Topics in bone and bone related disorders:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2007
|
| Schriftenreihe: | Oral and maxillofacial surgery clinics of North America
19,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X S., S. 456 - 595 Ill. |
| ISBN: | 9781416051015 1416051015 |
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| 650 | 4 | |a Bone Diseases |x surgery | |
| 650 | 4 | |a Jaw Diseases |x surgery | |
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| 650 | 4 | |a Jaws |x Abnormalities | |
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| adam_text | CONTENTS
Preface ix
Mark R. Stevens
Bone and Bone Graft Healing 455
Robert E. Marx
Bone is unique in connective tissue healing because it heals entirely by cellular
regeneration and the production of a mineral matrix rather than just collagen deposition
known as scar. This article discusses the cellular, tissue, and organ levels in each of the
following sections—skeletal embryology, normal bone, examples of abnormal bone, and
bone graft healing—as they relate to the jaws and the craniofacial skeleton.
Genetic Disorders and Bone Affecting the Craniofacial Skeleton 467
Guillermo E. Chacon, Carlos M. Ugalde, and Marvin F. Jabero
Genetic disorders of bone constitute a large number of alterations approaching almost
300 types. This article focuses on the most common disorders in this group, which at the
same time are the most clinically significant because of their incidence and degree of
involvement of the craniofacial skeleton.
Role of the Oral and Maxillofacial Surgeon in the Diagnosis and Treatment
of Patients with Osteoporosis 475
Carlos M. Isales
Because of the increasing prevalence of osteoporosis in the aging population, it is important
for oral surgeons to be aware of this condition. Oral health frequently reflects systemic
diseases, and calcium loss in the teeth may mirror systemic mineral losses in the skeleton.
Chronic health conditions, such as osteoporosis, also may affect surgical outcomes. In the
past, therapies of osteoporosis were limited to hormonal replacement therapy and fluoride.
Recently, there has been a proliferation of new therapies for osteoporosis that may affect
dental health. The association between bisphosphonate use and osteonecrosis of the jaw is
of concern. It is important that oral surgeons be aware of the medications a patient is using
for the treatment of osteoporosis before initiating any procedure.
Bisphosphonates and Bisphosphonate Induced Osteonecrosis 487
Yoh Sawatari and Robert E. Marx
Bisphosphonate induced osteonecrosis of the jaws is the correct term for this real drug
complication that most dental practitioners face. All nitrogen containing bisphospho¬
nates pose a risk, which is related to the route of administration, the potency of the
VOLUME 19 • NUMBER 4 • NOVEMBER 2007 v
bisphosphonate, and the duration of use. Although intravenous bisphosphonate
induced osteonecrosis of the jaws is mostly permanent, most cases can be prevented
or managed if they develop, with only a few cases requiring resection for resolution. Oral
bisphosphonate induced osteonecrosis of the jaws also can be prevented with knowl¬
edge of the risk level related to the duration of use and the C terminal telopeptide blood
test results. Most cases can be resolved with a drug holiday either spontaneously or via
straightforward debridement.
Bone Replacement Grafts for the Treatment of Periodontal Intrabony Defects 499
Philip J. Hanes
Bone replacement grafts, including autogenous grafts from intraoral donor sites,
allografts, xenografts, and alloplastic bone substitutes, are the most widely used
treatment modalities for the regeneration of periodontal osseous defects. Studies suggest
a favorable clinical outcome with the use of these materials in terms of improvements in
periodontal probing depths, probing attachment gains, and bone fill. In terms of bone
fill, most studies report more than 507o resolution of intrabony defects when treated with
bone replacement grafts. However, histologic evidence of periodontal regeneration,
including new bone, periodontal ligament, and cementum, has been reported only for
autogenous bone grafts and demineralized freeze dried bone allografts.
A Review of Bone Substitutes 513
Solon T. Kao and Daniel D. Scott
The use of bone grafts in the repair of defects has a long history of success, primarily
with the use of autologous bone. With increasing technologic advances, researchers have
been able to broaden the spectrum of grafting materials to allografts, xenografts, and
synthetic materials, which provide the surgeon and patient with options, each with
unique advantages. It is with the knowledge of each material that the clinician can
present and suggest the best material and tailor treatment plans to fit each individual. In
this article, we present an overview of the principles of bone grafting, the types of graft
materials available, and an outlook to what the future holds in this area of medicine and
dentistry.
