Microarray technology and its applications:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2005
|
| Schriftenreihe: | Biological and medical physics, biomedical engineering
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 3540229310 9783540229315 9783540265788 |
| DOI: | 10.1007/b137842 |
Internformat
MARC
| LEADER | 00000nmm a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV022824231 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 070926s2005 gw |||| o||u| ||||||eng d | ||
| 015 | |a 04,N35,0042 |2 dnb | ||
| 015 | |a 04,A51,0901 |2 dnb | ||
| 016 | 7 | |a 971899800 |2 DE-101 | |
| 020 | |a 3540229310 |c Pp. : EUR 128.35 (freier Pr.), sfr 203.00 (freier Pr.) |9 3-540-22931-0 | ||
| 020 | |a 9783540229315 |9 978-3-540-22931-5 | ||
| 020 | |a 9783540265788 |c Online |9 978-3-540-26578-8 | ||
| 024 | 7 | |a 10.1007/b137842 |2 doi | |
| 035 | |a (OCoLC)762183554 | ||
| 035 | |a (DE-599)BVBBV022824231 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BE | ||
| 049 | |a DE-355 | ||
| 084 | |a WC 4460 |0 (DE-625)148102: |2 rvk | ||
| 084 | |a 570 |2 sdnb | ||
| 245 | 1 | 0 | |a Microarray technology and its applications |c U. R. Müller ... (eds.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2005 | |
| 300 | |a 1 Online-Ressource | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Biological and medical physics, biomedical engineering | |
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Microarray |0 (DE-588)4544227-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Microarray |0 (DE-588)4544227-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Müller, Uwe R. |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/b137842 |x Verlag |3 Volltext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016029535&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ZDB-2-SBL | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016029535 | ||
| 966 | e | |u https://doi.org/10.1007/b137842 |l UBR01 |p ZDB-2-SBL |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804137104094003200 |
|---|---|
| adam_text | CONTENTS
PART I GENERAL MICROARRAY TECHNOLOGIES
1 ARRAY FORMATS
RALPH R. MARTEL, MATTHEW P. ROUNSEVILLE, IHAB W. BOTROS,
BRUCE E. SELIGMANN
..............................................
3
1.1 INTRODUCTION . ........................................... 3
1.2 REASONS TO USE ARRAYS . . . ................................ 4
1.3 ARRAYS FOR NUCLEIC ACID ANALYSIS .......................... 6
1.4 PROTEIN ARRAYS . . . ...................................... 8
1.5 THE ARRAYPLATE
TM
...................................... 9
1.6 CONCLUSION . . ........................................... 19
REFERENCES ................................................... 20
2 BIOMOLECULES AND CELLS ON SURFACES *
FUNDAMENTAL CONCEPTS
KRISTI L. HANSON, LUISA FILIPPONI, DAN V. NICOLAU
...................
23
2.1 INTRODUCTION . ........................................... 23
2.2 TYPES OF IMMOBILIZATION . . . .............................. 23
2.3 DNA IMMOBILIZATION ON SURFACES . . . ....................... 28
2.4 PROTEIN IMMOBILIZATION ON SURFACES . . . ..................... 32
2.5 CARBOHYDRATE IMMOBILIZATION ............................. 36
2.6 IMMOBILIZATION OF CELLS ON SURFACES ........................ 38
2.7 CONCLUSIONS ............................................ 41
REFERENCES ................................................... 42
3 SURFACES AND SUBSTRATES
ALVARO CARRILLO, KUNAL V. GUJRATY, RAVI S. KANE
.....................
45
3.1 INTRODUCTION . ........................................... 45
3.2 DNA MICROARRAYS . ...................................... 46
3.3 PROTEIN MICROARRAYS . .................................... 50
XII CONTENTS
3.4 CONCLUSION . . ........................................... 55
REFERENCES ................................................... 56
4 REAGENT JETTING BASED DEPOSITION TECHNOLOGIES
FOR ARRAY CONSTRUCTION
MITCHEL J. DOKTYCZ
...............................................
