TNF receptor associated factors (Trafs):
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Springer
2007
|
| Schriftenreihe: | Advances in experimental medicine and biology
597 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 206 S. Ill., graph. Darst. |
| ISBN: | 9780387706290 |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
FOREWORD v
Vishva M. Dixit
1. PHYLOGENY OF THE TRAF/MATH DOMAIN 1
Juan M. Zapata, Vanesa Martinez Garcia and Sophie Lefebvre
Abstract 1
Introduction 1
Ubiquitin Proteases (UBPs) 2
RluA and Filament Domains 9
BTB/POZ Domains 9
MATH Domain Only Proteins 12
TRIM37 12
Meprins 13
TRAFs 13
Viral Immune Evasion Strategies Interfering with MATH Dependent Pathways 18
SIAH 18
Concluding Remarks 19
2. TRAF1 AND ITS BIOLOGICAL FUNCTIONS 25
Soo Young Lee and Yongwon Choi
Abstract 25
Introduction 25
Discovery of TRAF1 25
Structural Domain of TRAF1 26
Expression and Regulation of TRAF1 26
TRAFl Binding Receptors and Intracellular Proteins 27
Antiapoptotic Role of TRAF1 27
Role of TRAF1: Lessons from Knockout Mice 29
Concluding Remarks 29
XV
xvi Contents
3. PHYSIOLOGICAL ROLES AND MECHANISMS
OF SIGNALING BY TRAF2 AND TRAF5 32
Ping Yee Billie Au and Wen Chen Yeh
Abstract 32
Introduction 32
Mechanisms of TRAF2/5 Mediated Signal Transduction 33
Receptors and Pathway Anchor Proteins That Utilize TRAF2 and TRAF5 35
Conclusion 42
4. TRAF3 AND ITS BIOLOGICAL FUNCTION 48
Jeannie Q. He, Gagik Oganesyan, Supriya K. Saha, Brian Zarnegar
and Genhong Cheng
Abstract 48
Introduction 48
Characterization of TRAF3 49
Structure Function Study of TRAF3 49
TRAF3 Association with Surface Membrane Receptors 49
TRAF3 Interacting Molecules 50
Phenotype of TRAF3 Defident Mice 50
Breakthrough in Identification of TRAF3 Function:
The Noncanonical NF kB Pathway 50
TRAF3 in Innate Immunity 53
Concluding Remarks 55
5. TRAF4, THE UNIQUE FAMILY MEMBER 60
Valerie Kedinger and Marie Christine Rio
Abstract 60
The Fourth Member of the TRAF Protein Family 60
TRAF4 Is Highly Conserved during Evolution 61
Physiological Expression 62
Subcellular Localization: A Matter of Debate 63
In Vivo Evidence That TRAF4 Is Biologically Relevant 64
Can TRAF4 Transduce Extracellular TNF Signals? 65
Can TRAF4 Transduce Extracellular Signals via Membrane Related Partners? 66
Does TRAF4 Regulate Cell Life and Death? 67
Miscellaneous TRAF4 Partners 68
Is TRAF4 Implicated in Human Diseases? 68
Conclusion and Perspective 69
Contents xvjj
6. CHARACTERISTICS AND BIOLOGICAL FUNCTIONS
OFTRAF6 72
Jun ichiro Inoue, Jin Gohda and Taishin Akiyama
Abstract 72
Introduction 72
Role of TRAF6 in Immune System 72
Toll Like Receptor Signaling 73
Role of TRAF6 in Development of Skin Appendices 76
Role of TRAF6 in Nervous System 77
Future Studies of TRAF6 77
7. UBIQUITINATION AND TRAF SIGNALING 80
Gabriel Pineda, Chee Kwee Ea and Zhijian J. Chen
Introduction 80
Roles of Ubiquitination in IKK Activation by TRAF Proteins 82
Signaling Pathways Downstream of TRAF Proteins 86
Conclusions and Perspectives 87
8. STRUCTURAL REVELATIONS OF TRAF2 FUNCTION
IN TNF RECEPTOR SIGNALING PATHWAY 93
Jee Y. Chung, Miao Lu, Qian Yin and Hao Wu
Abstract 93
Identification of TNF and Its Role in Death and Survival Signaling 93
Identification of TRAFs as Major Signal Transducers of the TNFR Superfamily 94
Domain and Oligomeric Structures of TRAF2 95
TRAF2 Receptor Interactions 100
Thermodynamics of TRAF Receptor Interactions 104
