Neuroimmunology of sleep:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer
2007
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 0387691464 9780387691466 |
| DOI: | 10.1007/978-0-387-69146-6 |
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| 245 | 1 | 0 | |a Neuroimmunology of sleep |c S. R. Pandi-Perumal ; Daniel P. Cardinali ; George P. Chrousos |
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Datensatz im Suchindex
| _version_ | 1804137223054950400 |
|---|---|
| adam_text | Contents
Preface xiii
Acknowledgments xv
Contributors xvii
Part I General Concepts 1
1. Bidirectional Communication Between the Brain and the Immune
System 3
Douglas A. Weigent and J. Edwin Blalock
1.1 Introduction 3
1.2 Nervous System Communication to the Immune System 6
1.3 Neuroendocrine Hormone Influence on the Immune System 8
1.4 Actions of Hypothalamic Releasing Hormones 10
1.5 Immune System Communication with the Nervous System
Hormones 11
1.6 Cytokine Influences on the Nervous System 12
1.7 Neuroendocrine Hormone Release by Cells of the Immune System 14
1.8 Neurotransmitter Release by Cells of the Immune System 16
1.9 Bidirectional Communication and Sleep 17
1.10 Summary and Conclusions 17
2. Neuroimmunological Correlates of Circadian Rhythmicity in Oral
Biology and Medicine 27
Francesco Chiappelli, Olivia S. Cajulis, Audrey Navarro and David R.
Moradi
2.1 Introduction 27
vi Contents
2.2 Allostatic Response and Allostatic Intervention: Relevance to Oral
Biology and Medicine 29
2.2.1 Allostasis 29
2.2.2 Allostatic Load 30
2.2.3 Allostatic Testing and Intervention 32
2.2.4 Allostasis Is Not Chaos or Is It? 34
2.3 Mucositis: A Case of Allostatic Load 36
2.3.1 Oral Mucositis 36
2.3.2 Neuroendocrine Immune Orderly Chaos in OM 39
2.3.3 Circadian Neurobiology and Neuroimmunopathology in
OM 46
2.4 Directions for the Future 49
3. Circadian Organization of the Immune Response: Lessons from the
Adjuvant Arthritis Model 59
Daniel P. Cardinali, Ana I. Esquifino, Georges J. M. Maestroni and
Seithikurippu R. Pandi Perumal
3.1 The Circadian Clock is One of the most Indispensable Biological
Functions 59
3.2 The Immune System Shows Circadian Organization 61
3.3 Sickness Behavior Includes Changes in Circadian Rhythms 64
3.4 The Rat Adjuvant Arthritis is an Experimental Model of
Rheumatoid Arthritis 66
3.5 Adjuvant Arthritis Disrupts Normal Chronobiological
Organization 68
3.6 Melatonin as a Circadian Immunoregulatory Signal in Adjuvant
Arthritis 72
Part II Basic Research 85
4. The Biological Clock in Inflammation and Sleep Switch Alterations 87
Marina Bentivoglio, Mikael Nygard, Maria Palomba and Krister
Kristensson
4.1 Introduction 87
4.2 Interactions Between the Biological Clock and the Sleep Switch 87
4.3 Effects of Inflammatory Molecules on the SCN and Sleep Switch
Structures 90
4.4 Intracellular Inflammatory Regulators 92
4.4.1 SHP, PIAS, and SOCS 92
4.4.2 Intracellular Regulation of Inflammation and the
Biological Clock 92
4.5 Concluding Remarks 94
5. Vasoactive Intestinal Polypeptide and Prolactin Cytokines: Role in
Sleep and Some Immune Aspects 97
Fabio Garcia Garcia, Tatiana Olivares Banuelos and Rene Drucker
