Appetite and body weight: integrative systems and the development of anti-obesity drugs
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2007
|
| Schlagworte: | |
| Online-Zugang: | Table of contents only Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | X, 371 S., [1] Bl. Ill., graph. Darst. |
| ISBN: | 0123706335 9780123706331 |
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| 245 | 1 | 0 | |a Appetite and body weight |b integrative systems and the development of anti-obesity drugs |c ed. by Tim C. Kirkham ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2007 | |
| 300 | |a X, 371 S., [1] Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Appétit | |
| 650 | 7 | |a Geneesmiddelen |2 gtt | |
| 650 | 4 | |a Obésité - Aspect psychologique | |
| 650 | 4 | |a Poids corporel | |
| 650 | 7 | |a Vetzucht |2 gtt | |
| 650 | 4 | |a Psychologie | |
| 650 | 4 | |a Appetite | |
| 650 | 4 | |a Body Weight | |
| 650 | 4 | |a Anti-Obesity Agents | |
| 650 | 4 | |a Obesity |x physiopathology | |
| 650 | 4 | |a Obesity |x Psychological aspects | |
| 650 | 4 | |a Body weight | |
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| 700 | 1 | |a Kirkham, Tim C. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804137105192910848 |
|---|---|
| adam_text | Contents
Contributors vii
1. Introduction and Overview 1
Steven J. Cooper and Tim C. Kirkham
2. Cortical Systems Involved in Appetite and Food Consumption 5
Morten L. Kringelbach
I. Introduction 5
II. Food Motivation 6
III. Cortical Representations of Sensory Inputs 8
IV. Conclusion 20
Acknowledgments 20
References 20
3. The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems
Regulating Food Intake 27
Thomas R. Stratford
I. Introduction 28
II. The Regulation of Feeding Behavior by the Nucleus Accumbens Shell 29
III. Afferent Projections to the AcbSh That May Be Involved in Regulating Food Intake 38
IV. Downstream Components of the Functional AcbSh Feeding Circuit 43
V. The AcbSh Feeding Circuit As a Potential Site for Pathology and Therapeutic
Intervention in the Treatment of Eating Disorders 53
References 55
4. Hypothalamic Neuropeptides and Feeding Regulation 67
Bernard Beck
I. Introduction 68
II. Neuropeptide Y 69
v
yi CONTENTS
III. The Orexins 75
IV. Melanin Concentrating Hormone 78
V. Conclusion 81
Acknowledgments 81
References 81
5. Brainstem Hypothalamic Neuropeptides and the Regulation of Feeding 99
Simon M. Luckman
I. The Control of Feeding 100
II. Neural Integration by the Dorsal Vagal Complex 103
III. Considerations in Assessing the Role of Neuropeptides 105
IV. Humoral Interactions with the Dorsal Vagal Complex 107
V. Intrinsic Peptidergic Neurons of the Dorsal Vagal Complex 114
VI. Descending Peptidergic Regulation of Brainstem Feeding Circuits 119
VII. Summary and Potential for Drug Development 122
References 123
6. The Gut Brain Axis in the Control of Eating 143
Thomas A. Lutz and Nori Geary
I. Introduction 144
II. Gastric Mechanoreception 145
III. Intestinal Cholecystokinin (CCK) 146
IV. Amylin 152
V. Ghrelin 155
VI. Potentials and Problems of Gut Brain Axis Signals in the Treatment of Obesity 158
References 160
7. Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite 167
Dianne Figlewicz Lattemann, Nicole M. Sanders, Amy MacDonald Naleid and Alfred]. Sipols
I. Introduction and Overview 168
II. Mesolimbic Dopamine Circuitry and Energy Regulatory Signals 170
III. Brain Opioid Systems and Energy Regulatory Signals 171
IV. Endocannabinoids and Energy Regulatory Signals 175
V. LHA Circuitry and Energy Regulatory Signals 176
VI. Other CNS Sites: Target for Future Studies? 178
VII. Human and Clinical Studies: At the Forefront of Our Knowledge 179
VIII. Concluding Remarks 183
Acknowledgments 183
References 183
8. Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating
Disorders 191
Kent C. Berridge
I. Introduction 192