TRAF2 TRADD Interaction: A Novel Mode of TRAF Signaling 105
Summary: Emerging Principles of Post Receptor Signal Transduction 109
9. PROTEIN PROTEIN INTERACTIONS IN TRAF3 114
Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu
Abstract 114
TRAF3 Is a Trimeric Assembly 114
Structurally and Functionally Adaptive Binding Crevice in TRAF3 115
Structural Framework forTRAF3 Recognition 116
Specific Recognition at theTRAF3 Site 117
Summary 120
xvili Contents
10. MOLECULAR BASIS FOR THE UNIQUE SPECIFICITY
OFTRAF6 122
Jee Y. Chung, Miao Lu, Qian Yin, Su Chang Lin and Hao Wu
Abstract 122
Introduction 122
Expression and Crystallization of TRAF6 123
Molecular Basis for the Distinct Specificity of TRAF6 123
Inhibitors of TRAF6 Signaling 127
Remaining Questions 129
11. TRAF PROTEINS IN CD40 SIGNALING 131
Gail A. Bishop, Carissa R. Moore, Ping Xie, Laura L. Stunz
and Zachary J. Kraus
Abstract 131
Introduction 131
Roles of TRAF Molecules in CD40 Function 136
Conclusions 144
12. TRAFs IN RANK SIGNALING 152
Bryant G. Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe
and Jorg J. Jacoby
Abstract 152
Introduction • 152
TRAF Interaction Motifs in the Cytoplasmic Domain of RANK 153
TRAF6—The Critical Adaptor for RANK Signaling 154
TRAFs in Osteoclast Differentiation 156
Conclusions and Future Directions 157
13. THE LT0R SIGNALING PATHWAY 160
Paula S. Norris and Carl F. Ware
Abstract 160
Introduction 160
The LTp Receptor 160
LTpR Signaling Pathway 162
Genetic Phenotypes of LT and TRAF Deficient Mice 167
Contents xix
14. LMP1 TRAFFICKING ACTIVATES GROWTH
AND SURVIVAL PATHWAYS 173
Vishal Soni, Ellen Cahir McFarland and Elliott Kieff
Abstract 173
Introduction 173
LMP1 TES1 and TES2 Recruit TRAFs 176
LMP1 TES1 Directly Recruits TRAFs 1, 2, 3 and 5 176
LMP1 TES2 Indirectly Recruits TRAF6 177
LMP1 Alters TRAF Partitioning 177
TRAF Induction or Degradation and LMP1 180
Summary 181
15. TARGETING TRAFs FOR THERAPEUTIC INTERVENTION 188
Juan M. Zapata, Sophie Lefebvre and John C. Reed
Abstract 188
TNF Receptor Associated Factors (TRAFs) 188
TRAFs and Disease 189
TRAF3 and Mantle Cell Lymphoma 192
Perspectives 194
INDEX 203
|
| adam_txt |
CONTENTS
FOREWORD v
Vishva M. Dixit
1. PHYLOGENY OF THE TRAF/MATH DOMAIN 1
Juan M. Zapata, Vanesa Martinez Garcia and Sophie Lefebvre
Abstract 1
Introduction 1
Ubiquitin Proteases (UBPs) 2
RluA and Filament Domains 9
BTB/POZ Domains 9
MATH Domain Only Proteins 12
TRIM37 12
Meprins 13
TRAFs 13
Viral Immune Evasion Strategies Interfering with MATH Dependent Pathways 18
SIAH 18
Concluding Remarks 19
2. TRAF1 AND ITS BIOLOGICAL FUNCTIONS 25
Soo Young Lee and Yongwon Choi
Abstract 25
Introduction 25
Discovery of TRAF1 25
Structural Domain of TRAF1 26
Expression and Regulation of TRAF1 26
TRAFl Binding Receptors and Intracellular Proteins 27
Antiapoptotic Role of TRAF1 27
Role of TRAF1: Lessons from Knockout Mice 29
Concluding Remarks 29
XV
xvi Contents
3. PHYSIOLOGICAL ROLES AND MECHANISMS
OF SIGNALING BY TRAF2 AND TRAF5 32
Ping Yee Billie Au and Wen Chen Yeh
Abstract 32
Introduction 32
Mechanisms of TRAF2/5 Mediated Signal Transduction 33
Receptors and Pathway Anchor Proteins That Utilize TRAF2 and TRAF5 35
Conclusion 42
4. TRAF3 AND ITS BIOLOGICAL FUNCTION 48
Jeannie Q. He, Gagik Oganesyan, Supriya K. Saha, Brian Zarnegar
and Genhong Cheng
Abstract 48
Introduction 48
Characterization of TRAF3 49