Coli n
Contents vii
5.1 Introduction 97
5.2 Vasoactive Intestinal Polypeptide (VIP) 98
5.2.1 Receptors 98
5.2.2 Gene Regulation 98
5.3 VIP: Brain Distribution 99
5.4 VIP and Sleep Regulation 99
5.5 How VIP Induces REMS: a Hypothesis 102
5.6 VIP Clinical Implications 102
5.7 Prolactin (PRL) 103
5.8 PRL Molecular Aspects 103
5.8.1 Gene Regulation 104
5.8.2 Posttranslational Modifications 104
5.9 PRL and Sleep Regulation 105
5.10 Relationship Between PRL and Stress 107
5.11 Stress and REMS: Role of PRL 108
5.12 PRL Expression and REMS 109
5.13 PRL Clinical Implications 109
6. Immune Signaling to Brain: Mechanisms and Potential Pathways
Influencing Sleep 119
Lisa Goehler and Ronald Gaykema
6.1 Introduction 119
6.2 Mechanisms of Immune Signaling to the Brain 119
6.2.1 Neural Pathways 119
6.2.2 Endocrine Like Pathways: Immune Sensing within the
Brain 122
6.3 Neurocircuitry Mediating Sleep and Waking States 124
6.4 What are the Links Between Immune Brain Interfaces and Sleep
Neurocircuitry? 124
6.4.1 Primary Sensory Relay Nuclei 126
6.4.2 Ascending Pathways Influencing Arousal 127
6.5 Conclusions and Perspectives 127
7. Aging, Sleep, and Immunity 133
Laura Yvette Gorczynski, Ender Terzioglu, Thierry Waelli andR.M.
Gorczynski
7.1 Introduction 133
7.2 Altered Sleep and Concomitant Alterations in Immune Function 133
7.3 Cytokines and Sleep 135
7.4 Relationship of Infection to Altered Sleep Behavior 138
7.5 Stress, Hormonal Change, Cytokines, and Sleep Behavior 140
7.6 Age Related Changes in Sleep and Relation to Altered Immunity 143
7.7 Summary and Conclusions 148
8. Cytokines and Sleep: Neuro immune Interactions and Regulations 155
Tetsuya Kushikala, Hitoshi Yoshida and Tadanohu Yasuda
8.1 Introduction 155
8.2 Effect of Sleep on Immune System 155
viii Contents
8.2.1 Sleep Pattern and Immune Function 155
8.2.2 Sleep Deprivation and Immune System 156
8.3 Effect of Modulation of Immune System on Sleep 156
8.3.1 Overview 156
8.3.2 Microbial Products, Cytokines, Sleep 157
8.3.3 Proinflammatory Cytokines on Sleep 157
8.3.4 Anti Inflammatory Cytokines on Sleep 160
8.3.5 Molecular Level Modulation of Cytokines on Sleep 160
8.4 Conclusion 161
9. Selective REM Sleep Deprivation and Its Impact on the Immune
Response 167
Javier Velazquez Moctezuma, Jose Angel Rojas Zamorano, Enrique
Esqueda Leon, Andres Quintanar Stephano and Anabel Jimenez
Anguiano
9.1 Introduction 167
9.2 Human Studies 168
9.3 Animal Studies 169
Part III Clinical Research 175
10. Sleep and Immune Correlates: Translational Research in Clinical
Populations 177
Sarosh J. Motivala and Michael Irwin
10.1 The Rationale for Studying Sleep and Immunity in Clinical
Populations 177
10.2 Sleep and Immunity in Primary Insomnia 178
10.2.1 Effects of Experimental Sleep Loss 178
10.2.2 Primary Insomnia 179
10.2.3 Insomnia in Aging: Influence on Immunity 180
10.2.4 Cytokines: Role in the Regulation of Sleep 181
10.3 Sleep and Immunity in Depression and Substance Dependence 182
10.3.1 Depression and Immunity 183
10.3.2 Alcohol Dependence, Sleep, and Immunity 184
10.4 Sleep and Cytokines in Rheumatoid Arthritis 187
10.5 Future Directions 189
