New strategies for the application of adeno-associated virus type 2 targeting vectors:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Hut
2006
|
| Ausgabe: | 1. Aufl. |
| Schriftenreihe: | Molekularbiologie
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: München, Univ., Diss., 2006 |
| Beschreibung: | 110 S. Ill., graph. Darst. 210 mm x 148 mm, 168 gr. |
| ISBN: | 9783899634112 389963411X |
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Datensatz im Suchindex
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| adam_text | CONTENTS CONTENTS SUMMARV .......... 1 1. INTRODUCTION S 1.1.
ADENO-ASSOCIATED VIRUS AS VECTOR FOR HUMAN GENE THERAPY 5 1.2. GENOMIC
AND STRUCTURAL ORGANIZATION OF AAV 8 1.3. AAV TARGETING VECTORS 12 2.
CHAPTER I - UNIVERSAL TARGETING OF AAV.... 14 2.1. INTRODUCTION CHAPTER
I 14 2.2. RESULTS CHAPTER 1 18 INSERTION OF CYSTEINE AS REACTION PARTNER
INTO THE AAV CAPSID 18 COUPLING OF RAAV TO LIGANDS VIA POLYIONIC FUSION
PEPTIDES 21 COUPLING BY MALEIMIDE REACTION 25 2.3. DLSCUSSION CHAPTER 1
28 AAV-2 TOLERATES INSERTION OF POLYIONIC SEQUENCE AND CYSTEINE INTO THE
CAPSID STRUCTURE 28 AAV-GLU CAN BE CONJUGATED TO OREGON GREEN DYE BY
THIOL MALEIMIDE REACTION 29 CONJUGATION OF AAV-GLU DID NOT RESULT IN
EFFICIENT TRANSDUCTION OF TARGET CELLS 29 CONJUGATION OF AAV-CYS TO
LIGANDS BY MALEIMIDE REACTION 31 3. CHAPTER 11 - DEVELOPMENT OF AN AAV
BASED ANTI-IDIOTYPIC VACCINE 33 3.1. INTRODUCTION CHAPTER II 33 IGE AS
THERAPEUTIC TARGET IN ALLERGIE DISEASES 33 3.2. RESULTS CHAPTER II 37
COUPLING OF GENO- AND PHENOTYPE 37 SELECTION OF AAV PARTICLES WITH
SPEEIFIE AFFINITY FOR A TARGET ANTIBODY FROM THE COUPLED VIRAL LIBRARY
46 3.3. DLSCUSSION AND OUTLOOK CHAPTER II 55 UPTAKE SEEMS TO ALLOW
UNSPEEIFIE INTERNALIZATION OF AAV 55 HOMOGENEOUS LIBRARY MUTANTS RESULT
FROM COUPLING THROUGH UPTAKE OR INFECTION 57 SELECTION OF ANTI-IDIOTYPIC
AAV MUTANTS ON ANTIBODIES BY SOLID PHASE 61 OUTLOO BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/984186956 DIGITALISIERT DURCH CONTENTS
ENZYMES 82 ANTIBODIES 82 SYNTHETIC OLIGONUCLEOTIDES 82 CHEMICALS AND
OTHER MATERIAL 82 PRIMERS 84 STANDARDS AND KITS 84 BUFFER AND SOLUTIONS
85 EQUIPMENT 87 5.2. METHODS 87 GENERAL METHODS 87 ESTABLISHED METHODS
93 6. ABBREVIATIONS 99 7. REFERENCES 101
|
| adam_txt |
CONTENTS CONTENTS SUMMARV . 1 1. INTRODUCTION S 1.1.
ADENO-ASSOCIATED VIRUS AS VECTOR FOR HUMAN GENE THERAPY 5 1.2. GENOMIC
AND STRUCTURAL ORGANIZATION OF AAV 8 1.3. AAV TARGETING VECTORS 12 2.
