Bile acids: biological actions and clinical relevance
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2007
|
| Schriftenreihe: | Falk Symposium
155 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XVII, 265 S. Ill., graph Darst. |
| ISBN: | 9781402062513 |
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| 245 | 1 | 0 | |a Bile acids |b biological actions and clinical relevance |c ed. by D. Keppler ... |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2007 | |
| 300 | |a XVII, 265 S. |b Ill., graph Darst. | ||
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| 490 | 1 | |a Falk Symposium |v 155 | |
| 650 | 4 | |a Bile Acids and Salts |v Congresses | |
| 650 | 4 | |a Bile acids |v Congresses | |
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Datensatz im Suchindex
| _version_ | 1804136633687080960 |
|---|---|
| adam_text | Contents
List of principal contributors
xi
List of chairpersons
xv
Preface
xvii
SECTION
1:
METABOLISM OF BILE ACIDS
Chair: AF
Hofmann, J
Sjövall
Analysis of mice deficient in the bile acid biosynthetic
enzyme
3ß-hydroxy-As-C27
steroid oxido-
reductase (HSD3B7)
HC Shea, KDR Setche/I, DW
Russel/
3
Role of oxysterols and cholestenoic acids in a crosstalk
between the brain and the liver
/
Björkhem,
S
Meaney,
M Heverín, U
Andersson,
M
Axelsson,
U
Panzenboeck, W
Sattler 8
Activation of a G-protein coupled receptor by conjugated
bile acids in primary hepatocytes and liver: effects on
glucose metabolism
PB
Hylemon,
Y
Fang,
E
Studer, WM
Pandák,
P
Dent
11
Discovery of a novel oxysterol,
ö-cholesten-Sß, 25-diol
3-sulphate, in nuclei and mitochondria following over-
expression of the gene encoding StarDI
S
Ren,
PB
Hylemon, X
Li, D
Rodríguez-Agudo,
H
Zhou,
S
Erickson,
G
Gil, WM
Pandák
20
SECTION II: HEPATOBILIARY TRANSPORT
OF BILE ACIDS
Chair:
W
Kramer, FJ
Suchy
Role of Ntcp phosphorylation in cAMP-mediated stimulation
of hepatic bile acid uptake
MS Anwer,
M
Ananthanarayanan, FJ
Suchy
39
CONTENTS
6
The concept of basolateral efflux pumps of the hepatocyte
D Keppler,
M
Rius
48
7
Insights into the regulation of expression of human
OSTa-OSTß
CJ Sorofca,
S
Хи,
S-Y
Cai,
N
Ballatori, JL
Boyer 53
8
Regulation of hepatobiliary transport proteins in chronic
cholestasis
R Kubitz, V Keitel, M Burdeiski, D
Häussinger 57
9
Assessment of inhibitory effect of many therapeutically
important drugs on bile acid transport by NTCP, BSEP and
other transporters
К
Maeda,
Y
Tian,
S Mita, H
Suzuki,
H Akita, H Hayashi,
R
Onuki,
AF
Hofmann,
У
Sugiyama
61
SECTION III: EXTRAHEPATOCYTIC TRANSPORT AND
ACTIONS OF BILE ACIDS
Chair: JL Boyer, PJ Meier-Abt
10
Extrahepatocytic transport of bile acids: the role of the
cholangiocyte
X Xia,
G
Alpini,
G LeSage
71
11
Molecular mechanisms of intestinal basolateral bile
acid transport
A Rao,
J
Haywood,
AL Craddock,
PA Dawson
76
12
Regulation of intestinal bile acid transport in health
and disease
BL Shneider
85
13
Evidence for a role of the FXR-driven intestinal regulatory
factor FGF-19 upon cholestyramine and chenodeoxycholic
acid treatment and during the diurnal regulation of bile
acid synthesis in humans
M
Rudllng,
T Lundåsen, B Angelin, C Gälman
92
SECTION IV: NUCLEAR RECEPTOR REGULATION
Chair:
DJ Mangelsdorf, DW
Russell
14
Bile acid-like hormones function as ligands for the
nematode orphan nuclear receptor DAF-12 and govern
dauer
formation, reproduction and lifespan
Z
Wang, CL Cummins, DL
Motóla,
DJ Mangelsdorf 99
CONTENTS
15 Regulation
of CYP7A1 by nuclear receptor signalling in
human liver cells
JYL Chiang,
Τ
Li,
K
-Н
Song,
M
Haghiac,
E
Owsley
109
16
Regulation of hepatic and intestinal bile acid transport
by FXR-controlled pathways
J J
Boränta, GA Kullak-Ublick
115
17
Regulation of bile acid homeostasis by the nuclear bile
acid receptor FXR and
fibroblast
growth factor
15
SR
Holmstrom,
M
Choi,
T
Inagaki,
DJ Mangelsdorf,
SAKIiewer
121
18
Bile salts activate endothelial NO synthase in sinusoidal
endothelial cells of the liver via the G-protein coupled
receptor TGR5
V Keitel,
R
Reinehr, D Häussinger,
R Kubitz
128
SECTION V: BILE ACIDS, CELLULAR INJURY,
AND DISEASE MECHANISMS
Chair:
M
Trauner,
U
Beuers
19
Bile salt-induced CD95 activation
D
Häussinger,
S
Becker,
D Graf, R
Reinehr 135
20
Role of Fas and caspase
8
in glycochenodeoxycholic acid-
induced hepatocellular apoptosis in human liver cell lines
С
Rust,
C Bernt, T
