Experimental focal cerebral ischemia: pathophysiology, metabolism and pharmacology of the ischemic penumbra
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Copenhagen
Univ. of Copenhagen
2007
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: København, Univ., Diss., 2007 |
| Beschreibung: | 56 S. Ill., graph. Darst. |
| ISBN: | 9788799213801 |
Internformat
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| 245 | 1 | 0 | |a Experimental focal cerebral ischemia |b pathophysiology, metabolism and pharmacology of the ischemic penumbra |c Thomas Christensen |
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Datensatz im Suchindex
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| adam_text | The penumbra in experimental focal cerebral ischemia
TABLE OF CONTENTS
Table of contents 1
List of abbreviations 3
Preface and acknowledgments 4
Organization of the thesis 4
Brief summary 5
Part one: Background 6
Introduction 6
Clinical background 6
Ischemic thresholds and the concept of an ischemic penumbra 6
Current definitions of the ischemic penumbra 7
Characteristics of the ischemic penumbra 9
Metabolism in the penumbra 9
Periinfarct depolarizations characteristics 12
Gene expression molcular markers of the penumbra 14
Part two: Own experimental investigations 16
Aim of the studies 16
Methodological considerations 16
Rat models of focal cerebral ischemia 16
Autoradiography 17
Volume measurements 17
Infarct volumes 17
Telemetric long term measurement of body temperature 19
Pharmacology of the compounds used in the studies 20
Results and comments 21
Paper I: Investigation of the Fos protein as a potential molecular marker of the penumbra 21
Paper II: Effect of NMDA and AMPA receptor blockade on protein synthesis in the ischemic penumbra.... 22
Paper III: Double tracer autoradiographic investigation of protein synthesis and glucose consumption in the
ischemic penumbra effect of MK 801 andNBQX 23
Paper IV: Effect of ketobemidone on metabolism in the penumbra and infarct size 24
Paper V: Effect of a PBN on periinfarct depolarizations and infarct size 24
Paper VI: Mitochondrial electron transport complex activity after transient MCAO 26
Paper VII: Effect of broad spectrum cation channel blockade on infarct size 27
Part three: General discussion 29
Mechanisms of focal ischemic brain damage 29
Calcium and other cations 29
Excitoxicity glutamate, glutamate receptors and antagonists 31
Periinfarct depolarizations role in infarct evolution 33
Reactive oxygen species 34
Dysfuntion of mitochondria 36
Cooperating pathogenetic mechanisms 37
Concluding remarks and outlook 38
Specific conclusions 38
General conclusions 39
Outlook and unresolved questions 40
Summary indanish 42
References 44
|
| adam_txt |
The penumbra in experimental focal cerebral ischemia
TABLE OF CONTENTS
Table of contents 1
List of abbreviations 3
Preface and acknowledgments 4
Organization of the thesis 4
Brief summary 5
Part one: Background 6
Introduction 6
Clinical background 6
Ischemic thresholds and the concept of an ischemic penumbra 6
Current definitions of the ischemic penumbra 7
Characteristics of the ischemic penumbra 9
Metabolism in the penumbra 9
Periinfarct depolarizations characteristics 12
Gene expression molcular markers of the penumbra 14
Part two: Own experimental investigations 16
Aim of the studies 16
Methodological considerations 16
Rat models of focal cerebral ischemia 16
Autoradiography 17
Volume measurements 17
Infarct volumes 17
Telemetric long term measurement of body temperature 19
Pharmacology of the compounds used in the studies 20
Results and comments 21
Paper I: Investigation of the Fos protein as a potential molecular marker of the penumbra 21
Paper II: Effect of NMDA and AMPA receptor blockade on protein synthesis in the ischemic penumbra. 22
Paper III: Double tracer autoradiographic investigation of protein synthesis and glucose consumption in the
ischemic penumbra effect of MK 801 andNBQX 23
Paper IV: Effect of ketobemidone on metabolism in the penumbra and infarct size 24
Paper V: Effect of a PBN on periinfarct depolarizations and infarct size 24
Paper VI: Mitochondrial electron transport complex activity after transient MCAO 26
Paper VII: Effect of broad spectrum cation channel blockade on infarct size 27
Part three: General discussion 29
Mechanisms of focal ischemic brain damage 29
Calcium and other cations 29
Excitoxicity glutamate, glutamate receptors and antagonists 31
Periinfarct depolarizations role in infarct evolution 33
Reactive oxygen species 34
Dysfuntion of mitochondria 36
Cooperating pathogenetic mechanisms 37
Concluding remarks and outlook 38
Specific conclusions 38
General conclusions 39
Outlook and unresolved questions 40
Summary indanish 42
References 44 |
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| spelling | Christensen, Thomas Verfasser aut Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra Thomas Christensen Copenhagen Univ. of Copenhagen 2007 56 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: København, Univ., Diss., 2007 Brain Ischemia Pathophysiology Animal models Ischämie (DE-588)4162456-7 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gehirn (DE-588)4019752-9 s Ischämie (DE-588)4162456-7 s Pathophysiologie (DE-588)4044898-8 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016143698&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Christensen, Thomas Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra Brain Ischemia Pathophysiology Animal models Ischämie (DE-588)4162456-7 gnd Pathophysiologie (DE-588)4044898-8 gnd Gehirn (DE-588)4019752-9 gnd |
| subject_GND | (DE-588)4162456-7 (DE-588)4044898-8 (DE-588)4019752-9 (DE-588)4113937-9 |
| title | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra |
| title_auth | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra |
| title_exact_search | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra |
| title_exact_search_txtP | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra |
| title_full | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra Thomas Christensen |
| title_fullStr | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra Thomas Christensen |
| title_full_unstemmed | Experimental focal cerebral ischemia pathophysiology, metabolism and pharmacology of the ischemic penumbra Thomas Christensen |
| title_short | Experimental focal cerebral ischemia |
| title_sort | experimental focal cerebral ischemia pathophysiology metabolism and pharmacology of the ischemic penumbra |
| title_sub | pathophysiology, metabolism and pharmacology of the ischemic penumbra |
| topic | Brain Ischemia Pathophysiology Animal models Ischämie (DE-588)4162456-7 gnd Pathophysiologie (DE-588)4044898-8 gnd Gehirn (DE-588)4019752-9 gnd |
| topic_facet | Brain Ischemia Pathophysiology Animal models Ischämie Pathophysiologie Gehirn Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016143698&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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