HOX gene expression:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Austin,Texas
Landes Bioscience/Eurekah.com
2007
New York Springer Science + Business Media |
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 0387689893 9780387689890 9780387689906 |
| DOI: | 10.1007/978-0-387-68990-6 |
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Datensatz im Suchindex
| _version_ | 1804137225812705280 |
|---|---|
| adam_text | CONTENTS |
Preface xiii
1. The Homeobox as a Key for Understanding die Principles
of die Genetic Control of Development 1
Walter ]. Gehring
Introduction 1
Molecular Cloning of the Homeotic Bithorax Complex
in Drosophila 3
Molecular Cloning of Antennapedia Complex and the Discovery
of die Homeobox 4
Specification and Redesigning of the Body Plan 5
The Structure and Function of the Homeodomain 8
Evolution of Homeobox Genes 10
2. Expression of Hox Genes in die Nervous System of Vertebrates 14
ChristofNolte and Robb Krumlauf
Introduction 14
The Hox Gene Family 14
The Embryonic Vertebrate Nervous System 16
Hox Gene Expression in the CNS 19
Regulation of Neural Expression 23
Expression and Neuronal Phenotypes 29
The Roles of Auto and Cross Regulatory Interactions
between Hox Genes 30
3. The Hox Gene Network in Vertebrate limb Development 42
Cheryll Tickle
Introduction to Vertebrate Limb Development 42
Hox Gene Expression in Vertebrate Limbs 43
Signals That Control Hox Gene Expression in the Limb 44
Tests of Hox Gene Function 46
Regulatory Regions That Drive Hox Gene Expression in the Limb 48
Wider Implications of die Hox Gene Network 49
4. Evolution of Hox Gene Clusters 53
David E.K. Ferrier
Introduction 53
Origin of the Cluster: Unraveling Patterns of Gene Duplication
and Duplicate Evolution 53
Evolution of Cluster Composition and the Impact of Hox
on Animal Phylogeny 59
Molecular Mechanisms and Evolution of Hox Cluster Organization ... 62
Conclusion 5
5. Evolutionary Genomics of Hox Gene Clusters 68
SonjaJ. Prohaska, Peter F. Stadler and Giinter P. Wagner
Introduction °
Genomic Features ™
Chordate Hox Cluster History: How Little Do We Know? 76
The Effects of Duplication 81
Hypotheses and Inferences 86
6. Chromatin and the Control of Hox Gene Expression 91
Laila Kobrossy and Mark Featherstone
Introduction 91
Anticipation 92
Initiation 93
Maintenance 95
Conclusions 97
7. Homeobox Containing Genes in limb Regeneration 102
David M. Gardiner and Susan V. Bryant
Early Studies 103
Future Directions 106
8. Hox Genes and Stem Cells Ill
Mina Gouti and Anthony Gavalas
Introduction Ill
Hox Genes and Drosophila Neuroblasts Ill
Hox Gene Function in Stem Cells
during Mammalian Development 112
Hox Genes and Hematopoietic Stem Cells 114
Hox Genes and Cancer Stem Cells 116
Conclusions 118
9. Deregulation of the Hox Gene Network and Cancer 121
Clemente Gilo
Introduction 121
Breast Cancer 123
Bladder Cancer 125
Prostate Cancer 125
Kidney Cancer 127
Conclusions 129
Appendix: Hypothesis: Pulling Forces Acting on Hox Gene
Clusters Cause Expression Collinearity 134
Spyros Papageorgiou
Introduction 134
A Physical Model for Hox Gene Collinearity 137
Attractive Electric Forces 138
Correlation of Morphogen Thresholds and Gene Translocations 140
Conclusions and Predictions 142
Index 147
The choice of italics or case for Hox is determined by the authors, preference and may differ
between chapters.
