Understanding drug release and absorption mechanisms: a physical and mathematical approach
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, FL [u.a.]
CRC Press
2007
|
| Schlagworte: | |
| Online-Zugang: | Publisher description Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes |
| Beschreibung: | 627 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| ISBN: | 0849330874 9780849330872 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV022874806 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 071010s2007 ad|| |||| 00||| eng d | ||
| 010 | |a 006019649 | ||
| 020 | |a 0849330874 |c Hardcover : alk. paper |9 0-8493-3087-4 | ||
| 020 | |a 9780849330872 |c Hardcover : alk. paper |9 978-0-8493-3087-2 | ||
| 035 | |a (OCoLC)70164438 | ||
| 035 | |a (DE-599)GBV513810412 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-19 | ||
| 050 | 0 | |a RM301.5 | |
| 082 | 0 | |a 615/.7 |2 22 | |
| 084 | |a VX 8550 |0 (DE-625)147830:253 |2 rvk | ||
| 245 | 1 | 0 | |a Understanding drug release and absorption mechanisms |b a physical and mathematical approach |c Mario Grassi ... |
| 264 | 1 | |a Boca Raton, FL [u.a.] |b CRC Press |c 2007 | |
| 300 | |a 627 S. |b Ill., graph. Darst. |e 1 CD-ROM (12 cm) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes | ||
| 650 | 4 | |a Mathematisches Modell | |
| 650 | 4 | |a Drugs |x Absorption and adsorption |x Mathematical models | |
| 650 | 4 | |a Drugs |x Controlled release |x Mathematical models | |
| 650 | 4 | |a Drugs |x Solubility |x Mathematical models | |
| 650 | 4 | |a Models, Theoretical | |
| 650 | 4 | |a Pharmaceutical Preparations |x metabolism | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Pharmacokinetics |x Mathematical models | |
| 700 | 1 | |a Grassi, Mario |e Sonstige |4 oth | |
| 856 | 4 | |u http://www.loc.gov/catdir/enhancements/fy0661/2006019649-d.html |z Publisher description |z lizenzfrei | |
| 856 | 4 | |u http://www.loc.gov/catdir/toc/ecip0615/2006019649.html |z lizenzfrei |3 Inhaltsverzeichnis | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016079860&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016079860 | ||
Datensatz im Suchindex
| _version_ | 1804137135582740480 |
|---|---|
| adam_text | Table of Contents
Chapter 1
Mathematical Modeling 1
1.1 Introduction 1
1.2 Model Building 3
1.2.1 Model Building: An Example 8
1.3 Model Fitting 11
1.3.1 Chi Square Fitting: Straight Line 19
1.3.2 Chi Square Fitting: General Case 21
1.3.3 Robust Fitting 22
1.4 Models Comparison 25
1.5 Conclusions 26
References 26
Chapter 2
Part 1 Gastrointestinal Tract 29
2.1 Macro and Microscopic Anatomy of the
Gastrointestinal Tract 29
2.1.1 The Stomach 29
2.1.2 The Small Intestine 30
2.1.3 The Colon 32
2.1.4 Absorptive Cells 32
2.1.5 Tight Junctions 33
2.1.6 Cellular Membrane 34
2.2 Intestinal Absorption 35
2.2.1 Positive and Negative Forces 35
2.2.2 Drug Absorption Pathways 36
2.2.3 Absorption in GI Diseases 38
2.2.4 Models of Intestinal Absorption 40
2.3 Human and Animal GI Tract: A Comparison 42
2.3.1 Anatomy 42
2.3.1.1 The Stomach 42
2.3.1.2 The Small Intestine 43
2.3.1.3 The Colon 43
2.3.2 Physiology 45
2.3.2.1 pH and Bile Fluid 45
2.3.2.2 Microflora and Mucin 49
2.3.2.3 Other Physiological Aspects 50
2.3.3 GI Tract Biochemistry 51
Part 2 Skin 53
2.4 Anatomy 53
2.4.1 Epidermis 53
2.4.1.1 Stratum Corneum Structure 56
2.4.2 Dermis 56