63
4.1 INTRODUCTION . ........................................... 63
4.2 REAGENT JETTING * TECHNOLOGY OVERVIEW .................... 63
4.3 THERMAL JET BASED DISPENSING . . . ......................... 65
4.4 PIEZO JET BASED DISPENSING .............................. 67
4.5 SOLENOID JET BASED DISPENSING . . .......................... 68
REFERENCES ................................................... 71
5 MANUFACTURING OF 2-D ARRAYS BY PIN-PRINTING TECHNOLOGIES
UWER.M¨
ULLER, ROELAND PAPEN
....................................
73
5.1 INTRODUCTION . ........................................... 73
5.2 DEFINITION OF *CONTACT* PIN*PRINTING . . ..................... 73
5.3 OVERVIEW OF DIFFERENT PIN TECHNOLOGIES . ................... 74
5.4 OTHER SYSTEM COMPONENTS AND ENVIRONMENTAL FACTORS . . .... 79
5.5 PIN PRINTING PROCESS .................................... 81
5.6 EXAMPLE OF A HIGH THROUGHPUT PIN*PRINTING SYSTEM FOR
MANUFACTURING OF 2D ARRAYS * THE CORNING GENII SYSTEM . . . 84
5.7 CONCLUSION . . ........................................... 86
REFERENCES ................................................... 87
6 NANOARRAYS
DAN V. NICOLAU, LINNETTE DEMERS, DAVID S. GINGER
...................
89
6.1 INTRODUCTION . ........................................... 89
6.2 PASSIVE NANO*SCALE ARRAYS ............................... 91
6.3 COMPUTATIONAL NANOARRAYS ...............................105
6.4 DYNAMIC NANOARRAYS . ...................................109
6.5 CONCLUSION . . ...........................................115
REFERENCES ...................................................115
7 THE USE OF MICROFLUIDIC TECHNIQUES
IN MICROARRAY APPLICATIONS
PIOTR GRODZINSKI, ROBIN H. LIU, RALF LENIGK, YINGJIE LIU
..............
119
7.1 INTRODUCTION . ...........................................119
7.2 BIOCHANNEL HYBRIDIZATION ARRAYS ..........................120
7.3 CHIPS WITH CAVITATION MICROSTREAMING MIXERS *
KINETICS STUDIES ........................................128
7.4 INTEGRATED MICROFLUIDIC REACTORS
FOR DNA AMPLIFICATION AND HYBRIDIZATION . .................135
7.5 SUMMARY AND CONCLUSIONS . . .............................142
CONTENTS XIII
REFERENCES ...................................................142
8 LABELS AND DETECTION METHODS
JAMES J. STORHOFF, SUDHAKAR S. MARLA, VISWANADHAM GARIMELLA,
CHAD A. MIRKIN
..................................................
147
8.1 INTRODUCTION . ...........................................147
8.2 FLUOROPHORE LABELLING AND DETECTION METHODS . .............148
8.3 ENHANCED FLUORESCENCE-BASED ASSAYS . .....................151
8.4 PHOSPHOR REPORTERS .....................................154
8.5 ELECTROCHEMICAL DETECTION . ...............................156
8.6 METAL NANOPARTICLE LABELS AND METAL THIN FILMS
FOR MICROARRAYS .........................................159
8.7 CONCLUSIONS ............................................172
REFERENCES ...................................................174
9 MARKER-FREE DETECTION ON MICROARRAYS
MATTHIAS VAUPEL, ANDREAS EING, KARL-OTTO GREULICH, JAN ROEGENER,
PETER SCHELLENBERG, HANS MARTIN. STRIEBEL, HEINRICH F. ARLINGHAUS
......
181
9.1 INTRODUCTION . ...........................................181
9.2 IMAGING ELLIPSOMETRY
AND IMAGING SURFACE PLASMON RESONANCE ON BIOCHIPS ........181
9.3 INTRINSIC UV FLUORESCENCE FOR CHIP ANALYSIS
OF RARE PROTEINS . . . .....................................190
9.4 GENETIC DIAGNOSTICS WITH UNLABELLED DNA .................197
REFERENCES ...................................................204
PART II DNA MICROARRAYS
10 ANALYSIS OF DNA SEQUENCE VARIATION
IN THE MICROARRAY FORMAT
ULRIKA LILJEDAHL, MONA FREDRIKSSON, ANN-CHRISTINE SYV¨ANEN
...........
