Principles in general pharmacology:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo
Springer
1988
|
| Schriftenreihe: | Springer series in pharmacologic science
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIII, 243 S. 88 Ill. u. graph. Darst. 25 cm |
| ISBN: | 3540966021 0387966021 |
Internformat
MARC
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| 264 | 1 | |a New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo |b Springer |c 1988 | |
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| 700 | 1 | |a MacGonigle, Paul |e Verfasser |4 aut | |
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Datensatz im Suchindex
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| adam_text | 3 RONALD J. TALLARIDA ROBERT B. RAFFA*, PAUL MCGONIGLE PRINCIPLES IN
GENERAL PHARMACOLOGY WITH 88 ILLUSTRATIONS SPRINGER-VERLAG NEW YORK
BERLIN HEIDELBERG LONDON PARIS TOKYO CONTENTS PREFACE VII SERIES PREFACE
IX 1 GENERAL PRINCIPLES: HISTORY AND OVERVIEW INTRODUCTION 1 HISTORICAL
PERSPECTIVE 2 PRINCIPLES 3 OVERVIEW OF PHARMACOLOGIC PRINCIPLES 4
REFERENCES 17 2 DOSE-EFFECT RELATIONS DOSE-EFFECT GRAPHS: POTENCY AND
EFFICACY 19 ANTAGONISTS * 20 QUANTAL (ALL-OR-NONE) DOSE-RESPONSE
RELATIONS 21 ADDITIVITY AND SYNERGISM * 29 REFERENCES 30 3
PHARMACOKINETICS ABSORPTION 31 DIFFUSION 32 RATE CONSTANT FOR ABSORPTION
34 LIPID-WATER PARTITION COEFFICIENT 35 TRANSPORT MECHANISMS 36
ELECTROCHEMICAL POTENTIAL 36 THE LIVER 37 DRUG ELIMINATION 38 VOLUME OF
DISTRIBUTION 40 CLEARANCE 42 XII CONTENTS DRUG-PROTEIN BINDING 43
PROTEIN BINDING AND DISEASE 44 RENAL EXCRETION 45 GLOMERULAR FILTRATION
47 URINE PH AND CLEARANCE 49 HEPATIC CLEARANCE 49 INTRAVENOUS DOSING 49
REPEATED INTRAVENOUS INJECTIONS 52 INTRAVENOUS INFUSION 54 ABSORPTION
AND ELIMINATION 55 EXTRAVASCULAR MULTIPLE DOSING 57 TIME COURSE OF
EFFECT AND DRUG RECEPTOR CONCENTRATION 59 REFERENCES 59 4 DRUG
METABOLISM (BIOTRANSFORMATION) GENERAL PRINCIPLES 61 ANATOMICAL SITES OF
BIOTRANSFORMATION 65 BIOTRANSFORMATION REACTIONS 73 FACTORS AFFECTING
DRUG METABOLISM 86 BIOTRANSFORMATIONS OF SELECTED COMMON DRUGS 90
REFERENCES 94 5 INTRODUCTION TO SPECIFIC DRUG ACTION AND MEMBRANE
SURFACE PHENOMENA NONSPECIFIC DRUG ACTION 96 SPECIFIC DRUG ACTION: THE
DEVELOPMENT OF THE CONCEPT OF RECEPTORS 97 COATED PITS AND COATED
VESICLES 101 MEMBRANE CAPPING 107 CONCLUSION .* ILL REFERENCES 112 6
DRUGS AND RECEPTORS: CHEMICAL BONDING GENERAL PRINCIPLES 115 TYPES OF
BONDS 119 BOND FORMATION IN THE DRUG-RECEPTOR INTERACTION 129 REFERENCES
133 APPENDIX A. PHYSICAL CONSTANTS 135 APPENDIX B. COMPARISON OF ATOMIC,
IONIC, AND HYDRATED RADII OF SOME CHEMICAL ELEMENTS 135 APPENDIX C.