2.4.3 Hypodermis 58
2.5 Skin Delivery Strategies 58
2.5.1 Electrically Based Enhancement 59
2.5.2 Vesicular Carriers 62
2.5.3 Chemical Enhancement 63
2.5.4 Microinvasive Delivery 64
2.5.5 Velocity Based Technique 64
2.6 Animal Model of Skin Delivery 65
2.6.1 Pig 65
2.6.2 Mouse 66
References 68
Chapter 3
Rheology 89
3.1 Introduction 89
3.2 Viscosity and Newtonian Fluids 91
3.3 Shear Dependent Viscosity and Non Newtonian Fluids 95
3.4 Shear Flows 99
3.5 Not Only Viscosity: Normal Stress Differences
and Other Material Functions 102
3.5.1 Tensional State 102
3.5.2 Deformation State 105
3.5.3 Normal Stress Differences 107
3.6 Extensional Flows and Complex Flows 108
3.7 Time Dependence: Thixotropy and Viscoelasticity 112
3.8 Linear Viscoelasticity 116
3.8.1 Oscillatory Shear Test and Linear Viscoelastic Quantities ... 116
3.8.2 Linear Viscoelastic Models 118
3.9 Rheological Properties and
Structural Features 123
3.9.1 Simple Fluids and Homogeneous Mixtures 124
3.9.1.1 Salt Solutions 125
3.9.2 Surfactant Solutions (From Dilute to Micellar
and Crystalline Systems) 126
3.9.3 Polymeric Systems 129
3.9.3.1 Flexible Chains and Ordinary
Polymer Solutions 129
3.9.3.2 Rigid Chains and Crystalline Polymer Solutions... 135
3.9.3.3 Time Temperature Superposition Principle 139
3.9.3.4 Associative Polymer Solutions and Gels 140
3.9.3.5 Weak and Strong Physical Gels 143
3.9.4 Disperse Systems 145
3.9.4.1 Colloidal Interactions and Dispersion State 146
3.9.4.2 Suspensions of Noninteracting Particles
(Hard Sphere Model) 149
3.9.4.3 Effects of Particle Size Distribution and Shape 152
3.9.4.4 Suspensions of Stabilized Particles 154
3.9.4.5 Suspensions of Attractive Particles 155
3.9.4.6 Emulsions 159
3.9.4.7 Microemulsions 163
3.9.4.8 Dispersions in Polymeric Matrices 163
3.10 Conclusive Considerations on Rheology Applications
to Drug Delivery Systems 164
References 168
Chapter 4
Mass Transport 177
4.1 Introduction 177
4.2 Thermodynamic Concepts 179
4.2.1 Thermodynamic Equilibrium 180
4.2.2 Gibbs Duhem Equation 183
4.2.3 Thermodynamic Potentials 184
4.3 Kinetics 185
4.3.1 Mass Conservation Law 187
4.3.2 Momentum Conservation Law 192
4.3.3 Energy Conservation Law 198
4.3.4 Final Considerations 201
4.4 Fick s Equation 202
4.4.1 Diffusion Coefficient 202
4.4.1.1 Diffusion in Solid or Solid Like Medium 204
4.4.2 Fickian Kinetics 215
4.5 Effect of Initial and Boundary Conditions 218
4.5.1 Finite Release Environment Volume
and Partition Coefficient 219
4.5.2 Initial Drug Distribution 221
4.5.3 Stagnant Layer 230
4.5.4 Holed Surfaces 231
4.5.4.1 Buchtel Model 236
4.6 Conclusions 244
References 246
Chapter 5
Drug Dissolution and Partitioning 249
5.1 Introduction 249
5.2 Dissolution 251
5.2.1 Surface Properties 253
5.2.1.1 Young s Equation 255
5.2.1.2 Surface Tension Determination 259
5.2.1.3 Wettability Effect on Drug Dissolution 265
5.2.2 Hydrodynamics 271
5.2.2.1 Rotating Disk Apparatus 272
5.2.2.2 Fixed Disk Apparatus 280
5.2.2.3 USP Apparatus 282
5.2.2.4 Channel Flow Method 285
5.2.3 Drug Solubility and Stability 288
5.2.3.1 Dissolution and Phase Changes 289
5.2.3.2 Dissolution of Polyphase Mixtures 291
5.2.3.3 Dissolution of Polyphase Mixtures:
A Particular Case 297
5.2.3.4 Dissolution and Drug Degradation 301
5.2.4 Dissolution of Paniculate Systems 302
5.3 Partitioning 306
5.3.1 Three Phases Partitioning 313
5.3.2 Partitioning and Permeation 318
