Pharmaceutical isothermal calorimetry:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.
Informa Healthcare
2007
|
| Schlagworte: | |
| Online-Zugang: | Publisher description Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | ix, 363 p. Ill., graph. Darst. 24 cm |
| ISBN: | 0849331552 9780849331558 |
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| 100 | 1 | |a Gaisford, Simon |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Pharmaceutical isothermal calorimetry |c Simon Gaisford, Michael A.A. O'Neill |
| 264 | 1 | |a New York [u.a. |b Informa Healthcare |c 2007 | |
| 300 | |a ix, 363 p. |b Ill., graph. Darst. |c 24 cm | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Calorimetry | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 4 | |a Drugs |x Design | |
| 650 | 4 | |a Drug Design | |
| 650 | 4 | |a Technology, Pharmaceutical |x methods | |
| 700 | 1 | |a O'Neill, Michael A. A. |e Verfasser |4 aut | |
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Datensatz im Suchindex
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| adam_text | PHARMACEUTICAL ISOTHERMAL CALORIMETRY SIMON LIIIISLNNL THE SCHOOL OF
PHARMACY UNIVERSITY OF LONDON, U.K. MICHAEL A. A. O NEILL DEPARTMENT OF
PHARMACY AND PHARMACOLOGY UNIVERSITY OF BATH, U.K. INFORMA HEALTHCARE
NEW YORK LONDON CONTENTS DEDICATION .... HI PREFACE .... V 1. PRINCIPLES
OF CALORIMETRY / INTRODUCTION .... / BRIEF HISTORY OF CALORIMETRY . . .
. 4 HEAT AS AN INDICATOR OF CHANGE .... 6 INTRODUCTION TO THERMODYNAMICS
.... X CLASSIFICATION OF CALORIMETERS .... /.? OPERATING PRINCIPLES ....
16 INSTRUMENTATION W SUMMARY .... 4X RESOURCES .... 49 REFERENCES ....
50 2. GOOD EXPERIMENTAL PRACTICE 55 INTRODUCTION .... 55 CIOOD
EXPERIMENTAL PRACTICE *6 CALIBRATION AND VALIDATION ^ GOOD GOOD GOOD
GOOD GOOD PRACTICE FOR AMPOULE BATCH CALONMETRX RACTICE FOR TITRATION
CALORMIETP. PRACTICE FOR SOLUTION CALORMIETIA RACTICE FOR PERFUMON
CALNNMETRS RACTICE FOILLOW CALORMIETIA ~4 APPLICATIONS OF TEST AND
REFERENCE RE.N.LIOII - I-APERIMENTAL DESITIN .... .S 5 SPECIAL
CONSIDERATIONS FOR ILIUV ( .TLORIMEIER- SUMMARS .... 100 REFERENCES ....
101 V JJJ CONTENTS 3. QUANTITATIVE DATA ANALYSIS 105 INTRODUCTION ....
105 EMPIRICAL FITTING .... 106 KINETIC MODELING .... 107 CALCULATION VS.
ITERATION .... 150 CALCULATION TECHNIQUES .... 151 SOLID-STATE SYSTEMS
.... 163 COMPLEX REACTION SYSTEMS .... 167 SUMMARY .... 174 REFERENCES
.... 174 4. ROLE OF CALORIMETRY IN PREFORMULATION STUDIES 177
INTRODUCTION .... 777 USE OF DIFFERENTIAL SCANNING CALORIMETRY IN
PREFORMULATION .... 178 USE OF ISOTHERMAL CALORIMETRY IN PREFORMULATION
.... 194 SUMMARY .... 209 REFERENCES .... 210 5. LEAD COMPOUND
OPTIMIZATION 217 INTRODUCTION .... 217 APPLICATION OF ISOTHERMAL
TITRATION CALORIMETRY TO RATIONAL DRUG DESIGN .... 218 LEAD OPTIMIZATION
USING ISOTHERMAL FLOW CALORIMETRY .... 231 SUMMARY .... 244 REFERENCES
.... 245 6. INVESTIGATION OF THE AMORPHOUS STATE 249 INTRODUCTION ....
249 AMORPHOUS MATERIAL .... 250 AGING OF AMORPHOUS MATERIAL .... 255
QUANTIFICATION OF AMORPHOUS CONTENT .... 259 SUMMARY .... 284 REFERENCES
.... 285 7. STABILITY ASSESSMENT 289 INTRODUCTION .... 289 CURRENT
METHODS FOR STABILITY ASSESSMENT .... 290 CALORIMETRY FOR STABILITY
ASSESSMENT .... 295 SUMMARY .... 329 REFERENCES .... 329 8. FUTURE
DEVELOPMENTS AND AREAS OF APPLICATION 335 INTRODUCTION .... 335 WHOLE
SYSTEM MEASUREMENTS .... 335 CONTENTS IX APPLICATIONS TO PROCESS
SCALE-UP AND PROCESS ANALYTICAL TECHNOLOGY .... 346 HIGH-THROUGHPUT
SCREENING METHODOLOGIES .... 348 SUMMARY .... 350 REFERENCES .... 351
INDEX 353
|
| adam_txt |
PHARMACEUTICAL ISOTHERMAL CALORIMETRY SIMON LIIIISLNNL THE SCHOOL OF
PHARMACY UNIVERSITY OF LONDON, U.K. MICHAEL A. A. O'NEILL DEPARTMENT OF
PHARMACY AND PHARMACOLOGY UNIVERSITY OF BATH, U.K. INFORMA HEALTHCARE
NEW YORK LONDON CONTENTS DEDICATION . HI PREFACE . V 1. PRINCIPLES
OF CALORIMETRY / INTRODUCTION . / BRIEF HISTORY OF CALORIMETRY . . .