211
10.1 INTRODUCTION . ...........................................211
10.2 PRINCIPLES OF GENOTYPING .................................213
10.3 PERFORMING THE ASSAYS IN PRACTICE . . .......................217
10.4 CONCLUSION . . ...........................................222
REFERENCES ...................................................223
11 HIGH SENSITIVITY EXPRESSION PROFILING
RAMESH RAMAKRISHNAN, PAUL BAO, UWE R. M¨ULLER
....................
229
11.1 INTRODUCTION . ...........................................229
11.2 OLIGONUCLEOTIDE EXPRESSION ARRAYS ........................230
11.3 CDNA-BASED EXPRESSION ARRAYS . . . ........................239
11.4 APPENDIX . . ............................................244
XIV CONTENTS
REFERENCES ...................................................245
12 APPLICATIONS OF MATRIX-CGH (ARRAY-CGH)
FOR GENOMIC RESEARCH AND CLINICAL DIAGNOSTICS
CARSTEN SCHWAENENA, MICHELLE NESSLINGA, BERNHARD RADLWIMMERA,
SWEN WESSENDORF, PETER LICHTERA
...................................
251
12.1 INTRODUCTION . ...........................................251
12.2 TECHNICAL ASPECTS . . . ....................................253
12.3 APPLICATIONS ............................................256
REFERENCES ...................................................260
13 ANALYSIS OF GENE REGULATORY CIRCUITS
ZIRONG LI
.......................................................
265
13.1 INTRODUCTION . ...........................................265
13.2 AN EXPERIMENTAL PROTOCOL
FOR GENOME WIDE LOCATION ANALYSIS . ......................268
13.3 EXAMPLE: IDENTIFYING THE TARGET GENES OF HUMAN E2F4 . . . . . . 273
13.4 SUMMARY . . ............................................275
REFERENCES ...................................................275
PART III PROTEIN MICROARRAYS
14 PROTEIN, ANTIBODY AND SMALL MOLECULE MICROARRAYS
HENDRIK WEINER, J¨ORN GL¨OKLER, CLAUS HULTSCHIG, KONRAD B¨USSOW,
GERALD WALTER
...................................................
279
14.1 INTRODUCTION . ...........................................279
14.2 PROTEIN MICROARRAYS . ....................................280
14.3 ANTIBODY MICROARRAYS . . .................................283
14.4 PEPTIDE AND OTHER SYNTHETIC ARRAYS . . .....................287
REFERENCES ...................................................290
15 PHOTOAPTAMER ARRAYS FOR PROTEOMICS APPLICATIONS
DREW SMITH, CHAD GREEF
..........................................
297
15.1 INTRODUCTION . ...........................................297
15.2 OVERVIEW OF PHOTOAPTAMER DISCOVERY
AND HIGH THROUGHPUT PRODUCTION . . .......................298
15.3 USING PHOTOAPTAMER MICROARRAYS .........................301
15.4 DISCUSSION . . ...........................................303
REFERENCES ...................................................305
16 BIOLOGICAL MEMBRANE MICROARRAYS
YE FANG, ANTHONY G. FRUTOS, YULONG HONG, JOYDEEP LAHIRI
............
309
16.1 INTRODUCTION . ...........................................309
CONTENTS XV
16.2 BIOSPECIFIC BINDING STUDIES USING MEMBRANE MICROARRAYS . . . . 313
16.3 CONCLUSIONS ............................................318
REFERENCES ...................................................319
PART IV CELL & TISSUE MICROARRAYS
17 USE OF REPORTER SYSTEMS
FOR REVERSE TRANSFECTION CELL ARRAYS
BRIAN L. WEBB
..................................................
323
17.1 INTRODUCTION . ...........................................323
17.2 REPORTER SYSTEMS FOR REVERSE TRANSFECTION .................325
17.3 REAGENTS AND PROTOCOLS ..................................332
REFERENCES ...................................................333
18 WHOLE CELL MICROARRAYS
RAVI KAPUR
.....................................................
