Mechanical stimulation of bone healing:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Shaker
2007
|
| Schriftenreihe: | Berichte aus der Biomechanik
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Hamburg, Techn. Univ., Diss., 2006 |
| Beschreibung: | IX, 153 S. Ill., graph. Darst. |
| ISBN: | 9783832266004 |
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| adam_text | BERICHTE AUS DER BIOMECHANIK NICHOLAS BISHOP MECHANICAL STIMULATION OF
BONE HEALING SHAKER VERLAG AACHEN 2007 CONTENTS TERMINOLOGY V GLOSSARY
VI CHAPTER1 INTRODUCTION 1 1.1 MOTIVATION 1 1.2 SKELETAL GENERATION,
TURNOVER AND REPAIR 1 1.3 MECHANICAL STIMULATION 2 1.4
MECHANOTRANSDUCTION 2 1.5 PROBLEMS 4 1.6 STUDY DESIGN 4 1.7 RESEARCH
QUESTIONS 4 1.8 OVERVIEW 5 CHAPTER 2 BACKGROUND 7 2.1 FRACTURE HEALING 7
2.2 INTERFRAGMENTARY MOTION 8 2.2.1 OVERVIEW 8 2.2.2 DEFORMATION
DIRECTION 9 2.2.3 MOTION MAGNITUDE 11 2.2.4 STIMULUS DOSE AND TIMING 11
2.2.5 DEFORMATION FREQUENCY 12 2.2.6 OTHER STIMULATORY EFFECTS 12 2.3
CELLULAR STIMULATION 13 2.3.1 OVERVIEW 13 2.3.2 LOCAL MECHANICAL
STIMULATION 14 2.3.3 STRETCHING 15 2.3.4 COMPRESSION 16 2.3.5
HYDROSTATIC PRESSURE 16 2.3.6 FLUID SHEAR 16 2.3.7 CONVECTIVE TRANSPORT
17 2.3.8 TRANSDUCTION PATHWAYS 17 2.4 THEORETICAL MODELS 17 2.4.1 BASIC
MECHANICAL MODELS 18 2.4.2 ELASTIC SOLID MODEIS 20 2.4.3 PORO-ELASTIC
MODEIS 23 2.4.4 OTHER MODELS 24 2.5 SUMMARY 25 CHAPTER 3 FIXATION SYSTEM
DEVELOPMENT 27 3.1 OVERVIEW 27 3.2 FIXATION SYSTEM SPECIFICATIONS 27
3.2.1 GENERAL SPECIFICATIONS 27 3.2.2 INTERFRAGMENTARY DISPLACEMENT 29
3.2.3 INTERFRAGMENTARY LOAD 30 CONTENTS 3.2.4 OTHER REQUIREMENTS 30 3.3
FIXATOR DESIGN 30 3.3.1 GENERAL CONSTRUCTION 30 * 3.4 ACTUATION /
MEASUREMENT UNIT 33 3.4.1 GENERAL LAYOUT 33 3.4.2 CONRROL SYSTEM 33
3.4.3 LOAD MEASUREMENT ERROR 35 3.5 FIXATION SYSTEM CHARACTERISATION 36
3.5.1 METHODS 36 3.5.2 RESULTS 40 3.5.3 DISCUSSION OF FIXATOR
PERFORMANCE 43 CHAPTER 4 IN VIVO EXPERIMENT 47 4.1 INTRODUCTION 47 4.2
METHODS 48 4.2.1 EXPERIMENTAL DESIGN 48 4.2.2 FIXATOR APPLICATION 49
4.2.3 LOADING 50 4.2.4 MEASUREMENTS 51 4.2.5 FOUR-WEEK EXPERIMENT 51
4.2.6 EIGHT-WEEK EXPERIMENT 52 4.2.7 DATA PROCESSING (4 AND 8 WEEKS) 52
4.3 RESULTS 54 4.3.1 OVERVIEW 54 4.3.2 LOAD AND DISPLACEMENT 55 4.3.3
WEEKLY X-RAYS 60 4.3.4 HISTOLOGY 61 4.3.5 CT SCAN PARAMETERS 64 4.4
DISCUSSION 68 4.4.1 OVERVIEW 68 4.4.2 SYNTHESIS OF RESULTS 68 4.4.3
EFFECTS OF PURE INTERFRAGMENTARY SHEAR 71 4.4.4 LIMITATIONS 72 4.4.5
