Verfügbarkeit: Pressure-driven microfluidics

Pressure-driven microfluidics:

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Bibliographische Detailangaben
1. Verfasser:	Tesař, Václav (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Boston [u.a.] Artech House 2007
Schriftenreihe:	Integrated microsystems series
Schlagworte:	Dispositifs fluidiques Fluides, Dynamique des Microfluidique Microfluidique - Applications industrielles Microfluidics Druck Mikrofluidik
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	Includes bibliographical references and index
Beschreibung:	XII, 410 S. Ill., graph. Darst.
ISBN:	1596931345 9781596931343

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Datensatz im Suchindex

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adam_text	Contents Preface ..............................................................................................xi Chapter 1 Introduction and Basic Concepts ....................................................1 1.1 Meaning and use of microfluidics ....................................................................... 2 1.1.1 Why fluids? ....................................................................................4 1.1.2 Why devices without moving parts? ........................................................7 1.1.3 Why the small size? ........................................................................ 10 1.2 Basic properties of devices ............................................................................ 12 1.2.1 Terminals ................................................................................... 12 1.2.2 Providing the driving pressure difference .............................................. 16 1.3 Flow characterization parameters ................................................................. 20 1.3.1 Character of the flow and the Reynolds number Re ................................ 20 1.3.2 Scaling down and Re .................................................................. 22 1.3.3 Compressibility and the Mach number Ma ........................................... 23 1.3.4 Relation to molecular scale: Knudsen number Kn ................................. 26 1.3.5 Periodic unsteady flows: Stokes and Strouhal numbers ............................. 27 1.4 Regions of operating parameters in microfluidics ................................................ 28 References ................................................................................................. 31 Chapter! Basics of Driving Fluid by Pressure ........................................... 33 2.1 Pressure and velocity .................................................................................. 33 2.2 Flow rate and channel cross-sections ................................................................ 36 2.2.1 Integral state parameter ................................................................... 36 2.2.2 Implications of manufacturing technology ........................................... 37 2.3 State parameters .................................................................................... 41 2.4 Dissipation of fluid energy ........................................................................... 45 2.4.1 Conversion e^-^ej .................................................................................. 45 2.4.2 Steady-state characteristic and the characterization parameter Q ................... 46 2.4.3 Total dissipation of jet energy ........................................................... 48 Pressure-Driven Microfluidics 2.4.4 Dissipation in separated regions ........................................................ 49 2.4.5 Friction loss mechanism ................................................................ 50 2.4.6 Asymptotic subdynamic regime .................................................... 55 2.5 State parameters for compressible flows ........................................................ 56 2.6 Laws of flow branching ............................................................................. 60 2.6.1 Branching factors ......................................................................... 62 2.6.2 Comparison with data for biological branchings ................................... 64 2.6.3 Optimality criteria dictated by manufacturing technology ....................... 67 2.7 Unsteady flow effects: inertance .................................................................. 71 2.8 Fluid accumulation: capacitance ................................................................... 74 2.8.1 Accumulation mechanisms ............................................................. 74 2.8.2 Gravitational capacitance ............................................................. 78 2.8.3 Fluid compression capacitance ........................................................ 80 2.8.4 Capacitance dueto wall elasticity .................................................... 