The biology of human longevity: inflammation, nutrition, and aging in the evolution of life spans
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
San Diego, Calif. [u.a.]
Elsevier, Acad. Press
2007
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturverz. S. 417 - 599 |
| Beschreibung: | XIII, 626 S. Ill., graph. Darst. |
| ISBN: | 9780123736574 |
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| 245 | 1 | 0 | |a The biology of human longevity |b inflammation, nutrition, and aging in the evolution of life spans |c Caleb E. Finch |
| 264 | 1 | |a San Diego, Calif. [u.a.] |b Elsevier, Acad. Press |c 2007 | |
| 300 | |a XIII, 626 S. |b Ill., graph. Darst. | ||
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| 500 | |a Literaturverz. S. 417 - 599 | ||
| 650 | 4 | |a Longevity |x Physiological aspects | |
| 650 | 4 | |a Aging |x Physiological aspects | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Nutrition | |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
Preface xi
Acknowledgments xiii
Chapter 1
Inflammation and Oxidation in Aging
and Chronic Diseases
PARTI
1.1. Overview 2
1.2. Experimental Models for Aging 10
1.2.1. Mortality Rate Accelerations 10
1.2.2. Mammals 12
1.2.3 Cultured Cell Models and Replicative Senescence 31
1.2.4. Invertebrate Models 32
1.2.5. Yeast 34
1.2.6. The Biochemistry of Aging 35
1.2.7. Biomarkers of Aging and Mortality Risk Markers 42
1.2.8. Evolutionary Theories of Aging 44
1.3. Outline of Inflammation 49
1.3.1. Innate Defense Mechanisms 50
1.3 2. Genetic Variations of Inflammatory Responses 54
1.3 3. Inflammation and Energy 56
1.3.4. Amyloids and Inflammation 59
1.4. Bystander Damage and Dependent Variables
in Senescence 60
1.4.1. Free Radical Bystander Damage (Type 1) 61
1.4.2. Glyco oxidation (Type 2) 63
1.4.3 Chronic Proliferation (Type 3) 63
1.4.4. Mechanical Bystander Effects (Type 4) 64
PARTII
1.5. Arterial Aging and Atherosclerosis 65
1.5.1. Overview and Ontogeny 66
v
vi Contents
1.5.2. Hazards of Hypertension 74
1.5.3 Mechanisms 75
1.5.3.1. Inflammation 75
1.5.3.2. Hemodynamics 79
1.5.3.3. Aging 81
1.5.3.4. Endothelial Progenitor Cells 84
1.5.4. Blood Risk Factors for Vascular Disease and
Overlap with Acute Phase Responses 84
1.6. Alzheimer Disease and Vascular related Dementias 86
1.6.1. Neuropathology of Alzheimer Disease 87
1.6.2. Inflammation in Alzheimer Disease 91
1.6.3 Prodromal Stages of Alzheimer Disease 94
1.6.4. Overlap of Alzheimer and Cerebrovascular Changes 95
1.6.5. Insulin and IGF 1 in Vascular Disease and
Alzheimer Disease 99
1.6.6. Blood Inflammatory Proteins: Markers for
Disease or Aging, or Both? 101
1.7. Inflammation in Obesity 103
1.8. Processes of Normal Aging in the Absence of
Specific Diseases 106
1.8.1. Brain 107
1.8.2. Generalized Inflammatory Changes in Normal
Tissue Aging 107
1.9. Summary 112
Chapter 2
Infections, Inflammogens, and Drugs
2.1. Introduction 114
2.2. Vascular Disease 114
2.2.1. Historical Associations of Infections and Vascular
Mortality 114
2.2.2. Modern Serologic Associations 115
2.3. Infections from the Central Tube: Metchnikoff
Revisited 121
2.3.1. Humans: Leakage from Periodontal Disease
and Possibly the Lower Intestine 121
2.3 2. Worms and Flies as Models for Human
Intestinal Microbial Intrusion 125
2.4. Aerosols and Dietary Inflammogens 126
2.4.1. Aerosols 127
2.4.2. Food 129
Contents vii