Contemporary Concepts in the Treatment of Chronic Osteomyelitis 523
Vincent Coviello and Mark R. Stevens
Although there are relatively standard treatment approaches for chronic osteomyelitis,
many avenues of investigation are being pursued to reflect contemporary concerns. The
mainstays of care continue to include timely and thorough surgical debridement and
culture directed antibiotics. Sensitive diagnostic screening is essential, and advances in
radiology can lead to early confirmation of disease and accurate surveillance. There is
potential to greatly reduce overall morbidity, chance of recurrent infection, and
treatment courses by using the local delivery systems currently researched by orthopedic
surgeons. The challenges posed by multidrug resistant bacterium may be countered by
sound culturing techniques and new antibiotics. The general purpose of this article is to
survey the new directions in oral surgery, orthopedics, infectious disease, immunology,
and radiology that may have application to the treatment of maxillofacial osteomyelitis.
Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting
for Alveolar Reconstruction 535
Ulf M.E. Wikesjo, Yi Hao Huang, Giuseppe Polimeni, and Mohammed Qahash
Preclinical studies have shown that rhBMP 2 induces normal physiologic bone in
clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes
vi CONTENTS
characteristics of the adjacent resident bone and allows placement, osseointegration/
re osseointegration, and functional loading of endosseous implants. Clinical studies
optimizing dose, delivery technologies, and conditions for stimulation of bone growth
will bring about a new era in dentistry. The ability to predictably promote osteogenesis
through the use of bone morphogenetic protein technologies is not far from becoming a
clinical reality and will have an astounding effect on how dentistry is practiced.
Advances in Head and Neck Radiotherapy to the Mandible 553
Henry W. Ferguson and Mark R. Stevens
Management of radiation exposed bone in the mandible is a dilemma many oral and
maxillofacial surgeons must confront and manage. Current advances in radiotherapy
techniques using pin point computerized accuracy in combination with other advances,
such as morphed imaging, fractionalization protocols, minimization of scatter, and
pretreatment dental examinations, have greatly decreased the late effects of radiation
and osteoradionecrosis. The intent of this article is to provide a brief overview of the
following topics: radiotherapy physics and radiobiology, effects of radiotherapy on
normal tissues, including the pathogenesis of osteoradionecrosis, and advances in
contemporary radiotherapy treatment.
Distraction Osteogenesis: Advancements in the Last 10 Years 565
Joseph E. Van Sickels
Distraction is still evolving in the management of patients with orthopedic and
craniomaxillofacial deformities. The relationship among latency, gap size, rate, rhythm,
and duration of fixation is not totally understood for all of the individual patients and
variations in their needs seen in a clinical practice. Numerous factors can influence the
quality and quantity of bone seen with distraction, including the age and nutritional
status of the patient and the type of distractor that is used.
Bone Morphogenetic Proteins and the Induction of Bone Formation:
From Laboratory to Patients 575
Ugo Ripamonti, Manolis Heliotis, and Carlo Ferretti
This article revisits the induction of bone by the osteogenic proteins of the transforming
growth factor (3 superfamily in nonhuman and human primates and proposes that the
translation in clinical contexts of the phenomenon of bone; formation by autoinduction, is
predictably achievable by the binary application of relatively low doses of transforming
growth factor p proteins with a recombinant human osteogenic protein. The synergistic
induction of bone formation is a cost effective clinical strategy because published data in
nonhuman primates have shown that doses of recombinant human recombinant
osteogenic protein 1 can be reduced at least fivefold and still increase bone formation
compared with higher doses of single applications of human recombinant osteogenic
protein 1.
