Molecular biology of human cancers: an advanced student's textbook
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| Sprache: | English |
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Springer
2007
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| Beschreibung: | XVII, 508 S. Ill., graph. Darst. |
| ISBN: | 9781402065590 9781402031854 9781402031861 |
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| 020 | |a 9781402031854 |9 978-1-4020-3185-4 | ||
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| 100 | 1 | |a Schulz, Wolfgang Arthur |d 1954- |e Verfasser |0 (DE-588)1118879279 |4 aut | |
| 245 | 1 | 0 | |a Molecular biology of human cancers |b an advanced student's textbook |c by Wolfgang Arthur Schulz |
| 264 | 1 | |a Dordrecht |b Springer |c 2007 | |
| 300 | |a XVII, 508 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cancer cells |v Textbooks | |
| 650 | 4 | |a Cancer |x Molecular aspects |v Textbooks | |
| 650 | 4 | |a Carcinogenesis |v Textbooks | |
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Datensatz im Suchindex
| _version_ | 1804137209273516032 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
Preface: How to read this book
......................................................... xiii
Acknowledgements
...................................................................... xvii
PART I
-
MOLECULES, MECHANISMS, AND CELLS
1
An Introduction to Human Cancers
.....................................................................1
1.1
An overview of the cancer problem
..................................................................1
1.2
Causes of cancer
...............................................................................................5
Box
1.1
Reactive oxygen species
........................................................................10
1.3
Characteristic Properties of Cancers and Cancer Cells
................................11
Box
1.2:
Hallmarks of Cancer
.............................................................................18
1.4
Characterization and Classification of Cancers in the Clinic
.......................17
1.5
Treatment of Cancer
.......................................................................................21
Further reading
.....................................................................................................23
2
Tumor Genetics
....................................................................................................25
2.1
Cancer as a genetic disease
............................................................................26
2.2.
Genetic alterations in cancer cells
................................................................27
2.3
Inherited predisposition to cancer
..................................................................37
2.4
Cancer genes
..................................................................................................42
2.5
Accumulation of genetic and epigenetic changes in human cancers
.............44
Further reading
.....................................................................................................45
Box
2.1
Tumor viruses in human cancers
...........................................................46
3 DNA
Damage and
DNA
Repair
..........................................................................47
3.1 DNA
damage during replication: base excision and nucleotide excision
repair
..............................................................................................................48
3.2
Nucleotide excision repair and crosslink repair
............................................55
3.3
Strand-break repair
........................................................................................62
3.4
Defects in
DNA
repair and cancer susceptibility
...........................................66
3.5
Cell protection mechanisms in cancer.
...........................................................68
Further reading
.....................................................................................................70
4
Oncogenes
..............................................................................................................71
4.1
Retroviraloncogenes
......................................................................................72
4.2
Slow-acting transforming retroviruses
...........................................................75
4.3
Approaches to the identification of human oncogenes
...................................78
4.4
Functions of human oncogenes
......................................................................84
Further reading
.....................................................................................................89
Box
4.1
Carcinogenesis by HTLV-1
....................................................................90
5
Tumor Suppressor Genes
....................................................................................91
5./
Tumor suppressor genes in hereditary cancers
..............................................92
5.2
RBI and the cell cycle.
