Principles and methods of toxicology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Boca Raton[u.a.]
CRC Press
2008
|
| Edition: | 5. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIII, 2270 S. Ill., graph. Darst. |
| ISBN: | 084933778X 9780849337789 |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV023014266 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 071121s2008 ad|| |||| 00||| eng d | ||
| 020 | |a 084933778X |9 0-8493-3778-X | ||
| 020 | |a 9780849337789 |9 978-0-8493-3778-9 | ||
| 035 | |a (OCoLC)76901949 | ||
| 035 | |a (DE-599)BVBBV023014266 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-19 | ||
| 050 | 0 | |a RA1211 | |
| 082 | 0 | |a 615.9 |2 22 | |
| 084 | |a VT 5300 |0 (DE-625)147745:253 |2 rvk | ||
| 245 | 1 | 0 | |a Principles and methods of toxicology |c A. Wallace Hayes |
| 250 | |a 5. ed. | ||
| 264 | 1 | |a Boca Raton[u.a.] |b CRC Press |c 2008 | |
| 300 | |a XXIII, 2270 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Toxicologie | |
| 650 | 4 | |a Poisoning | |
| 650 | 4 | |a Poisons | |
| 650 | 4 | |a Toxicology | |
| 650 | 4 | |a Toxicology |x methods | |
| 650 | 0 | 7 | |a Toxikologie |0 (DE-588)4060538-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Toxikologie |0 (DE-588)4060538-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Hayes, Andrew Wallace |d 1939- |e Sonstige |0 (DE-588)15317319X |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016218451&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016218451 | ||
Record in the Search Index
| _version_ | 1804137230299561984 |
|---|---|
| adam_text | Contents
Contributors ix
Acknowledgments xv
Foreword to the Third Edition xvii
Foreword to the Fourth Edition xix
Foreword to the Fifth Edition xxi
Preface xxiii
PART 1 Principles of Toxicology
1 Harming and Helping through Time: The History of Toxicology 3
Richard W. Lane and Joseph F. Borzelleca
2 The Use of Toxicology in the Regulatory Process 45
Barbara D. Beck, Edward J. Calabrese, Tracey M. Slayton, and Ruthann Rudel
3 Metabolism: A Determinant of Toxicity 103
Raymond A. Kemper, Johnnie R. Hayes, and Matthew S. Bogdanffy
4 Toxicokinetics 179
Andrew Gordon Renwick
5 Physiologically Based Pharmacokinetic and Toxicokinetic Models 231
Kannan Krishnan and Melvin E. Andersen
6 Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics
in Predictive and Mechanistic Toxicology 293
Don Robertson, Sven Beushausen, and William Pennie
7 The Toxicologic Assessment of Pharmaceutical and Biotechnology Products 325
Michael A. Dorato, Carl L. McMillian, and Mary Jo Vodicnik
8 Statistics for Toxicologists 369
Shayne C. Gad
9 Quantitative Extrapolations in Toxicology 453
Joseph V. Rodricks, David W. Gaylor, and Duncan Turnbull
10 The Practice of Exposure Assessment 475
Dennis J. Paustenbach and Amy K. Madl
vi Principles and Methods of Toxicology, Fifth Edition
11 Epidemiology for Toxicologists 549
Ralph R. Cook
12 Principles of Pathology for Toxicology Studies 591
Steven R. Frame and Peter C. Mann
13 The Information Infrastructure of Toxicology 611
Philip Wexler, Pertti (Bert) Hakkinen, Patricia Nance, Ann Parker, and Jacqueline Patterson
PART 2 Agents
14 Foodborne Toxicants 633
Chada S. Reddy and A. Wallace Hayes
15 Solvents and Industrial Hygiene 693
David L. Dahlstrom and Margaret Buckalew
16 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 727
Charles B. Breckenridge and James T. Stevens
17 Metals 841
Jill C. Merrill, Joseph JJP. Morton, and Stephen D. Soileau
18 Ionizing Radiation 897
Lorris G. Cockerham, Thomas L. Walden, Jr., Cham E. Dallas, G. Andrew Mickley, Jr., and Michael A. Landauer
19 Plant and Animal Toxins 983
Frederick W. Oehme and Daniel E. Keyler
PART 3 Methods
20 The Use of Laboratory Animals in Toxicology Research 1055
William J. White, C. Terrance Hawk, and Mary Ann Vasbinder
21 Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods.. 1103
William S. Stokes and Leonard M. Schechtman
22 Acute Toxicity and Eye Irritancy : 1131
Mark E. Blazka and A. Wallace Hayes
23 Genetic Toxicology 1179
David J. Brusick, Wanda R. Fields, Brian C. Myhr, and David J. Dootittle
24 Short Term, Subchronic, and Chronic Toxicology Studies 1223
Nelson H. Wilson, Jerry F. Hardisty, and Johnnie R. Hayes
Contents vii
25 Principles of Testing for Carcinogenic Activity 1265
Gary M. Williams, Michael J. Iatropoulos, and Harald G. Enzmann
26 Principles of Clinical Pathology for Toxicology Studies 1317
Robert L. Hall and Nancy E. Everds
27 Dermatotoxicology 1359
Benjamin B. Hayes, Esther Patrick, and Howard J. Maibach
28 Inhalation Toxicology 1407
Rudolph Valentine and Gerald L. Kennedy
29 Detection and Evaluation of Chemically Induced Liver Injury 1465
Gabriel L. Plaa and Michel Charbonneau
30 Principles and Methods for Renal Toxicology 1509
Lawrence H. Lash
31 Gastrointestinal Toxicology 1541
Robert W. Kapp, Jr.