335
18.1 INTRODUCTION . ...........................................335
18.2 THE NEED ..............................................336
18.3 THE SOLUTION . . .........................................336
18.4 CHALLENGES AND OPPORTUNITIES FOR CELLULAR MICRROARRAYS ......341
REFERENCES ...................................................343
19 TISSUE MICROARRAYS FOR MINIATURIZED HIGH-THROUGHPUT
MOLECULAR PROFILING OF TUMORS
RONALD SIMON, MARTINA MIRLACHER, GUIDO SAUTER
.....................
345
19.1 INTRODUCTION . ...........................................345
19.2 THE TMA TECHNOLOGY . ..................................346
19.3 THE REPRESENTATIVITY ISSUE ...............................346
19.4 TMA APPLICATIONS ......................................349
19.5 FUTURE DIRECTIONS .......................................351
19.6 PROTOCOL . . .............................................352
REFERENCES ...................................................354
20 APPLICATION OF MICROARRAY TECHNOLOGIES
FOR TRANSLATIONAL GENOMICS
SPYRO MOUSSES, NATASHA CAPLEN, MARK BASIK, ANNE KALLIONIEMI,
OLLI KALLIONIEMI
..................................................
361
20.1 INTRODUCTION . ...........................................361
20.2 HIGH THROUGHPUT CLINICAL TARGET VALIDATION USING TISSUE
MICROARRAYS . . . .........................................363
20.3 EXAMPLES OF STUDIES INTEGRATING DNA AND TISSUE MICROARRAY
TECHNOLOGIES FOR THE RAPID CLINICAL TRANSLATION
OF GENOMIC DISCOVERIES . . ................................365
XVI CONTENTS
20.4 HIGH THROUGHPUT CHARACTERIZATION
OF GENE FUNCTION USING LIVE CELL MICROARRAYS ..............368
20.5 CONCLUSIONS ............................................370
REFERENCES ...................................................372
INDEX
..........................................................
375
|
| adam_txt |
CONTENTS
PART I GENERAL MICROARRAY TECHNOLOGIES
1 ARRAY FORMATS
RALPH R. MARTEL, MATTHEW P. ROUNSEVILLE, IHAB W. BOTROS,
BRUCE E. SELIGMANN
.
3
1.1 INTRODUCTION . . 3
1.2 REASONS TO USE ARRAYS . . . . 4
1.3 ARRAYS FOR NUCLEIC ACID ANALYSIS . 6
1.4 PROTEIN ARRAYS . . . . 8
1.5 THE ARRAYPLATE
TM
. 9
1.6 CONCLUSION . . . 19
REFERENCES . 20
2 BIOMOLECULES AND CELLS ON SURFACES *
FUNDAMENTAL CONCEPTS
KRISTI L. HANSON, LUISA FILIPPONI, DAN V. NICOLAU
.
23
2.1 INTRODUCTION . . 23
2.2 TYPES OF IMMOBILIZATION . . . . 23
2.3 DNA IMMOBILIZATION ON SURFACES . . . . 28
2.4 PROTEIN IMMOBILIZATION ON SURFACES . . . . 32
2.5 CARBOHYDRATE IMMOBILIZATION . 36
2.6 IMMOBILIZATION OF CELLS ON SURFACES . 38
2.7 CONCLUSIONS . 41
REFERENCES . 42
3 SURFACES AND SUBSTRATES
ALVARO CARRILLO, KUNAL V. GUJRATY, RAVI S. KANE
.
45
3.1 INTRODUCTION . . 45
3.2 DNA MICROARRAYS . . 46
3.3 PROTEIN MICROARRAYS . . 50
XII CONTENTS
3.4 CONCLUSION . . . 55
REFERENCES . 56
4 REAGENT JETTING BASED DEPOSITION TECHNOLOGIES
FOR ARRAY CONSTRUCTION
MITCHEL J. DOKTYCZ
.