11. The Stress of Inadequate Sleep and Immune Consequences 195
Beatriz Duarte Palma, Sergio Tufik and Deborah Suchecki
11.1 Introduction 195
11.2 Inadequate Sleep and Disease 197
11.3 Immune Function in Sleep Disorders 198
11.4 Hospitalized Patients 199
11.5 Chronic Inflammatory Diseases and Sleep 200
11.6 Concluding remarks 202
Contents ix
12. Neuroimmunology of Pregnancy Related Sleep Disturbances 207
Michele L. Ohm and Mary E. Coussons Read
12.1 Introduction 207
12.2 Pregnancy and Alterations in Sleep 207
12.2.1 Generalized Sleep Patterns across Pregnancy 207
12.2.2 Sleep Measured by In lab Polysomnography 208
12.2.3 Sleep Measured by Ambulatory PSG 209
12.2.4 Sleep Measured by Subjective Reports 210
12.3 Understanding Sleep in Pregnancy via Animal Models 212
12.4 Factors That May Contribute to Disrupted Sleep During Pregnancy 212
12.4.1 Psychosocial Factors 212
12.4.2 Immunological Factors—Cytokines 214
12.4.3 Endocrinological Factors—Hormones 215
12.5 Where Does Sleep Fit In? The Cytokine and Hormone Changes
Associated with Sleep Deprivation/Sleep Disorders 216
12.6 Pregnancy Complications 218
12.7 Summary 220
13. Changes in Sleep and Behavior Following Experimental Immune
Stimulation Using Bacterial Endotoxin in Humans 227
Andreas Schuld, Monika Haack, Janet Mullington, and Thomas
Pollmdcher
13.1 Introduction 227
13.2 The Role of the Neuroendocrine Immune CNS Interplay in
Clinical Medicine 228
13.3 Changes in Sleep Wake Behavior Following Endotoxin 229
13.4 Changes in Memory, Mood, and Food Intake Following Endotoxin 230
14. Inflammation and Sleep 233
Rita A. Trammell, Krishna Jhaveri, and Linda A. Toth
14.1 Inflammation 233
14.2 Cytokines and Sleep 234
14.3 Acute Inflammation and Sleep 234
14.4 Chronic Inflammation and Sleep 236
14.4.1 Chronic infections 236
14.4.2 Chronic Fatigue Syndrome 237
14.4.3 Obesity and Type 2 Diabetes 238
14.4.4 Cancer 239
14.4.5 Age Related Inflammation 240
14.5 Genetic Variation in Sleep and Inflammation 240
14.5.1 Genetic Variation in the Inflammatory Response 240
14.5.2 Genetic Variation in Sleep Under Normal Conditions and
during Inflammatory Disease 241
14.5.3 The Intersection of Genetic Variation in Sleep and
Inflammation 243
14.6 Summary and Conclusions 245
x Contents
15. Neuroimmune Activation in Sleep Apnea 257
Paul J. Mills, Michael G. Ziegier, and Joel E. Dimsdale
15.1 Introduction 257
15.2 Adrenergic Agonists and Receptors 257
15.3 Norepinephrine Release and Clearance 261
15.4 Cytokines in OSA 263
15.4.1 Cytokines and Normal Sleep 263
15.4.2 Cytokines and OSA 263
15.4.3 What Features of OSA Might Lead to Elevations of
Inflammatory Cytokines? 264
15.4.4 Cytokines in the Context of Mood and Quality Of Life in
OSA 265
15.5 Nasal Continuous Positive Airway Pressure 266
15.5.1 CPAP Effects on NE levels and Adrenergic Receptors 267
15.5.2 CPAP Effects on NE Kinetics 269
15.5.3 CPAP Effects on Inflammation 271
15.6 Summary 271
16. Role and Circadian Rhythms of Proinflammatory Cytokines,
Cortisol, and Melatonin in Children with Obstructive Sleep Apnea
Syndrome 275
Luana Nosetti and Luigi Nespoli
16.1 Obstructive Sleep Apnea Syndrome in Children: Clinical Features 275
