Introduction to computational genomics: a case studies approach
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge Univ. Press
2007
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Table of contents only Publisher description Contributor biographical information Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references (p. [173]-178) and index |
| Beschreibung: | XVII, 182 S. graph. Darst. 26 cm |
| ISBN: | 9780521856034 0521856035 0521671914 |
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| 100 | 1 | |a Cristianini, Nello |d 1968- |e Verfasser |0 (DE-588)133181499 |4 aut | |
| 245 | 1 | 0 | |a Introduction to computational genomics |b a case studies approach |c Nello Cristianini and Matthew W. Hahn |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge |b Cambridge Univ. Press |c 2007 | |
| 300 | |a XVII, 182 S. |b graph. Darst. |c 26 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 500 | |a Includes bibliographical references (p. [173]-178) and index | ||
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| 650 | 7 | |a Genomica |2 gtt | |
| 650 | 4 | |a Datenverarbeitung | |
| 650 | 4 | |a Genomics |x Statistical methods | |
| 650 | 4 | |a Computational biology | |
| 650 | 4 | |a Genomics |x Data processing | |
| 650 | 4 | |a Genomics |x methods | |
| 650 | 4 | |a Computational Biology |x methods | |
| 650 | 0 | 7 | |a Genanalyse |0 (DE-588)4200230-8 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
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| adam_text | INTRODUCTION TO COMPUTATIONAL GENOMICS NELLO CRISTIANINI AND MATTHEW W.
HAHN SUB GOTTINGEN 7 220 002 533 2007 A 20 UNIVERSITY PRESS CONTENTS
PREFACE PAGE IX PROLOGUE: IN PRAISE OF CELLS XI CHAPTER I THE FIRST LOOK
AT A GENOME: SEQUENCE STATISTICS 1 1.1 GENOMIC ERA, YEAR ZERO 1 1.2 THE
ANATOMY OF A GENOME 3 1.3 PROBABILISTIC MODELS OF GENOME SEQUENCES 5 1.4
ANNOTATING A GENOME: STATISTICAL SEQUENCE ANALYSIS 10 1.5 FINDING DATA:
GENBANK, EMBL, AND DDBJ 18 1.6 EXERCISES 20 1.7 READING LIST 21 CHAPTER
2 ALL THE SEQUENCE S MEN: GENE FINDING 22 2.1 THE HUMAN GENOME
SWEEPSTAKES 22 2.2 AN INTRODUCTION TO GENES AND PROTEINS 23 2.3 GENOME
ANNOTATION: GENE FINDING 29 2.4 DETECTING SPURIOUS SIGNALS: HYPOTHESIS
TESTING 31 2.5 EXERCISES 37 2.6 READING LIST 37 CHAPTER 3 ALL IN THE
FAMILY: SEQUENCE ALIGNMENT 38 3.1 EYE OF THE TIGER 38 3.2 ON SEQUENCE
ALIGNMENT 39 3.3 ON SEQUENCE SIMILARITY 40 3.4 SEQUENCE ALIGNMENT:
GLOBAL AND LOCAL 42 3.5 STATISTICAL ANALYSIS OF ALIGNMENTS 47 3.6 BLAST:
FAST APPROXIMATE LOCAL ALIGNMENT 50 3.7 MULTIPLE SEQUENCE ALIGNMENT 53
3.8* COMPUTING THE ALIGNMENTS 55 3.9 EXERCISES 60 3.10 READING LIST 60
CHAPTER 4 THE BOULEVARD OF BROKEN GENES: HIDDEN MARKOV MODELS 61 4.1 THE
NOSE KNOWS 61 4.2 HIDDEN MARKOV MODELS 63 4.3 PROFILE HMMS 67 4.4
FINDING GENES WITH HIDDEN MARKOV MODELS 69 4.5 CASE STUDY: ODORANT
RECEPTORS 70 4.6* ALGORITHMS FOR HMM COMPUTATIONS 75 4.7 EXERCISES 77
4.8 READING LIST 77 CONTENTS CHAPTER 5 ARE NEANDERTHALS AMONG US?:
VARIATION WITHIN AND BETWEEN SPECIES 78 5.1 VARIATION IN DNA SEQUENCES
79 5.2 MITOCHONDRIAL DNA: A MODEL FOR THE ANALYSIS OF VARIATION . . 83
5.3 VARIATION BETWEEN SPECIES 85 5.4 ESTIMATING GENETIC DISTANCE 87 5.5
CASE STUDY: ARE NEANDERTHALS STILL AMONG US? 92 5.6 EXERCISES 94 5.7
READING LIST 95 CHAPTER 6 FIGHTING HIV: NATURAL SELECTION AT THE
MOLECULAR LEVEL 96 6.1 A MYSTERIOUS DISEASE 96 6.2 EVOLUTION AND NATURAL
SELECTION 97 6.3 HIV AND THE HUMAN IMMUNE SYSTEM 98 6.4 QUANTIFYING
NATURAL SELECTION ON DNA SEQUENCES 99 6.5 ESTIMATING K A /K S 102 6.6
CASE STUDY: NATURAL SELECTION AND THE HIV GENOME 105 6.7 EXERCISES 108
6.8 READING LIST 109 CHAPTER 7 SARS - A POST-GENOMIC EPIDEMIC:
PHYLOGENETIC ANALYSIS HO 7.1 OUTBREAK 110 7.2 ON TREES AND EVOLUTION 112
7.3 INFERRING TREES 115 7.4 CASE STUDY: PHYLOGENETIC ANALYSIS OF THE
SARS EPIDEMIC 120 7.5 THE NEWICK FORMAT 126 7.6 EXERCISES 127 7.7
READING LIST *: 127 CHAPTER 8 WELCOME TO THE HOTEL CHLAMYDIA: WHOLE
GENOME COMPARISONS 128 8.1 UNINVITED GUESTS 128 8.2 BY LEAPS AND BOUNDS:
PATTERNS OF GENOME EVOLUTION 129 8.3 BEANBAG GENOMICS 130 8.4 SYNTENY
135 8.5 EXERCISES 138 8.6 READING LIST 139 CHAPTER 9 THE GENOMICS OF
WINE-MAKING: ANALYSIS OF GENE EXPRESSION 141 9.1 CHATEAU HAJJI FERUZ
TEPE 141 9.2 MONITORING CELLULAR COMMUNICATION 143 9.3 MICROARRAY
TECHNOLOGIES 145 9.4 CASE STUDY: THE DIAUXIC SHIFT AND YEAST GENE
EXPRESSION 147 9.5 BONUS CASE STUDY: CELL-CYCLE REGULATED GENES 155
CONTENTS 9.6 EXERCISES 158 9.7 READING LIST 158 CHAPTER 10 A BED-TIME
STORY: IDENTIFICATION OF REGULATORY SEQUENCES 159 10.1 THE CIRCADIAN
CLOCK 159 10.2 BASIC MECHANISMS OF GENE EXPRESSION 161 10.3
MOTIF-FINDING STRATEGIES 162 10.4 CASE STUDY: THE CLOCK AGAIN 167 10.5
EXERCISES 172 10.6 READING LIST 172 BIBLIOGRAPHY 173 INDEX 179
|
| adam_txt |
INTRODUCTION TO COMPUTATIONAL GENOMICS NELLO CRISTIANINI AND MATTHEW W.