....................................................................................97
5.3
TP53 as a different kind of tumor suppressor
..............................................101
VII
5.4
Classification
of tumor
suppressor
genes.....................................................109
Further reading
...................................................................................................111
Box
5.1
Human papilloma viruses
.....................................................................112
6
Cancer Pathways
................................................................................................113
6.1
Cancer Pathways
..........................................................................................114
6.2
МАРК
signaling as a cancer pathway
.........................................................115
6.3
The PI3Kpathway
........................................................................................119
6.4
Regulation of the cell cycle by the
МАРК
and PI3K pathways
...................123
6.5
Modulators of the
МАРК
and PI3K pathways
.............................................126
6.6
The TP53 network
.........................................................................................129
6.7
Signaling by TGF
β
factors
..........................................................................131
6.8
Signaling through
STAT
factors
...................................................................132
6.9
The NFkBpathway
.......................................................................................135
6.10
Developmental regulatory systems as cancer pathways
............................137
Further reading
...................................................................................................144
7
Apoptosis and Replicative Senescence in Cancer
............................................145
7.1
Limits to cell proliferation
............................................................................146
7.2
Mechanisms of apoptosis
..............................................................................150
7.3
Mechanisms of diminished apoptosis in cancer
...........................................156
7.4
Replicative senescence and its disturbances in human cancers
...................159
Further reading
...................................................................................................164
Box
7.1:
Human aging and cancer
.....................................................................165
8
Cancer Epigenetics
.............................................................................................167
8.1
Mechanisms ofepigenetic inheritance
.........................................................168
8.2
Imprinting andX-inactivation
......................................................................770
8.3 DNA methylation..........................................................................................174
8.4
Chromatin structure
......................................................................................179
8.5
Epigenetics of cell differentiation
.................................................................182
8.6
Epigenetics of tissue homeostasis
.................................................................185
Further reading
...................................................................................................191
Box
8.1
Carcinogenesis by
HIV 192
9
Invasion and metastasis
.....................................................................................193
9.1
Invasion and metastasis as multistep processes
...........................................194
9.2
Genes and proteins involved in cell-to-cell and cell-matrix adhesion
.........197
9.3
Genes and proteins involved in extracellular matrix remodeling
during tumor invasion
.................................................................................202
9.4
Angiogenesis
.................................................................................................206
9.5
Interactions of invasive tumors with the immune system
.............................210
9.6
The importance oftumor-stroma interactions
..............................................212
Further reading
...................................................................................................216
Box
9.1
Tumor hypoxia and its consequences
..................................................217
PART II
-
HUMAN CANCERS
10
Leukémiás
and Lymphomas
............................................................................219
10.1
Common properties of
hematologica!
cancers
...........................................221
10.2
Genetic aberrations in
leukémiás
and lymphomas
.....................................223
10.3
Molecular biology ofBurkitt lymphoma
.....................................................226
10.4
Molecular biology ofCML
.........................................................................232
10.5
Molecular biology ofPML
.........................................................................237
Further reading
...................................................................................................242
11
Wilms Tumor (nephroblastoma)
................................................................243
11.1
Histology, etiology and clinical behavior of Wilms tumors
.......................244
11.2
Genetics of Wilms tumors and the WT1 gene
.............................................246
11.3
Epigenetics of Wilms tumors and the WT2
locus
.....................................250
11.4
Towards an improved classification of Wilms tumors
...............................252
Further reading
...................................................................................................253
12
Cancers of the skin
...........................................................................................255
12.1
Carcinogenesis in the skin
..........................................................................256
12.2
Squamous cell carcinoma
...........................................................................260
12.3
Basal Cell Carcinoma.
................................................................................262
12.4
Melanoma
...................................................................................................266
12.5
Tumor antigens
...........................................................................................269
Further reading
...................................................................................................270
13
Colon Cancer
....................................................................................................271
13. 1
Natural history of colorectal cancer
.........................................................272
13.2
Familial Adenomatous Polyposis
Coli
and the
WNT
pathway
..................273
13.3
Progression of Colon Cancer and the Multi-Step Model
ofTumorigenesis
..........................................................................................280
13.4
Hereditary nonpolyposis colon
carcinoma
................................................282
13.5
Genomic instability in colon carcinoma.