II. Possible Roles of Brain Reward Systems in Eating Disorders 192
III. Understanding Brain Reward Systems for Food Liking and Wanting 193
CONTENTS Vii
IV. Wanting Without Liking 201
V. A Brief History of Appetite: Food Incentives, Not Hunger Drives 208
VI. Connecting Brain Reward and Regulatory Systems 210
VII. Conclusion 210
Acknowledgments 211
References 211
9. Pharmacology of Food, Taste and Learned Flavor Preferences 217
Steven]. Cooper
I. Introduction 217
II. Pharmacology of Food Preference 219
III. Pharmacology of Unlearned Taste Preference and Reactivity 224
IV. Pharmacology of Learned Flavor Preference 232
V. Concluding Remarks 236
Acknowledgments 238
References 238
10. The Role of Palatability in Control of Human Appetite: Implications for Understanding
and Treating Obesity 247
Martin R. Yeomans
I. Introduction 248
II. Assessing the Effects of Palatability on Appetite 248
III. Palatability and the Control of Normal Appetite 250
IV. Palatability and Obesity 262
V. Conclusion 264
References 264
11. Learned Influences on Appetite, Food Choice, and Intake: Evidence in Human
Beings 271
E.L. Gibson and].M. Brunstrom
I. Introduction 272
II. Innate Influences on Human Eating 273
III. Types of Learning 274
IV. The Learned Appetite for Energy 277
V. Learned Modulation of Appetite and Meal Size by Associated States 278
VI. Nutrient Specific Learned Appetites 283
VII. Flavor Flavor Learning 286
VIII. Awareness and Dietary Learning 290
IX. Summary 293
References 294
12. Gene Environment Interactions and the Origin of the Modern Obesity Epidemic:
A Novel Nonadaptive Drift Scenario 301
John R. Speakman
I. Introduction 302
II. Evidence Supporting the Famine Hypothesis 303
Viii CONTENTS
III. Evidence Against the Famine Hypothesis 304
IV. The Challenge Facing Evolutionary Scenarios for the Genetic Predisposition to
Obesity in Modern Societies 306
V. An Alternative Model for the Evolution of the Genetic Basis for Obesity 306
VI. Time Trends in Obesity Prevalence: The Interaction of Physiology and Social
Factors 314
VII. Implications 316
Acknowledgments 318
References 318
13. Preclinical Developments in Antiobesity Drugs 323
Steven P. Vickers and Sharon C. Cheetham
I. Introduction 324
II. CNS Targets for Novel Antiobesity Drugs 325
III. Peripheral Targets for Novel Antiobesity Drugs 330
IV. Conclusion 332
References 333
14. Clinical Investigations of Antiobesity Drugs 337
John Wilding
I. Introduction 338
II. A Brief History of Obesity Pharmacotherapy 338
III. Currently Available Drugs Licensed for Obesity Treatment 339
IV. Potential New Targets for Obesity Drug Development 342
V. Preclinical Testing 345
VI. Regulatory Requirements for Clinical Development 346
References 352
Index 357
|
| adam_txt |
Contents
Contributors vii
1. Introduction and Overview 1
Steven J. Cooper and Tim C. Kirkham
2. Cortical Systems Involved in Appetite and Food Consumption 5
Morten L. Kringelbach
I. Introduction 5
II. Food Motivation 6
III. Cortical Representations of Sensory Inputs 8
IV. Conclusion 20
Acknowledgments 20
References 20
3. The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems
Regulating Food Intake 27
Thomas R. Stratford
I. Introduction 28
II. The Regulation of Feeding Behavior by the Nucleus Accumbens Shell 29
III. Afferent Projections to the AcbSh That May Be Involved in Regulating Food Intake 38
IV. Downstream Components of the Functional AcbSh Feeding Circuit 43
V. The AcbSh Feeding Circuit As a Potential Site for Pathology and Therapeutic
Intervention in the Treatment of Eating Disorders 53
References 55
4. Hypothalamic Neuropeptides and Feeding Regulation 67
Bernard Beck
I. Introduction 68
II. Neuropeptide Y 69
v
yi CONTENTS
III. The Orexins 75
IV. Melanin Concentrating Hormone 78
V. Conclusion 81
Acknowledgments 81
References 81
5. Brainstem Hypothalamic Neuropeptides and the Regulation of Feeding 99