STRUCTURES OF DRUG GROUPS 136 CONTENTS XIII 7 THE RATE OF DRUG-RECEPTOR
INTERACTIONS INTRODUCTION 137 MEASURING THE RATE OF CHEMICAL REACTIONS
137 RATES OF EQUILIBRIUM REACTIONS 140 RATE OF THE DRUG-RECEPTOR
INTERACTION 147 INFLUENCE OF DIFFUSION ON REACTION RATE 148 SUGGESTED
READING 150 8 PHARMACODYNAMICS: THE INTERACTION OF DRUGS WITH RECEPTORS
PHARMACOLOGIC RECEPTORS 151 FORMATION OF THE DRUG-RECEPTOR COMPLEX 153
CLASSICAL THEORY 156 ALTERATIONS IN CLASSICAL DRUG-RECEPTOR THEORY AND
ALTERNATIVE APPROACHES 158 DISSOCIATION CONSTANTS 166 DRUG COMBINATIONS:
ISOBOLES 192 A CHANGING RECEPTOR CONCENTRATION: MODIFICATION OF RATE
EQUATIONS 193 REFERENCES 194 9 RADIOLIGAND BINDING INTRODUCTION 198
DIRECT BINDING 200 ANALYSIS OF RECEPTOR SUBTYPES 214 RADIOLIGAND-BINDING
TECHNIQUES 216 REFERENCES 219 APPENDIX: MATHEMATICAL TABLES 223 INDEX
237
|
| adam_txt |
3 RONALD J. TALLARIDA ROBERT B. RAFFA*, PAUL MCGONIGLE PRINCIPLES IN
GENERAL PHARMACOLOGY WITH 88 ILLUSTRATIONS SPRINGER-VERLAG NEW YORK
BERLIN HEIDELBERG LONDON PARIS TOKYO CONTENTS PREFACE VII SERIES PREFACE
IX 1 GENERAL PRINCIPLES: HISTORY AND OVERVIEW INTRODUCTION 1 HISTORICAL
PERSPECTIVE 2 PRINCIPLES 3 OVERVIEW OF PHARMACOLOGIC PRINCIPLES 4
REFERENCES 17 2 DOSE-EFFECT RELATIONS DOSE-EFFECT GRAPHS: POTENCY AND
EFFICACY 19 ANTAGONISTS * 20 QUANTAL (ALL-OR-NONE) DOSE-RESPONSE
RELATIONS 21 ADDITIVITY AND SYNERGISM * 29 REFERENCES 30 3
PHARMACOKINETICS ABSORPTION 31 DIFFUSION 32 RATE CONSTANT FOR ABSORPTION
34 LIPID-WATER PARTITION COEFFICIENT 35 TRANSPORT MECHANISMS 36
ELECTROCHEMICAL POTENTIAL 36 THE LIVER 37 DRUG ELIMINATION 38 VOLUME OF
DISTRIBUTION 40 CLEARANCE 42 XII CONTENTS DRUG-PROTEIN BINDING 43
PROTEIN BINDING AND DISEASE 44 RENAL EXCRETION 45 GLOMERULAR FILTRATION
47 URINE PH AND CLEARANCE 49 HEPATIC CLEARANCE 49 INTRAVENOUS DOSING 49
REPEATED INTRAVENOUS INJECTIONS 52 INTRAVENOUS INFUSION 54 ABSORPTION
AND ELIMINATION 55 EXTRAVASCULAR MULTIPLE DOSING 57 TIME COURSE OF
EFFECT AND DRUG RECEPTOR CONCENTRATION 59 REFERENCES 59 4 DRUG
METABOLISM (BIOTRANSFORMATION) GENERAL PRINCIPLES 61 ANATOMICAL SITES OF
BIOTRANSFORMATION 65 BIOTRANSFORMATION REACTIONS 73 FACTORS AFFECTING
DRUG METABOLISM 86 BIOTRANSFORMATIONS OF SELECTED COMMON DRUGS 90
REFERENCES 94 5 INTRODUCTION TO SPECIFIC DRUG ACTION AND MEMBRANE
SURFACE PHENOMENA NONSPECIFIC DRUG ACTION 96 SPECIFIC DRUG ACTION: THE
DEVELOPMENT OF THE CONCEPT OF RECEPTORS 97 COATED PITS AND COATED
VESICLES 101 MEMBRANE CAPPING 107 CONCLUSION .* ILL REFERENCES 112 6
DRUGS AND RECEPTORS: CHEMICAL BONDING GENERAL PRINCIPLES 115 TYPES OF
BONDS 119 BOND FORMATION IN THE DRUG-RECEPTOR INTERACTION 129 REFERENCES
133 APPENDIX A. PHYSICAL CONSTANTS 135 APPENDIX B. COMPARISON OF ATOMIC,
IONIC, AND HYDRATED RADII OF SOME CHEMICAL ELEMENTS 135 APPENDIX C.