16.2 Pathophysiology of OSAS 276
16.3 OSAS Neuroimmunology 277
16.4 Melatonin Role and Circadian Rhythms in Children with OSAS 278
16.5 Cortisol Role and Circadian Rhythms in OSAS 280
16.6 Proinflammatory Cytokines Role and Circadian Rhythms in OSAS 281
16.6.1 TNF, IL ip 281
16.6.2 Other Cytokines 281
16.6.3 Proinflammatory Cytokines Circadian Rhythms in OSAS 282
17. Neuroendocrine Immune Correlates of Sleep and Traumatic Brain
Injury (TBI) 285
Paolo Prolo and Anna N. Taylor
17.1 Introduction 285
17.2 TBI and the Neuroendocrine System 285
17.3 TBI and Immune Surveillance 288
17.4 TBI and Sleep 288
17.5 Conclusions 291
18. Neuroimmune Correlates of Sleep in Depression: Role of Cytokines 295
J. Szelenyi and E.S. Vizi
18.1 Introduction 295
18.2 Cytokines and the CNS 295
18.2.1 Cross Talk Between the Innate Immune Response
and Sleep 295
Contents xi
18.3 Administering Different Types and Dosages of Cytokines and
Their Effects on Sleep 298
18.4 Effect of Deprivation of Cytokines on the Duration and Pattern of
Sleep 299
18.5 Studying the Effects of Sleep Deprivation/Disruption on Cytokine
Production 300
18.6 Regulation of Cytokine Balance by Monoamines in Healthy and in
Depressed States 301
18.7 Sleep Disturbances in Diseased States Associated with Altered
Cytokine Profile 304
18.7.1 Infection 304
18.7.2 Depression 305
18.8 Cytokine Balance and Antidepressants 308
18.8.1 Effect of Multitarget Drugs (e.g. Monoamine Transporter
Blockers) 308
18.9 Conclusions 311
19. Sleep and Neuroimmune Function in Chronic Fatigue Syndrome 321
Fumiharu Togo, Benjamin H. Natelson, and Neil Cherniack
19.1 Introduction 321
19.2 Neurological and Neuropsychological Dysfunction in CFS 322
19.3 Sleep Studies in CFS 323
19.4 The Neural Immune System in CFS 327
20. Narcolepsy with Cataplexy. Hypocretin and Immunological Aspects 337
Yves Dauvilliers
20.1 Epidemiology and Clinical Features 337
20.1.1 Excessive Daytime Sleepiness 338
20.1.2 Cataplexy 338
20.1.3 Associated Features 338
20.1.4 Diagnostic Criteria 339
20.2 Pathophysiology 339
20.2.1 Hypocretin (Orexin) System 339
20.2.2 Genetic and Environmental Factors in Human Narcolepsy 343
20.2.3 Autoimmunity Hypothesis in Human Narcolepsy 345
20.3 Treatment 347
20.4 Conclusion 349
Index 353
|
| adam_txt |
Contents
Preface xiii
Acknowledgments xv
Contributors xvii
Part I General Concepts 1
1. Bidirectional Communication Between the Brain and the Immune
System 3
Douglas A. Weigent and J. Edwin Blalock
1.1 Introduction 3
1.2 Nervous System Communication to the Immune System 6
1.3 Neuroendocrine Hormone Influence on the Immune System 8
1.4 Actions of Hypothalamic Releasing Hormones 10
1.5 Immune System Communication with the Nervous System
Hormones 11
1.6 Cytokine Influences on the Nervous System 12
1.7 Neuroendocrine Hormone Release by Cells of the Immune System 14
1.8 Neurotransmitter Release by Cells of the Immune System 16
1.9 Bidirectional Communication and Sleep 17
1.10 Summary and Conclusions 17
2. Neuroimmunological Correlates of Circadian Rhythmicity in Oral
Biology and Medicine 27
Francesco Chiappelli, Olivia S. Cajulis, Audrey Navarro and David R.