84 2.8.5 Capillary capacitance .................................................................. 86 References ................................................................................................ 91 Chapter 3 Simple Components and Devices ............................................. 93 3.1 Connecting channels ................................................................................. 94 3.2 Area contractions and nozzles ..................................................................... 97 3.2.1 Characterization: search for a nozzle invariant ...................................... 98 3.2.2 Generation of free jets and droplets .................................................. 104 3.2.3 Generating submerged jets ............................................................. 105 3.3 Diffusers and collectors ............................................................................ 112 3.4 Restrictors: obstacles to the flow .................................................................. 115 3.5 Diodes ................................................................................................. 118 3.5.1 Labyrinth diodes ........................................................................ 119 3.5.2 Vortex diodes .............................................................................................. 122 3.5.3 Reverse flow diverters ................................................................... 124 3.6 Reactors, and heat exchangers .................................................................... 125 3.7 Mixers ................................................................................................. 127 3.8 Three-terminal jet pump transformers ............................................................ 134 3.8.1 Venturi transformers: a nozzle and a diffuser ...................................... 134 3.8.2 Essential facts about jet pump transformers: two nozzles and a diffuser ...... 136 3.8.3 Common terminal and different connections into the circuit .................... 139 3.9 Toward the subdynamic limit ...................................................................... 142 References .................................................................................................. 147 Chapter 4 Valves and Sophisticated Devices .......................................... 149 4.1 Loading characteristics ............................................................................. 150 4.1.1 Loading a simple jet-type device .................................................... 150 4.1.2 Passive flow control valves .................................................................... 158 4.1.3 Load switching in a passive Coanda-effect valve .................................. 159 4.1.4 Passive jet-type pressure regulators .................................................. 161 4.2 Fluidic control action: active valves ............................................................... 163 4.2.1 Jet deflection ........................................................................... 165 4.2.2 Colliding jets ........................................................................... 166 4.2.3 Centrifugal action: vortex valves ..................................................... 167 Contents vii 4.2.4 Separation and supercirculation ..................................................... 171 4.2.5 Displacement ........................................................................... 172 4.2.6 Fluid plug ............................................................................. 173 4.3 Jet deflection ........................................................................................ 174 4.3.1 The deflection mechanism ............................................................. 175 4.3.2 Simplest example of the jet-deflection valve ....................................... 177 4.3.3 Symmetric proportional control valves ............................................ 181 4.3.4 Laminar proportional amplifiers ..................................................... 184 4.4 Switching valves based on the Coanda effect ................................................... 185 4.4.1 Bistable diverter .......................................................................... 186 4.4.2 Internal stabilizing feedback ........................................................... 189 4.4.3 Monostable diverters .................................................................. 190 4.4.4 Pressure recovery ..................................................................... 193 4.4.5 Matching and importance of the no-spillover state ............................... 194 4.5 Multielement valves and modules ............................................................... 199 4.5.1 Amplified logical operations ......................................................... 