2.5. Infections, inflammation, and life Span 131
2.5.1. Historical Human Populations 131
2.52. Longer Rodent Life Spans with Improved
Husbandry 136
2.6. Are Infections a Cause of Obesity? 142
2.7. Inflammation, Dementia, and Cognitive Decline 143
2.7.1. Alzheimer Disease 143
2.7.2. HIV, Dementia, and Amyloid 145
2.7.3 Peripheral Amyloids 147
2.7.4. Inflammation and Cognitive Decline
During Usual Aging 147
2.8. Immunosenescence and Stem Cells 150
2.8.1. Immunosenescence and Cumulative Exposure 150
2.8.2. Immunosenescence and Telomere Loss 152
2.8.3 Inflammation and Stem Cells 153
2.9 Cancer, Infection, and inflammation 154
2.9 1. Helicobacter Pylori and Hepatitis B Virus 154
2.92. Smoking and Lung Cancer 156
2.10. Pharmacopleiotropies in Vascular Disease,
Dementia, and Cancer 158
2.10.1. Anti inflammatory and Anti coagulant Drugs 158
2.10.2. Aspirin and Other NSAIDs 161
2.10.3. Statins 162
2.10.31. Vascular Disease 162
2.10.3.2. Dementia 164
2.10.4. Sex Steroid Replacement (Hormone Therapy) 165
2.10.5. Plant derived Micronutrients and Neutriceuticals 169
2.11. Summary 172
Chapter 3
Energy Balance, Inflammation, and Aging
3.1. Introduction 176
3.2. Diet Restriction and Aging 177
3.2.1. Overview of Animal Models 177
3.2.2. Diet Restriction and Disease in Rodent Models 184
3 2.3. Diet Restriction, Starvation, Vascular Disease,
and Longevity in Humans 186
3.2.4. Diet Restriction, Infections and Inflammation 192
3 2.5. Somatic Repair and Regeneration 199
viii Contents
3.3. Energy Sensing in Diet Restriction and Satiety 200
3.3.1. Physiology 201
3.3.2. Biochemistry 202
3.3.3. Relevance to Arterial Disease and Cancer 210
3.4. Exercise, Cardiovascular Health, and Longevity 211
3.4.1. Humans 212
3.4.2. Rodent Models 215
3.4.3. Mechanisms in Exercise and Longevity 216
3.5. Diet, Exercise, and Neurodegeneration 219
3.5.1. Alzheimer Disease 219
3.5.2. Synaptic Atrophy in the Absence of
Neurodegeneration 221
3.6. Laboratory Rodents as Models 225
for the Couch Potato
3.7. Energy Balance in the Life History 228
3.8. Summary 231
Chapter 4
Nutrition and Infection in the Developmental
Influences on Aging
4.1. Introduction 234
4.2. Synopsis of the Fetal Origins Theory 236
4.3. The Barker Studies of Infections 241
and Vascular Disease
4.4. Size, Health, and Longevity 245
4.4.1. Adult Height, Vascular Disease, and Longevity 246
4.4.2. Size at Birth and Adult Height 249
4.4.3. Criteria for Growth Retardation 252
4.4.4. Maternal Metabolism and Fetal Growth 254
4.4.5. Birth Size and Adult Vascular
and Metabolic Disease 258
4.4.6. Twins: Small Size at Birth and Catch up
Growth, but Normal Longevity 262
4.5. Infection and Undernutrition on Birthweight
and Later Disease 262
4.5.1. The Tangle 263
4.5.2. Maternal Infections and Nutrition 263
4.5.3. Smoking and Aerosols 267
Contents ix
4.6. Infection and Nutrition in Postnatal
Development and Later Disease 267
4.6.1. Diarrheas in Growth Retardation 267
4.6.2. Seasonal Effects 268
4.6.3 Serum Immune Response Markers of Chronic
Infection in Health Poor Children 270
4.6.4. Infections During Development 272
4.6.5. The Cost of Infections to Postnatal Growth:
Evidence from Migration and Antibiotics 273
4.6.6. Unknowns 275
4.7. Famine 276
4.7.1. World War II (WWII) 276
4.7.2. 19th Century Famines 286
4.8. Maternal Physiology, Fetal Growth,
and Later Chronic Disease 289