HAHN SUB GOTTINGEN 7 220 002 533 2007 A 20 UNIVERSITY PRESS CONTENTS
PREFACE PAGE IX PROLOGUE: IN PRAISE OF CELLS XI CHAPTER I THE FIRST LOOK
AT A GENOME: SEQUENCE STATISTICS 1 1.1 GENOMIC ERA, YEAR ZERO 1 1.2 THE
ANATOMY OF A GENOME 3 1.3 PROBABILISTIC MODELS OF GENOME SEQUENCES 5 1.4
ANNOTATING A GENOME: STATISTICAL SEQUENCE ANALYSIS 10 1.5 FINDING DATA:
GENBANK, EMBL, AND DDBJ 18 1.6 EXERCISES 20 1.7 READING LIST 21 CHAPTER
2 ALL THE SEQUENCE'S MEN: GENE FINDING 22 2.1 THE HUMAN GENOME
SWEEPSTAKES 22 2.2 AN INTRODUCTION TO GENES AND PROTEINS 23 2.3 GENOME
ANNOTATION: GENE FINDING 29 2.4 DETECTING SPURIOUS SIGNALS: HYPOTHESIS
TESTING 31 2.5 EXERCISES 37 2.6 READING LIST 37 CHAPTER 3 ALL IN THE
FAMILY: SEQUENCE ALIGNMENT 38 3.1 EYE OF THE TIGER 38 3.2 ON SEQUENCE
ALIGNMENT 39 3.3 ON SEQUENCE SIMILARITY 40 3.4 SEQUENCE ALIGNMENT:
GLOBAL AND LOCAL 42 3.5 STATISTICAL ANALYSIS OF ALIGNMENTS 47 3.6 BLAST:
FAST APPROXIMATE LOCAL ALIGNMENT 50 3.7 MULTIPLE SEQUENCE ALIGNMENT 53
3.8* COMPUTING THE ALIGNMENTS 55 3.9 EXERCISES 60 3.10 READING LIST 60
CHAPTER 4 THE BOULEVARD OF BROKEN GENES: HIDDEN MARKOV MODELS 61 4.1 THE
NOSE KNOWS 61 4.2 HIDDEN MARKOV MODELS 63 4.3 PROFILE HMMS 67 4.4
FINDING GENES WITH HIDDEN MARKOV MODELS 69 4.5 CASE STUDY: ODORANT
RECEPTORS 70 4.6* ALGORITHMS FOR HMM COMPUTATIONS 75 4.7 EXERCISES 77
4.8 READING LIST 77 CONTENTS CHAPTER 5 ARE NEANDERTHALS AMONG US?:
VARIATION WITHIN AND BETWEEN SPECIES 78 5.1 VARIATION IN DNA SEQUENCES
79 5.2 MITOCHONDRIAL DNA: A MODEL FOR THE ANALYSIS OF VARIATION . . 83
5.3 VARIATION BETWEEN SPECIES 85 5.4 ESTIMATING GENETIC DISTANCE 87 5.5
CASE STUDY: ARE NEANDERTHALS STILL AMONG US? 92 5.6 EXERCISES 94 5.7
READING LIST 95 CHAPTER 6 FIGHTING HIV: NATURAL SELECTION AT THE
MOLECULAR LEVEL 96 6.1 A MYSTERIOUS DISEASE 96 6.2 EVOLUTION AND NATURAL
SELECTION 97 6.3 HIV AND THE HUMAN IMMUNE SYSTEM 98 6.4 QUANTIFYING
NATURAL SELECTION ON DNA SEQUENCES 99 6.5 ESTIMATING K A /K S 102 6.6
CASE STUDY: NATURAL SELECTION AND THE HIV GENOME 105 6.7 EXERCISES 108
6.8 READING LIST 109 CHAPTER 7 SARS - A POST-GENOMIC EPIDEMIC:
PHYLOGENETIC ANALYSIS HO 7.1 OUTBREAK 110 7.2 ON TREES AND EVOLUTION 112
7.3 INFERRING TREES 115 7.4 CASE STUDY: PHYLOGENETIC ANALYSIS OF THE
SARS EPIDEMIC 120 7.5 THE NEWICK FORMAT 126 7.6 EXERCISES 127 7.7
READING LIST *: 127 CHAPTER 8 WELCOME TO THE HOTEL CHLAMYDIA: WHOLE
GENOME COMPARISONS 128 8.1 UNINVITED GUESTS 128 8.2 BY LEAPS AND BOUNDS:
PATTERNS OF GENOME EVOLUTION 129 8.3 BEANBAG GENOMICS 130 8.4 SYNTENY
135 8.5 EXERCISES 138 8.6 READING LIST 139 CHAPTER 9 THE GENOMICS OF
WINE-MAKING: ANALYSIS OF GENE EXPRESSION 141 9.1 CHATEAU HAJJI FERUZ
TEPE 141 9.2 MONITORING CELLULAR COMMUNICATION 143 9.3 MICROARRAY
TECHNOLOGIES 145 9.4 CASE STUDY: THE DIAUXIC SHIFT AND YEAST GENE
EXPRESSION 147 9.5 BONUS CASE STUDY: CELL-CYCLE REGULATED GENES 155
CONTENTS 9.6 EXERCISES 158 9.7 READING LIST 158 CHAPTER 10 A BED-TIME
STORY: IDENTIFICATION OF REGULATORY SEQUENCES 159 10.1 THE CIRCADIAN
CLOCK 159 10.2 BASIC MECHANISMS OF GENE EXPRESSION 161 10.3
MOTIF-FINDING STRATEGIES 162 10.4 CASE STUDY: THE CLOCK AGAIN 167 10.5
EXERCISES 172 10.6 READING LIST 172 BIBLIOGRAPHY 173 INDEX 179 |
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| indexdate | 2024-07-09T21:10:18Z |
| institution | BVB |
| isbn | 9780521856034 0521856035 0521671914 |
| language | English |
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| publisher | Cambridge Univ. Press |
| record_format | marc |