Moradi
2.1 Introduction 27
vi Contents
2.2 Allostatic Response and Allostatic Intervention: Relevance to Oral
Biology and Medicine 29
2.2.1 Allostasis 29
2.2.2 Allostatic Load 30
2.2.3 Allostatic Testing and Intervention 32
2.2.4 Allostasis Is Not Chaos or Is It? 34
2.3 Mucositis: A Case of Allostatic Load 36
2.3.1 Oral Mucositis 36
2.3.2 Neuroendocrine Immune Orderly Chaos in OM 39
2.3.3 Circadian Neurobiology and Neuroimmunopathology in
OM 46
2.4 Directions for the Future 49
3. Circadian Organization of the Immune Response: Lessons from the
Adjuvant Arthritis Model 59
Daniel P. Cardinali, Ana I. Esquifino, Georges J. M. Maestroni and
Seithikurippu R. Pandi Perumal
3.1 The Circadian Clock is One of the most Indispensable Biological
Functions 59
3.2 The Immune System Shows Circadian Organization 61
3.3 "Sickness Behavior" Includes Changes in Circadian Rhythms 64
3.4 The Rat Adjuvant Arthritis is an Experimental Model of
Rheumatoid Arthritis 66
3.5 Adjuvant Arthritis Disrupts Normal Chronobiological
Organization 68
3.6 Melatonin as a Circadian Immunoregulatory Signal in Adjuvant
Arthritis 72
Part II Basic Research 85
4. The Biological Clock in Inflammation and Sleep Switch Alterations 87
Marina Bentivoglio, Mikael Nygard, Maria Palomba and Krister
Kristensson
4.1 Introduction 87
4.2 Interactions Between the Biological Clock and the Sleep Switch 87
4.3 Effects of Inflammatory Molecules on the SCN and Sleep Switch
Structures 90
4.4 Intracellular Inflammatory Regulators 92
4.4.1 SHP, PIAS, and SOCS 92
4.4.2 Intracellular Regulation of Inflammation and the
Biological Clock 92
4.5 Concluding Remarks 94
5. Vasoactive Intestinal Polypeptide and Prolactin Cytokines: Role in
Sleep and Some Immune Aspects 97
Fabio Garcia Garcia, Tatiana Olivares Banuelos and Rene Drucker
Coli'n
Contents vii
5.1 Introduction 97
5.2 Vasoactive Intestinal Polypeptide (VIP) 98
5.2.1 Receptors 98
5.2.2 Gene Regulation 98
5.3 VIP: Brain Distribution 99
5.4 VIP and Sleep Regulation 99
5.5 How VIP Induces REMS: a Hypothesis 102
5.6 VIP Clinical Implications 102
5.7 Prolactin (PRL) 103
5.8 PRL Molecular Aspects 103
5.8.1 Gene Regulation 104
5.8.2 Posttranslational Modifications 104
5.9 PRL and Sleep Regulation 105
5.10 Relationship Between PRL and Stress 107
5.11 Stress and REMS: Role of PRL 108
5.12 PRL Expression and REMS 109
5.13 PRL Clinical Implications 109
6. Immune Signaling to Brain: Mechanisms and Potential Pathways
Influencing Sleep 119
Lisa Goehler and Ronald Gaykema
6.1 Introduction 119
6.2 Mechanisms of Immune Signaling to the Brain 119
6.2.1 Neural Pathways 119
6.2.2 Endocrine Like Pathways: Immune Sensing within the
Brain 122
6.3 Neurocircuitry Mediating Sleep and Waking States 124
6.4 What are the Links Between Immune Brain Interfaces and Sleep
Neurocircuitry? 124
6.4.1 Primary Sensory Relay Nuclei 126
6.4.2 Ascending Pathways Influencing Arousal 127
6.5 Conclusions and Perspectives 127
7. Aging, Sleep, and Immunity 133
Laura Yvette Gorczynski, Ender Terzioglu, Thierry Waelli andR.M.