199 4.5.2 Bistable vortex valves ................................................................. 200 4.5.3 Valves with guard flows ......................................................... 202 4.6 Capillary valves .................................................................................. 203 4.7 Oscillators .......................................................................................... 206 4.7.1 The twin valve flip-flop ............................................................... 207 4.7.2 Jet-type valve with feedback loops ................................................... 208 4.7.3 Feedback loop mechanisms ......................................................... 211 4.7.4 The internal feedback ................................................................ 213 4.7.5 Frequency dividers .................................................................... 216 4.8 Fluidic rectifiers ................................................................................... 217 4.8.1 The Grätz bridge circuit ............................................................... 217 4.8.2 Jet-type rectifiers ....................................................................... 220 4.8.3 Traveling wave pump ................................................................. 222 References ................................................................................................ 224 Chapter 5 Conversion Devices ................................................................ 225 5.1 Classification and basic concepts ................................................................. 226 5.1.1 Signals .................................................................................. 226 5.1.2 Conversion chains .................................................................... 228 5.1.3 Incomplete fluidic systems ........................................................ 229 5.2 M/F: conversion to and from mechanical motion .............................................. 230 5.2.1 Mechanical pumps and valves ...................................................... 231 5.2.2 Sensing position and motion by fluidics ............................................. 234 5.2.3 F/M actuators ......................................................................... 242 5.2.4 F/M sensors and transducers ....................................................... 244 5.3 E/F: conversion to and from electric effects ..................................................... 246 5.3.1 Electric pumps and valves ............................................................. 246 5.3.2 E/F transducing ...................................................................... 264 5.3.3 F/E power conversion ................................................................. 266 5.3.4 F/E signal transducers ............................................................... 267 5.4 A/F: collaboration with acoustics ............................................................. 274 5.4.1 Acoustically driven pumps and separators .......................................... 275 Pressure-Driven Microfluidics 5.4.2 A/F signal conversion ............................................................. 278 5.4.3 F/A fluidically driven acoustic power generation ................................. 280 5.4.4 Fluidic and acoustic signal processing ............................................ 281 5.5 O/F: collaboration with optical devices ........................................................ 282 5.5.1 O/F: driving a fluid flow by light ................................................... 283 5.5.2 F/O: optical power controlled by a fluid ........................................... 283 5.5.3 O/F: optically generated change in a fluid at the signal level ................... 284 5.5.4 F/O: optical signal generated in response to fluid flow or properties ......... 285 5.6 T/F: thermal effects ................................................................................. 288 5.6.1 F/T - thermal power produced by fluid flow ..................................... 288 5.6.2 T/F - driving a fluid flow by heat .................................................. 289 5.6.3 Generating and using a temperature-dependent signal in a fluid ................ 290 5.7 F/F: fluidic input as well as output .............................................................. 293 5.7.1 Pressure signal derived from measured flow .................................... 293 5.7.2 Regenerative circuits ................................................................. 294 5.7.3 Generating a signal carrying information about fluid composition ............... 298 5.7.4 Fluidic power amplifiers ............................................................. 299 5.8 Special cases ....................................................................................... 301 5.8.1 Sensing based on nuclear magnetic resonance ...................................... 