Genomics in regulatory ecotoxicology: applications and challenges
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press / Taylor & Francis
2008
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVII, 168 S. Ill. |
| ISBN: | 9781420066821 142006682x |
Internformat
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| 245 | 1 | 0 | |a Genomics in regulatory ecotoxicology |b applications and challenges |c ed. by Gerald T. Ankley ... |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press / Taylor & Francis |c 2008 | |
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| 650 | 4 | |a Ecological risk assessment |x Methodology | |
| 650 | 4 | |a Environmental Pollutants |x toxicity | |
| 650 | 4 | |a Environmental toxicology | |
| 650 | 4 | |a Genetic toxicology | |
| 650 | 4 | |a Genomics | |
| 650 | 4 | |a Microarray Analysis |x methods | |
| 650 | 4 | |a Risk Assessment | |
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| adam_text | Contents
SETAC Publications..................................................................................................v
List of Figures...........................................................................................................ix
List of Tables.............................................................................................................xi
Foreword................................................................................................................xiii
Preface...................................................................................................................xvii
Acknowledgments...................................................................................................xix
The Editors..............................................................................................................xxi
Contributors...........................................................................................................xxv
Chapter 1 Toxicogenomics in Ecological Risk Assessments: Regulatory
Context, Technical Background, and Workshop Overview.................1
Gerald T Ankley, Ann L Miracle, and Edward J Perkins
Chapter 2 Application of Genomics to Screening..............................................13
Sean W Kennedy, Susan Euling, Duane B Huggett,
L Wim De Coen, Jason R Snape, Timothy R Zacharewski, and
Jun Kanno
Chapter 3 Application of Genomics to Tiered Testing.......................................33
Charles R Tyler, Amy L Filby, Taisen Iguchi, Vincent J Kramer,
DG Joakim Larsson, Graham van Aggelen, Kees van Leeuwen,
Mark R Viant, and Donald E Tillitt
Chapter 4
Application of Genomics to Regulatory Ecological Risk
Assessments for Pesticides................................................
.63
Sigmund J Degitz, Robert A Hoke, Steven Bradbury,
Richard Brennan, Lee Ferguson, Rebecca Klaper, Laszlo
Orban, David Spurgeon, and Susan Tilton
Chapter 5 Application of Genomics to Assessment of the Ecological Risk
of Complex Mixtures.........................................................................87
Edward J Perkins, Nancy Denslow, J Kevin Chipman,
Patrick D Guiney, James R. Oris, Helen Poynton,
Pierre Yves Robidoux, Richard Scroggins, and Glen VanDerKraak
VII
VIII
Chapter 6 Application of Genomic Technologies to Ecological Risk
Assessment at Remediation and Restoration Sites...........................123
Ann L Miracle, Clive W Evans, Elizabeth A Ferguson,
Bruce Greenberg, Peter Kille, Anton R Schaeffner,
Mark Sprenger, Ronny van Aerie, and Donald J Versteeg
Chapter 7 Toxicogenomics in Ecological Risk Assessments:
A Prospectus....................................................................................151
George P Daston, Ann L Miracle, Edward J Perkins, and
Gerald T Ankley
Glossary................................................................................................................157
Index......................................................................................................................161
List of Figures
FIGURE 3.1 Framework illustrating how combining use and exposure information and
effects information obtained from (quantitative) structure-activity relationships ([QJSARs),
read-across methods, thresholds of toxicological concern (TTCs), and in vitro tests prior to in
vivo testing can provide a more rapid, efficient, and cost-effective way to perform risk assess-
ment of chemicals...................................................................................................................37
FIGURE 3.2 Generic tiered-testing and risk assessment framework for prospective ecologi-
cal risk assessments indicating where toxicogenomic data could be incorporated relative to
other models. Rapid prioritization arrows indicate where genomics could be used to inform
on hazard assessment and better direct higher tiers of testing...............................................45
FIGURE 3.3 Conceptual timeline and relative resource requirements for the development