. 4 HEAT AS AN INDICATOR OF CHANGE . 6 INTRODUCTION TO THERMODYNAMICS
. X CLASSIFICATION OF CALORIMETERS . /.? OPERATING PRINCIPLES .
16 INSTRUMENTATION W SUMMARY . 4X RESOURCES . 49 REFERENCES .
50 2. GOOD EXPERIMENTAL PRACTICE 55 INTRODUCTION . 55 CIOOD
EXPERIMENTAL PRACTICE *6 CALIBRATION AND VALIDATION ^ GOOD GOOD GOOD
GOOD GOOD PRACTICE FOR AMPOULE BATCH CALONMETRX 'RACTICE FOR TITRATION
CALORMIETP. ' PRACTICE FOR SOLUTION CALORMIETIA ' 'RACTICE FOR PERFUMON
CALNNMETRS 'RACTICE FOILLOW CALORMIETIA ~4 APPLICATIONS OF TEST AND
REFERENCE RE.N.LIOII'- I-APERIMENTAL DESITIN . .S'5 SPECIAL
CONSIDERATIONS FOR ILIUV ('.TLORIMEIER- SUMMARS . 100 REFERENCES .
101 V JJJ CONTENTS 3. QUANTITATIVE DATA ANALYSIS 105 INTRODUCTION .
105 EMPIRICAL FITTING . 106 KINETIC MODELING . 107 CALCULATION VS.
ITERATION . 150 CALCULATION TECHNIQUES . 151 SOLID-STATE SYSTEMS
. 163 COMPLEX REACTION SYSTEMS . 167 SUMMARY . 174 REFERENCES
. 174 4. ROLE OF CALORIMETRY IN PREFORMULATION STUDIES 177
INTRODUCTION . 777 USE OF DIFFERENTIAL SCANNING CALORIMETRY IN
PREFORMULATION . 178 USE OF ISOTHERMAL CALORIMETRY IN PREFORMULATION
. 194 SUMMARY . 209 REFERENCES . 210 5. LEAD COMPOUND
OPTIMIZATION 217 INTRODUCTION . 217 APPLICATION OF ISOTHERMAL
TITRATION CALORIMETRY TO RATIONAL DRUG DESIGN . 218 LEAD OPTIMIZATION
USING ISOTHERMAL FLOW CALORIMETRY . 231 SUMMARY . 244 REFERENCES
. 245 6. INVESTIGATION OF THE AMORPHOUS STATE 249 INTRODUCTION .
249 AMORPHOUS MATERIAL . 250 AGING OF AMORPHOUS MATERIAL . 255
QUANTIFICATION OF AMORPHOUS CONTENT . 259 SUMMARY . 284 REFERENCES
. 285 7. STABILITY ASSESSMENT 289 INTRODUCTION . 289 CURRENT
METHODS FOR STABILITY ASSESSMENT . 290 CALORIMETRY FOR STABILITY
ASSESSMENT . 295 SUMMARY . 329 REFERENCES . 329 8. FUTURE
DEVELOPMENTS AND AREAS OF APPLICATION 335 INTRODUCTION . 335 WHOLE
SYSTEM MEASUREMENTS . 335 CONTENTS IX APPLICATIONS TO PROCESS
SCALE-UP AND PROCESS ANALYTICAL TECHNOLOGY . 346 HIGH-THROUGHPUT
SCREENING METHODOLOGIES . 348 SUMMARY . 350 REFERENCES . 351
INDEX 353 |
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| author | Gaisford, Simon O'Neill, Michael A. A. |
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| bvnumber | BV022947324 |
| callnumber-first | R - Medicine |
| callnumber-label | RS403 |
| callnumber-raw | RS403 |
| callnumber-search | RS403 |
| callnumber-sort | RS 3403 |
| callnumber-subject | RS - Pharmacy |
| classification_rvk | VS 5300 |
| ctrlnum | (OCoLC)70327750 (DE-599)DNB 2006049525 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.19 |
| dewey-search | 615/.19 |
| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| discipline_str_mv | Chemie / Pharmazie Medizin |
| format | Book |
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| institution | BVB |
| isbn | 0849331552 9780849331558 |
| language | English |
| lccn | 2006049525 |
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| spelling | Gaisford, Simon Verfasser aut Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill New York [u.a. Informa Healthcare 2007 ix, 363 p. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods O'Neill, Michael A. A. Verfasser aut http://www.loc.gov/catdir/enhancements/fy0665/2006049525-d.html Publisher description GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016151865&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gaisford, Simon O'Neill, Michael A. A. Pharmaceutical isothermal calorimetry Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods |
| title | Pharmaceutical isothermal calorimetry |
| title_auth | Pharmaceutical isothermal calorimetry |
| title_exact_search | Pharmaceutical isothermal calorimetry |
| title_exact_search_txtP | Pharmaceutical isothermal calorimetry |
| title_full | Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill |
| title_fullStr | Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill |
| title_full_unstemmed | Pharmaceutical isothermal calorimetry Simon Gaisford, Michael A.A. O'Neill |
| title_short | Pharmaceutical isothermal calorimetry |
| title_sort | pharmaceutical isothermal calorimetry |
| topic | Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods |
| topic_facet | Calorimetry Pharmaceutical chemistry Drugs Design Drug Design Technology, Pharmaceutical methods |
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