637-0 gnd rswk-swf Immunologie (DE-588)4026637-0 s DE-604 Roitt, Ivan M. Sonstige oth Delves, Peter J. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016301982&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016301982&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Roitt's essential immunology Immunologie (DE-588)4026637-0 gnd |
| subject_GND | (DE-588)4026637-0 |
| title | Roitt's essential immunology |
| title_alt | Essential immunology |
| title_auth | Roitt's essential immunology |
| title_exact_search | Roitt's essential immunology |
| title_exact_search_txtP | Roitt's essential immunology |
| title_full | Roitt's essential immunology Peter J. Delves ... |
| title_fullStr | Roitt's essential immunology Peter J. Delves ... |
| title_full_unstemmed | Roitt's essential immunology Peter J. Delves ... |
| title_short | Roitt's essential immunology |
| title_sort | roitt s essential immunology |
| topic | Immunologie (DE-588)4026637-0 gnd |
| topic_facet | Immunologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016301982&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016301982&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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