Verfügbarkeit: Principles and methods of toxicology

Principles and methods of toxicology:

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Format:	Buch
Sprache:	English
Veröffentlicht:	Boca Raton[u.a.] CRC Press 2008
Ausgabe:	5. ed.
Schlagworte:	Toxicologie Poisoning Poisons Toxicology Toxicology > methods Toxikologie
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXIII, 2270 S. Ill., graph. Darst.
ISBN:	084933778X 9780849337789

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MARC


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Datensatz im Suchindex

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adam_text	Contents Contributors ix Acknowledgments xv Foreword to the Third Edition xvii Foreword to the Fourth Edition xix Foreword to the Fifth Edition xxi Preface xxiii PART 1 Principles of Toxicology 1 Harming and Helping through Time: The History of Toxicology 3 Richard W. Lane and Joseph F. Borzelleca 2 The Use of Toxicology in the Regulatory Process 45 Barbara D. Beck, Edward J. Calabrese, Tracey M. Slayton, and Ruthann Rudel 3 Metabolism: A Determinant of Toxicity 103 Raymond A. Kemper, Johnnie R. Hayes, and Matthew S. Bogdanffy 4 Toxicokinetics 179 Andrew Gordon Renwick 5 Physiologically Based Pharmacokinetic and Toxicokinetic Models 231 Kannan Krishnan and Melvin E. Andersen 6 Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology 293 Don Robertson, Sven Beushausen, and William Pennie 7 The Toxicologic Assessment of Pharmaceutical and Biotechnology Products 325 Michael A. Dorato, Carl L. McMillian, and Mary Jo Vodicnik 8 Statistics for Toxicologists 369 Shayne C. Gad 9 Quantitative Extrapolations in Toxicology 453 Joseph V. Rodricks, David W. Gaylor, and Duncan Turnbull 10 The Practice of Exposure Assessment 475 Dennis J. Paustenbach and Amy K. Madl vi Principles and Methods of Toxicology, Fifth Edition 11 Epidemiology for Toxicologists 549 Ralph R. Cook 12 Principles of Pathology for Toxicology Studies 591 Steven R. Frame and Peter C. Mann 13 The Information Infrastructure of Toxicology 611 Philip Wexler, Pertti (Bert) Hakkinen, Patricia Nance, Ann Parker, and Jacqueline Patterson PART 2 Agents 14 Foodborne Toxicants 633 Chada S. Reddy and A. Wallace Hayes 15 Solvents and Industrial Hygiene 693 David L. Dahlstrom and Margaret Buckalew 16 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 727 Charles B. Breckenridge and James T. Stevens 17 Metals 841 Jill C. Merrill, Joseph JJP. Morton, and Stephen D. Soileau 18 Ionizing Radiation 897 Lorris G. Cockerham, Thomas L. Walden, Jr., Cham E. Dallas, G. Andrew Mickley, Jr., and Michael A. Landauer 19 Plant and Animal Toxins 983 Frederick W. Oehme and Daniel E. Keyler PART 3 Methods 20 The Use of Laboratory Animals in Toxicology Research 1055 William J. White, C. Terrance Hawk, and Mary Ann Vasbinder 21 Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods.. 1103 William S. Stokes and Leonard M. Schechtman 22 Acute Toxicity and Eye Irritancy : 1131 Mark E. Blazka and A. Wallace Hayes 23 Genetic Toxicology 1179 David J. Brusick, Wanda R. Fields, Brian C. Myhr, and David J. Dootittle 24 Short Term, Subchronic, and Chronic Toxicology Studies 1223 Nelson H. Wilson, Jerry F. Hardisty, and Johnnie R. Hayes Contents vii 25 Principles of Testing for Carcinogenic Activity 1265 Gary M. Williams, Michael J. Iatropoulos, and Harald G. Enzmann 26 Principles of Clinical Pathology for Toxicology Studies 1317 Robert L. Hall and Nancy E. Everds 27 Dermatotoxicology 