Simon M. Luckman
I. The Control of Feeding 100
II. Neural Integration by the Dorsal Vagal Complex 103
III. Considerations in Assessing the Role of "Neuropeptides" 105
IV. "Humoral" Interactions with the Dorsal Vagal Complex 107
V. Intrinsic Peptidergic Neurons of the Dorsal Vagal Complex 114
VI. Descending Peptidergic Regulation of Brainstem Feeding Circuits 119
VII. Summary and Potential for Drug Development 122
References 123
6. The Gut Brain Axis in the Control of Eating 143
Thomas A. Lutz and Nori Geary
I. Introduction 144
II. Gastric Mechanoreception 145
III. Intestinal Cholecystokinin (CCK) 146
IV. Amylin 152
V. Ghrelin 155
VI. Potentials and Problems of Gut Brain Axis Signals in the Treatment of Obesity 158
References 160
7. Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite 167
Dianne Figlewicz Lattemann, Nicole M. Sanders, Amy MacDonald Naleid and Alfred]. Sipols
I. Introduction and Overview 168
II. Mesolimbic Dopamine Circuitry and Energy Regulatory Signals 170
III. Brain Opioid Systems and Energy Regulatory Signals 171
IV. Endocannabinoids and Energy Regulatory Signals 175
V. LHA Circuitry and Energy Regulatory Signals 176
VI. Other CNS Sites: Target for Future Studies? 178
VII. Human and Clinical Studies: At the Forefront of Our Knowledge 179
VIII. Concluding Remarks 183
Acknowledgments 183
References 183
8. Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating
Disorders 191
Kent C. Berridge
I. Introduction 192
II. Possible Roles of Brain Reward Systems in Eating Disorders 192
III. Understanding Brain Reward Systems for Food "Liking" and "Wanting" 193
CONTENTS Vii
IV. "Wanting" Without "Liking" 201
V. A Brief History of Appetite: Food Incentives, Not Hunger Drives 208
VI. Connecting Brain Reward and Regulatory Systems 210
VII. Conclusion 210
Acknowledgments 211
References 211
9. Pharmacology of Food, Taste and Learned Flavor Preferences 217
Steven]. Cooper
I. Introduction 217
II. Pharmacology of Food Preference 219
III. Pharmacology of Unlearned Taste Preference and Reactivity 224
IV. Pharmacology of Learned Flavor Preference 232
V. Concluding Remarks 236
Acknowledgments 238
References 238
10. The Role of Palatability in Control of Human Appetite: Implications for Understanding
and Treating Obesity 247
Martin R. Yeomans
I. Introduction 248
II. Assessing the Effects of Palatability on Appetite 248
III. Palatability and the Control of Normal Appetite 250
IV. Palatability and Obesity 262
V. Conclusion 264
References 264
11. Learned Influences on Appetite, Food Choice, and Intake: Evidence in Human
Beings 271
E.L. Gibson and].M. Brunstrom
I. Introduction 272
II. Innate Influences on Human Eating 273
III. Types of Learning 274
IV. The Learned Appetite for Energy 277
V. Learned Modulation of Appetite and Meal Size by Associated States 278
VI. Nutrient Specific Learned Appetites 283
VII. Flavor Flavor Learning 286
VIII. Awareness and Dietary Learning 290
IX. Summary 293
References 294
12. Gene Environment Interactions and the Origin of the Modern Obesity Epidemic:
A Novel "Nonadaptive Drift" Scenario 301
John R. Speakman
I. Introduction 302
II. Evidence Supporting the Famine Hypothesis 303
Viii CONTENTS
III. Evidence Against the Famine Hypothesis 304
IV. The Challenge Facing Evolutionary Scenarios for the Genetic Predisposition to
Obesity in Modern Societies 306
V. An Alternative Model for the Evolution of the Genetic Basis for Obesity 306
VI. Time Trends in Obesity Prevalence: The Interaction of Physiology and Social
Factors 314
VII. Implications 316
Acknowledgments 318
References 318
13. Preclinical Developments in Antiobesity Drugs 323
Steven P. Vickers and Sharon C. Cheetham
I. Introduction 324
II. CNS Targets for Novel Antiobesity Drugs 325
III. Peripheral Targets for Novel Antiobesity Drugs 330
IV. Conclusion 332
References 333
14. Clinical Investigations of Antiobesity Drugs 337