4.9 Growth in Adaptive Responses to the
Environment 295
4.10. Genomics of Fetal Growth Regulation 298
4.10.1. Inherited Genetic Variations 299
4.10.2. Gene Imprinting: Inherited but Epigenetic
Influences on Development 299
4.11. Summary 302
Chapter 5
Genetics
5.1. Introduction 306
5.2. Sources of Individual Variations in Aging
and life Span 306
5.3. Sex Differences in Longevity 310
5.4. Metabolism and Host Defense in Worm
and Fly 315
5.4.1. Metabolic Gene Signaling 315
5.4.2. Immunity and Metabolism 318
5.5. The Worm 323
5.5.1. Overview 323
5 5.2. Slower Eating Increases Life Span 325
5.5.3 Metabolism and Host Defense 325
5.6. Fly 329
5.6.1. Overview 329
5.6.2. Metabolism and Diet Restriction 330
X Contents
5.6.3. Heart 333
5.6.4. Infections, Host Defense, and Stress Resistance 335
5.6.5. Natural Variations in Longevity Pathways 337
5.7. Mammals 338
5.7.1. Growth and Metabolism 338
5.7.1.1. Rodent Mutants with Altered Insulin
Signaling and Fat Metabolism 343
5.7.1.2. Human Hereditary Variations
in Metabolic Genes 351
5.7.1.3. Size and Longevity 354
5.7.1.4. The Insulin Sensitivity Paradox 355
5.7.2. Inflammation 355
5.7.3 Lipoproteins and Cholesterol Metabolism 357
5.7.4. ApoE4 Interactions with Diet, Cognition,
and Vascular Aging 363
5.7.5. ApoE Alleles, Infection, and Reproduction 368
5.8. Summary 370
Chapter 6
The Human Life Span: Present, Past, and Future
6.1. Introduction 373
6.2. From Great Ape to Human 376
6.2.1. Human Life History Evolution 376
6.2.2. Chimpanzee Aging 383
6.2.3. The Evolution of Meat Eating 385
6.2.4. Meat Adaptive Genes 391
6.2.5. The Increase in Life Expectancy 402
6.3. Four Major Shifts in Human life History from
Genetic and Cultural Evolution 404
6.4. The Instability of life Spans 406
6.4.1. Infections 406
6.4.2. Air Quality 409
6.4.3. Obesity and Diabetes 410
6.4.4. Prospects 412
6.5. Summary of Chapters 1 6: Mechanisms in
Aging and life History Evolution 413
References 417
Name Index 599
Subject Index 625
|
| adam_txt |
CONTENTS
Preface xi
Acknowledgments xiii
Chapter 1
Inflammation and Oxidation in Aging
and Chronic Diseases
PARTI
1.1. Overview 2
1.2. Experimental Models for Aging 10
1.2.1. Mortality Rate Accelerations 10
1.2.2. Mammals 12
1.2.3 Cultured Cell Models and Replicative Senescence 31
1.2.4. Invertebrate Models 32
1.2.5. Yeast 34
1.2.6. The Biochemistry of Aging 35
1.2.7. Biomarkers of Aging and Mortality Risk Markers 42
1.2.8. Evolutionary Theories of Aging 44
1.3. Outline of Inflammation 49
1.3.1. Innate Defense Mechanisms 50
1.3 2. Genetic Variations of Inflammatory Responses 54
1.3 3. Inflammation and Energy 56
1.3.4. Amyloids and Inflammation 59
1.4. Bystander Damage and Dependent Variables
in Senescence 60
1.4.1. Free Radical Bystander Damage (Type 1) 61
1.4.2. Glyco oxidation (Type 2) 63
1.4.3 Chronic Proliferation (Type 3) 63
1.4.4. Mechanical Bystander Effects (Type 4) 64
PARTII
1.5. Arterial Aging and Atherosclerosis 65
1.5.1. Overview and Ontogeny 66
v
vi Contents
1.5.2. Hazards of Hypertension 74
1.5.3 Mechanisms 75
1.5.3.1. Inflammation 75
1.5.3.2. Hemodynamics 79
1.5.3.3. Aging 81
1.5.3.4. Endothelial Progenitor Cells 84
1.5.4. Blood Risk Factors for Vascular Disease and
Overlap with Acute Phase Responses 84
1.6. Alzheimer Disease and Vascular related Dementias 86
1.6.1. Neuropathology of Alzheimer Disease 87
1.6.2. Inflammation in Alzheimer Disease 91