Gorczynski
7.1 Introduction 133
7.2 Altered Sleep and Concomitant Alterations in Immune Function 133
7.3 Cytokines and Sleep 135
7.4 Relationship of Infection to Altered Sleep Behavior 138
7.5 Stress, Hormonal Change, Cytokines, and Sleep Behavior 140
7.6 Age Related Changes in Sleep and Relation to Altered Immunity 143
7.7 Summary and Conclusions 148
8. Cytokines and Sleep: Neuro immune Interactions and Regulations 155
Tetsuya Kushikala, Hitoshi Yoshida and Tadanohu Yasuda
8.1 Introduction 155
8.2 Effect of Sleep on Immune System 155
viii Contents
8.2.1 Sleep Pattern and Immune Function 155
8.2.2 Sleep Deprivation and Immune System 156
8.3 Effect of Modulation of Immune System on Sleep 156
8.3.1 Overview 156
8.3.2 Microbial Products, Cytokines, Sleep 157
8.3.3 Proinflammatory Cytokines on Sleep 157
8.3.4 Anti Inflammatory Cytokines on Sleep 160
8.3.5 Molecular Level Modulation of Cytokines on Sleep 160
8.4 Conclusion 161
9. Selective REM Sleep Deprivation and Its Impact on the Immune
Response 167
Javier Velazquez Moctezuma, Jose Angel Rojas Zamorano, Enrique
Esqueda Leon, Andres Quintanar Stephano and Anabel Jimenez
Anguiano
9.1 Introduction 167
9.2 Human Studies 168
9.3 Animal Studies 169
Part III Clinical Research 175
10. Sleep and Immune Correlates: Translational Research in Clinical
Populations 177
Sarosh J. Motivala and Michael Irwin
10.1 The Rationale for Studying Sleep and Immunity in Clinical
Populations 177
10.2 Sleep and Immunity in Primary Insomnia 178
10.2.1 Effects of Experimental Sleep Loss 178
10.2.2 Primary Insomnia 179
10.2.3 Insomnia in Aging: Influence on Immunity 180
10.2.4 Cytokines: Role in the Regulation of Sleep 181
10.3 Sleep and Immunity in Depression and Substance Dependence 182
10.3.1 Depression and Immunity 183
10.3.2 Alcohol Dependence, Sleep, and Immunity 184
10.4 Sleep and Cytokines in Rheumatoid Arthritis 187
10.5 Future Directions 189
11. The Stress of Inadequate Sleep and Immune Consequences 195
Beatriz Duarte Palma, Sergio Tufik and Deborah Suchecki
11.1 Introduction 195
11.2 Inadequate Sleep and Disease 197
11.3 Immune Function in Sleep Disorders 198
11.4 Hospitalized Patients 199
11.5 Chronic Inflammatory Diseases and Sleep 200
11.6 Concluding remarks 202
Contents ix
12. Neuroimmunology of Pregnancy Related Sleep Disturbances 207
Michele L. Ohm and Mary E. Coussons Read
12.1 Introduction 207
12.2 Pregnancy and Alterations in Sleep 207
12.2.1 Generalized Sleep Patterns across Pregnancy 207
12.2.2 Sleep Measured by In lab Polysomnography 208
12.2.3 Sleep Measured by Ambulatory PSG 209
12.2.4 Sleep Measured by Subjective Reports 210
12.3 Understanding Sleep in Pregnancy via Animal Models 212
12.4 Factors That May Contribute to Disrupted Sleep During Pregnancy 212
12.4.1 Psychosocial Factors 212
12.4.2 Immunological Factors—Cytokines 214
12.4.3 Endocrinological Factors—Hormones 215
12.5 Where Does Sleep Fit In? The Cytokine and Hormone Changes
Associated with Sleep Deprivation/Sleep Disorders 216
12.6 Pregnancy Complications 218
12.7 Summary 220
13. Changes in Sleep and Behavior Following Experimental Immune
Stimulation Using Bacterial Endotoxin in Humans 227
Andreas Schuld, Monika Haack, Janet Mullington, and Thomas
Pollmdcher
13.1 Introduction 227
