Animal models of cognitive impairment:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
2006
|
| Schriftenreihe: | Frontiers in neuroscience
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 376 S. Ill., graph. Darst. 25 cm |
| ISBN: | 0849328349 9780849328343 |
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| 245 | 1 | 0 | |a Animal models of cognitive impairment |c ed. by Edward D. Levin ... |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press |c 2006 | |
| 300 | |a 376 S. |b Ill., graph. Darst. |c 25 cm | ||
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| 490 | 0 | |a Frontiers in neuroscience | |
| 650 | 4 | |a Cognition, Troubles de la - Modèles animaux | |
| 650 | 4 | |a Cognition disorders |x Animal models | |
| 650 | 4 | |a Cognition Disorders |x drug therapy | |
| 650 | 4 | |a Disease Models, Animal | |
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| 689 | 0 | |5 DE-188 | |
| 700 | 1 | |a Levin, Edward D. |e Sonstige |4 oth | |
| 856 | 4 | 1 | |u http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=frcogimp |x Verlag |z kostenfrei |3 Volltext |
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Datensatz im Suchindex
| _version_ | 1804137314405842944 |
|---|---|
| adam_text | Contents
Chapter 1 Introduction 1
Edward D. Levin and Jerry J. Buccafusco
SECTION I Pharmacologic Models
Chapter 2 Muscarinic Receptor Antagonists in Rats 5
Alvin V. Terry, Jr.
Chapter 3 Nicotinic Receptor Antagonists in Rats 21
Cindy S. Roegge and Edward D. Levin
Chapter 4 Involvement of the NMDA System in Learning and Memory 37
Amir H. Rezvani
Chapter 5 Animal Models and the Cognitive Effects of Ethanol 49
Merle G. Paule
SECTION II Toxicologic Models
Chapter 6 Animal Models of Cognitive Impairment Produced
by Developmental Lead Exposure 73
Deborah C. Rice
Chapter 7 Developmental Behavioral Toxicity of Methyl mercury:
Consequences, Conditioning, and Cortex 101
M. Christopher Newland, Wendy D. Donlin, Elliott M. Paletz,
and Kelly M. Banna
Chapter 8 Executive Function following Developmental Exposure to
Polychlorinated Biphenyls (PCBs): What Animal Models
Have Told Us 147
Helen J.K. Sable and Susan L. Schantz
Chapter 9 Modeling Cognitive Deficits Associated with Parkinsonism
in the Chronic-Low-Dose MPTP-Treated Monkey 169
J.S. Schneider
SECTION III Mouse Genetic Models
Chapter 10 Cognitive Impairment in Transgenic Mouse Models
of Amyloid Deposition 183
Dave Morgan
Chapter 11 Cholinergic Receptor Knockout Mice 199
Lu Zhang
Chapter 12 Assessments of Cognitive Deficits in Mutant Mice 223
Ramona Marie Rodriguiz and William C. Wetsel
SECTION IV Model Applications and
Future Developments
Chapter 13 Cognitive Pharmacology in Aging Macaques 285
Jerry J. Buccafusco
Chapter 14 Cognitive Impairment following Traumatic Brain Injury 301
Mark D. Whiting, Anna I. Baranova, and Robert J. Hamm
Chapter 15 Cognitive Impairment Models Using Complementary Species 315
Daniel T. Cerutti and Edward D. Levin
Chapter 16 Cognition Models and Drug Discovery 343
Michael W. Decker
Index 355
List of Illustrations
FIGURE 2.1 Dose-related effects of scopolamine on performance of rats
in a water-maze test 10
FIGURE 2.2 Dose-related effects of scopolamine on performance of rats
in a step-through latency test 11
FIGURE 2.3 Dose-related effects of scopolamine on performance of rats
in a test of prepulse inhibition of the auditory gating response 12
FIGURE 2.4 Dose-related effects of scopolamine on performance of rats
in a delayed stimulus discrimination task (DSDT) 13
FIGURE 6.1 A: Cumulative records for session 10 for the four control (top)
and four lead-treated (bottom) monkeys on an FI-TO schedule of
reinforcement. B: Interresponse time (IRT) absolute frequency distribution