5.3.3 Log(F) Calculation 320
5.4 Dissolution and Partitioning 321
5.5 Conclusions 324
References 327
Chapter 6
Dissolution of Crystallites: Effects of Size on Solubility 333
6.1 Introduction 333
6.2 Thermodynamic Concepts 334
6.2.1 Ideal Solutions 335
6.2.2 Melting Temperature Dependence
on Crystal Dimension 340
6.2.3 Solubility Dependence on Crystal Dimension 350
6.2.3.1 Liquid Vapor System 350
6.2.3.2 Solid Liquid System 352
6.3 Experimental Methods and Limitations 354
6.4 Conclusions 365
References 366
Chapter 7
Drug Release from Matrix Systems 371
7.1 Introduction 371
7.2 Matrices 372
7.2.1 Matrix Topology 373
7.2.2 Release Mechanisms 381
7.3 Mathematical Modeling 387
7.3.1 Diffusion Controlled Systems 394
7.3.2 Diffusion and Matrix/Drug Interactions
Controlled Systems 401
7.3.3 Diffusion and Chemical Reaction Controlled Systems 411
7.3.4 Diffusion and Dissolution Controlled Systems 414
7.3.5 Diffusion , Dissolution , and Swelling
Controlled Systems 429
7.3.5.1 Matrix Swelling Equilibrium 429
7.3.5.2 Matrix Swelling Kinetics 439
7.3.5.3 Drug Dissolution and Diffusion 449
7.3.6 Erosion Controlled Systems 452
7.3.7 Polydisperse Systems 460
7.3.8 Diffusion in Fractal Matrices 474
7.4 Conclusions 478
References 479
Chapter 8
Drug Release from Microemulsions 493
8.1 Introduction 493
8.2 Microemulsions: Structure 495
8.3 Microemulsions: Thermodynamics 498
8.3.1 Discrete Microemulsions Droplet Size Distribution 499
8.3.2 Liquid Liquid Interfacial Composition 500
8.4 Microemulsions: Experimental Characterization 509
8.4.1 Scattering Techniques 509
8.4.2 Nuclear Magnetic Resonance Techniques 510
8.4.3 Electronic Microscopy 510
8.4.4 Conductivity and Dielectric Spectroscopy 511
8.4.5 Rheology 511
8.5 Microemulsions and Drug Release 512
8.5.1 Microemulsion Administration Routes 513
8.5.2 Modeling of Drug Release from Microemulsions 515
8.5.2.1 Simple Case 519
8.5.2.2 More Complex Situation 525
8.6 Conclusions 534
References 535
Chapter 9
Drug Permeation through Membranes 539
9.1 Introduction 539
9.2 Synthetic Membranes 540
9.2.1 Synthetic Membranes Permeability Determination 541
9.2.2 Microencapsulated Systems 550
9.2.2.1 Physical Frame 551
9.2.2.2 Modeling 553
9.3 Biological Membranes 565
9.3.1 Intestinal Mucosa 565
9.3.1.1 In Silico Methods 565
9.3.1.2 Physicochemical Methods 567
9.3.1.3 In Vitro Methods 569
9.3.1.4 In Situ Methods 571
9.3.1.5 In Vivo Methods 571
9.3.1.6 Modeling: Everted Gut 572
9.3.1.7 Modeling: Single Pass and
Recirculating Perfusion 575
9.3.2 Skin 583
9.3.2.1 Mechanistic Models 586
9.3.2.2 Empirical Models 596
9.4 Conclusions 598
References 598
Index 607
|
| adam_txt |
Table of Contents
Chapter 1
Mathematical Modeling 1
1.1 Introduction 1
1.2 Model Building 3
1.2.1 Model Building: An Example 8
1.3 Model Fitting 11
1.3.1 Chi Square Fitting: Straight Line 19
1.3.2 Chi Square Fitting: General Case 21
1.3.3 Robust Fitting 22
1.4 Models Comparison 25
1.5 Conclusions 26
References 26
Chapter 2
Part 1 Gastrointestinal Tract 29
2.1 Macro and Microscopic Anatomy of the
Gastrointestinal Tract 29
2.1.1 The Stomach 29
2.1.2 The Small Intestine 30
2.1.3 The Colon 32
2.1.4 Absorptive Cells 32
2.1.5 Tight Junctions 33
2.1.6 Cellular Membrane 34
2.2 Intestinal Absorption 35
2.2.1 Positive and Negative Forces 35
2.2.2 Drug Absorption Pathways 36
2.2.3 Absorption in GI Diseases 38