Structure Function Study of TRAF3 49
TRAF3 Association with Surface Membrane Receptors 49
TRAF3 Interacting Molecules 50
Phenotype of TRAF3 Defident Mice 50
Breakthrough in Identification of TRAF3 Function:
The Noncanonical NF kB Pathway 50
TRAF3 in Innate Immunity 53
Concluding Remarks 55
5. TRAF4, THE UNIQUE FAMILY MEMBER 60
Valerie Kedinger and Marie Christine Rio
Abstract 60
The Fourth Member of the TRAF Protein Family 60
TRAF4 Is Highly Conserved during Evolution 61
Physiological Expression 62
Subcellular Localization: A Matter of Debate 63
In Vivo Evidence That TRAF4 Is Biologically Relevant 64
Can TRAF4 Transduce Extracellular TNF Signals? 65
Can TRAF4 Transduce Extracellular Signals via Membrane Related Partners? 66
Does TRAF4 Regulate Cell Life and Death? 67
Miscellaneous TRAF4 Partners 68
Is TRAF4 Implicated in Human Diseases? 68
Conclusion and Perspective 69
Contents xvjj
6. CHARACTERISTICS AND BIOLOGICAL FUNCTIONS
OFTRAF6 72
Jun ichiro Inoue, Jin Gohda and Taishin Akiyama
Abstract 72
Introduction 72
Role of TRAF6 in Immune System 72
Toll Like Receptor Signaling 73
Role of TRAF6 in Development of Skin Appendices 76
Role of TRAF6 in Nervous System 77
Future Studies of TRAF6 77
7. UBIQUITINATION AND TRAF SIGNALING 80
Gabriel Pineda, Chee Kwee Ea and Zhijian J. Chen
Introduction 80
Roles of Ubiquitination in IKK Activation by TRAF Proteins 82
Signaling Pathways Downstream of TRAF Proteins 86
Conclusions and Perspectives 87
8. STRUCTURAL REVELATIONS OF TRAF2 FUNCTION
IN TNF RECEPTOR SIGNALING PATHWAY 93
Jee Y. Chung, Miao Lu, Qian Yin and Hao Wu
Abstract 93
Identification of TNF and Its Role in Death and Survival Signaling 93
Identification of TRAFs as Major Signal Transducers of the TNFR Superfamily 94
Domain and Oligomeric Structures of TRAF2 95
TRAF2 Receptor Interactions 100
Thermodynamics of TRAF Receptor Interactions 104
TRAF2 TRADD Interaction: A Novel Mode of TRAF Signaling 105
Summary: Emerging Principles of Post Receptor Signal Transduction 109
9. PROTEIN PROTEIN INTERACTIONS IN TRAF3 114
Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu
Abstract 114
TRAF3 Is a Trimeric Assembly 114
Structurally and Functionally Adaptive Binding Crevice in TRAF3 115
Structural Framework forTRAF3 Recognition 116
Specific Recognition at theTRAF3 Site 117
Summary 120
xvili Contents
10. MOLECULAR BASIS FOR THE UNIQUE SPECIFICITY
OFTRAF6 122
Jee Y. Chung, Miao Lu, Qian Yin, Su Chang Lin and Hao Wu
Abstract 122
Introduction 122
Expression and Crystallization of TRAF6 123
Molecular Basis for the Distinct Specificity of TRAF6 123
Inhibitors of TRAF6 Signaling 127
Remaining Questions 129
11. TRAF PROTEINS IN CD40 SIGNALING 131
Gail A. Bishop, Carissa R. Moore, Ping Xie, Laura L. Stunz
and Zachary J. Kraus
Abstract 131
Introduction 131
Roles of TRAF Molecules in CD40 Function 136
Conclusions 144
12. TRAFs IN RANK SIGNALING 152
Bryant G. Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe
and Jorg J. Jacoby
Abstract 152
Introduction • 152
TRAF Interaction Motifs in the Cytoplasmic Domain of RANK 153
TRAF6—The Critical Adaptor for RANK Signaling 154
TRAFs in Osteoclast Differentiation 156
Conclusions and Future Directions 157
13. THE LT0R SIGNALING PATHWAY 160
Paula S. Norris and Carl F. Ware
Abstract 160
Introduction 160
The LTp Receptor 160
LTpR Signaling Pathway 162
Genetic Phenotypes of LT and TRAF Deficient Mice 167
Contents xix