....................................................284
13.6
Inflammation and colon cancer
..................................................................285
Further reading
...................................................................................................287
Box
13.1
Positional cloning of tumor suppressor genes in hereditary cancers
. 288
14
Bladder Cancer
.....................„..........................................................................289
14.1
Histology and etiology of bladder cancer
..................................................290
14.2
Molecular alterations in invasive bladder cancers
....................................297
14.3
Molecular alterations in papillary bladder cancers
..................................302
14.4
A comparison of bladder cancer subtypes
..................................................304
Further reading
...................................................................................................305
Box
14.1:
Tumor suppressor candidates at 9q in bladder cancer
......................306
15
Renal Cell Carcinoma
___________..„_____________________________307
15.1
The diversity of renal cancers
....................................................................308
15.2
Cytogenetics of renal cell carcinomas
........................................................310
15.3
Molecular
biology of inherited kidney cancers
..........................................311
15.4
Von-Hippel-Lindau syndrome and renal carcinoma
..................................316
15.5
Molecular biology of clear cell renal carcinoma
.......................................321
15.6
Chemotherapy and immunotherapy of renal carcinomas
..........................324
Further reading
...................................................................................................326
16
Liver Cancer
.....................................................................................................327
16.1
Etiology of liver cancer
..............................................................................328
16.2
Genetic changes in hepatocellular carcinoma
...........................................331
16.3
Viruses in HCC
...........................................................................................336
Further reading
...................................................................................................339
Box
16.1
Hepatocellular carcinoma in experimental animals
...........................340
17
Stomach Cancer
................................................................................................341
¡7.1
Etiology of stomach cancer
........................................................................342
17.2
Molecular mechanisms in gastric cancer
...................................................345
17.3
Helicobacter pylori and stomach cancer
....................................................348
Further reading
...................................................................................................354
Box
17.1:
Barrett esophagus and esophageai cancer
.........................................355
18
Breast Cancer
....................................................................................................357
¡8.1
Breast biology
.............................................................................................358
18.2
Etiology of breast cancer
............................................................................364
18.3
Hereditary breast cancer
............................................................................365
18.4
Estrogen receptors and ERBB proteins in breast cancer
...........................3 73
18.5
Classification of breast cancers
.................................................................378
Further reading:
..................................................................................................382
19
Prostate Cancer
................................................................................................383
19.1
Epidemiology of prostate cancer
................................................................384
19.2
Androgens in prostate cancer
.....................................................................389
¡9.3
Genetics and epigenetics of prostate cancer
..............................................394
¡9.4
Tumor-stroma interactions in prostate cancer
...........................................398
Further reading
...................................................................................................402
PART III
-
PREVENTION, DIAGNOSIS, AND THERAPY
20
Cancer Prevention
............................................................................................403
20.1
The importance of cancer prevention
.........................................................403
20.2
Primary prevention
.....................................................................................404
20.3
Cancer prevention and diet
........................................................................408
20.4
Prevention of cancers in groups at high risk.
.............................................415
20.5
Prevention of prostate cancer by screening the aging male population....
420
20.6
Other types of prevention
...........................................................................423
Further reading
...................................................................................................426
21
Cancer
Diagnosis
..............................................................................................427
21.1
The evolving scope of
molecular
diagnostics
.............................................427
21.2
Molecular diagnosis of
hematologicul
cancers
..........................................429
21.3
Molecular detection of carcinomas
............................................................433
21.4
Molecular classification of carcinomas
.....................................................439
21.5
Prospects of molecular diagnostics in the age of individualized therapy..
442
Further reading
...................................................................................................447
22
Cancer Therapy
................................................................................................449
22.1
Limitations of current cancer therapies
.....................................................449
22.2
Molecular mechanisms of cancer chemotherapy
.......................................450
22.3
Principles of targeted drug therapy
............................................................459
22.4
Examples of new target-directed drug therapies
........................................464
22.5
New concepts in cancer therapy: Immunotherapy
.....................................475
22.6
New concepts in cancer therapy: Gene therapy
.........................................479
22.7
The future of cancer therapy
......................................................................486
Further reading
...................................................................................................488
KEYWORD INDEX
.............................................................................................489
Molecular Biology of
Human
Cancers
Wolfgang Arthur
Schulz
Over the iast three decades, knowiedge on the molecular biology of human cancers
has vastly expanded. A host of genes and proteins involved in cancer development
and progression have been defined and many mechanisms at the molecular, cellular
and even tissue ievel have been, at least partly, elucidated. Insights have aiso been
gained into the molecular mechanisms underlying carcinogenesis by chemical,
physical, and biological agents and, most notably, into inherited susceptibility to
cancer.
Accordingly, Part
[
of the book presents many of the molecules and mechanisms
generally important in human cancers. Following an overview on the cancer
problem, individual chapters deal with cancer genetics and epigenetics,
DNA
damage and repair, oticogenes, tumor suppressors, regulatory pathways in cancer,
apoptosis, cellular senescence, tumor invasion and metastasis.
Å
consensus is emerging that while these common mechanisms and molecules
areali
relevant to human cancers, in each cancer type (or even subtype) a selection
of them are extremely important. For selected cancers, the route from genetic and
epigenetfc changes to their biological and clinical behavior can already be traced.
Part II of the book presents a broad, but exemplary selection of cancers that serve
as
paradigmas
to illustrate this point.
In fact, cancer research has now reached a critical stage in which the accumulated
knowledge on molecular mechanisms is gradually translated into improved
prevention, diagnosis, and treatment. The state, pitfalls, and potential of these
efforts is summarized in Part HI.