2.2.4 Models of Intestinal Absorption 40
2.3 Human and Animal GI Tract: A Comparison 42
2.3.1 Anatomy 42
2.3.1.1 The Stomach 42
2.3.1.2 The Small Intestine 43
2.3.1.3 The Colon 43
2.3.2 Physiology 45
2.3.2.1 pH and Bile Fluid 45
2.3.2.2 Microflora and Mucin 49
2.3.2.3 Other Physiological Aspects 50
2.3.3 GI Tract Biochemistry 51
Part 2 Skin 53
2.4 Anatomy 53
2.4.1 Epidermis 53
2.4.1.1 Stratum Corneum Structure 56
2.4.2 Dermis 56
2.4.3 Hypodermis 58
2.5 Skin Delivery Strategies 58
2.5.1 Electrically Based Enhancement 59
2.5.2 Vesicular Carriers 62
2.5.3 Chemical Enhancement 63
2.5.4 Microinvasive Delivery 64
2.5.5 Velocity Based Technique 64
2.6 Animal Model of Skin Delivery 65
2.6.1 Pig 65
2.6.2 Mouse 66
References 68
Chapter 3
Rheology 89
3.1 Introduction 89
3.2 Viscosity and Newtonian Fluids 91
3.3 Shear Dependent Viscosity and Non Newtonian Fluids 95
3.4 Shear Flows 99
3.5 Not Only Viscosity: Normal Stress Differences
and Other Material Functions 102
3.5.1 Tensional State 102
3.5.2 Deformation State 105
3.5.3 Normal Stress Differences 107
3.6 Extensional Flows and Complex Flows 108
3.7 Time Dependence: Thixotropy and Viscoelasticity 112
3.8 Linear Viscoelasticity 116
3.8.1 Oscillatory Shear Test and Linear Viscoelastic Quantities . 116
3.8.2 Linear Viscoelastic Models 118
3.9 Rheological Properties and
Structural Features 123
3.9.1 Simple Fluids and Homogeneous Mixtures 124
3.9.1.1 Salt Solutions 125
3.9.2 Surfactant Solutions (From Dilute to Micellar
and Crystalline Systems) 126
3.9.3 Polymeric Systems 129
3.9.3.1 Flexible Chains and Ordinary
Polymer Solutions 129
3.9.3.2 Rigid Chains and Crystalline Polymer Solutions. 135
3.9.3.3 Time Temperature Superposition Principle 139
3.9.3.4 Associative Polymer Solutions and Gels 140
3.9.3.5 Weak and Strong Physical Gels 143
3.9.4 Disperse Systems 145
3.9.4.1 Colloidal Interactions and Dispersion State 146
3.9.4.2 Suspensions of Noninteracting Particles
(Hard Sphere Model) 149
3.9.4.3 Effects of Particle Size Distribution and Shape 152
3.9.4.4 Suspensions of Stabilized Particles 154
3.9.4.5 Suspensions of Attractive Particles 155
3.9.4.6 Emulsions 159
3.9.4.7 Microemulsions 163
3.9.4.8 Dispersions in Polymeric Matrices 163
3.10 Conclusive Considerations on Rheology Applications
to Drug Delivery Systems 164
References 168
Chapter 4
Mass Transport 177
4.1 Introduction 177
4.2 Thermodynamic Concepts 179
4.2.1 Thermodynamic Equilibrium 180
4.2.2 Gibbs Duhem Equation 183
4.2.3 Thermodynamic Potentials 184
4.3 Kinetics 185
4.3.1 Mass Conservation Law 187
4.3.2 Momentum Conservation Law 192
4.3.3 Energy Conservation Law 198
4.3.4 Final Considerations 201
4.4 Fick's Equation 202
4.4.1 Diffusion Coefficient 202
4.4.1.1 Diffusion in Solid or Solid Like Medium 204
4.4.2 Fickian Kinetics 215
4.5 Effect of Initial and Boundary Conditions 218
4.5.1 Finite Release Environment Volume
and Partition Coefficient 219
4.5.2 Initial Drug Distribution 221
4.5.3 Stagnant Layer 230
4.5.4 Holed Surfaces 231
4.5.4.1 Buchtel Model 236
4.6 Conclusions 244
References 246
Chapter 5
Drug Dissolution and Partitioning 249
5.1 Introduction 249
5.2 Dissolution 251
5.2.1 Surface Properties 253
5.2.1.1 Young's Equation 255
5.2.1.2 Surface Tension Determination 259
5.2.1.3 Wettability Effect on Drug Dissolution 265
5.2.2 Hydrodynamics 271
5.2.2.1 Rotating Disk Apparatus 272
5.2.2.2 Fixed Disk Apparatus 280