histograms for control (top) and lead-treated (bottom) monkeys for
session 7 75
FIGURE 6.2 Representative transitions showing behavior change subsequent
to a change in the reinforcement densities on the two levers for a control
monkey (top) and lead-exposed monkey (bottom) on a concurrent RI-RI
schedule 82
FIGURE 6.3 Top: Session length and number of incorrect responses on a
delayed spatial alternation task in monkeys for all sessions at the 15-sec
(longest) delay 86
FIGURE 6.4 Delay value at which control (C) and lead-treated (T) monkeys
performed at chance levels on a nonspatial delayed matching-to-sample task
(A) and the ratio of incorrect responses made on the button that had been
responded to correctly in the previous trial (B) 88
FIGURE 7.1 Three-term contingency describing the control of operant
behavior 107
FIGURE 7.2 Matching functions 111
FIGURE 7.3 Lead- and MeHg-exposed monkeys, behavior in transition,
showing the acquisition of choice in three squirrel monkeys 114
FIGURE 7.4 A single-session transition in the expression in choice 115
FIGURE 7.5 Mercury on choice in transition in middle-aged and old rats 118
FIGURE 7.6 Rapid acquisition of fixed-ratio performance in rats exposed
to MeHg (about 0, 40, or 400 ug/kg/day via 0, 0.5, or 5 ppm in maternal
drinking water) during gestation 120
FIGURE 7.7 Progressive ratio responding in rats exposed during gestation
to MeHg 122
FIGURE 7.8 Age-related declines in the completion of a nine-response
sequence of lever pressing within 4 sec, as required under a DRH 9:4
schedule of reinforcement 123
FIGURE 7.9 How DRH performance declined 124
FIGURE 8.1 Structural formula of an unsubstituted PCB molecule 148
FIGURE 9.1 Variable delayed-response performance prior to (black bars)
and following chronic-low-dose MPTP exposure (white bars) and the effect
of attentional cueing (shaded bars) on task performance 173
FIGURE 9.2 Performance of an attention set-shifting task before (black bars)
and after (white bars) chronic-low-dose MPTP exposure 174
FIGURE 12.1 Zero maze for testing anxietylike behaviors 226
FIGURE 12.2 Cognitive testing for the mouse 231
FIGURE 12.3 Prepulse inhibition 232
FIGURE 12.4 Orientation and habituation 234
FIGURE 12.5 Multiple-choice serial-reaction test of attention and vigilance 236
FIGURE 12.6 Go/no-go testing 238
FIGURE 12.7 Learning and memory 242
FIGURE 12.8 Avoidance testing 243
FIGURE 12.9 Object discrimination 248
FIGURE 12.10 Social transmission of food preference 249
FIGURE 12.11 Nonspatial transverse-pattern testing 251
FIGURE 12.12 Morris Water Maze 255
FIGURE 12.13 Conditioned taste aversion 261
FIGURE 12.14 Fear-potentiated startle 263
FIGURE 12.15 Fear conditioning 265
FIGURE 13.1 The increase in performance efficiency by aged ( 19 yr)
macaques well trained in the performance of the DMTS task initiated after
the administration of potential memory-enhancing agents 290
FIGURE 13.2 The delayed matching-to-sample (DMTS) performance by
macaques during task acquisition plotted as a function of age 294
FIGURE 13.3 The performance of three neuropsychological tests of memory
and cognition by 54 healthy elderly human participants plotted as a function
of age 296
FIGURE 15.1 Apparatuses used to study learning and adaptive behavior in
goldfish 320
FIGURE 15.2 Four apparatuses used to study learning and adaptive
procedure in zebrafish 323
FIGURE 15.3 Three-chamber shuttle maze used to study learning and
memory in zebrafish 326
FIGURE 15.4 Persistent effect of early exposure to chlorpyrifos on delayed
spatial alternation in the three-chamber shuttle maze 327
|
| adam_txt |
Contents
Chapter 1 Introduction 1
Edward D. Levin and Jerry J. Buccafusco
SECTION I Pharmacologic Models
Chapter 2 Muscarinic Receptor Antagonists in Rats 5
Alvin V. Terry, Jr.