13.2 The Role of the Neuroendocrine Immune CNS Interplay in
Clinical Medicine 228
13.3 Changes in Sleep Wake Behavior Following Endotoxin 229
13.4 Changes in Memory, Mood, and Food Intake Following Endotoxin 230
14. Inflammation and Sleep 233
Rita A. Trammell, Krishna Jhaveri, and Linda A. Toth
14.1 Inflammation 233
14.2 Cytokines and Sleep 234
14.3 Acute Inflammation and Sleep 234
14.4 Chronic Inflammation and Sleep 236
14.4.1 Chronic infections 236
14.4.2 Chronic Fatigue Syndrome 237
14.4.3 Obesity and Type 2 Diabetes 238
14.4.4 Cancer 239
14.4.5 Age Related Inflammation 240
14.5 Genetic Variation in Sleep and Inflammation 240
14.5.1 Genetic Variation in the Inflammatory Response 240
14.5.2 Genetic Variation in Sleep Under Normal Conditions and
during Inflammatory Disease 241
14.5.3 The Intersection of Genetic Variation in Sleep and
Inflammation 243
14.6 Summary and Conclusions 245
x Contents
15. Neuroimmune Activation in Sleep Apnea 257
Paul J. Mills, Michael G. Ziegier, and Joel E. Dimsdale
15.1 Introduction 257
15.2 Adrenergic Agonists and Receptors 257
15.3 Norepinephrine Release and Clearance 261
15.4 Cytokines in OSA 263
15.4.1 Cytokines and Normal Sleep 263
15.4.2 Cytokines and OSA 263
15.4.3 What Features of OSA Might Lead to Elevations of
Inflammatory Cytokines? 264
15.4.4 Cytokines in the Context of Mood and Quality Of Life in
OSA 265
15.5 Nasal Continuous Positive Airway Pressure 266
15.5.1 CPAP Effects on NE levels and Adrenergic Receptors 267
15.5.2 CPAP Effects on NE Kinetics 269
15.5.3 CPAP Effects on Inflammation 271
15.6 Summary 271
16. Role and Circadian Rhythms of Proinflammatory Cytokines,
Cortisol, and Melatonin in Children with Obstructive Sleep Apnea
Syndrome 275
Luana Nosetti and Luigi Nespoli
16.1 Obstructive Sleep Apnea Syndrome in Children: Clinical Features 275
16.2 Pathophysiology of OSAS 276
16.3 OSAS Neuroimmunology 277
16.4 Melatonin Role and Circadian Rhythms in Children with OSAS 278
16.5 Cortisol Role and Circadian Rhythms in OSAS 280
16.6 Proinflammatory Cytokines Role and Circadian Rhythms in OSAS 281
16.6.1 TNF, IL ip 281
16.6.2 Other Cytokines 281
16.6.3 Proinflammatory Cytokines Circadian Rhythms in OSAS 282
17. Neuroendocrine Immune Correlates of Sleep and Traumatic Brain
Injury (TBI) 285
Paolo Prolo and Anna N. Taylor
17.1 Introduction 285
17.2 TBI and the Neuroendocrine System 285
17.3 TBI and Immune Surveillance 288
17.4 TBI and Sleep 288
17.5 Conclusions 291
18. Neuroimmune Correlates of Sleep in Depression: Role of Cytokines 295
J. Szelenyi and E.S. Vizi
18.1 Introduction 295
18.2 Cytokines and the CNS 295
18.2.1 Cross Talk Between the Innate Immune Response
and Sleep 295
Contents xi
18.3 Administering Different Types and Dosages of Cytokines and
Their Effects on Sleep 298
18.4 Effect of Deprivation of Cytokines on the Duration and Pattern of
Sleep 299
18.5 Studying the Effects of Sleep Deprivation/Disruption on Cytokine
Production 300
18.6 Regulation of Cytokine Balance by Monoamines in Healthy and in
Depressed States 301
18.7 Sleep Disturbances in Diseased States Associated with Altered
Cytokine Profile 304
18.7.1 Infection 304
18.7.2 Depression 305
18.8 Cytokine Balance and Antidepressants 308
18.8.1 Effect of Multitarget Drugs (e.g. Monoamine Transporter
Blockers) 308