5.2.2.3 USP Apparatus 282
5.2.2.4 Channel Flow Method 285
5.2.3 Drug Solubility and Stability 288
5.2.3.1 Dissolution and Phase Changes 289
5.2.3.2 Dissolution of Polyphase Mixtures 291
5.2.3.3 Dissolution of Polyphase Mixtures:
A Particular Case 297
5.2.3.4 Dissolution and Drug Degradation 301
5.2.4 Dissolution of Paniculate Systems 302
5.3 Partitioning 306
5.3.1 Three Phases Partitioning 313
5.3.2 Partitioning and Permeation 318
5.3.3 Log(F) Calculation 320
5.4 Dissolution and Partitioning 321
5.5 Conclusions 324
References 327
Chapter 6
Dissolution of Crystallites: Effects of Size on Solubility 333
6.1 Introduction 333
6.2 Thermodynamic Concepts 334
6.2.1 Ideal Solutions 335
6.2.2 Melting Temperature Dependence
on Crystal Dimension 340
6.2.3 Solubility Dependence on Crystal Dimension 350
6.2.3.1 Liquid Vapor System 350
6.2.3.2 Solid Liquid System 352
6.3 Experimental Methods and Limitations 354
6.4 Conclusions 365
References 366
Chapter 7
Drug Release from Matrix Systems 371
7.1 Introduction 371
7.2 Matrices 372
7.2.1 Matrix Topology 373
7.2.2 Release Mechanisms 381
7.3 Mathematical Modeling 387
7.3.1 Diffusion Controlled Systems 394
7.3.2 Diffusion and Matrix/Drug Interactions
Controlled Systems 401
7.3.3 Diffusion and Chemical Reaction Controlled Systems 411
7.3.4 Diffusion and Dissolution Controlled Systems 414
7.3.5 Diffusion , Dissolution , and Swelling
Controlled Systems 429
7.3.5.1 Matrix Swelling Equilibrium 429
7.3.5.2 Matrix Swelling Kinetics 439
7.3.5.3 Drug Dissolution and Diffusion 449
7.3.6 Erosion Controlled Systems 452
7.3.7 Polydisperse Systems 460
7.3.8 Diffusion in Fractal Matrices 474
7.4 Conclusions 478
References 479
Chapter 8
Drug Release from Microemulsions 493
8.1 Introduction 493
8.2 Microemulsions: Structure 495
8.3 Microemulsions: Thermodynamics 498
8.3.1 Discrete Microemulsions' Droplet Size Distribution 499
8.3.2 Liquid Liquid Interfacial Composition 500
8.4 Microemulsions: Experimental Characterization 509
8.4.1 Scattering Techniques 509
8.4.2 Nuclear Magnetic Resonance Techniques 510
8.4.3 Electronic Microscopy 510
8.4.4 Conductivity and Dielectric Spectroscopy 511
8.4.5 Rheology 511
8.5 Microemulsions and Drug Release 512
8.5.1 Microemulsion Administration Routes 513
8.5.2 Modeling of Drug Release from Microemulsions 515
8.5.2.1 Simple Case 519
8.5.2.2 More Complex Situation 525
8.6 Conclusions 534
References 535
Chapter 9
Drug Permeation through Membranes 539
9.1 Introduction 539
9.2 Synthetic Membranes 540
9.2.1 Synthetic Membranes Permeability Determination 541
9.2.2 Microencapsulated Systems 550
9.2.2.1 Physical Frame 551
9.2.2.2 Modeling 553
9.3 Biological Membranes 565
9.3.1 Intestinal Mucosa 565
9.3.1.1 In Silico Methods 565
9.3.1.2 Physicochemical Methods 567
9.3.1.3 In Vitro Methods 569
9.3.1.4 In Situ Methods 571
9.3.1.5 In Vivo Methods 571
9.3.1.6 Modeling: Everted Gut 572
9.3.1.7 Modeling: Single Pass and
Recirculating Perfusion 575
9.3.2 Skin 583
9.3.2.1 Mechanistic Models 586
9.3.2.2 Empirical Models 596
9.4 Conclusions 598
References 598
Index 607 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| building | Verbundindex |
| bvnumber | BV022874806 |
| callnumber-first | R - Medicine |
| callnumber-label | RM301 |
| callnumber-raw | RM301.5 |
| callnumber-search | RM301.5 |
| callnumber-sort | RM 3301.5 |
| callnumber-subject | RM - Therapeutics and Pharmacology |