1359 Benjamin B. Hayes, Esther Patrick, and Howard J. Maibach 28 Inhalation Toxicology 1407 Rudolph Valentine and Gerald L. Kennedy 29 Detection and Evaluation of Chemically Induced Liver Injury 1465 Gabriel L. Plaa and Michel Charbonneau 30 Principles and Methods for Renal Toxicology 1509 Lawrence H. Lash 31 Gastrointestinal Toxicology 1541 Robert W. Kapp, Jr. 32 Principles and Methods of Cardiac Toxicology 1585 Y. James Kang 33 Assessment of Male Reproductive Toxicity 1605 Sally D. Perreault, Gary R. Klinefelter, and Eric Clegg 34 Test Methods for Assessing Female Reproductive and Developmental Toxicology 1641 Mildred S. Christian 35 Hormone Assays and Endocrine Function 1713 Robert W. Kapp, Jr., and John A. Thomas 36 Immunotoxicology: Effects of and Response to Drugs and Chemicals 1755 Jack H. Dean, Robert V. House, and Michael I. Luster 37 Assessment of Behavioral Toxicity 1797 Deborah A. Cory Slechta and Bernard Weiss 38 Application of Isolated Organ Perfusion Techniques in Toxicology 1865 Harihara M. Mehendale 39 Organelles as Tools in Toxicology 1923 Bruce A. Fowler, Mary L. Haasch, Katherine S. Squibb, and A. Wallace Hayes 40 Analysis and Characterization of Enzymes and Nucleic Acids 1973 F. Peter Guengerich and Cheryl J. Bartleson viii Principles and Methods of Toxicology, Fifth Edition 41 Modern Instrumental Methods for Studying Mechanisms of Toxicology 2041 Peter A. Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell 42 Methods in Environmental Toxicology 2113 Michael A. Lewis, Anne Fairbrother, and Robert E. Menzer Glossary 2155 Index 2193
adam_txt	Contents Contributors ix Acknowledgments xv Foreword to the Third Edition xvii Foreword to the Fourth Edition xix Foreword to the Fifth Edition xxi Preface xxiii PART 1 Principles of Toxicology 1 Harming and Helping through Time: The History of Toxicology 3 Richard W. Lane and Joseph F. Borzelleca 2 The Use of Toxicology in the Regulatory Process 45 Barbara D. Beck, Edward J. Calabrese, Tracey M. Slayton, and Ruthann Rudel 3 Metabolism: A Determinant of Toxicity 103 Raymond A. Kemper, Johnnie R. Hayes, and Matthew S. Bogdanffy 4 Toxicokinetics 179 Andrew Gordon Renwick 5 Physiologically Based Pharmacokinetic and Toxicokinetic Models 231 Kannan Krishnan and Melvin E. Andersen 6 Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology 293 Don Robertson, Sven Beushausen, and William Pennie 7 The Toxicologic Assessment of Pharmaceutical and Biotechnology Products 325 Michael A. Dorato, Carl L. McMillian, and Mary Jo Vodicnik 8 Statistics for Toxicologists 369 Shayne C. Gad 9 Quantitative Extrapolations in Toxicology 453 Joseph V. Rodricks, David W. Gaylor, and Duncan Turnbull 10 The Practice of Exposure Assessment 475 Dennis J. Paustenbach and Amy K. Madl vi Principles and Methods of Toxicology, Fifth Edition 11 Epidemiology for Toxicologists 549 Ralph R. Cook 12 Principles of Pathology for Toxicology Studies 591 Steven R. Frame and Peter C. Mann 13 The Information Infrastructure of Toxicology 611 Philip Wexler, Pertti (Bert) Hakkinen, Patricia Nance, Ann Parker, and Jacqueline Patterson PART 2 Agents 14 Foodborne Toxicants 633 Chada S. Reddy and A. Wallace Hayes 15 Solvents and Industrial Hygiene 693 David L. Dahlstrom and Margaret Buckalew 16 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 727 Charles B. Breckenridge and James T. Stevens 17 Metals 841 Jill C. Merrill, Joseph JJP. Morton, and Stephen D. Soileau 18 Ionizing Radiation 897 Lorris G. Cockerham, Thomas