| spelling | Cristianini, Nello 1968- Verfasser (DE-588)133181499 aut Introduction to computational genomics a case studies approach Nello Cristianini and Matthew W. Hahn 1. publ. Cambridge Cambridge Univ. Press 2007 XVII, 182 S. graph. Darst. 26 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (p. [173]-178) and index Computermethoden gtt Genomica gtt Datenverarbeitung Genomics Statistical methods Computational biology Genomics Data processing Genomics methods Computational Biology methods Genanalyse (DE-588)4200230-8 gnd rswk-swf Bioinformatik (DE-588)4611085-9 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Genanalyse (DE-588)4200230-8 s Bioinformatik (DE-588)4611085-9 s DE-604 Hahn, Matthew W. Verfasser aut http://www.loc.gov/catdir/enhancements/fy0702/2007273397-t.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0702/2007273397-d.html Publisher description http://www.loc.gov/catdir/enhancements/fy0733/2007273397-b.html Contributor biographical information http://www3.ub.tu-berlin.de/ihv/001734609.pdf Inhaltsverzeichnis GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016272958&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cristianini, Nello 1968- Hahn, Matthew W. Introduction to computational genomics a case studies approach Computermethoden gtt Genomica gtt Datenverarbeitung Genomics Statistical methods Computational biology Genomics Data processing Genomics methods Computational Biology methods Genanalyse (DE-588)4200230-8 gnd Bioinformatik (DE-588)4611085-9 gnd |
| subject_GND | (DE-588)4200230-8 (DE-588)4611085-9 (DE-588)4151278-9 |
| title | Introduction to computational genomics a case studies approach |
| title_auth | Introduction to computational genomics a case studies approach |
| title_exact_search | Introduction to computational genomics a case studies approach |
| title_exact_search_txtP | Introduction to computational genomics a case studies approach |
| title_full | Introduction to computational genomics a case studies approach Nello Cristianini and Matthew W. Hahn |
| title_fullStr | Introduction to computational genomics a case studies approach Nello Cristianini and Matthew W. Hahn |
| title_full_unstemmed | Introduction to computational genomics a case studies approach Nello Cristianini and Matthew W. Hahn |
| title_short | Introduction to computational genomics |
| title_sort | introduction to computational genomics a case studies approach |
| title_sub | a case studies approach |
| topic | Computermethoden gtt Genomica gtt Datenverarbeitung Genomics Statistical methods Computational biology Genomics Data processing Genomics methods Computational Biology methods Genanalyse (DE-588)4200230-8 gnd Bioinformatik (DE-588)4611085-9 gnd |
| topic_facet | Computermethoden Genomica Datenverarbeitung Genomics Statistical methods Computational biology Genomics Data processing Genomics methods Computational Biology methods Genanalyse Bioinformatik Einführung |
| url | http://www.loc.gov/catdir/enhancements/fy0702/2007273397-t.html http://www.loc.gov/catdir/enhancements/fy0702/2007273397-d.html http://www.loc.gov/catdir/enhancements/fy0733/2007273397-b.html http://www3.ub.tu-berlin.de/ihv/001734609.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016272958&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT cristianininello introductiontocomputationalgenomicsacasestudiesapproach AT hahnmattheww introductiontocomputationalgenomicsacasestudiesapproach |
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