Index 591
CONTENTS vii
|
| adam_txt |
CONTENTS
Preface ix
Mark R. Stevens
Bone and Bone Graft Healing 455
Robert E. Marx
Bone is unique in connective tissue healing because it heals entirely by cellular
regeneration and the production of a mineral matrix rather than just collagen deposition
known as scar. This article discusses the cellular, tissue, and organ levels in each of the
following sections—skeletal embryology, normal bone, examples of abnormal bone, and
bone graft healing—as they relate to the jaws and the craniofacial skeleton.
Genetic Disorders and Bone Affecting the Craniofacial Skeleton 467
Guillermo E. Chacon, Carlos M. Ugalde, and Marvin F. Jabero
Genetic disorders of bone constitute a large number of alterations approaching almost
300 types. This article focuses on the most common disorders in this group, which at the
same time are the most clinically significant because of their incidence and degree of
involvement of the craniofacial skeleton.
Role of the Oral and Maxillofacial Surgeon in the Diagnosis and Treatment
of Patients with Osteoporosis 475
Carlos M. Isales
Because of the increasing prevalence of osteoporosis in the aging population, it is important
for oral surgeons to be aware of this condition. Oral health frequently reflects systemic
diseases, and calcium loss in the teeth may mirror systemic mineral losses in the skeleton.
Chronic health conditions, such as osteoporosis, also may affect surgical outcomes. In the
past, therapies of osteoporosis were limited to hormonal replacement therapy and fluoride.
Recently, there has been a proliferation of new therapies for osteoporosis that may affect
dental health. The association between bisphosphonate use and osteonecrosis of the jaw is
of concern. It is important that oral surgeons be aware of the medications a patient is using
for the treatment of osteoporosis before initiating any procedure.
Bisphosphonates and Bisphosphonate Induced Osteonecrosis 487
Yoh Sawatari and Robert E. Marx
Bisphosphonate induced osteonecrosis of the jaws is the correct term for this real drug
complication that most dental practitioners face. All nitrogen containing bisphospho¬
nates pose a risk, which is related to the route of administration, the potency of the
VOLUME 19 • NUMBER 4 • NOVEMBER 2007 v
bisphosphonate, and the duration of use. Although intravenous bisphosphonate
induced osteonecrosis of the jaws is mostly permanent, most cases can be prevented
or managed if they develop, with only a few cases requiring resection for resolution. Oral
bisphosphonate induced osteonecrosis of the jaws also can be prevented with knowl¬
edge of the risk level related to the duration of use and the C terminal telopeptide blood
test results. Most cases can be resolved with a drug holiday either spontaneously or via
straightforward debridement.
Bone Replacement Grafts for the Treatment of Periodontal Intrabony Defects 499
Philip J. Hanes
Bone replacement grafts, including autogenous grafts from intraoral donor sites,
allografts, xenografts, and alloplastic bone substitutes, are the most widely used
treatment modalities for the regeneration of periodontal osseous defects. Studies suggest
a favorable clinical outcome with the use of these materials in terms of improvements in
periodontal probing depths, probing attachment gains, and bone fill. In terms of bone
fill, most studies report more than 507o resolution of intrabony defects when treated with
bone replacement grafts. However, histologic evidence of periodontal regeneration,
including new bone, periodontal ligament, and cementum, has been reported only for
autogenous bone grafts and demineralized freeze dried bone allografts.
A Review of Bone Substitutes 513
Solon T. Kao and Daniel D. Scott
The use of bone grafts in the repair of defects has a long history of success, primarily
with the use of autologous bone. With increasing technologic advances, researchers have
been able to broaden the spectrum of grafting materials to allografts, xenografts, and
synthetic materials, which provide the surgeon and patient with options, each with
unique advantages. It is with the knowledge of each material that the clinician can
present and suggest the best material and tailor treatment plans to fit each individual. In
this article, we present an overview of the principles of bone grafting, the types of graft
materials available, and an outlook to what the future holds in this area of medicine and
dentistry.