More than ever, cancer research is now an interdisciplinary effort which requires a
basic knowledge of commonly used terms, farts, issues, and concepts. The aim of
this book
isto
provide advanced students and practitioners of different disciplines
with this basts, bridging the gap between standard textbooks of molecular biology,
pathology, and oncology on the one hand and specialized cancer literature on the
other.
|
| adam_txt |
TABLE
OF
CONTENTS
Preface: How to read this book
. xiii
Acknowledgements
. xvii
PART I
-
MOLECULES, MECHANISMS, AND CELLS
1
An Introduction to Human Cancers
.1
1.1
An overview of the cancer problem
.1
1.2
Causes of cancer
.5
Box
1.1
Reactive oxygen species
.10
1.3
Characteristic Properties of Cancers and Cancer Cells
.11
Box
1.2:
Hallmarks of Cancer
.18
1.4
Characterization and Classification of Cancers in the Clinic
.17
1.5
Treatment of Cancer
.21
Further reading
.23
2
Tumor Genetics
.25
2.1
Cancer as a genetic disease
.26
2.2.
Genetic alterations in cancer cells
.27
2.3
Inherited predisposition to cancer
.37
2.4
Cancer genes
.42
2.5
Accumulation of genetic and epigenetic changes in human cancers
.44
Further reading
.45
Box
2.1
Tumor viruses in human cancers
.46
3 DNA
Damage and
DNA
Repair
.47
3.1 DNA
damage during replication: base excision and nucleotide excision
repair
.48
3.2
Nucleotide excision repair and crosslink repair
.55
3.3
Strand-break repair
.62
3.4
Defects in
DNA
repair and cancer susceptibility
.66
3.5
Cell protection mechanisms in cancer.
.68
Further reading
.70
4
Oncogenes
.71
4.1
Retroviraloncogenes
.72
4.2
Slow-acting transforming retroviruses
.75
4.3
Approaches to the identification of human oncogenes
.78
4.4
Functions of human oncogenes
.84
Further reading
.89
Box
4.1
Carcinogenesis by HTLV-1
.90
5
Tumor Suppressor Genes
.91
5./
Tumor suppressor genes in hereditary cancers
.92
5.2
RBI and the cell cycle.
.97
5.3
TP53 as a different kind of tumor suppressor
.101
VII
5.4
Classification
of tumor
suppressor
genes.109
Further reading
.111
Box
5.1
Human papilloma viruses
.112
6
Cancer Pathways
.113
6.1
Cancer Pathways
.114
6.2
МАРК
signaling as a cancer pathway
.115
6.3
The PI3Kpathway
.119
6.4
Regulation of the cell cycle by the
МАРК
and PI3K pathways
.123
6.5
Modulators of the
МАРК
and PI3K pathways
.126
6.6
The TP53 network
.129
6.7
Signaling by TGF
β
factors
.131
6.8
Signaling through
STAT
factors
.132
6.9
The NFkBpathway
.135
6.10
Developmental regulatory systems as cancer pathways
.137
Further reading
.144
7
Apoptosis and Replicative Senescence in Cancer
.145
7.1
Limits to cell proliferation
.146
7.2
Mechanisms of apoptosis
.150
7.3
Mechanisms of diminished apoptosis in cancer
.156
7.4
Replicative senescence and its disturbances in human cancers
.159
Further reading
.164
Box
7.1:
Human aging and cancer
.165
8
Cancer Epigenetics
.167
8.1
Mechanisms ofepigenetic inheritance
.168
8.2
Imprinting andX-inactivation
.770
8.3 DNA methylation.174
8.4
Chromatin structure
.179
8.5
Epigenetics of cell differentiation
.182
8.6
Epigenetics of tissue homeostasis
.185
Further reading
.191
Box
8.1
Carcinogenesis by
HIV 192
9
Invasion and metastasis
.193
9.1
Invasion and metastasis as multistep processes
.194
9.2
Genes and proteins involved in cell-to-cell and cell-matrix adhesion
.197
9.3
Genes and proteins involved in extracellular matrix remodeling
during tumor invasion
.202
9.4
Angiogenesis
.206
9.5
Interactions of invasive tumors with the immune system
.210
9.6
The importance oftumor-stroma interactions
.212
Further reading
.216
Box
9.1
Tumor hypoxia and its consequences
.217
PART II
-
HUMAN CANCERS
10
Leukémiás
and Lymphomas
.219
10.1
Common properties of
hematologica!