1.6.3 Prodromal Stages of Alzheimer Disease 94
1.6.4. Overlap of Alzheimer and Cerebrovascular Changes 95
1.6.5. Insulin and IGF 1 in Vascular Disease and
Alzheimer Disease 99
1.6.6. Blood Inflammatory Proteins: Markers for
Disease or Aging, or Both? 101
1.7. Inflammation in Obesity 103
1.8. Processes of Normal Aging in the Absence of
Specific Diseases 106
1.8.1. Brain 107
1.8.2. Generalized Inflammatory Changes in Normal
Tissue Aging 107
1.9. Summary 112
Chapter 2
Infections, Inflammogens, and Drugs
2.1. Introduction 114
2.2. Vascular Disease 114
2.2.1. Historical Associations of Infections and Vascular
Mortality 114
2.2.2. Modern Serologic Associations 115
2.3. Infections from the Central Tube: Metchnikoff
Revisited 121
2.3.1. Humans: Leakage from Periodontal Disease
and Possibly the Lower Intestine 121
2.3 2. Worms and Flies as Models for Human
Intestinal Microbial Intrusion 125
2.4. Aerosols and Dietary Inflammogens 126
2.4.1. Aerosols 127
2.4.2. Food 129
Contents vii
2.5. Infections, inflammation, and life Span 131
2.5.1. Historical Human Populations 131
2.52. Longer Rodent Life Spans with Improved
Husbandry 136
2.6. Are Infections a Cause of Obesity? 142
2.7. Inflammation, Dementia, and Cognitive Decline 143
2.7.1. Alzheimer Disease 143
2.7.2. HIV, Dementia, and Amyloid 145
2.7.3 Peripheral Amyloids 147
2.7.4. Inflammation and Cognitive Decline
During 'Usual' Aging 147
2.8. Immunosenescence and Stem Cells 150
2.8.1. Immunosenescence and Cumulative Exposure 150
2.8.2. Immunosenescence and Telomere Loss 152
2.8.3 Inflammation and Stem Cells 153
2.9 Cancer, Infection, and inflammation 154
2.9 1. Helicobacter Pylori and Hepatitis B Virus 154
2.92. Smoking and Lung Cancer 156
2.10. Pharmacopleiotropies in Vascular Disease,
Dementia, and Cancer 158
2.10.1. Anti inflammatory and Anti coagulant Drugs 158
2.10.2. Aspirin and Other NSAIDs 161
2.10.3. Statins 162
2.10.31. Vascular Disease 162
2.10.3.2. Dementia 164
2.10.4. Sex Steroid Replacement (Hormone Therapy) 165
2.10.5. Plant derived Micronutrients and Neutriceuticals 169
2.11. Summary 172
Chapter 3
Energy Balance, Inflammation, and Aging
3.1. Introduction 176
3.2. Diet Restriction and Aging 177
3.2.1. Overview of Animal Models 177
3.2.2. Diet Restriction and Disease in Rodent Models 184
3 2.3. Diet Restriction, Starvation, Vascular Disease,
and Longevity in Humans 186
3.2.4. Diet Restriction, Infections and Inflammation 192
3 2.5. Somatic Repair and Regeneration 199
viii Contents
3.3. Energy Sensing in Diet Restriction and Satiety 200
3.3.1. Physiology 201
3.3.2. Biochemistry 202
3.3.3. Relevance to Arterial Disease and Cancer 210
3.4. Exercise, Cardiovascular Health, and Longevity 211
3.4.1. Humans 212
3.4.2. Rodent Models 215
3.4.3. Mechanisms in Exercise and Longevity 216
3.5. Diet, Exercise, and Neurodegeneration 219
3.5.1. Alzheimer Disease 219
3.5.2. Synaptic Atrophy in the Absence of
Neurodegeneration 221
3.6. Laboratory Rodents as Models 225
for the 'Couch Potato'
3.7. Energy Balance in the Life History 228
3.8. Summary 231
Chapter 4
Nutrition and Infection in the Developmental
Influences on Aging
4.1. Introduction 234
4.2. Synopsis of the Fetal Origins Theory 236
4.3. The Barker Studies of Infections 241
and Vascular Disease
4.4. Size, Health, and Longevity 245
4.4.1. Adult Height, Vascular Disease, and Longevity 246