| classification_rvk | VX 8550 |
| ctrlnum | (OCoLC)70164438 (DE-599)GBV513810412 |
| dewey-full | 615/.7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.7 |
| dewey-search | 615/.7 |
| dewey-sort | 3615 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| discipline_str_mv | Chemie / Pharmazie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02250nam a2200469 c 4500</leader><controlfield tag="001">BV022874806</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">071010s2007 ad|| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">006019649</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0849330874</subfield><subfield code="c">Hardcover : alk. paper</subfield><subfield code="9">0-8493-3087-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780849330872</subfield><subfield code="c">Hardcover : alk. paper</subfield><subfield code="9">978-0-8493-3087-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)70164438</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBV513810412</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-19</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM301.5</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.7</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VX 8550</subfield><subfield code="0">(DE-625)147830:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Understanding drug release and absorption mechanisms</subfield><subfield code="b">a physical and mathematical approach</subfield><subfield code="c">Mario Grassi ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton, FL [u.a.]</subfield><subfield code="b">CRC Press</subfield><subfield code="c">2007</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">627 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield><subfield code="e">1 CD-ROM (12 cm)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mathematisches Modell</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs</subfield><subfield code="x">Absorption and adsorption</subfield><subfield code="x">Mathematical models</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs</subfield><subfield code="x">Controlled release</subfield><subfield code="x">Mathematical models</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs</subfield><subfield code="x">Solubility</subfield><subfield code="x">Mathematical models</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Models, Theoretical</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical Preparations</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacokinetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacokinetics</subfield><subfield code="x">Mathematical models</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grassi, Mario</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/enhancements/fy0661/2006019649-d.html</subfield><subfield code="z">Publisher description</subfield><subfield code="z">lizenzfrei</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/toc/ecip0615/2006019649.html</subfield><subfield code="z">lizenzfrei</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016079860&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016079860</subfield></datafield></record></collection> |
| id | DE-604.BV022874806 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:48:37Z |
| indexdate | 2024-07-09T21:07:29Z |
| institution | BVB |