32 Principles and Methods of Cardiac Toxicology 1585
Y. James Kang
33 Assessment of Male Reproductive Toxicity 1605
Sally D. Perreault, Gary R. Klinefelter, and Eric Clegg
34 Test Methods for Assessing Female Reproductive and Developmental Toxicology 1641
Mildred S. Christian
35 Hormone Assays and Endocrine Function 1713
Robert W. Kapp, Jr., and John A. Thomas
36 Immunotoxicology: Effects of and Response to Drugs and Chemicals 1755
Jack H. Dean, Robert V. House, and Michael I. Luster
37 Assessment of Behavioral Toxicity 1797
Deborah A. Cory Slechta and Bernard Weiss
38 Application of Isolated Organ Perfusion Techniques in Toxicology 1865
Harihara M. Mehendale
39 Organelles as Tools in Toxicology 1923
Bruce A. Fowler, Mary L. Haasch, Katherine S. Squibb, and A. Wallace Hayes
40 Analysis and Characterization of Enzymes and Nucleic Acids 1973
F. Peter Guengerich and Cheryl J. Bartleson
viii Principles and Methods of Toxicology, Fifth Edition
41 Modern Instrumental Methods for Studying Mechanisms of Toxicology 2041
Peter A. Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell
42 Methods in Environmental Toxicology 2113
Michael A. Lewis, Anne Fairbrother, and Robert E. Menzer
Glossary 2155
Index 2193
|
| adam_txt |
Contents
Contributors ix
Acknowledgments xv
Foreword to the Third Edition xvii
Foreword to the Fourth Edition xix
Foreword to the Fifth Edition xxi
Preface xxiii
PART 1 Principles of Toxicology
1 Harming and Helping through Time: The History of Toxicology 3
Richard W. Lane and Joseph F. Borzelleca
2 The Use of Toxicology in the Regulatory Process 45
Barbara D. Beck, Edward J. Calabrese, Tracey M. Slayton, and Ruthann Rudel
3 Metabolism: A Determinant of Toxicity 103
Raymond A. Kemper, Johnnie R. Hayes, and Matthew S. Bogdanffy
4 Toxicokinetics 179
Andrew Gordon Renwick
5 Physiologically Based Pharmacokinetic and Toxicokinetic Models 231
Kannan Krishnan and Melvin E. Andersen
6 Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics
in Predictive and Mechanistic Toxicology 293
Don Robertson, Sven Beushausen, and William Pennie
7 The Toxicologic Assessment of Pharmaceutical and Biotechnology Products 325
Michael A. Dorato, Carl L. McMillian, and Mary Jo Vodicnik
8 Statistics for Toxicologists 369
Shayne C. Gad
9 Quantitative Extrapolations in Toxicology 453
Joseph V. Rodricks, David W. Gaylor, and Duncan Turnbull
10 The Practice of Exposure Assessment 475
Dennis J. Paustenbach and Amy K. Madl
vi Principles and Methods of Toxicology, Fifth Edition
11 Epidemiology for Toxicologists 549
Ralph R. Cook
12 Principles of Pathology for Toxicology Studies 591
Steven R. Frame and Peter C. Mann
13 The Information Infrastructure of Toxicology 611
Philip Wexler, Pertti (Bert) Hakkinen, Patricia Nance, Ann Parker, and Jacqueline Patterson
PART 2 Agents
14 Foodborne Toxicants 633
Chada S. Reddy and A. Wallace Hayes
15 Solvents and Industrial Hygiene 693
David L. Dahlstrom and Margaret Buckalew
16 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 727
Charles B. Breckenridge and James T. Stevens
17 Metals 841
Jill C. Merrill, Joseph JJP. Morton, and Stephen D. Soileau
18 Ionizing Radiation 897
Lorris G. Cockerham, Thomas L. Walden, Jr., Cham E. Dallas, G. Andrew Mickley, Jr., and Michael A. Landauer
19 Plant and Animal Toxins 983
Frederick W. Oehme and Daniel E. Keyler
PART 3 Methods
20 The Use of Laboratory Animals in Toxicology Research 1055
William J. White, C. Terrance Hawk, and Mary Ann Vasbinder
21 Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods. 1103
William S. Stokes and Leonard M. Schechtman
22 Acute Toxicity and Eye Irritancy : 1131
Mark E. Blazka and A. Wallace Hayes
23 Genetic Toxicology 1179
David J. Brusick, Wanda R. Fields, Brian C. Myhr, and David J. Dootittle
24 Short Term, Subchronic, and Chronic Toxicology Studies 1223
Nelson H. Wilson, Jerry F. Hardisty, and Johnnie R. Hayes
Contents vii
25 Principles of Testing for Carcinogenic Activity 1265
Gary M. Williams, Michael J. Iatropoulos, and Harald G. Enzmann
26 Principles of Clinical Pathology for Toxicology Studies 1317
Robert L. Hall and Nancy E. Everds
27 Dermatotoxicology 1359
Benjamin B. Hayes, Esther Patrick, and Howard J. Maibach
28 Inhalation Toxicology 1407
Rudolph Valentine and Gerald L. Kennedy
29 Detection and Evaluation of Chemically Induced Liver Injury 1465
Gabriel L. Plaa and Michel Charbonneau
30 Principles and Methods for Renal Toxicology 1509
Lawrence H. Lash
31 Gastrointestinal Toxicology 1541
Robert W. Kapp, Jr.