301 5.8.2 Micropyrotechnics ..................................................................... 301 5.8.3 Motility of micro-organisms ......................................................... 302 5.8.4 Devices based on properties of special membranes .............................. 302 5.8.5 Fluidic pumps employing captive bacteria ......................................... 304 References ............................................................................................... 304 Chapter 6 Applications ........................................................................ 307 6.1 Simple solutions ..................................................................................... 308 6.1.1 Controlled injection of liquid droplets ............................................... 308 6.1.2 Cooling garment and the problem of portable power units ....................... 311 6.1.3 Filling a vessel or keeping a constant liquid level ................................ 320 6.1.4 Chromatographs ......................................................................... 321 6.1.5 Keeping a (nearly) constant flowrate ................................................. 325 6.1.6 Simple pressure regulator .............................................................. 327 6.2 Taking part in revolutionary changes in cars ..................................................... 329 6.2.1 Sensors for the intelligent cars ........................................................ 329 6.2.2 Replacing the combustion engine .................................................... 331 6.3 Discovering new materials and drugs ............................................................ 339 6.3.1 Combinatorial tests ...................................................................... 339 6.3.2 Sampling ................................................................................... 341 6.3.3 Guard flows .......................................................................... 345 6.3.4 Low Reynolds numbers: jet pumping by control flow ............................. 346 6.3.5 Biological tests ........................................................................ 347 6.4 Artificial nose and tongue .......................................................................... 348 6.5 Food — and waste ..................................................................................... 355 6.5.1 Quality monitoring .................................................................... 355 6.5.2 Food processing and meals preparation ............................................ 357 6.5.3 Waste liquidation ........................................................................ 368 6.6 Identification of persons .......................................................................... 373 Contents ix 6.6.1 Identification based on hand silhouette geometry ...................................373 6.6.2 Fluidic devices for DNA analysis ................................................... 374 6.7 Medical applications ............................................................................... 378 6.7.1 Monitoring of the health state ........................................................ 379 6.7.2 Diagnosis and choice of therapy .................................................... 382 6.7.3 Drug delivery .......................................................................... 383 6.7.4 Implanted devices ..................................................................... 385 6.7.5 Tissue engineering .................................................................... 387 6.8 Against terrorism and crime ....................................................................... 389 6.8.1 Portal detector and its sample collectors ........................................... 392 6.8.2 Fluidic decontamination .............................................................. 393 6.9 Interfacing the central nervous system .......................................................... 394 6.9.1 Therapeutic uses ....................................................................... 395 6.9.2 Cyber-animals .......................................................................... 396 References ................................................................................................. 398 Concluding Remarks .......................................................................................401 About the Author ........................................................................................ 403 Index .........................................................................................................405