63
4.1 INTRODUCTION . . 63
4.2 REAGENT JETTING * TECHNOLOGY OVERVIEW . 63
4.3 THERMAL JET BASED DISPENSING . . . . 65
4.4 PIEZO JET BASED DISPENSING . 67
4.5 SOLENOID JET BASED DISPENSING . . . 68
REFERENCES . 71
5 MANUFACTURING OF 2-D ARRAYS BY PIN-PRINTING TECHNOLOGIES
UWER.M¨
ULLER, ROELAND PAPEN
.
73
5.1 INTRODUCTION . . 73
5.2 DEFINITION OF *CONTACT* PIN*PRINTING . . . 73
5.3 OVERVIEW OF DIFFERENT PIN TECHNOLOGIES . . 74
5.4 OTHER SYSTEM COMPONENTS AND ENVIRONMENTAL FACTORS . . . 79
5.5 PIN PRINTING PROCESS . 81
5.6 EXAMPLE OF A HIGH THROUGHPUT PIN*PRINTING SYSTEM FOR
MANUFACTURING OF 2D ARRAYS * THE CORNING GENII SYSTEM . . . 84
5.7 CONCLUSION . . . 86
REFERENCES . 87
6 NANOARRAYS
DAN V. NICOLAU, LINNETTE DEMERS, DAVID S. GINGER
.
89
6.1 INTRODUCTION . . 89
6.2 PASSIVE NANO*SCALE ARRAYS . 91
6.3 COMPUTATIONAL NANOARRAYS .105
6.4 DYNAMIC NANOARRAYS . .109
6.5 CONCLUSION . . .115
REFERENCES .115
7 THE USE OF MICROFLUIDIC TECHNIQUES
IN MICROARRAY APPLICATIONS
PIOTR GRODZINSKI, ROBIN H. LIU, RALF LENIGK, YINGJIE LIU
.
119
7.1 INTRODUCTION . .119
7.2 BIOCHANNEL HYBRIDIZATION ARRAYS .120
7.3 CHIPS WITH CAVITATION MICROSTREAMING MIXERS *
KINETICS STUDIES .128
7.4 INTEGRATED MICROFLUIDIC REACTORS
FOR DNA AMPLIFICATION AND HYBRIDIZATION . .135
7.5 SUMMARY AND CONCLUSIONS . . .142
CONTENTS XIII
REFERENCES .142
8 LABELS AND DETECTION METHODS
JAMES J. STORHOFF, SUDHAKAR S. MARLA, VISWANADHAM GARIMELLA,
CHAD A. MIRKIN
.
147
8.1 INTRODUCTION . .147
8.2 FLUOROPHORE LABELLING AND DETECTION METHODS . .148
8.3 ENHANCED FLUORESCENCE-BASED ASSAYS . .151
8.4 PHOSPHOR REPORTERS .154
8.5 ELECTROCHEMICAL DETECTION . .156
8.6 METAL NANOPARTICLE LABELS AND METAL THIN FILMS
FOR MICROARRAYS .159
8.7 CONCLUSIONS .172
REFERENCES .174
9 MARKER-FREE DETECTION ON MICROARRAYS
MATTHIAS VAUPEL, ANDREAS EING, KARL-OTTO GREULICH, JAN ROEGENER,
PETER SCHELLENBERG, HANS MARTIN. STRIEBEL, HEINRICH F. ARLINGHAUS
.
181
9.1 INTRODUCTION . .181
9.2 IMAGING ELLIPSOMETRY
AND IMAGING SURFACE PLASMON RESONANCE ON BIOCHIPS .181
9.3 INTRINSIC UV FLUORESCENCE FOR CHIP ANALYSIS
OF RARE PROTEINS . . . .190
9.4 GENETIC DIAGNOSTICS WITH UNLABELLED DNA .197
REFERENCES .204
PART II DNA MICROARRAYS
10 ANALYSIS OF DNA SEQUENCE VARIATION
IN THE MICROARRAY FORMAT
ULRIKA LILJEDAHL, MONA FREDRIKSSON, ANN-CHRISTINE SYV¨ANEN
.
211
10.1 INTRODUCTION . .211
10.2 PRINCIPLES OF GENOTYPING .213
10.3 PERFORMING THE ASSAYS IN PRACTICE . . .217
10.4 CONCLUSION . . .222
REFERENCES .223
11 HIGH SENSITIVITY EXPRESSION PROFILING
RAMESH RAMAKRISHNAN, PAUL BAO, UWE R. M¨ULLER
.