STRUCTURES OF DRUG GROUPS 136 CONTENTS XIII 7 THE RATE OF DRUG-RECEPTOR
INTERACTIONS INTRODUCTION 137 MEASURING THE RATE OF CHEMICAL REACTIONS
137 RATES OF EQUILIBRIUM REACTIONS 140 RATE OF THE DRUG-RECEPTOR
INTERACTION 147 INFLUENCE OF DIFFUSION ON REACTION RATE 148 SUGGESTED
READING 150 8 PHARMACODYNAMICS: THE INTERACTION OF DRUGS WITH RECEPTORS
PHARMACOLOGIC RECEPTORS 151 FORMATION OF THE DRUG-RECEPTOR COMPLEX 153
CLASSICAL THEORY 156 ALTERATIONS IN CLASSICAL DRUG-RECEPTOR THEORY AND
ALTERNATIVE APPROACHES 158 DISSOCIATION CONSTANTS 166 DRUG COMBINATIONS:
ISOBOLES 192 A CHANGING RECEPTOR CONCENTRATION: MODIFICATION OF RATE
EQUATIONS 193 REFERENCES 194 9 RADIOLIGAND BINDING INTRODUCTION 198
DIRECT BINDING 200 ANALYSIS OF RECEPTOR SUBTYPES 214 RADIOLIGAND-BINDING
TECHNIQUES 216 REFERENCES 219 APPENDIX: MATHEMATICAL TABLES 223 INDEX
237 |
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| discipline | Chemie / Pharmazie Medizin |
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| index_date | 2024-07-02T18:24:48Z |
| indexdate | 2024-07-09T21:02:48Z |
| institution | BVB |
| isbn | 3540966021 0387966021 |
| language | German |
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| oclc_num | 889043118 |
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| physical | XIII, 243 S. 88 Ill. u. graph. Darst. 25 cm |
| publishDate | 1988 |
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| series2 | Springer series in pharmacologic science |
| spelling | Tallarida, Ronald J. Verfasser aut Principles in general pharmacology Ronald J. Tallarida ; Robert B. Raffa ; Paul McGonigle New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo Springer 1988 XIII, 243 S. 88 Ill. u. graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Springer series in pharmacologic science Literaturangaben Pharmacologie moléculaire Pharmacologie Molecular pharmacology Pharmacology Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pharmakologie Pharmakologie (DE-588)4045687-0 s DE-604 Raffa, Robert B. Verfasser aut MacGonigle, Paul Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015865678&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tallarida, Ronald J. Raffa, Robert B. MacGonigle, Paul Principles in general pharmacology Pharmacologie moléculaire Pharmacologie Molecular pharmacology Pharmacology Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4045687-0 |
| title | Principles in general pharmacology |
| title_auth | Principles in general pharmacology |
| title_exact_search | Principles in general pharmacology |
| title_exact_search_txtP | Principles in general pharmacology |
| title_full | Principles in general pharmacology Ronald J. Tallarida ; Robert B. Raffa ; Paul McGonigle |
| title_fullStr | Principles in general pharmacology Ronald J. Tallarida ; Robert B. Raffa ; Paul McGonigle |
| title_full_unstemmed | Principles in general pharmacology Ronald J. Tallarida ; Robert B. Raffa ; Paul McGonigle |
| title_short | Principles in general pharmacology |
| title_sort | principles in general pharmacology |
| topic | Pharmacologie moléculaire Pharmacologie Molecular pharmacology Pharmacology Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Pharmacologie moléculaire Pharmacologie Molecular pharmacology Pharmacology Pharmakologie |
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