adam_txt	Contents Preface .xi Chapter 1 Introduction and Basic Concepts .1 1.1 Meaning and use of microfluidics . 2 1.1.1 Why fluids? .4 1.1.2 Why devices without moving parts? .7 1.1.3 Why the small size? . 10 1.2 Basic properties of devices . 12 1.2.1 Terminals . 12 1.2.2 Providing the driving pressure difference . 16 1.3 Flow characterization parameters . 20 1.3.1 Character of the flow and the Reynolds number Re . 20 1.3.2 Scaling down and Re . 22 1.3.3 Compressibility and the Mach number Ma . 23 1.3.4 Relation to molecular scale: Knudsen number Kn . 26 1.3.5 Periodic unsteady flows: Stokes and Strouhal numbers . 27 1.4 Regions of operating parameters in microfluidics . 28 References . 31 Chapter! Basics of Driving Fluid by Pressure . 33 2.1 Pressure and velocity . 33 2.2 Flow rate and channel cross-sections . 36 2.2.1 Integral state parameter . 36 2.2.2 Implications of manufacturing technology . 37 2.3 State parameters . 41 2.4 Dissipation of fluid energy . 45 2.4.1 Conversion e^-^ej . 45 2.4.2 Steady-state characteristic and the characterization parameter Q . 46 2.4.3 Total dissipation of jet energy . 48 Pressure-Driven Microfluidics 2.4.4 Dissipation in separated regions . 49 2.4.5 Friction loss mechanism . 50 2.4.6 Asymptotic subdynamic regime . 55 2.5 State parameters for compressible flows . 56 2.6 Laws of flow branching . 60 2.6.1 Branching factors . 62 2.6.2 Comparison with data for biological branchings . 64 2.6.3 Optimality criteria dictated by manufacturing technology . 67 2.7 Unsteady flow effects: inertance . 71 2.8 Fluid accumulation: capacitance . 74 2.8.1 Accumulation mechanisms . 74 2.8.2 Gravitational capacitance . 78 2.8.3 Fluid compression capacitance . 80 2.8.4 Capacitance dueto wall elasticity . 84 2.8.5 Capillary capacitance . 86 References . 91 Chapter 3 Simple Components and Devices . 93 3.1 Connecting channels . 94 3.2 Area contractions and nozzles . 97 3.2.1 Characterization: search for a nozzle invariant . 98 3.2.2 Generation of free jets and droplets . 104 3.2.3 Generating submerged jets . 105 3.3 Diffusers and collectors . 112 3.4 Restrictors: obstacles to the flow . 115 3.5 Diodes . 118 3.5.1 Labyrinth diodes . 119 3.5.2 Vortex diodes . 122 3.5.3 Reverse flow diverters . 124 3.6 Reactors, and heat exchangers . 125 3.7 Mixers . 127 3.8 Three-terminal jet pump transformers . 134 3.8.1 Venturi transformers: a nozzle and a diffuser . 134 3.8.2 Essential facts about jet pump transformers: two nozzles and a diffuser . 136 3.8.3 Common terminal and different connections into the circuit . 139 3.9 Toward the subdynamic limit . 142 References . 147 Chapter 4 Valves and Sophisticated Devices . 149 4.1 Loading characteristics . 150 4.1.1 Loading a simple jet-type device . 150 4.1.2 Passive flow control valves . 158 4.1.3 Load switching in a passive Coanda-effect valve . 159 4.1.4 Passive jet-type pressure regulators . 161 4.2 Fluidic control action: active valves . 163 4.2.1 Jet deflection . 165 4.2.2 Colliding jets . 166 4.2.3 Centrifugal action: vortex valves . 167 Contents vii 4.2.4 Separation and supercirculation . 171 4.2.5 Displacement . 172 4.2.6 Fluid "plug" . 173 4.3 Jet deflection . 174 4.3.1 The deflection mechanism . 175 4.3.2 Simplest example of the jet-deflection valve . 177 4.3.3 Symmetric proportional control valves . 181 4.3.4 Laminar proportional amplifiers . 184 4.4 Switching valves based on the Coanda effect . 185 4.4.1 Bistable diverter . 186 4.4.2 Internal stabilizing feedback . 189 4.4.3 Monostable diverters . 190 4.4.4 Pressure recovery . 193 4.4.5 Matching and importance of the no-spillover state . 194 4.5 Multielement valves and modules . 199 4.5.1 Amplified logical operations . 199 4.5.2 Bistable vortex valves . 200 4.5.3 Valves with "guard" flows . 202 4.6 Capillary valves . 203 4.7 Oscillators . 206 4.7.1 The twin valve flip-flop . 207 4.7.2 Jet-type valve with feedback loops . 208 4.7.3 Feedback loop mechanisms . 211 4.7.4 The internal feedback . 213 4.7.5 Frequency dividers . 216 4.8 Fluidic rectifiers . 217 4.8.1 The Grätz bridge circuit . 217 4.8.2 Jet-type rectifiers . 220 4.8.3 Traveling wave pump . 222 References . 224 Chapter 5 Conversion Devices . 225 5.1 Classification and basic concepts . 226 5.1.1 Signals . 226 5.1.2 Conversion chains . 228 5.1.3 "Incomplete" fluidic systems . 229 5.2 M/F: conversion to and from mechanical motion . 230 5.2.1 Mechanical pumps and valves . 231 5.2.2 Sensing position and motion by fluidics . 234 5.2.3 F/M actuators . 242 5.2.4 F/M sensors and transducers . 244 5.3 E/F: conversion to and from electric effects . 246 5.3.1 Electric pumps and valves . 246 5.3.2 E/F transducing . 264 5.3.3 F/E power conversion . 266 5.3.4 F/E signal transducers . 267 5.4 A/F: collaboration with acoustics . 274 5.4.1 Acoustically driven pumps and separators . 275 Pressure-Driven Microfluidics 5.4.2 A/F signal conversion . 278 5.4.3 F/A fluidically driven acoustic power generation . 280 5.4.4 Fluidic and acoustic signal processing . 281 5.5 O/F: collaboration with optical devices . 282 5.5.1 O/F: driving a fluid flow by light . 283 5.5.2 F/O: optical power controlled by a fluid . 283 5.5.3 O/F: optically generated change in a fluid at the signal level . 