RESULTS IN TERMS OF LOCAL MECHANICAL STIMULATION 72 4.4.6 CLINICAL
RELEVANCE 72 4.4.7 CONCLUSION 73 CHAPTER 5 MECHANICAL MODELLING . 75 5.1
OVERVIEW 75 5.2 INTRODUCTION 75 5.3 METHODS 76 5.3.1 MODEL DESIGN 78
5.3.2 GEOMETRY 78 5.3.3 LOADING 79 5.3.4 BOUNDARY CONDITIONS 79 5.3.5
MATERIALS 80 5.3.6 MATERIALS AND BOUNDARY CONDITIONS IN THE EXPERIMENT
83 5.3.7 MECHANO-REGULATION 84 5.4 RESULTS 85 5.4.1 BASIC MODEL RESULTS
85 CONTENTS 5.4.2 ESTIMATION OF MECHANICAL CONDITIONS IN THE CALLUS 87
5.4.3 LOCAL MECHANICAL STIMULI 90 5.4.4 TISSUE DISTRIBUTION 93 5.5
DISCUSSION 96 5.5.1 OVERVIEW 96 5.5.2 RESEARCH QUESTION 96 5.5.3
HEALINGRATE 97 5.5.4 ABSOLUTE STIMULATION 97 5.5.5 LIMITATIONS 98 5.5.6
SUMMARY 98 CHAPTER 6 DISCUSSION 99 6.1 OVERVIEW OF THE THESIS 99 6.2
RESEARCH QUESTIONS 99 6.3 INTERFRAGMENTARY SHEAR 100 6.4 LOCAL
MECHANICAL CONDITIONS 100 6.5 MECHANO-REGULATION SCHEMES 102 6.6
ESTIMATION OFINACCURACIES 104 6.6.1 FIXATOR INACCURACIES 104 6.6.2
EXPERIMENTAL INACCURACIES 104 6.6.3 MODELLING INACCURACIES 104 6.6.4
SUMMARY 105 6.7 FUTURE STUDIES 105 6.7.1 PLANNED STUDIES 105 6.7.2
FIXATION SYSTEM 105 6.7.3 EFFECT OF THE TENOTOMY 106 6.7.4 PAUWELS
NON-UNION SCENARIO 106 6.7.5 ISOLATION OF PRESSURE 107 6.7.6 CANAL
BOUNDARY CONDITIONS 107 6.7.7 MECHANO-BIOLOGICAL REGULATION SCHEMES 107
6.8 CONCLUSIONS 107 REFERENCE LIST 109 APPENDICES 117
APPENDKA:LOADINGMODES 117 APPENDIX B:LOADCUT-OFF 123 APPENDIX C:
CALIBRATION OF DISPIACEMENT EQUIPMENT 126 APPENDIX D:STRAINCALCULATION
128 APPENDIXE: CONVERGENCEANALYSIS 132 APPENDIX F:LOAD TRANSFER
MECHANISMS 136 APPENDDCG: EXPERIMENTAL ASSUMPTIONS 147
APPENDDCH:CURRICULUMVLTAE 153
|
| adam_txt |
BERICHTE AUS DER BIOMECHANIK NICHOLAS BISHOP MECHANICAL STIMULATION OF
BONE HEALING SHAKER VERLAG AACHEN 2007 CONTENTS TERMINOLOGY V GLOSSARY
VI CHAPTER1 INTRODUCTION 1 1.1 MOTIVATION 1 1.2 SKELETAL GENERATION,
TURNOVER AND REPAIR 1 1.3 MECHANICAL STIMULATION 2 1.4
MECHANOTRANSDUCTION 2 1.5 PROBLEMS 4 1.6 STUDY DESIGN 4 1.7 RESEARCH
QUESTIONS 4 1.8 OVERVIEW 5 CHAPTER 2 BACKGROUND 7 2.1 FRACTURE HEALING 7
2.2 INTERFRAGMENTARY MOTION 8 2.2.1 OVERVIEW 8 2.2.2 DEFORMATION
DIRECTION 9 2.2.3 MOTION MAGNITUDE 11 2.2.4 STIMULUS DOSE AND TIMING 11
2.2.5 DEFORMATION FREQUENCY 12 2.2.6 OTHER STIMULATORY EFFECTS 12 2.3
CELLULAR STIMULATION 13 2.3.1 OVERVIEW 13 2.3.2 LOCAL MECHANICAL
STIMULATION 14 2.3.3 STRETCHING 15 2.3.4 COMPRESSION 16 2.3.5
HYDROSTATIC PRESSURE 16 2.3.6 FLUID SHEAR 16 2.3.7 CONVECTIVE TRANSPORT