Chapter 3 Nicotinic Receptor Antagonists in Rats 21
Cindy S. Roegge and Edward D. Levin
Chapter 4 Involvement of the NMDA System in Learning and Memory 37
Amir H. Rezvani
Chapter 5 Animal Models and the Cognitive Effects of Ethanol 49
Merle G. Paule
SECTION II Toxicologic Models
Chapter 6 Animal Models of Cognitive Impairment Produced
by Developmental Lead Exposure 73
Deborah C. Rice
Chapter 7 Developmental Behavioral Toxicity of Methyl mercury:
Consequences, Conditioning, and Cortex 101
M. Christopher Newland, Wendy D. Donlin, Elliott M. Paletz,
and Kelly M. Banna
Chapter 8 Executive Function following Developmental Exposure to
Polychlorinated Biphenyls (PCBs): What Animal Models
Have Told Us 147
Helen J.K. Sable and Susan L. Schantz
Chapter 9 Modeling Cognitive Deficits Associated with Parkinsonism
in the Chronic-Low-Dose MPTP-Treated Monkey 169
J.S. Schneider
SECTION III Mouse Genetic Models
Chapter 10 Cognitive Impairment in Transgenic Mouse Models
of Amyloid Deposition 183
Dave Morgan
Chapter 11 Cholinergic Receptor Knockout Mice 199
Lu Zhang
Chapter 12 Assessments of Cognitive Deficits in Mutant Mice 223
Ramona Marie Rodriguiz and William C. Wetsel
SECTION IV Model Applications and
Future Developments
Chapter 13 Cognitive Pharmacology in Aging Macaques 285
Jerry J. Buccafusco
Chapter 14 Cognitive Impairment following Traumatic Brain Injury 301
Mark D. Whiting, Anna I. Baranova, and Robert J. Hamm
Chapter 15 Cognitive Impairment Models Using Complementary Species 315
Daniel T. Cerutti and Edward D. Levin
Chapter 16 Cognition Models and Drug Discovery 343
Michael W. Decker
Index 355
List of Illustrations
FIGURE 2.1 Dose-related effects of scopolamine on performance of rats
in a water-maze test 10
FIGURE 2.2 Dose-related effects of scopolamine on performance of rats
in a step-through latency test 11
FIGURE 2.3 Dose-related effects of scopolamine on performance of rats
in a test of prepulse inhibition of the auditory gating response 12
FIGURE 2.4 Dose-related effects of scopolamine on performance of rats
in a delayed stimulus discrimination task (DSDT) 13
FIGURE 6.1 A: Cumulative records for session 10 for the four control (top)
and four lead-treated (bottom) monkeys on an FI-TO schedule of
reinforcement. B: Interresponse time (IRT) absolute frequency distribution
histograms for control (top) and lead-treated (bottom) monkeys for
session 7 75
FIGURE 6.2 Representative transitions showing behavior change subsequent
to a change in the reinforcement densities on the two levers for a control
monkey (top) and lead-exposed monkey (bottom) on a concurrent RI-RI
schedule 82
FIGURE 6.3 Top: Session length and number of incorrect responses on a
delayed spatial alternation task in monkeys for all sessions at the 15-sec
(longest) delay 86
FIGURE 6.4 Delay value at which control (C) and lead-treated (T) monkeys
performed at chance levels on a nonspatial delayed matching-to-sample task
(A) and the ratio of incorrect responses made on the button that had been
responded to correctly in the previous trial (B) 88
FIGURE 7.1 Three-term contingency describing the control of operant
behavior 107
FIGURE 7.2 Matching functions 111
FIGURE 7.3 Lead- and MeHg-exposed monkeys, behavior in transition,
showing the acquisition of choice in three squirrel monkeys 114
FIGURE 7.4 A single-session transition in the expression in choice 115
FIGURE 7.5 Mercury on choice in transition in middle-aged and old rats 118
FIGURE 7.6 Rapid acquisition of fixed-ratio performance in rats exposed
to MeHg (about 0, 40, or 400 ug/kg/day via 0, 0.5, or 5 ppm in maternal
drinking water) during gestation 120
FIGURE 7.7 Progressive ratio responding in rats exposed during gestation
to MeHg 122
FIGURE 7.8 Age-related declines in the completion of a nine-response
sequence of lever pressing within 4 sec, as required under a DRH 9:4
schedule of reinforcement 123
FIGURE 7.9 How DRH performance declined 124
FIGURE 8.1 Structural formula of an unsubstituted PCB molecule 148
FIGURE 9.1 Variable delayed-response performance prior to (black bars)
and following chronic-low-dose MPTP exposure (white bars) and the effect