cancers
.221
10.2
Genetic aberrations in
leukémiás
and lymphomas
.223
10.3
Molecular biology ofBurkitt lymphoma
.226
10.4
Molecular biology ofCML
.232
10.5
Molecular biology ofPML
.237
Further reading
.242
11
Wilms Tumor (nephroblastoma)
.243
11.1
Histology, etiology and clinical behavior of Wilms tumors
.244
11.2
Genetics of Wilms tumors and the WT1 gene
.246
11.3
Epigenetics of Wilms tumors and the 'WT2
'
locus
.250
11.4
Towards an improved classification of Wilms tumors
.252
Further reading
.253
12
Cancers of the skin
.255
12.1
Carcinogenesis in the skin
.256
12.2
Squamous cell carcinoma
.260
12.3
Basal Cell Carcinoma.
.262
12.4
Melanoma
.266
12.5
Tumor antigens
.269
Further reading
.270
13
Colon Cancer
.271
13. 1
Natural history of colorectal cancer
.272
13.2
Familial Adenomatous Polyposis
Coli
and the
WNT
pathway
.273
13.3
Progression of Colon Cancer and the Multi-Step Model
ofTumorigenesis
.280
13.4
Hereditary nonpolyposis colon
carcinoma
.282
13.5
Genomic instability in colon carcinoma.
.284
13.6
Inflammation and colon cancer
.285
Further reading
.287
Box
13.1
Positional cloning of tumor suppressor genes in hereditary cancers
. 288
14
Bladder Cancer
.„.289
14.1
Histology and etiology of bladder cancer
.290
14.2
Molecular alterations in invasive bladder cancers
.297
14.3
Molecular alterations in papillary bladder cancers
.302
14.4
A comparison of bladder cancer subtypes
.304
Further reading
.305
Box
14.1:
Tumor suppressor candidates at 9q in bladder cancer
.306
15
Renal Cell Carcinoma
_.„_307
15.1
The diversity of renal cancers
.308
15.2
Cytogenetics of renal cell carcinomas
.310
15.3
Molecular
biology of inherited kidney cancers
.311
15.4
Von-Hippel-Lindau syndrome and renal carcinoma
.316
15.5
Molecular biology of clear cell renal carcinoma
.321
15.6
Chemotherapy and immunotherapy of renal carcinomas
.324
Further reading
.326
16
Liver Cancer
.327
16.1
Etiology of liver cancer
.328
16.2
Genetic changes in hepatocellular carcinoma
.331
16.3
Viruses in HCC
.336
Further reading
.339
Box
16.1
Hepatocellular carcinoma in experimental animals
.340
17
Stomach Cancer
.341
¡7.1
Etiology of stomach cancer
.342
17.2
Molecular mechanisms in gastric cancer
.345
17.3
Helicobacter pylori and stomach cancer
.348
Further reading
.354
Box
17.1:
Barrett esophagus and esophageai cancer
.355
18
Breast Cancer
.357
¡8.1
Breast biology
.358
18.2
Etiology of breast cancer
.364
18.3
Hereditary breast cancer
.365
18.4
Estrogen receptors and ERBB proteins in breast cancer
.3 73
18.5
Classification of breast cancers
.378
Further reading:
.382
19
Prostate Cancer
.383
19.1
Epidemiology of prostate cancer
.384
19.2
Androgens in prostate cancer
.389
¡9.3
Genetics and epigenetics of prostate cancer
.394
¡9.4
Tumor-stroma interactions in prostate cancer
.398
Further reading
.402
PART III
-
PREVENTION, DIAGNOSIS, AND THERAPY
20
Cancer Prevention
.403
20.1
The importance of cancer prevention
.403
20.2
Primary prevention
.404
20.3
Cancer prevention and diet
.408
20.4
Prevention of cancers in groups at high risk.
.415
20.5
Prevention of prostate cancer by screening the aging male population.
420
20.6
Other types of prevention
.423
Further reading
.426
21
Cancer
Diagnosis
.427
21.1
The evolving scope of
molecular
diagnostics
.427
21.2
Molecular diagnosis of
hematologicul
cancers
.429
21.3
Molecular detection of carcinomas
.433
21.4
Molecular classification of carcinomas
.439
21.5
Prospects of molecular diagnostics in the age of individualized therapy.