| isbn | 0849330874 9780849330872 |
| language | English |
| lccn | 006019649 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016079860 |
| oclc_num | 70164438 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | 627 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Understanding drug release and absorption mechanisms a physical and mathematical approach Mario Grassi ... Boca Raton, FL [u.a.] CRC Press 2007 627 S. Ill., graph. Darst. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes Mathematisches Modell Drugs Absorption and adsorption Mathematical models Drugs Controlled release Mathematical models Drugs Solubility Mathematical models Models, Theoretical Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Mathematical models Grassi, Mario Sonstige oth http://www.loc.gov/catdir/enhancements/fy0661/2006019649-d.html Publisher description lizenzfrei http://www.loc.gov/catdir/toc/ecip0615/2006019649.html lizenzfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016079860&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Understanding drug release and absorption mechanisms a physical and mathematical approach Mathematisches Modell Drugs Absorption and adsorption Mathematical models Drugs Controlled release Mathematical models Drugs Solubility Mathematical models Models, Theoretical Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Mathematical models |
| title | Understanding drug release and absorption mechanisms a physical and mathematical approach |
| title_auth | Understanding drug release and absorption mechanisms a physical and mathematical approach |
| title_exact_search | Understanding drug release and absorption mechanisms a physical and mathematical approach |
| title_exact_search_txtP | Understanding drug release and absorption mechanisms a physical and mathematical approach |
| title_full | Understanding drug release and absorption mechanisms a physical and mathematical approach Mario Grassi ... |
| title_fullStr | Understanding drug release and absorption mechanisms a physical and mathematical approach Mario Grassi ... |
| title_full_unstemmed | Understanding drug release and absorption mechanisms a physical and mathematical approach Mario Grassi ... |
| title_short | Understanding drug release and absorption mechanisms |
| title_sort | understanding drug release and absorption mechanisms a physical and mathematical approach |
| title_sub | a physical and mathematical approach |
| topic | Mathematisches Modell Drugs Absorption and adsorption Mathematical models Drugs Controlled release Mathematical models Drugs Solubility Mathematical models Models, Theoretical Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Mathematical models |
| topic_facet | Mathematisches Modell Drugs Absorption and adsorption Mathematical models Drugs Controlled release Mathematical models Drugs Solubility Mathematical models Models, Theoretical Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Mathematical models |
| url | http://www.loc.gov/catdir/enhancements/fy0661/2006019649-d.html http://www.loc.gov/catdir/toc/ecip0615/2006019649.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016079860&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT grassimario understandingdrugreleaseandabsorptionmechanismsaphysicalandmathematicalapproach |
Es ist kein Print-Exemplar vorhanden.
Inhaltsverzeichnis