John Wilding
I. Introduction 338
II. A Brief History of Obesity Pharmacotherapy 338
III. Currently Available Drugs Licensed for Obesity Treatment 339
IV. Potential New Targets for Obesity Drug Development 342
V. Preclinical Testing 345
VI. Regulatory Requirements for Clinical Development 346
References 352
Index 357 |
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| spelling | Appetite and body weight integrative systems and the development of anti-obesity drugs ed. by Tim C. Kirkham ... Amsterdam [u.a.] Elsevier 2007 X, 371 S., [1] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Appétit Geneesmiddelen gtt Obésité - Aspect psychologique Poids corporel Vetzucht gtt Psychologie Appetite Body Weight Anti-Obesity Agents Obesity physiopathology Obesity Psychological aspects Body weight Psychopharmakon (DE-588)4047729-0 gnd rswk-swf Essgewohnheit (DE-588)4139275-9 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Übergewicht (DE-588)4061388-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Essgewohnheit (DE-588)4139275-9 s Physiologie (DE-588)4045981-0 s DE-604 Übergewicht (DE-588)4061388-4 s Psychopharmakon (DE-588)4047729-0 s Kirkham, Tim C. Sonstige oth http://www.loc.gov/catdir/toc/fy0710/2007273988.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016030180&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Appetite and body weight integrative systems and the development of anti-obesity drugs Appétit Geneesmiddelen gtt Obésité - Aspect psychologique Poids corporel Vetzucht gtt Psychologie Appetite Body Weight Anti-Obesity Agents Obesity physiopathology Obesity Psychological aspects Body weight Psychopharmakon (DE-588)4047729-0 gnd Essgewohnheit (DE-588)4139275-9 gnd Physiologie (DE-588)4045981-0 gnd Übergewicht (DE-588)4061388-4 gnd |
| subject_GND | (DE-588)4047729-0 (DE-588)4139275-9 (DE-588)4045981-0 (DE-588)4061388-4 (DE-588)4143413-4 |
| title | Appetite and body weight integrative systems and the development of anti-obesity drugs |
| title_auth | Appetite and body weight integrative systems and the development of anti-obesity drugs |
| title_exact_search | Appetite and body weight integrative systems and the development of anti-obesity drugs |
| title_exact_search_txtP | Appetite and body weight integrative systems and the development of anti-obesity drugs |
| title_full | Appetite and body weight integrative systems and the development of anti-obesity drugs ed. by Tim C. Kirkham ... |
| title_fullStr | Appetite and body weight integrative systems and the development of anti-obesity drugs ed. by Tim C. Kirkham ... |
| title_full_unstemmed | Appetite and body weight integrative systems and the development of anti-obesity drugs ed. by Tim C. Kirkham ... |
| title_short | Appetite and body weight |
| title_sort | appetite and body weight integrative systems and the development of anti obesity drugs |
| title_sub | integrative systems and the development of anti-obesity drugs |
| topic | Appétit Geneesmiddelen gtt Obésité - Aspect psychologique Poids corporel Vetzucht gtt Psychologie Appetite Body Weight Anti-Obesity Agents Obesity physiopathology Obesity Psychological aspects Body weight Psychopharmakon (DE-588)4047729-0 gnd Essgewohnheit (DE-588)4139275-9 gnd Physiologie (DE-588)4045981-0 gnd Übergewicht (DE-588)4061388-4 gnd |
| topic_facet | Appétit Geneesmiddelen Obésité - Aspect psychologique Poids corporel Vetzucht Psychologie Appetite Body Weight Anti-Obesity Agents Obesity physiopathology Obesity Psychological aspects Body weight Psychopharmakon Essgewohnheit Physiologie Übergewicht Aufsatzsammlung |
| url | http://www.loc.gov/catdir/toc/fy0710/2007273988.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016030180&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kirkhamtimc appetiteandbodyweightintegrativesystemsandthedevelopmentofantiobesitydrugs |