229
11.1 INTRODUCTION . .229
11.2 OLIGONUCLEOTIDE EXPRESSION ARRAYS .230
11.3 CDNA-BASED EXPRESSION ARRAYS . . . .239
11.4 APPENDIX . . .244
XIV CONTENTS
REFERENCES .245
12 APPLICATIONS OF MATRIX-CGH (ARRAY-CGH)
FOR GENOMIC RESEARCH AND CLINICAL DIAGNOSTICS
CARSTEN SCHWAENENA, MICHELLE NESSLINGA, BERNHARD RADLWIMMERA,
SWEN WESSENDORF, PETER LICHTERA
.
251
12.1 INTRODUCTION . .251
12.2 TECHNICAL ASPECTS . . . .253
12.3 APPLICATIONS .256
REFERENCES .260
13 ANALYSIS OF GENE REGULATORY CIRCUITS
ZIRONG LI
.
265
13.1 INTRODUCTION . .265
13.2 AN EXPERIMENTAL PROTOCOL
FOR GENOME WIDE LOCATION ANALYSIS . .268
13.3 EXAMPLE: IDENTIFYING THE TARGET GENES OF HUMAN E2F4 . . . . . . 273
13.4 SUMMARY . . .275
REFERENCES .275
PART III PROTEIN MICROARRAYS
14 PROTEIN, ANTIBODY AND SMALL MOLECULE MICROARRAYS
HENDRIK WEINER, J¨ORN GL¨OKLER, CLAUS HULTSCHIG, KONRAD B¨USSOW,
GERALD WALTER
.
279
14.1 INTRODUCTION . .279
14.2 PROTEIN MICROARRAYS . .280
14.3 ANTIBODY MICROARRAYS . . .283
14.4 PEPTIDE AND OTHER SYNTHETIC ARRAYS . . .287
REFERENCES .290
15 PHOTOAPTAMER ARRAYS FOR PROTEOMICS APPLICATIONS
DREW SMITH, CHAD GREEF
.
297
15.1 INTRODUCTION . .297
15.2 OVERVIEW OF PHOTOAPTAMER DISCOVERY
AND HIGH THROUGHPUT PRODUCTION . . .298
15.3 USING PHOTOAPTAMER MICROARRAYS .301
15.4 DISCUSSION . . .303
REFERENCES .305
16 BIOLOGICAL MEMBRANE MICROARRAYS
YE FANG, ANTHONY G. FRUTOS, YULONG HONG, JOYDEEP LAHIRI
.
309
16.1 INTRODUCTION . .309
CONTENTS XV
16.2 BIOSPECIFIC BINDING STUDIES USING MEMBRANE MICROARRAYS . . . . 313
16.3 CONCLUSIONS .318
REFERENCES .319
PART IV CELL & TISSUE MICROARRAYS
17 USE OF REPORTER SYSTEMS
FOR REVERSE TRANSFECTION CELL ARRAYS
BRIAN L. WEBB
.
323
17.1 INTRODUCTION . .323
17.2 REPORTER SYSTEMS FOR REVERSE TRANSFECTION .325
17.3 REAGENTS AND PROTOCOLS .332
REFERENCES .333
18 WHOLE CELL MICROARRAYS
RAVI KAPUR
.
335
18.1 INTRODUCTION . .335
18.2 THE NEED .336
18.3 THE SOLUTION . . .336
18.4 CHALLENGES AND OPPORTUNITIES FOR CELLULAR MICRROARRAYS .341
REFERENCES .343
19 TISSUE MICROARRAYS FOR MINIATURIZED HIGH-THROUGHPUT
MOLECULAR PROFILING OF TUMORS
RONALD SIMON, MARTINA MIRLACHER, GUIDO SAUTER
.
