Holdings: Pharmaceutical isothermal calorimetry

Pharmaceutical isothermal calorimetry:

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Bibliographic Details
Main Authors:	Gaisford, Simon (Author), O'Neill, Michael A. A. (Author)
Format:	Book
Language:	English
Published:	New York [u.a. Informa Healthcare 2007
Subjects:	Calorimetry Pharmaceutical chemistry Drugs > Design Drug Design Technology, Pharmaceutical > methods
Online Access:	Publisher description Inhaltsverzeichnis
Item Description:	Includes bibliographical references and index
Physical Description:	ix, 363 p. Ill., graph. Darst. 24 cm
ISBN:	0849331552 9780849331558

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MARC


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650		4	\|a Calorimetry
650		4	\|a Pharmaceutical chemistry
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650		4	\|a Technology, Pharmaceutical \|x methods
700	1		\|a O'Neill, Michael A. A. \|e Verfasser \|4 aut
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adam_text	PHARMACEUTICAL ISOTHERMAL CALORIMETRY SIMON LIIIISLNNL THE SCHOOL OF PHARMACY UNIVERSITY OF LONDON, U.K. MICHAEL A. A. O NEILL DEPARTMENT OF PHARMACY AND PHARMACOLOGY UNIVERSITY OF BATH, U.K. INFORMA HEALTHCARE NEW YORK LONDON CONTENTS DEDICATION .... HI PREFACE .... V 1. PRINCIPLES OF CALORIMETRY / INTRODUCTION .... / BRIEF HISTORY OF CALORIMETRY . . . . 4 HEAT AS AN INDICATOR OF CHANGE .... 6 INTRODUCTION TO THERMODYNAMICS .... X CLASSIFICATION OF CALORIMETERS .... /.? OPERATING PRINCIPLES .... 16 INSTRUMENTATION W SUMMARY .... 4X RESOURCES .... 49 REFERENCES .... 50 2. GOOD EXPERIMENTAL PRACTICE 55 INTRODUCTION .... 55 CIOOD EXPERIMENTAL PRACTICE *6 CALIBRATION AND VALIDATION ^ GOOD GOOD GOOD GOOD GOOD PRACTICE FOR AMPOULE BATCH CALONMETRX RACTICE FOR TITRATION CALORMIETP. PRACTICE FOR SOLUTION CALORMIETIA RACTICE FOR PERFUMON CALNNMETRS RACTICE FOILLOW CALORMIETIA ~4 APPLICATIONS OF TEST AND REFERENCE RE.N.LIOII - I-APERIMENTAL DESITIN .... .S 5 SPECIAL CONSIDERATIONS FOR ILIUV ( .TLORIMEIER- SUMMARS .... 100 REFERENCES .... 101 V JJJ CONTENTS 3. QUANTITATIVE DATA ANALYSIS 105 INTRODUCTION .... 105 EMPIRICAL FITTING .... 106 KINETIC MODELING .... 107 CALCULATION VS. ITERATION .... 150 CALCULATION TECHNIQUES .... 151 SOLID-STATE SYSTEMS .... 163 COMPLEX REACTION SYSTEMS .... 167 SUMMARY .... 174 REFERENCES .... 174 4. ROLE OF CALORIMETRY IN PREFORMULATION STUDIES 177 INTRODUCTION .... 777 USE OF DIFFERENTIAL SCANNING CALORIMETRY IN PREFORMULATION .... 178 USE OF ISOTHERMAL CALORIMETRY IN PREFORMULATION .... 194 SUMMARY .... 209 REFERENCES .... 210 5. LEAD COMPOUND OPTIMIZATION 217 INTRODUCTION .... 217 APPLICATION OF ISOTHERMAL TITRATION CALORIMETRY TO RATIONAL DRUG DESIGN .... 218 LEAD OPTIMIZATION USING ISOTHERMAL FLOW CALORIMETRY .... 231 SUMMARY .... 244 REFERENCES .... 245 6. INVESTIGATION OF THE AMORPHOUS STATE 249 INTRODUCTION .... 249 AMORPHOUS MATERIAL .... 250 AGING OF AMORPHOUS MATERIAL .... 255 QUANTIFICATION OF AMORPHOUS CONTENT .... 259 SUMMARY .... 284 REFERENCES .... 285 7. STABILITY ASSESSMENT 289 INTRODUCTION .... 289 CURRENT METHODS FOR STABILITY ASSESSMENT .... 290 CALORIMETRY FOR STABILITY ASSESSMENT .... 295 SUMMARY .... 329 REFERENCES .... 329 8. FUTURE DEVELOPMENTS AND AREAS OF APPLICATION 335 INTRODUCTION .... 335 WHOLE SYSTEM MEASUREMENTS .... 335 CONTENTS IX APPLICATIONS TO PROCESS SCALE-UP AND PROCESS ANALYTICAL TECHNOLOGY .... 346 HIGH-THROUGHPUT SCREENING METHODOLOGIES .... 348 SUMMARY .... 350 REFERENCES .... 351 INDEX 353