and integration of toxicogenomic data into regulatory programs..........................................48
FIGURE 5.1 Integration of genomics with monitoring in a tiered assessment. The ecologi-
cal risk assessment framework is shown as a tiered process.................................................90
FIGURE 5.2 The linkage between genomic responses and adverse outcomes of concern to
regulators. Note that this also is the area of greatest uncertainty—extrapolating results down
to low doses...........................................................................................................................103
FIGURE 5.3 Schematic of systems toxicology.................................................................113
FIGURE 6.1 Ecological risk assessment (ERA) framework............................................126
FIGURE 6.2 Areas within the characterization of ecological risk assessment in which
genomic technologies can provide clarity within the remediation framework....................132
IX
List of Tables
TABLE 1.1 Plenary session for Pellston workshop entitled Molecular Biology and Risk As-
sessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology ......7
TABLE 2.1 Priority research questions and recommendations for the development of
genomics-based ecotoxicological screening assays...............................................................22
TABLE 2.2 Information required to assist in validation of assays for use in regulatory deci-
sion making.............................................................................................................................23
TABLE 4.1 Typical species utilized for toxicity testing in support of pesticide risk
assessment...............................................................................................................................69
TABLE 4.2 Selected biomarkers for exposure to various types of chemicals....................71
TABLE 4.3 Typical toxicity testing endpoints for aquatic and terrestrial species used in
pesticide risk assessments.......................................................................................................73
TABLE 5.1 Examples of regulatory and status and trend environmental monitoring pro-
grams and tools.......................................................................................................................91
TABLE 6.1 Selected examples of the application of genomic technologies to
remediation..........................................................................................................................135
TABLE 6.2 Specific genomic tools by molecular compartment that identify relevant appli-
cation and how it has been used in environmental assessments..........................................141
TABLE 6.3 Considerations for effective use of genomics technologies in the retrospective
risk assessment process........................................................................................................144
|
| adam_txt |
Contents
SETAC Publications.v
List of Figures.ix
List of Tables.xi
Foreword.xiii
Preface.xvii
Acknowledgments.xix
The Editors.xxi
Contributors.xxv
Chapter 1 Toxicogenomics in Ecological Risk Assessments: Regulatory
Context, Technical Background, and Workshop Overview.1
Gerald T Ankley, Ann L Miracle, and Edward J Perkins
Chapter 2 Application of Genomics to Screening.13
Sean W Kennedy, Susan Euling, Duane B Huggett,
L Wim De Coen, Jason R Snape, Timothy R Zacharewski, and
Jun Kanno
Chapter 3 Application of Genomics to Tiered Testing.33
Charles R Tyler, Amy L Filby, Taisen Iguchi, Vincent J Kramer,
DG Joakim Larsson, Graham van Aggelen, Kees van Leeuwen,
Mark R Viant, and Donald E Tillitt
Chapter 4
Application of Genomics to Regulatory Ecological Risk
Assessments for Pesticides.
.63
Sigmund J Degitz, Robert A Hoke, Steven Bradbury,
Richard Brennan, Lee Ferguson, Rebecca Klaper, Laszlo
Orban, David Spurgeon, and Susan Tilton
Chapter 5 Application of Genomics to Assessment of the Ecological Risk
of Complex Mixtures.87
Edward J Perkins, Nancy Denslow, J Kevin Chipman,
Patrick D Guiney, James R. Oris, Helen Poynton,
Pierre Yves Robidoux, Richard Scroggins, and Glen VanDerKraak
VII
VIII
Chapter 6 Application of Genomic Technologies to Ecological Risk
Assessment at Remediation and Restoration Sites.123
Ann L Miracle, Clive W Evans, Elizabeth A Ferguson,
Bruce Greenberg, Peter Kille, Anton R Schaeffner,
Mark Sprenger, Ronny van Aerie, and Donald J Versteeg
Chapter 7 Toxicogenomics in Ecological Risk Assessments:
A Prospectus.151
George P Daston, Ann L Miracle, Edward J Perkins, and
Gerald T Ankley
Glossary.157
Index.161
List of Figures
FIGURE 3.1 Framework illustrating how combining use and exposure information and
effects information obtained from (quantitative) structure-activity relationships ([QJSARs),
read-across methods, thresholds of toxicological concern (TTCs), and in vitro tests prior to in