4.4.2. Size at Birth and Adult Height 249
4.4.3. Criteria for Growth Retardation 252
4.4.4. Maternal Metabolism and Fetal Growth 254
4.4.5. Birth Size and Adult Vascular
and Metabolic Disease 258
4.4.6. Twins: Small Size at Birth and Catch up
Growth, but Normal Longevity 262
4.5. Infection and Undernutrition on Birthweight
and Later Disease 262
4.5.1. The Tangle 263
4.5.2. Maternal Infections and Nutrition 263
4.5.3. Smoking and Aerosols 267
Contents ix
4.6. Infection and Nutrition in Postnatal
Development and Later Disease 267
4.6.1. Diarrheas in Growth Retardation 267
4.6.2. Seasonal Effects 268
4.6.3 Serum Immune Response Markers of Chronic
Infection in Health Poor Children 270
4.6.4. Infections During Development 272
4.6.5. The Cost of Infections to Postnatal Growth:
Evidence from Migration and Antibiotics 273
4.6.6. Unknowns 275
4.7. Famine 276
4.7.1. World War II (WWII) 276
4.7.2. 19th Century Famines 286
4.8. Maternal Physiology, Fetal Growth,
and Later Chronic Disease 289
4.9 Growth in Adaptive Responses to the
Environment 295
4.10. Genomics of Fetal Growth Regulation 298
4.10.1. Inherited Genetic Variations 299
4.10.2. Gene Imprinting: Inherited but Epigenetic
Influences on Development 299
4.11. Summary 302
Chapter 5
Genetics
5.1. Introduction 306
5.2. Sources of Individual Variations in Aging
and life Span 306
5.3. Sex Differences in Longevity 310
5.4. Metabolism and Host Defense in Worm
and Fly 315
5.4.1. Metabolic Gene Signaling 315
5.4.2. Immunity and Metabolism 318
5.5. The Worm 323
5.5.1. Overview 323
5 5.2. Slower Eating Increases Life Span 325
5.5.3 Metabolism and Host Defense 325
5.6. Fly 329
5.6.1. Overview 329
5.6.2. Metabolism and Diet Restriction 330
X Contents
5.6.3. Heart 333
5.6.4. Infections, Host Defense, and Stress Resistance 335
5.6.5. Natural Variations in Longevity Pathways 337
5.7. Mammals 338
5.7.1. Growth and Metabolism 338
5.7.1.1. Rodent Mutants with Altered Insulin
Signaling and Fat Metabolism 343
5.7.1.2. Human Hereditary Variations
in Metabolic Genes 351
5.7.1.3. Size and Longevity 354
5.7.1.4. The Insulin Sensitivity Paradox 355
5.7.2. Inflammation 355
5.7.3 Lipoproteins and Cholesterol Metabolism 357
5.7.4. ApoE4 Interactions with Diet, Cognition,
and Vascular Aging 363
5.7.5. ApoE Alleles, Infection, and Reproduction 368
5.8. Summary 370
Chapter 6
The Human Life Span: Present, Past, and Future
6.1. Introduction 373
6.2. From Great Ape to Human 376
6.2.1. Human Life History Evolution 376
6.2.2. Chimpanzee Aging 383
6.2.3. The Evolution of Meat Eating 385
6.2.4. Meat Adaptive Genes 391
6.2.5. The Increase in Life Expectancy 402
6.3. Four Major Shifts in Human life History from
Genetic and Cultural Evolution 404
6.4. The Instability of life Spans 406
6.4.1. Infections 406
6.4.2. Air Quality 409
6.4.3. Obesity and Diabetes 410
6.4.4. Prospects 412
6.5. Summary of Chapters 1 6: Mechanisms in
Aging and life History Evolution 413
References 417
Name Index 599
Subject Index 625 |
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| author | Finch, Caleb Ellicott 1939- |
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| author_facet | Finch, Caleb Ellicott 1939- |
| author_role | aut |
| author_sort | Finch, Caleb Ellicott 1939- |
| author_variant | c e f ce cef |
| building | Verbundindex |
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| ctrlnum | (OCoLC)633508296 (DE-599)BVBBV022962566 |