adam_txt	PHARMACEUTICAL ISOTHERMAL CALORIMETRY SIMON LIIIISLNNL THE SCHOOL OF PHARMACY UNIVERSITY OF LONDON, U.K. MICHAEL A. A. O'NEILL DEPARTMENT OF PHARMACY AND PHARMACOLOGY UNIVERSITY OF BATH, U.K. INFORMA HEALTHCARE NEW YORK LONDON CONTENTS DEDICATION . HI PREFACE . V 1. PRINCIPLES OF CALORIMETRY / INTRODUCTION . / BRIEF HISTORY OF CALORIMETRY . . . . 4 HEAT AS AN INDICATOR OF CHANGE . 6 INTRODUCTION TO THERMODYNAMICS . X CLASSIFICATION OF CALORIMETERS . /.? OPERATING PRINCIPLES . 16 INSTRUMENTATION W SUMMARY . 4X RESOURCES . 49 REFERENCES . 50 2. GOOD EXPERIMENTAL PRACTICE 55 INTRODUCTION . 55 CIOOD EXPERIMENTAL PRACTICE *6 CALIBRATION AND VALIDATION ^ GOOD GOOD GOOD GOOD GOOD PRACTICE FOR AMPOULE BATCH CALONMETRX 'RACTICE FOR TITRATION CALORMIETP. ' PRACTICE FOR SOLUTION CALORMIETIA ' 'RACTICE FOR PERFUMON CALNNMETRS 'RACTICE FOILLOW CALORMIETIA ~4 APPLICATIONS OF TEST AND REFERENCE RE.N.LIOII'- I-APERIMENTAL DESITIN . .S'5 SPECIAL CONSIDERATIONS FOR ILIUV ('.TLORIMEIER- SUMMARS . 100 REFERENCES . 101 V JJJ CONTENTS 3. QUANTITATIVE DATA ANALYSIS 105 INTRODUCTION . 105 EMPIRICAL FITTING . 106 KINETIC MODELING . 107 CALCULATION VS. ITERATION . 150 CALCULATION TECHNIQUES . 151 SOLID-STATE SYSTEMS . 163 COMPLEX REACTION SYSTEMS . 167 SUMMARY . 174 REFERENCES . 174 4. ROLE OF CALORIMETRY IN PREFORMULATION STUDIES 177 INTRODUCTION . 777 USE OF DIFFERENTIAL SCANNING CALORIMETRY IN PREFORMULATION . 178 USE OF ISOTHERMAL CALORIMETRY IN PREFORMULATION . 194 SUMMARY . 209 REFERENCES . 210 5. LEAD COMPOUND OPTIMIZATION 217 INTRODUCTION . 217 APPLICATION OF ISOTHERMAL TITRATION CALORIMETRY TO RATIONAL DRUG DESIGN . 218 LEAD OPTIMIZATION USING ISOTHERMAL FLOW CALORIMETRY . 231 SUMMARY . 244 REFERENCES . 245 6. INVESTIGATION OF THE AMORPHOUS STATE 249 INTRODUCTION . 249 AMORPHOUS MATERIAL . 250 AGING OF AMORPHOUS MATERIAL . 255 QUANTIFICATION OF AMORPHOUS CONTENT . 259 SUMMARY . 284 REFERENCES . 285 7. STABILITY ASSESSMENT 289 INTRODUCTION . 289 CURRENT METHODS FOR STABILITY ASSESSMENT . 290 CALORIMETRY FOR STABILITY ASSESSMENT . 295 SUMMARY . 329 REFERENCES . 329 8. FUTURE DEVELOPMENTS AND AREAS OF APPLICATION 335 INTRODUCTION . 335 WHOLE SYSTEM MEASUREMENTS . 335 CONTENTS IX APPLICATIONS TO PROCESS SCALE-UP AND PROCESS ANALYTICAL TECHNOLOGY . 346 HIGH-THROUGHPUT SCREENING METHODOLOGIES . 348 SUMMARY . 350 REFERENCES . 351 INDEX 353
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author	Gaisford, Simon O'Neill, Michael A. A.
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discipline_str_mv	Chemie / Pharmazie Medizin
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spelling	Gaisford, Simon Verfasser aut Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill New York [u.a. Informa Healthcare 2007 ix, 363 p. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods O'Neill, Michael A. A. Verfasser aut http://www.loc.gov/catdir/enhancements/fy0665/2006049525-d.html Publisher description GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016151865&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Gaisford, Simon O'Neill, Michael A. A. Pharmaceutical isothermal calorimetry Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods
title	Pharmaceutical isothermal calorimetry
title_auth	Pharmaceutical isothermal calorimetry
title_exact_search	Pharmaceutical isothermal calorimetry
title_exact_search_txtP	Pharmaceutical isothermal calorimetry
title_full	Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill
title_fullStr	Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill
title_full_unstemmed	Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill
title_short	Pharmaceutical isothermal calorimetry
title_sort	pharmaceutical isothermal calorimetry
topic	Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods
topic_facet	Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods
url	http://www.loc.gov/catdir/enhancements/fy0665/2006049525-d.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016151865&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT gaisfordsimon pharmaceuticalisothermalcalorimetry AT oneillmichaelaa pharmaceuticalisothermalcalorimetry

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