|
| adam_txt |
CONTENTS |
Preface xiii
1. The Homeobox as a Key for Understanding die Principles
of die Genetic Control of Development 1
Walter ]. Gehring
Introduction 1
Molecular Cloning of the Homeotic Bithorax Complex
in Drosophila 3
Molecular Cloning of Antennapedia Complex and the Discovery
of die Homeobox 4
Specification and Redesigning of the Body Plan 5
The Structure and Function of the Homeodomain 8
Evolution of Homeobox Genes 10
2. Expression of Hox Genes in die Nervous System of Vertebrates 14
ChristofNolte and Robb Krumlauf
Introduction 14
The Hox Gene Family 14
The Embryonic Vertebrate Nervous System 16
Hox Gene Expression in the CNS 19
Regulation of Neural Expression 23
Expression and Neuronal Phenotypes 29
The Roles of Auto and Cross Regulatory Interactions
between Hox Genes 30
3. The Hox Gene Network in Vertebrate limb Development 42
Cheryll Tickle
Introduction to Vertebrate Limb Development 42
Hox Gene Expression in Vertebrate Limbs 43
Signals That Control Hox Gene Expression in the Limb 44
Tests of Hox Gene Function 46
Regulatory Regions That Drive Hox Gene Expression in the Limb 48
Wider Implications of die Hox Gene Network 49
4. Evolution of Hox Gene Clusters 53
David E.K. Ferrier
Introduction 53
Origin of the Cluster: Unraveling Patterns of Gene Duplication
and Duplicate Evolution 53
Evolution of Cluster Composition and the Impact of Hox
on Animal Phylogeny 59
Molecular Mechanisms and Evolution of Hox Cluster Organization . 62
Conclusion "5
5. Evolutionary Genomics of Hox Gene Clusters 68
SonjaJ. Prohaska, Peter F. Stadler and Giinter P. Wagner
Introduction "°
Genomic Features ™
Chordate Hox Cluster History: How Little Do We Know? 76
The Effects of Duplication 81
Hypotheses and Inferences 86
6. Chromatin and the Control of Hox Gene Expression 91
Laila Kobrossy and Mark Featherstone
Introduction 91
Anticipation 92
Initiation 93
Maintenance 95
Conclusions 97
7. Homeobox Containing Genes in limb Regeneration 102
David M. Gardiner and Susan V. Bryant
Early Studies 103
Future Directions 106
8. Hox Genes and Stem Cells Ill
Mina Gouti and Anthony Gavalas
Introduction Ill
Hox Genes and Drosophila Neuroblasts Ill
Hox Gene Function in Stem Cells
during Mammalian Development 112
Hox Genes and Hematopoietic Stem Cells 114
Hox Genes and Cancer Stem Cells 116
Conclusions 118
9. Deregulation of the Hox Gene Network and Cancer 121
Clemente Gilo
Introduction 121
Breast Cancer 123
Bladder Cancer 125
Prostate Cancer 125
Kidney Cancer 127
Conclusions 129
Appendix: Hypothesis: Pulling Forces Acting on Hox Gene
Clusters Cause Expression Collinearity 134
Spyros Papageorgiou
Introduction 134
A Physical Model for Hox Gene Collinearity 137
Attractive Electric Forces 138
Correlation of Morphogen Thresholds and Gene Translocations 140
Conclusions and Predictions 142
Index 147
The choice of italics or case for Hox is determined by the authors, preference and may differ
between chapters. |
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| index_date | 2024-07-02T19:09:27Z |
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| isbn | 0387689893 9780387689890 9780387689906 |
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| spelling | HOX gene expression Spyros Papageorgiou Austin,Texas Landes Bioscience/Eurekah.com 2007 New York Springer Science + Business Media 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Molecular biology intelligence unit Homeobox genes Evolutionary genetics Homöobox (DE-588)4295375-3 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf Homöobox (DE-588)4295375-3 s Genexpression (DE-588)4020136-3 s b DE-604 Papageorgiou, Spyros Sonstige oth https://doi.org/10.1007/978-0-387-68990-6 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016215502&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | HOX gene expression Homeobox genes Evolutionary genetics Homöobox (DE-588)4295375-3 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4295375-3 (DE-588)4020136-3 |
| title | HOX gene expression |
| title_auth | HOX gene expression |
| title_exact_search | HOX gene expression |
| title_exact_search_txtP | HOX gene expression |
| title_full | HOX gene expression Spyros Papageorgiou |
| title_fullStr | HOX gene expression Spyros Papageorgiou |
| title_full_unstemmed | HOX gene expression Spyros Papageorgiou |
| title_short | HOX gene expression |
| title_sort | hox gene expression |
| topic | Homeobox genes Evolutionary genetics Homöobox (DE-588)4295375-3 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | Homeobox genes Evolutionary genetics Homöobox Genexpression |
| url | https://doi.org/10.1007/978-0-387-68990-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016215502&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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