CHAPTER I - UNIVERSAL TARGETING OF AAV. 14 2.1. INTRODUCTION CHAPTER
I 14 2.2. RESULTS CHAPTER 1 18 INSERTION OF CYSTEINE AS REACTION PARTNER
INTO THE AAV CAPSID 18 COUPLING OF RAAV TO LIGANDS VIA POLYIONIC FUSION
PEPTIDES 21 COUPLING BY MALEIMIDE REACTION 25 2.3. DLSCUSSION CHAPTER 1
28 AAV-2 TOLERATES INSERTION OF POLYIONIC SEQUENCE AND CYSTEINE INTO THE
CAPSID STRUCTURE 28 AAV-GLU CAN BE CONJUGATED TO OREGON GREEN DYE BY
THIOL MALEIMIDE REACTION 29 CONJUGATION OF AAV-GLU DID NOT RESULT IN
EFFICIENT TRANSDUCTION OF TARGET CELLS 29 CONJUGATION OF AAV-CYS TO
LIGANDS BY MALEIMIDE REACTION 31 3. CHAPTER 11 - DEVELOPMENT OF AN AAV
BASED ANTI-IDIOTYPIC VACCINE 33 3.1. INTRODUCTION CHAPTER II 33 IGE AS
THERAPEUTIC TARGET IN ALLERGIE DISEASES 33 3.2. RESULTS CHAPTER II 37
COUPLING OF GENO- AND PHENOTYPE 37 SELECTION OF AAV PARTICLES WITH
SPEEIFIE AFFINITY FOR A TARGET ANTIBODY FROM THE COUPLED VIRAL LIBRARY
46 3.3. DLSCUSSION AND OUTLOOK CHAPTER II 55 UPTAKE SEEMS TO ALLOW
UNSPEEIFIE INTERNALIZATION OF AAV 55 HOMOGENEOUS LIBRARY MUTANTS RESULT
FROM COUPLING THROUGH UPTAKE OR INFECTION 57 SELECTION OF ANTI-IDIOTYPIC
AAV MUTANTS ON ANTIBODIES BY SOLID PHASE 61 OUTLOO BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/984186956 DIGITALISIERT DURCH CONTENTS
ENZYMES 82 ANTIBODIES 82 SYNTHETIC OLIGONUCLEOTIDES 82 CHEMICALS AND
OTHER MATERIAL 82 PRIMERS 84 STANDARDS AND KITS 84 BUFFER AND SOLUTIONS
85 EQUIPMENT 87 5.2. METHODS 87 GENERAL METHODS 87 ESTABLISHED METHODS
93 6. ABBREVIATIONS 99 7. REFERENCES 101 |
| any_adam_object | 1 |
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| author | Goldnau, Daniela 1975- |
| author_GND | (DE-588)133304752 |
| author_facet | Goldnau, Daniela 1975- |
| author_role | aut |
| author_sort | Goldnau, Daniela 1975- |
| author_variant | d g dg |
| building | Verbundindex |
| bvnumber | BV022867639 |
| ctrlnum | (OCoLC)644673824 (DE-599)DNB984186956 |
| dewey-full | 615.895 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.895 |
| dewey-search | 615.895 |
| dewey-sort | 3615.895 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 1. Aufl. |
| format | Book |
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| id | DE-604.BV022867639 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:45:50Z |
| indexdate | 2024-07-09T21:07:19Z |
| institution | BVB |
| isbn | 9783899634112 389963411X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016072796 |
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| owner_facet | DE-19 DE-BY-UBM DE-29T DE-12 |
| physical | 110 S. Ill., graph. Darst. 210 mm x 148 mm, 168 gr. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
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| publisher | Hut |
| record_format | marc |
| series2 | Molekularbiologie |
| spelling | Goldnau, Daniela 1975- Verfasser (DE-588)133304752 aut New strategies for the application of adeno-associated virus type 2 targeting vectors Daniela Goldnau Molekularbiologie 1. Aufl. München Hut 2006 110 S. Ill., graph. Darst. 210 mm x 148 mm, 168 gr. txt rdacontent n rdamedia nc rdacarrier Zugl.: München, Univ., Diss., 2006 Dependoviren (DE-588)4363893-4 gnd rswk-swf Gentherapie (DE-588)4296957-8 gnd rswk-swf Typ 2 (DE-588)4326601-0 gnd rswk-swf Vektor Genetik (DE-588)4279246-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gentherapie (DE-588)4296957-8 s Dependoviren (DE-588)4363893-4 s Typ 2 (DE-588)4326601-0 s Vektor Genetik (DE-588)4279246-0 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016072796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Goldnau, Daniela 1975- New strategies for the application of adeno-associated virus type 2 targeting vectors Dependoviren (DE-588)4363893-4 gnd Gentherapie (DE-588)4296957-8 gnd Typ 2 (DE-588)4326601-0 gnd Vektor Genetik (DE-588)4279246-0 gnd |
| subject_GND | (DE-588)4363893-4 (DE-588)4296957-8 (DE-588)4326601-0 (DE-588)4279246-0 (DE-588)4113937-9 |
| title | New strategies for the application of adeno-associated virus type 2 targeting vectors |
| title_alt | Molekularbiologie |
| title_auth | New strategies for the application of adeno-associated virus type 2 targeting vectors |
| title_exact_search | New strategies for the application of adeno-associated virus type 2 targeting vectors |
| title_exact_search_txtP | New strategies for the application of adeno-associated virus type 2 targeting vectors |
| title_full | New strategies for the application of adeno-associated virus type 2 targeting vectors Daniela Goldnau |
| title_fullStr | New strategies for the application of adeno-associated virus type 2 targeting vectors Daniela Goldnau |
| title_full_unstemmed | New strategies for the application of adeno-associated virus type 2 targeting vectors Daniela Goldnau |
| title_short | New strategies for the application of adeno-associated virus type 2 targeting vectors |
| title_sort | new strategies for the application of adeno associated virus type 2 targeting vectors |
| topic | Dependoviren (DE-588)4363893-4 gnd Gentherapie (DE-588)4296957-8 gnd Typ 2 (DE-588)4326601-0 gnd Vektor Genetik (DE-588)4279246-0 gnd |
| topic_facet | Dependoviren Gentherapie Typ 2 Vektor Genetik Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016072796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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