14. LMP1 TRAFFICKING ACTIVATES GROWTH
AND SURVIVAL PATHWAYS 173
Vishal Soni, Ellen Cahir McFarland and Elliott Kieff
Abstract 173
Introduction 173
LMP1 TES1 and TES2 Recruit TRAFs 176
LMP1 TES1 Directly Recruits TRAFs 1, 2, 3 and 5 176
LMP1 TES2 Indirectly Recruits TRAF6 177
LMP1 Alters TRAF Partitioning 177
TRAF Induction or Degradation and LMP1 180
Summary 181
15. TARGETING TRAFs FOR THERAPEUTIC INTERVENTION 188
Juan M. Zapata, Sophie Lefebvre and John C. Reed
Abstract 188
TNF Receptor Associated Factors (TRAFs) 188
TRAFs and Disease 189
TRAF3 and Mantle Cell Lymphoma 192
Perspectives 194
INDEX 203 |
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| index_date | 2024-07-02T19:09:16Z |
| indexdate | 2024-07-09T21:08:54Z |
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| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | TNF receptor associated factors (Trafs) ed. by Hao Wu New York Springer 2007 XIX, 206 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 597 Cellular signal transduction Receptors, Tumor Necrosis Factor metabolism Signal Transduction Tumor Necrosis Factor Receptor-Associated Peptides and Proteins physiology Tumor Necrosis Factors metabolism Tumor necrosis factor Receptors Rezeptor (DE-588)4049722-7 gnd rswk-swf Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Tumor-Nekrose-Faktor (DE-588)4202932-6 s Rezeptor (DE-588)4049722-7 s Signaltransduktion (DE-588)4318717-1 s DE-604 Wu, Hao Sonstige oth Advances in experimental medicine and biology 597 (DE-604)BV000003102 597 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016214965&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | TNF receptor associated factors (Trafs) Advances in experimental medicine and biology Cellular signal transduction Receptors, Tumor Necrosis Factor metabolism Signal Transduction Tumor Necrosis Factor Receptor-Associated Peptides and Proteins physiology Tumor Necrosis Factors metabolism Tumor necrosis factor Receptors Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4202932-6 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | TNF receptor associated factors (Trafs) |
| title_auth | TNF receptor associated factors (Trafs) |
| title_exact_search | TNF receptor associated factors (Trafs) |
| title_exact_search_txtP | TNF receptor associated factors (Trafs) |
| title_full | TNF receptor associated factors (Trafs) ed. by Hao Wu |
| title_fullStr | TNF receptor associated factors (Trafs) ed. by Hao Wu |
| title_full_unstemmed | TNF receptor associated factors (Trafs) ed. by Hao Wu |
| title_short | TNF receptor associated factors (Trafs) |
| title_sort | tnf receptor associated factors trafs |
| topic | Cellular signal transduction Receptors, Tumor Necrosis Factor metabolism Signal Transduction Tumor Necrosis Factor Receptor-Associated Peptides and Proteins physiology Tumor Necrosis Factors metabolism Tumor necrosis factor Receptors Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cellular signal transduction Receptors, Tumor Necrosis Factor metabolism Signal Transduction Tumor Necrosis Factor Receptor-Associated Peptides and Proteins physiology Tumor Necrosis Factors metabolism Tumor necrosis factor Receptors Rezeptor Tumor-Nekrose-Faktor Signaltransduktion Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016214965&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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