| dewey-full | 612.68 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.68 |
| dewey-search | 612.68 |
| dewey-sort | 3612.68 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Psychologie Medizin |
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| id | DE-604.BV022962566 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:05:23Z |
| indexdate | 2024-07-09T21:08:40Z |
| institution | BVB |
| isbn | 9780123736574 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016166919 |
| oclc_num | 633508296 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-578 DE-384 |
| owner_facet | DE-19 DE-BY-UBM DE-578 DE-384 |
| physical | XIII, 626 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| spelling | Finch, Caleb Ellicott 1939- Verfasser (DE-588)17207519X aut The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans Caleb E. Finch San Diego, Calif. [u.a.] Elsevier, Acad. Press 2007 XIII, 626 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. 417 - 599 Longevity Physiological aspects Aging Physiological aspects Inflammation Nutrition Altern (DE-588)4068596-2 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Langlebigkeit (DE-588)4166707-4 gnd rswk-swf Lebensdauer (DE-588)4034837-4 gnd rswk-swf Lebensdauer (DE-588)4034837-4 s Langlebigkeit (DE-588)4166707-4 s Altern (DE-588)4068596-2 s Physiologie (DE-588)4045981-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016166919&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Finch, Caleb Ellicott 1939- The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans Longevity Physiological aspects Aging Physiological aspects Inflammation Nutrition Altern (DE-588)4068596-2 gnd Physiologie (DE-588)4045981-0 gnd Langlebigkeit (DE-588)4166707-4 gnd Lebensdauer (DE-588)4034837-4 gnd |
| subject_GND | (DE-588)4068596-2 (DE-588)4045981-0 (DE-588)4166707-4 (DE-588)4034837-4 |
| title | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans |
| title_auth | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans |
| title_exact_search | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans |
| title_exact_search_txtP | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans |
| title_full | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans Caleb E. Finch |
| title_fullStr | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans Caleb E. Finch |
| title_full_unstemmed | The biology of human longevity inflammation, nutrition, and aging in the evolution of life spans Caleb E. Finch |
| title_short | The biology of human longevity |
| title_sort | the biology of human longevity inflammation nutrition and aging in the evolution of life spans |
| title_sub | inflammation, nutrition, and aging in the evolution of life spans |
| topic | Longevity Physiological aspects Aging Physiological aspects Inflammation Nutrition Altern (DE-588)4068596-2 gnd Physiologie (DE-588)4045981-0 gnd Langlebigkeit (DE-588)4166707-4 gnd Lebensdauer (DE-588)4034837-4 gnd |
| topic_facet | Longevity Physiological aspects Aging Physiological aspects Inflammation Nutrition Altern Physiologie Langlebigkeit Lebensdauer |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016166919&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT finchcalebellicott thebiologyofhumanlongevityinflammationnutritionandagingintheevolutionoflifespans |