vivo testing can provide a more rapid, efficient, and cost-effective way to perform risk assess-
ment of chemicals.37
FIGURE 3.2 Generic tiered-testing and risk assessment framework for prospective ecologi-
cal risk assessments indicating where toxicogenomic data could be incorporated relative to
other models. Rapid prioritization arrows indicate where genomics could be used to inform
on hazard assessment and better direct higher tiers of testing.45
FIGURE 3.3 Conceptual timeline and relative resource requirements for the development
and integration of toxicogenomic data into regulatory programs.48
FIGURE 5.1 Integration of genomics with monitoring in a tiered assessment. The ecologi-
cal risk assessment framework is shown as a tiered process.90
FIGURE 5.2 The linkage between genomic responses and adverse outcomes of concern to
regulators. Note that this also is the area of greatest uncertainty—extrapolating results down
to low doses.103
FIGURE 5.3 Schematic of systems toxicology.113
FIGURE 6.1 Ecological risk assessment (ERA) framework.126
FIGURE 6.2 Areas within the characterization of ecological risk assessment in which
genomic technologies can provide clarity within the remediation framework.132
IX
List of Tables
TABLE 1.1 Plenary session for Pellston workshop entitled "Molecular Biology and Risk As-
sessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology".7
TABLE 2.1 Priority research questions and recommendations for the development of
genomics-based ecotoxicological screening assays.22
TABLE 2.2 Information required to assist in validation of assays for use in regulatory deci-
sion making.23
TABLE 4.1 Typical species utilized for toxicity testing in support of pesticide risk
assessment.69
TABLE 4.2 Selected biomarkers for exposure to various types of chemicals.71
TABLE 4.3 Typical toxicity testing endpoints for aquatic and terrestrial species used in
pesticide risk assessments.73
TABLE 5.1 Examples of regulatory and status and trend environmental monitoring pro-
grams and tools.91
TABLE 6.1 Selected examples of the application of genomic technologies to
remediation.135
TABLE 6.2 Specific genomic tools by molecular compartment that identify relevant appli-
cation and how it has been used in environmental assessments.141
TABLE 6.3 Considerations for effective use of genomics technologies in the retrospective
risk assessment process.144 |
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| spelling | Genomics in regulatory ecotoxicology applications and challenges ed. by Gerald T. Ankley ... Boca Raton [u.a.] CRC Press / Taylor & Francis 2008 XXVII, 168 S. Ill. txt rdacontent n rdamedia nc rdacarrier Ecological risk assessment Methodology Environmental Pollutants toxicity Environmental toxicology Genetic toxicology Genomics Microarray Analysis methods Risk Assessment Toxicogenetics methods Genanalyse (DE-588)4200230-8 gnd rswk-swf Umwelttoxizität (DE-588)4577864-4 gnd rswk-swf Genanalyse (DE-588)4200230-8 s Umwelttoxizität (DE-588)4577864-4 s DE-604 Ankley, Gerald Thomas Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016140709&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genomics in regulatory ecotoxicology applications and challenges Ecological risk assessment Methodology Environmental Pollutants toxicity Environmental toxicology Genetic toxicology Genomics Microarray Analysis methods Risk Assessment Toxicogenetics methods Genanalyse (DE-588)4200230-8 gnd Umwelttoxizität (DE-588)4577864-4 gnd |
| subject_GND | (DE-588)4200230-8 (DE-588)4577864-4 |
| title | Genomics in regulatory ecotoxicology applications and challenges |
| title_auth | Genomics in regulatory ecotoxicology applications and challenges |
| title_exact_search | Genomics in regulatory ecotoxicology applications and challenges |
| title_exact_search_txtP | Genomics in regulatory ecotoxicology applications and challenges |
| title_full | Genomics in regulatory ecotoxicology applications and challenges ed. by Gerald T. Ankley ... |
| title_fullStr | Genomics in regulatory ecotoxicology applications and challenges ed. by Gerald T. Ankley ... |
| title_full_unstemmed | Genomics in regulatory ecotoxicology applications and challenges ed. by Gerald T. Ankley ... |
| title_short | Genomics in regulatory ecotoxicology |
| title_sort | genomics in regulatory ecotoxicology applications and challenges |
| title_sub | applications and challenges |
| topic | Ecological risk assessment Methodology Environmental Pollutants toxicity Environmental toxicology Genetic toxicology Genomics Microarray Analysis methods Risk Assessment Toxicogenetics methods Genanalyse (DE-588)4200230-8 gnd Umwelttoxizität (DE-588)4577864-4 gnd |
| topic_facet | Ecological risk assessment Methodology Environmental Pollutants toxicity Environmental toxicology Genetic toxicology Genomics Microarray Analysis methods Risk Assessment Toxicogenetics methods Genanalyse Umwelttoxizität |
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