442
Further reading
.447
22
Cancer Therapy
.449
22.1
Limitations of current cancer therapies
.449
22.2
Molecular mechanisms of cancer chemotherapy
.450
22.3
Principles of targeted drug therapy
.459
22.4
Examples of new target-directed drug therapies
.464
22.5
New concepts in cancer therapy: Immunotherapy
.475
22.6
New concepts in cancer therapy: Gene therapy
.479
22.7
The future of cancer therapy
.486
Further reading
.488
KEYWORD INDEX
.489
Molecular Biology of
Human
Cancers
Wolfgang Arthur
Schulz
Over the iast three decades, knowiedge on the molecular biology of human cancers
has vastly expanded. A host of genes and proteins involved in cancer development
and progression have been defined and many mechanisms at the molecular, cellular
and even tissue ievel have been, at least partly, elucidated. Insights have aiso been
gained into the molecular mechanisms underlying carcinogenesis by chemical,
physical, and biological agents and, most notably, into inherited susceptibility to
cancer.
Accordingly, Part
[
of the book presents many of the molecules and mechanisms
generally important in human cancers. Following an overview on the cancer
problem, individual chapters deal with cancer genetics and epigenetics,
DNA
damage and repair, oticogenes, tumor suppressors, regulatory pathways in cancer,
apoptosis, cellular senescence, tumor invasion and metastasis.
Å
consensus is emerging that while these common mechanisms and molecules
areali
relevant to human cancers, in each cancer type (or even subtype) a selection
of them are extremely important. For selected cancers, the route from genetic and
epigenetfc changes to their biological and clinical behavior can already be traced.
Part II of the book presents a broad, but exemplary selection of cancers that serve
as
paradigmas
to illustrate this point.
In fact, cancer research has now reached a critical stage in which the accumulated
knowledge on molecular mechanisms is gradually translated into improved
prevention, diagnosis, and treatment. The state, pitfalls, and potential of these
efforts is summarized in Part HI.
More than ever, cancer research is now an interdisciplinary effort which requires a
basic knowledge of commonly used terms, farts, issues, and concepts. The aim of
this book
isto
provide advanced students and practitioners of different disciplines
with this basts, bridging the gap between standard textbooks of molecular biology,
pathology, and oncology on the one hand and specialized cancer literature on the
other. |
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| classification_tum | BIO 220f MED 320f |
| ctrlnum | (OCoLC)173498171 (DE-599)BVBBV022961965 |
| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| format | Book |
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| id | DE-604.BV022961965 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:05:06Z |
| indexdate | 2024-07-09T21:08:39Z |
| institution | BVB |
| isbn | 9781402065590 9781402031854 9781402031861 |
| language | English |
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| spelling | Schulz, Wolfgang Arthur 1954- Verfasser (DE-588)1118879279 aut Molecular biology of human cancers an advanced student's textbook by Wolfgang Arthur Schulz Dordrecht Springer 2007 XVII, 508 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer cells Textbooks Cancer Molecular aspects Textbooks Carcinogenesis Textbooks Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Molekularbiologie (DE-588)4039983-7 s DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016166325&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016166325&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Schulz, Wolfgang Arthur 1954- Molecular biology of human cancers an advanced student's textbook Cancer cells Textbooks Cancer Molecular aspects Textbooks Carcinogenesis Textbooks Krebs Medizin (DE-588)4073781-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
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| title | Molecular biology of human cancers an advanced student's textbook |
| title_auth | Molecular biology of human cancers an advanced student's textbook |
| title_exact_search | Molecular biology of human cancers an advanced student's textbook |
| title_exact_search_txtP | Molecular biology of human cancers an advanced student's textbook |
| title_full | Molecular biology of human cancers an advanced student's textbook by Wolfgang Arthur Schulz |
| title_fullStr | Molecular biology of human cancers an advanced student's textbook by Wolfgang Arthur Schulz |
| title_full_unstemmed | Molecular biology of human cancers an advanced student's textbook by Wolfgang Arthur Schulz |
| title_short | Molecular biology of human cancers |
| title_sort | molecular biology of human cancers an advanced student s textbook |
| title_sub | an advanced student's textbook |
| topic | Cancer cells Textbooks Cancer Molecular aspects Textbooks Carcinogenesis Textbooks Krebs Medizin (DE-588)4073781-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Cancer cells Textbooks Cancer Molecular aspects Textbooks Carcinogenesis Textbooks Krebs Medizin Molekularbiologie Aufsatzsammlung |
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