18.9 Conclusions 311
19. Sleep and Neuroimmune Function in Chronic Fatigue Syndrome 321
Fumiharu Togo, Benjamin H. Natelson, and Neil Cherniack
19.1 Introduction 321
19.2 Neurological and Neuropsychological Dysfunction in CFS 322
19.3 Sleep Studies in CFS 323
19.4 The Neural Immune System in CFS 327
20. Narcolepsy with Cataplexy. Hypocretin and Immunological Aspects 337
Yves Dauvilliers
20.1 Epidemiology and Clinical Features 337
20.1.1 Excessive Daytime Sleepiness 338
20.1.2 Cataplexy 338
20.1.3 Associated Features 338
20.1.4 Diagnostic Criteria 339
20.2 Pathophysiology 339
20.2.1 Hypocretin (Orexin) System 339
20.2.2 Genetic and Environmental Factors in Human Narcolepsy 343
20.2.3 Autoimmunity Hypothesis in Human Narcolepsy 345
20.3 Treatment 347
20.4 Conclusion 349
Index 353 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
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| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| doi_str_mv | 10.1007/978-0-387-69146-6 |
| format | Electronic eBook |
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| id | DE-604.BV023009348 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T19:08:46Z |
| indexdate | 2024-07-09T21:08:52Z |
| institution | BVB |
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| language | English |
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| spelling | Neuroimmunology of sleep S. R. Pandi-Perumal ; Daniel P. Cardinali ; George P. Chrousos Dordrecht Springer 2007 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Schlaf (DE-588)4052580-6 gnd rswk-swf Neuroimmunologie (DE-588)4115376-5 gnd rswk-swf Schlaf (DE-588)4052580-6 s Neuroimmunologie (DE-588)4115376-5 s b DE-604 Pandi-Perumal, Seithikurippu R. 1964- Sonstige (DE-588)131380419 oth Cardinali, Daniel P. Sonstige oth Chrousos, George P. Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 0-387-69144-8 Erscheint auch als Druck-Ausgabe, Hardcover 978-0-387-69144-2 https://doi.org/10.1007/978-0-387-69146-6 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016213587&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neuroimmunology of sleep Schlaf (DE-588)4052580-6 gnd Neuroimmunologie (DE-588)4115376-5 gnd |
| subject_GND | (DE-588)4052580-6 (DE-588)4115376-5 |
| title | Neuroimmunology of sleep |
| title_auth | Neuroimmunology of sleep |
| title_exact_search | Neuroimmunology of sleep |
| title_exact_search_txtP | Neuroimmunology of sleep |
| title_full | Neuroimmunology of sleep S. R. Pandi-Perumal ; Daniel P. Cardinali ; George P. Chrousos |
| title_fullStr | Neuroimmunology of sleep S. R. Pandi-Perumal ; Daniel P. Cardinali ; George P. Chrousos |
| title_full_unstemmed | Neuroimmunology of sleep S. R. Pandi-Perumal ; Daniel P. Cardinali ; George P. Chrousos |
| title_short | Neuroimmunology of sleep |
| title_sort | neuroimmunology of sleep |
| topic | Schlaf (DE-588)4052580-6 gnd Neuroimmunologie (DE-588)4115376-5 gnd |
| topic_facet | Schlaf Neuroimmunologie |
| url | https://doi.org/10.1007/978-0-387-69146-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016213587&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pandiperumalseithikurippur neuroimmunologyofsleep AT cardinalidanielp neuroimmunologyofsleep AT chrousosgeorgep neuroimmunologyofsleep |