345
19.1 INTRODUCTION . .345
19.2 THE TMA TECHNOLOGY . .346
19.3 THE REPRESENTATIVITY ISSUE .346
19.4 TMA APPLICATIONS .349
19.5 FUTURE DIRECTIONS .351
19.6 PROTOCOL . . .352
REFERENCES .354
20 APPLICATION OF MICROARRAY TECHNOLOGIES
FOR TRANSLATIONAL GENOMICS
SPYRO MOUSSES, NATASHA CAPLEN, MARK BASIK, ANNE KALLIONIEMI,
OLLI KALLIONIEMI
.
361
20.1 INTRODUCTION . .361
20.2 HIGH THROUGHPUT CLINICAL TARGET VALIDATION USING TISSUE
MICROARRAYS . . . .363
20.3 EXAMPLES OF STUDIES INTEGRATING DNA AND TISSUE MICROARRAY
TECHNOLOGIES FOR THE RAPID CLINICAL TRANSLATION
OF GENOMIC DISCOVERIES . . .365
XVI CONTENTS
20.4 HIGH THROUGHPUT CHARACTERIZATION
OF GENE FUNCTION USING LIVE CELL MICROARRAYS .368
20.5 CONCLUSIONS .370
REFERENCES .372
INDEX
.
375 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| building | Verbundindex |
| bvnumber | BV022824231 |
| classification_rvk | WC 4460 |
| collection | ZDB-2-SBL |
| ctrlnum | (OCoLC)762183554 (DE-599)BVBBV022824231 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| doi_str_mv | 10.1007/b137842 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01850nmm a2200481 c 4500</leader><controlfield tag="001">BV022824231</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">070926s2005 gw |||| o||u| ||||||eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">04,N35,0042</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">04,A51,0901</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">971899800</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540229310</subfield><subfield code="c">Pp. : EUR 128.35 (freier Pr.), sfr 203.00 (freier Pr.)</subfield><subfield code="9">3-540-22931-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783540229315</subfield><subfield code="9">978-3-540-22931-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783540265788</subfield><subfield code="c">Online</subfield><subfield code="9">978-3-540-26578-8</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/b137842</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)762183554</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV022824231</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 4460</subfield><subfield code="0">(DE-625)148102:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Microarray technology and its applications</subfield><subfield code="c">U. R. Müller ... (eds.)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Biological and medical physics, biomedical engineering</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturangaben</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Microarray</subfield><subfield code="0">(DE-588)4544227-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Microarray</subfield><subfield code="0">(DE-588)4544227-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Müller, Uwe R.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/b137842</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016029535&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016029535</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/b137842</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV022824231 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T18:41:08Z |
| indexdate | 2024-07-09T21:06:59Z |
| institution | BVB |
| isbn | 3540229310 9783540229315 9783540265788 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016029535 |
| oclc_num | 762183554 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource |
| psigel | ZDB-2-SBL |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Springer |
| record_format | marc |
| series2 | Biological and medical physics, biomedical engineering |
| spelling | Microarray technology and its applications U. R. Müller ... (eds.) Berlin [u.a.] Springer 2005 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Biological and medical physics, biomedical engineering Literaturangaben Microarray (DE-588)4544227-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Microarray (DE-588)4544227-7 s DE-604 Müller, Uwe R. Sonstige oth https://doi.org/10.1007/b137842 Verlag Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016029535&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Microarray technology and its applications Microarray (DE-588)4544227-7 gnd |
| subject_GND | (DE-588)4544227-7 (DE-588)4143413-4 |
| title | Microarray technology and its applications |
| title_auth | Microarray technology and its applications |
| title_exact_search | Microarray technology and its applications |
| title_exact_search_txtP | Microarray technology and its applications |
| title_full | Microarray technology and its applications U. R. Müller ... (eds.) |
| title_fullStr | Microarray technology and its applications U. R. Müller ... (eds.) |
| title_full_unstemmed | Microarray technology and its applications U. R. Müller ... (eds.) |
| title_short | Microarray technology and its applications |
| title_sort | microarray technology and its applications |
| topic | Microarray (DE-588)4544227-7 gnd |
| topic_facet | Microarray Aufsatzsammlung |
| url | https://doi.org/10.1007/b137842 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016029535&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mulleruwer microarraytechnologyanditsapplications |