17 2.3.8 TRANSDUCTION PATHWAYS 17 2.4 THEORETICAL MODELS 17 2.4.1 BASIC
MECHANICAL MODELS 18 2.4.2 ELASTIC SOLID MODEIS 20 2.4.3 PORO-ELASTIC
MODEIS 23 2.4.4 OTHER MODELS 24 2.5 SUMMARY 25 CHAPTER 3 FIXATION SYSTEM
DEVELOPMENT 27 3.1 OVERVIEW 27 3.2 FIXATION SYSTEM SPECIFICATIONS 27
3.2.1 GENERAL SPECIFICATIONS 27 3.2.2 INTERFRAGMENTARY DISPLACEMENT 29
3.2.3 INTERFRAGMENTARY LOAD 30 CONTENTS 3.2.4 OTHER REQUIREMENTS 30 3.3
FIXATOR DESIGN 30 3.3.1 GENERAL CONSTRUCTION 30 * 3.4 ACTUATION /
MEASUREMENT UNIT 33 3.4.1 GENERAL LAYOUT 33 3.4.2 CONRROL SYSTEM 33
3.4.3 LOAD MEASUREMENT ERROR 35 3.5 FIXATION SYSTEM CHARACTERISATION 36
3.5.1 METHODS 36 3.5.2 RESULTS 40 3.5.3 DISCUSSION OF FIXATOR
PERFORMANCE 43 CHAPTER 4 IN VIVO EXPERIMENT 47 4.1 INTRODUCTION 47 4.2
METHODS 48 4.2.1 EXPERIMENTAL DESIGN 48 4.2.2 FIXATOR APPLICATION 49
4.2.3 LOADING 50 4.2.4 MEASUREMENTS 51 4.2.5 FOUR-WEEK EXPERIMENT 51
4.2.6 EIGHT-WEEK EXPERIMENT 52 4.2.7 DATA PROCESSING (4 AND 8 WEEKS) 52
4.3 RESULTS 54 4.3.1 OVERVIEW 54 4.3.2 LOAD AND DISPLACEMENT 55 4.3.3
WEEKLY X-RAYS 60 4.3.4 HISTOLOGY 61 4.3.5 CT SCAN PARAMETERS 64 4.4
DISCUSSION 68 4.4.1 OVERVIEW 68 4.4.2 SYNTHESIS OF RESULTS 68 4.4.3
EFFECTS OF PURE INTERFRAGMENTARY SHEAR 71 4.4.4 LIMITATIONS 72 4.4.5
RESULTS IN TERMS OF LOCAL MECHANICAL STIMULATION 72 4.4.6 CLINICAL
RELEVANCE 72 4.4.7 CONCLUSION 73 CHAPTER 5 MECHANICAL MODELLING . 75 5.1
OVERVIEW 75 5.2 INTRODUCTION 75 5.3 METHODS 76 5.3.1 MODEL DESIGN 78
5.3.2 GEOMETRY 78 5.3.3 LOADING 79 5.3.4 BOUNDARY CONDITIONS 79 5.3.5
MATERIALS 80 5.3.6 MATERIALS AND BOUNDARY CONDITIONS IN THE EXPERIMENT
83 5.3.7 MECHANO-REGULATION 84 5.4 RESULTS 85 5.4.1 BASIC MODEL RESULTS
85 CONTENTS 5.4.2 ESTIMATION OF MECHANICAL CONDITIONS IN THE CALLUS 87
5.4.3 LOCAL MECHANICAL STIMULI 90 5.4.4 TISSUE DISTRIBUTION 93 5.5
DISCUSSION 96 5.5.1 OVERVIEW 96 5.5.2 RESEARCH QUESTION 96 5.5.3
HEALINGRATE 97 5.5.4 ABSOLUTE STIMULATION 97 5.5.5 LIMITATIONS 98 5.5.6
SUMMARY 98 CHAPTER 6 DISCUSSION 99 6.1 OVERVIEW OF THE THESIS 99 6.2
RESEARCH QUESTIONS 99 6.3 INTERFRAGMENTARY SHEAR 100 6.4 LOCAL
MECHANICAL CONDITIONS 100 6.5 MECHANO-REGULATION SCHEMES 102 6.6
ESTIMATION OFINACCURACIES 104 6.6.1 FIXATOR INACCURACIES 104 6.6.2
EXPERIMENTAL INACCURACIES 104 6.6.3 MODELLING INACCURACIES 104 6.6.4
SUMMARY 105 6.7 FUTURE STUDIES 105 6.7.1 PLANNED STUDIES 105 6.7.2
FIXATION SYSTEM 105 6.7.3 EFFECT OF THE TENOTOMY 106 6.7.4 PAUWELS'
NON-UNION SCENARIO 106 6.7.5 ISOLATION OF PRESSURE 107 6.7.6 CANAL