32 Principles and Methods of Cardiac Toxicology 1585
Y. James Kang
33 Assessment of Male Reproductive Toxicity 1605
Sally D. Perreault, Gary R. Klinefelter, and Eric Clegg
34 Test Methods for Assessing Female Reproductive and Developmental Toxicology 1641
Mildred S. Christian
35 Hormone Assays and Endocrine Function 1713
Robert W. Kapp, Jr., and John A. Thomas
36 Immunotoxicology: Effects of and Response to Drugs and Chemicals 1755
Jack H. Dean, Robert V. House, and Michael I. Luster
37 Assessment of Behavioral Toxicity 1797
Deborah A. Cory Slechta and Bernard Weiss
38 Application of Isolated Organ Perfusion Techniques in Toxicology 1865
Harihara M. Mehendale
39 Organelles as Tools in Toxicology 1923
Bruce A. Fowler, Mary L. Haasch, Katherine S. Squibb, and A. Wallace Hayes
40 Analysis and Characterization of Enzymes and Nucleic Acids 1973
F. Peter Guengerich and Cheryl J. Bartleson
viii Principles and Methods of Toxicology, Fifth Edition
41 Modern Instrumental Methods for Studying Mechanisms of Toxicology 2041
Peter A. Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell
42 Methods in Environmental Toxicology 2113
Michael A. Lewis, Anne Fairbrother, and Robert E. Menzer
Glossary 2155
Index 2193 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)15317319X |
| building | Verbundindex |
| bvnumber | BV023014266 |
| callnumber-first | R - Medicine |
| callnumber-label | RA1211 |
| callnumber-raw | RA1211 |
| callnumber-search | RA1211 |
| callnumber-sort | RA 41211 |
| callnumber-subject | RA - Public Medicine |
| classification_rvk | VT 5300 |
| ctrlnum | (OCoLC)76901949 (DE-599)BVBBV023014266 |
| dewey-full | 615.9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.9 |
| dewey-search | 615.9 |
| dewey-sort | 3615.9 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| discipline_str_mv | Chemie / Pharmazie Medizin |
| edition | 5. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01442nam a2200421 c 4500</leader><controlfield tag="001">BV023014266</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">071121s2008 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">084933778X</subfield><subfield code="9">0-8493-3778-X</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780849337789</subfield><subfield code="9">978-0-8493-3778-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)76901949</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV023014266</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-19</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1211</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.9</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VT 5300</subfield><subfield code="0">(DE-625)147745:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Principles and methods of toxicology</subfield><subfield code="c">A. Wallace Hayes</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">5. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton[u.a.]</subfield><subfield code="b">CRC Press</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXIII, 2270 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicologie</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Poisoning</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Poisons</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield><subfield code="x">methods</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hayes, Andrew Wallace</subfield><subfield code="d">1939-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)15317319X</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016218451&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016218451</subfield></datafield></record></collection> |
| id | DE-604.BV023014266 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:10:38Z |
| indexdate | 2024-07-09T21:08:59Z |
| institution | BVB |
| isbn | 084933778X 9780849337789 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016218451 |
| oclc_num | 76901949 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XXIII, 2270 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Principles and methods of toxicology A. Wallace Hayes 5. ed. Boca Raton[u.a.] CRC Press 2008 XXIII, 2270 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie (DE-588)4060538-3 gnd rswk-swf Toxikologie (DE-588)4060538-3 s DE-604 Hayes, Andrew Wallace 1939- Sonstige (DE-588)15317319X oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016218451&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Principles and methods of toxicology Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4060538-3 |
| title | Principles and methods of toxicology |
| title_auth | Principles and methods of toxicology |
| title_exact_search | Principles and methods of toxicology |
| title_exact_search_txtP | Principles and methods of toxicology |
| title_full | Principles and methods of toxicology A. Wallace Hayes |
| title_fullStr | Principles and methods of toxicology A. Wallace Hayes |
| title_full_unstemmed | Principles and methods of toxicology A. Wallace Hayes |
| title_short | Principles and methods of toxicology |
| title_sort | principles and methods of toxicology |
| topic | Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016218451&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hayesandrewwallace principlesandmethodsoftoxicology |