284 5.5.4 F/O: optical signal generated in response to fluid flow or properties . 285 5.6 T/F: thermal effects . 288 5.6.1 F/T - thermal power produced by fluid flow . 288 5.6.2 T/F - driving a fluid flow by heat . 289 5.6.3 Generating and using a temperature-dependent signal in a fluid . 290 5.7 F/F: fluidic input as well as output . 293 5.7.1 Pressure signal derived from measured flow . 293 5.7.2 Regenerative circuits . 294 5.7.3 Generating a signal carrying information about fluid composition . 298 5.7.4 Fluidic power amplifiers . 299 5.8 Special cases . 301 5.8.1 Sensing based on nuclear magnetic resonance . 301 5.8.2 Micropyrotechnics . 301 5.8.3 Motility of micro-organisms . 302 5.8.4 Devices based on properties of special membranes . 302 5.8.5 Fluidic pumps employing captive bacteria . 304 References . 304 Chapter 6 Applications . 307 6.1 Simple solutions . 308 6.1.1 Controlled injection of liquid droplets . 308 6.1.2 Cooling garment and the problem of portable power units . 311 6.1.3 Filling a vessel or keeping a constant liquid level . 320 6.1.4 Chromatographs . 321 6.1.5 Keeping a (nearly) constant flowrate . 325 6.1.6 Simple pressure regulator . 327 6.2 Taking part in revolutionary changes in cars . 329 6.2.1 Sensors for the intelligent cars . 329 6.2.2 Replacing the combustion engine . 331 6.3 Discovering new materials and drugs . 339 6.3.1 Combinatorial tests . 339 6.3.2 Sampling . 341 6.3.3 "Guard" flows . 345 6.3.4 Low Reynolds numbers: jet pumping by control flow . 346 6.3.5 Biological tests . 347 6.4 Artificial nose and tongue . 348 6.5 Food — and waste . 355 6.5.1 Quality monitoring . 355 6.5.2 Food processing and meals preparation . 357 6.5.3 Waste liquidation . 368 6.6 Identification of persons . 373 Contents ix 6.6.1 Identification based on hand silhouette geometry .373 6.6.2 Fluidic devices for DNA analysis . 374 6.7 Medical applications . 378 6.7.1 Monitoring of the health state . 379 6.7.2 Diagnosis and choice of therapy . 382 6.7.3 Drug delivery . 383 6.7.4 Implanted devices . 385 6.7.5 Tissue engineering . 387 6.8 Against terrorism and crime . 389 6.8.1 Portal detector and its sample collectors . 392 6.8.2 Fluidic decontamination . 393 6.9 Interfacing the central nervous system . 394 6.9.1 Therapeutic uses . 395 6.9.2 Cyber-animals . 396 References . 398 Concluding Remarks .401 About the Author . 403 Index .405
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id	DE-604.BV023075125
illustrated	Illustrated
index_date	2024-07-02T19:34:44Z
indexdate	2024-07-09T21:10:25Z
institution	BVB
isbn	1596931345 9781596931343
language	English
lccn	2007299203
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-016278235
oclc_num	141383067
open_access_boolean
owner	DE-29T DE-703
owner_facet	DE-29T DE-703
physical	XII, 410 S. Ill., graph. Darst.
publishDate	2007
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publisher	Artech House
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series2	Integrated microsystems series
spelling	Tesař, Václav Verfasser aut Pressure-driven microfluidics Václav Tesař Boston [u.a.] Artech House 2007 XII, 410 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Integrated microsystems series Includes bibliographical references and index Dispositifs fluidiques Fluides, Dynamique des Microfluidique Microfluidique - Applications industrielles Microfluidics Druck (DE-588)4013083-6 gnd rswk-swf Mikrofluidik (DE-588)4803438-1 gnd rswk-swf Mikrofluidik (DE-588)4803438-1 s Druck (DE-588)4013083-6 s DE-604 Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016278235&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Tesař, Václav Pressure-driven microfluidics Dispositifs fluidiques Fluides, Dynamique des Microfluidique Microfluidique - Applications industrielles Microfluidics Druck (DE-588)4013083-6 gnd Mikrofluidik (DE-588)4803438-1 gnd
subject_GND	(DE-588)4013083-6 (DE-588)4803438-1
title	Pressure-driven microfluidics
title_auth	Pressure-driven microfluidics
title_exact_search	Pressure-driven microfluidics
title_exact_search_txtP	Pressure-driven microfluidics
title_full	Pressure-driven microfluidics Václav Tesař
title_fullStr	Pressure-driven microfluidics Václav Tesař
title_full_unstemmed	Pressure-driven microfluidics Václav Tesař
title_short	Pressure-driven microfluidics
title_sort	pressure driven microfluidics
topic	Dispositifs fluidiques Fluides, Dynamique des Microfluidique Microfluidique - Applications industrielles Microfluidics Druck (DE-588)4013083-6 gnd Mikrofluidik (DE-588)4803438-1 gnd
topic_facet	Dispositifs fluidiques Fluides, Dynamique des Microfluidique Microfluidique - Applications industrielles Microfluidics Druck Mikrofluidik
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016278235&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT tesarvaclav pressuredrivenmicrofluidics

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