Contemporary Concepts in the Treatment of Chronic Osteomyelitis 523
Vincent Coviello and Mark R. Stevens
Although there are relatively standard treatment approaches for chronic osteomyelitis,
many avenues of investigation are being pursued to reflect contemporary concerns. The
mainstays of care continue to include timely and thorough surgical debridement and
culture directed antibiotics. Sensitive diagnostic screening is essential, and advances in
radiology can lead to early confirmation of disease and accurate surveillance. There is
potential to greatly reduce overall morbidity, chance of recurrent infection, and
treatment courses by using the local delivery systems currently researched by orthopedic
surgeons. The challenges posed by multidrug resistant bacterium may be countered by
sound culturing techniques and new antibiotics. The general purpose of this article is to
survey the new directions in oral surgery, orthopedics, infectious disease, immunology,
and radiology that may have application to the treatment of maxillofacial osteomyelitis.
Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting
for Alveolar Reconstruction 535
Ulf M.E. Wikesjo, Yi Hao Huang, Giuseppe Polimeni, and Mohammed Qahash
Preclinical studies have shown that rhBMP 2 induces normal physiologic bone in
clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes
vi CONTENTS
characteristics of the adjacent resident bone and allows placement, osseointegration/
re osseointegration, and functional loading of endosseous implants. Clinical studies
optimizing dose, delivery technologies, and conditions for stimulation of bone growth
will bring about a new era in dentistry. The ability to predictably promote osteogenesis
through the use of bone morphogenetic protein technologies is not far from becoming a
clinical reality and will have an astounding effect on how dentistry is practiced.
Advances in Head and Neck Radiotherapy to the Mandible 553
Henry W. Ferguson and Mark R. Stevens
Management of radiation exposed bone in the mandible is a dilemma many oral and
maxillofacial surgeons must confront and manage. Current advances in radiotherapy
techniques using pin point computerized accuracy in combination with other advances,
such as morphed imaging, fractionalization protocols, minimization of scatter, and
pretreatment dental examinations, have greatly decreased the late effects of radiation
and osteoradionecrosis. The intent of this article is to provide a brief overview of the
following topics: radiotherapy physics and radiobiology, effects of radiotherapy on
normal tissues, including the pathogenesis of osteoradionecrosis, and advances in
contemporary radiotherapy treatment.
Distraction Osteogenesis: Advancements in the Last 10 Years 565
Joseph E. Van Sickels
Distraction is still evolving in the management of patients with orthopedic and
craniomaxillofacial deformities. The relationship among latency, gap size, rate, rhythm,
and duration of fixation is not totally understood for all of the individual patients and
variations in their needs seen in a clinical practice. Numerous factors can influence the
quality and quantity of bone seen with distraction, including the age and nutritional
status of the patient and the type of distractor that is used.
Bone Morphogenetic Proteins and the Induction of Bone Formation:
From Laboratory to Patients 575
Ugo Ripamonti, Manolis Heliotis, and Carlo Ferretti
This article revisits the induction of bone by the osteogenic proteins of the transforming
growth factor (3 superfamily in nonhuman and human primates and proposes that the
translation in clinical contexts of the phenomenon of bone; formation by autoinduction, is
predictably achievable by the binary application of relatively low doses of transforming
growth factor p proteins with a recombinant human osteogenic protein. The synergistic
induction of bone formation is a cost effective clinical strategy because published data in
nonhuman primates have shown that doses of recombinant human recombinant
osteogenic protein 1 can be reduced at least fivefold and still increase bone formation
compared with higher doses of single applications of human recombinant osteogenic
protein 1.
Index 591
CONTENTS vii |
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| title_short | Topics in bone and bone related disorders |
| title_sort | topics in bone and bone related disorders |
| topic | Bone Diseases surgery Jaw Diseases surgery Jaw surgery Jaws Abnormalities Jaws Diseases Jaws Surgery Mund-Kiefer-Gesichts-Chirurgie (DE-588)4114649-9 gnd Knochenersatz (DE-588)4164283-1 gnd |
| topic_facet | Bone Diseases surgery Jaw Diseases surgery Jaw surgery Jaws Abnormalities Jaws Diseases Jaws Surgery Mund-Kiefer-Gesichts-Chirurgie Knochenersatz Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016247591&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002758944 |
| work_keys_str_mv | AT stevensmarkr topicsinboneandbonerelateddisorders |