BOUNDARY CONDITIONS 107 6.7.7 MECHANO-BIOLOGICAL REGULATION SCHEMES 107
6.8 CONCLUSIONS 107 REFERENCE LIST 109 APPENDICES 117
APPENDKA:LOADINGMODES 117 APPENDIX B:LOADCUT-OFF 123 APPENDIX C:
CALIBRATION OF DISPIACEMENT EQUIPMENT 126 APPENDIX D:STRAINCALCULATION
128 APPENDIXE: CONVERGENCEANALYSIS 132 APPENDIX F:LOAD TRANSFER
MECHANISMS 136 APPENDDCG: EXPERIMENTAL ASSUMPTIONS 147
APPENDDCH:CURRICULUMVLTAE 153 |
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| spelling | Bishop, Nicholas Verfasser aut Mechanical stimulation of bone healing Nicholas Bishop Aachen Shaker 2007 IX, 153 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Biomechanik Zugl.: Hamburg, Techn. Univ., Diss., 2006 Frakturheilung - Biomechanische Stimulation - Tiermodell Tiermodell (DE-588)4140660-6 gnd rswk-swf Biomechanische Stimulation (DE-588)4653266-3 gnd rswk-swf Frakturheilung (DE-588)4209626-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Frakturheilung (DE-588)4209626-1 s Biomechanische Stimulation (DE-588)4653266-3 s Tiermodell (DE-588)4140660-6 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016154284&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bishop, Nicholas Mechanical stimulation of bone healing Frakturheilung - Biomechanische Stimulation - Tiermodell Tiermodell (DE-588)4140660-6 gnd Biomechanische Stimulation (DE-588)4653266-3 gnd Frakturheilung (DE-588)4209626-1 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4653266-3 (DE-588)4209626-1 (DE-588)4113937-9 |
| title | Mechanical stimulation of bone healing |
| title_auth | Mechanical stimulation of bone healing |
| title_exact_search | Mechanical stimulation of bone healing |
| title_exact_search_txtP | Mechanical stimulation of bone healing |
| title_full | Mechanical stimulation of bone healing Nicholas Bishop |
| title_fullStr | Mechanical stimulation of bone healing Nicholas Bishop |
| title_full_unstemmed | Mechanical stimulation of bone healing Nicholas Bishop |
| title_short | Mechanical stimulation of bone healing |
| title_sort | mechanical stimulation of bone healing |
| topic | Frakturheilung - Biomechanische Stimulation - Tiermodell Tiermodell (DE-588)4140660-6 gnd Biomechanische Stimulation (DE-588)4653266-3 gnd Frakturheilung (DE-588)4209626-1 gnd |
| topic_facet | Frakturheilung - Biomechanische Stimulation - Tiermodell Tiermodell Biomechanische Stimulation Frakturheilung Hochschulschrift |
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