L. Walden, Jr., Cham E. Dallas, G. Andrew Mickley, Jr., and Michael A. Landauer 19 Plant and Animal Toxins 983 Frederick W. Oehme and Daniel E. Keyler PART 3 Methods 20 The Use of Laboratory Animals in Toxicology Research 1055 William J. White, C. Terrance Hawk, and Mary Ann Vasbinder 21 Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods. 1103 William S. Stokes and Leonard M. Schechtman 22 Acute Toxicity and Eye Irritancy : 1131 Mark E. Blazka and A. Wallace Hayes 23 Genetic Toxicology 1179 David J. Brusick, Wanda R. Fields, Brian C. Myhr, and David J. Dootittle 24 Short Term, Subchronic, and Chronic Toxicology Studies 1223 Nelson H. Wilson, Jerry F. Hardisty, and Johnnie R. Hayes Contents vii 25 Principles of Testing for Carcinogenic Activity 1265 Gary M. Williams, Michael J. Iatropoulos, and Harald G. Enzmann 26 Principles of Clinical Pathology for Toxicology Studies 1317 Robert L. Hall and Nancy E. Everds 27 Dermatotoxicology 1359 Benjamin B. Hayes, Esther Patrick, and Howard J. Maibach 28 Inhalation Toxicology 1407 Rudolph Valentine and Gerald L. Kennedy 29 Detection and Evaluation of Chemically Induced Liver Injury 1465 Gabriel L. Plaa and Michel Charbonneau 30 Principles and Methods for Renal Toxicology 1509 Lawrence H. Lash 31 Gastrointestinal Toxicology 1541 Robert W. Kapp, Jr. 32 Principles and Methods of Cardiac Toxicology 1585 Y. James Kang 33 Assessment of Male Reproductive Toxicity 1605 Sally D. Perreault, Gary R. Klinefelter, and Eric Clegg 34 Test Methods for Assessing Female Reproductive and Developmental Toxicology 1641 Mildred S. Christian 35 Hormone Assays and Endocrine Function 1713 Robert W. Kapp, Jr., and John A. Thomas 36 Immunotoxicology: Effects of and Response to Drugs and Chemicals 1755 Jack H. Dean, Robert V. House, and Michael I. Luster 37 Assessment of Behavioral Toxicity 1797 Deborah A. Cory Slechta and Bernard Weiss 38 Application of Isolated Organ Perfusion Techniques in Toxicology 1865 Harihara M. Mehendale 39 Organelles as Tools in Toxicology 1923 Bruce A. Fowler, Mary L. Haasch, Katherine S. Squibb, and A. Wallace Hayes 40 Analysis and Characterization of Enzymes and Nucleic Acids 1973 F. Peter Guengerich and Cheryl J. Bartleson viii Principles and Methods of Toxicology, Fifth Edition 41 Modern Instrumental Methods for Studying Mechanisms of Toxicology 2041 Peter A. Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell 42 Methods in Environmental Toxicology 2113 Michael A. Lewis, Anne Fairbrother, and Robert E. Menzer Glossary 2155 Index 2193
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spellingShingle	Principles and methods of toxicology Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie (DE-588)4060538-3 gnd
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title	Principles and methods of toxicology
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title_exact_search	Principles and methods of toxicology
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title_full	Principles and methods of toxicology A. Wallace Hayes
title_fullStr	Principles and methods of toxicology A. Wallace Hayes
title_full_unstemmed	Principles and methods of toxicology A. Wallace Hayes
title_short	Principles and methods of toxicology
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topic	Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie (DE-588)4060538-3 gnd
topic_facet	Toxicologie Poisoning Poisons Toxicology Toxicology methods Toxikologie
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