of attentional cueing (shaded bars) on task performance 173
FIGURE 9.2 Performance of an attention set-shifting task before (black bars)
and after (white bars) chronic-low-dose MPTP exposure 174
FIGURE 12.1 Zero maze for testing anxietylike behaviors 226
FIGURE 12.2 Cognitive testing for the mouse 231
FIGURE 12.3 Prepulse inhibition 232
FIGURE 12.4 Orientation and habituation 234
FIGURE 12.5 Multiple-choice serial-reaction test of attention and vigilance 236
FIGURE 12.6 Go/no-go testing 238
FIGURE 12.7 Learning and memory 242
FIGURE 12.8 Avoidance testing 243
FIGURE 12.9 Object discrimination 248
FIGURE 12.10 Social transmission of food preference 249
FIGURE 12.11 Nonspatial transverse-pattern testing 251
FIGURE 12.12 Morris Water Maze 255
FIGURE 12.13 Conditioned taste aversion 261
FIGURE 12.14 Fear-potentiated startle 263
FIGURE 12.15 Fear conditioning 265
FIGURE 13.1 The increase in performance efficiency by aged ( 19 yr)
macaques well trained in the performance of the DMTS task initiated after
the administration of potential memory-enhancing agents 290
FIGURE 13.2 The delayed matching-to-sample (DMTS) performance by
macaques during task acquisition plotted as a function of age 294
FIGURE 13.3 The performance of three neuropsychological tests of memory
and cognition by 54 healthy elderly human participants plotted as a function
of age 296
FIGURE 15.1 Apparatuses used to study learning and adaptive behavior in
goldfish 320
FIGURE 15.2 Four apparatuses used to study learning and adaptive
procedure in zebrafish 323
FIGURE 15.3 Three-chamber shuttle maze used to study learning and
memory in zebrafish 326
FIGURE 15.4 Persistent effect of early exposure to chlorpyrifos on delayed
spatial alternation in the three-chamber shuttle maze 327 |
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| index_date | 2024-07-02T19:33:06Z |
| indexdate | 2024-07-09T21:10:19Z |
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| series2 | Frontiers in neuroscience |
| spelling | Animal models of cognitive impairment ed. by Edward D. Levin ... Boca Raton [u.a.] CRC Press 2006 376 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Frontiers in neuroscience Cognition, Troubles de la - Modèles animaux Cognition disorders Animal models Cognition Disorders drug therapy Disease Models, Animal Tiermodell (DE-588)4140660-6 gnd rswk-swf Wahrnehmungsstörung (DE-588)4126861-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Wahrnehmungsstörung (DE-588)4126861-1 s Tiermodell (DE-588)4140660-6 s DE-188 Levin, Edward D. Sonstige oth http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=frcogimp Verlag kostenfrei Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016274282&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Animal models of cognitive impairment Cognition, Troubles de la - Modèles animaux Cognition disorders Animal models Cognition Disorders drug therapy Disease Models, Animal Tiermodell (DE-588)4140660-6 gnd Wahrnehmungsstörung (DE-588)4126861-1 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4126861-1 (DE-588)4143413-4 |
| title | Animal models of cognitive impairment |
| title_auth | Animal models of cognitive impairment |
| title_exact_search | Animal models of cognitive impairment |
| title_exact_search_txtP | Animal models of cognitive impairment |
| title_full | Animal models of cognitive impairment ed. by Edward D. Levin ... |
| title_fullStr | Animal models of cognitive impairment ed. by Edward D. Levin ... |
| title_full_unstemmed | Animal models of cognitive impairment ed. by Edward D. Levin ... |
| title_short | Animal models of cognitive impairment |
| title_sort | animal models of cognitive impairment |
| topic | Cognition, Troubles de la - Modèles animaux Cognition disorders Animal models Cognition Disorders drug therapy Disease Models, Animal Tiermodell (DE-588)4140660-6 gnd Wahrnehmungsstörung (DE-588)4126861-1 gnd |
| topic_facet | Cognition, Troubles de la - Modèles animaux Cognition disorders Animal models Cognition Disorders drug therapy Disease Models, Animal Tiermodell Wahrnehmungsstörung Aufsatzsammlung |
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