Vennegeerts,
U
Beuers
143
21
Disulphated progesterone metabolites in urine relate to
pruritus in intrahepatic cholestasis of pregnancy treated
with ursodeoxycholic acid
A Glantz, S-J Reilly,
L
Benthin,
F Lammert,
L
-А
Mattsson,
J
Sjövall,
Н
-U
Marschall 147
22 Adolf Windaus
Prize Lecture: Primary biliary cirrhosis:
from ursodeoxycholic acid towards targeting strategies
for therapies
R
Poupon
156
CONTENTS
SECTION
VI: BILE
ACIDS, CELLULAR INJURY,
AND HEPATIC FIBROSIS
Chair:
D
Häussinger, PLM Jansen
23
Bile acids and liver fibrosis
-
causative agent and
therapeutic tool
Ρ
Fickert, A Fuchsbichler,
Τ
Moustafa,
E Halilbasic,
С
Langner,
Η
Denk,
M Trauner
169
24
Mechanisms of bile acid-induced cell death in vivo and
in vitro
H
Moshage
175
25
Bile acids enhance cellular motility of the hepatic
myofibroblast-like cell through the regulation of
рЗб
/JNK
signalling
У
Zhang,
T
Ikegami, A Honda,
B Bouscarel,
Y Matsuzaki
179
SECTION
VII: BILE
ACIDS AS THERAPEUTIC AGENTS:
MECHANISMS AND ACTIONS
Chair: GP van
Berge Henegouwen,
A
Stiehl
26
Side-chain-shortened bile acids for the treatment of
cholestasis: lessons from nor-ursodeoxycholic acid
M
Trauner,
T
Moustafa,
Ρ
Fickert,
E
Halilbasic,
С
Guelly,
A Fuchsbichler,
Η
Denk,
К
Zatloukal,
M Wagner, G
Zollner 187
27
Ursodeoxycholic acid-disulphate
(SUDCA)
-
a
potent
chemopreventive agent
against
colon cancer
KDR Setchell, NM
Brown,
К
Bove
194
28
Prevention of cholesterol gallstones by the potent
cholesterol absorption inhibitor ezetimibe in gallstone-
susceptible C57L/J mice
HH Wang,
P Porťmcasa, DQ-H
Wang
201
29
Tauroursodeoxycholie acid antagonizes taurolithocholic
acid-induced cholestasis via a cooperative protein kinase
C- and protein kinase
А
-dependent signalling pathway in
the perfused rat liver
R
Wimmer,
S Hohenester, T
Pusi,
С
Rust,
U
Beuers 215
viü
CONTENTS
SECTION
VIII:
BILE
ACIDS IN THE TREATMENT OF
CHOLESTATIC LIVER DISEASE
Chair:
Н
-U
Marschall,
U
Leuschner
30
Ursodeoxycholic acid for the treatment of primary
scierosing cholangitis
KD Lindor
221
31
Role of polymorphisms in genes involved in bile acid
detoxification pathways in primary scierosing cholangitis
TH
Karlsen,
KM
Boberg,
E
Schrumpf 226
32
High-dose ursodeoxycholic acid in the treatment of primary
scierosing cholangitis
RW Chapman
238
33
Primary scierosing cholangitis: bile duct and
colonie
carcinomas after long-term ursodeoxycholic acid
A
Stiehl,
D
Rost,
H Kulaksiz
251
Index
257
About the Book
Since the last International Bile Acid Meeting in
Stockholm in
2004,
bile acid research has
continued to flourish and therapeutic use of bile
acids has attained a broader role. New insights
have been gained into ihe mechanisms
responsible for maintenance of bile acid
homeostasis, and effects of bile acids on the cell
signalling pathways have been further
elucidated. Knowledge of the genetic basis of
bile acid physiology has further increased.
Therapy of chronic cholestatic liver diseases
with ursodeoxycholic acid and new aspects of its
chemopreventive properties continue to
stimulate basic and clinical research and
contribute to the understanding of underlying
modes of action and to optimized treatment
schedules.
This book contains the presentations at the
1
9th
International Bile Acid Meeting, entitled Bile
Acids: Biological Actions and Clinical Relevance
(Falk
Symposium
155),
which was held in
Freiburg, Germany, on October
6-7, 2006,
with
Gustav
Paumgartner
as president. As in
previous Bile Acid Meetings, this symposium
attracted a large number of basic scientists and
clinical hepatologists from all over the world.
Chapters reflect the recent progress in bile acid
metabolism and transport, nuclear receptor
regulation and signaling by bile acids, as well as
mechanisms of bile acid-induced cellular injury.
Bile acids as therapeutic agents, particularly for
the treatment of cholestaiic liver diseases, are
the focus of several clinically oriented
contributions. This volume in the
Falk
Symposium series therefore contributes
successfully to the bridging of basic science and
clinical hepatotogy in the field of bile acids.
|
| adam_txt |
Contents
List of principal contributors
xi
List of chairpersons
xv
Preface
xvii
SECTION
1:
METABOLISM OF BILE ACIDS
Chair: AF
Hofmann, J
Sjövall
Analysis of mice deficient in the bile acid biosynthetic
enzyme
3ß-hydroxy-As-C27
steroid oxido-
reductase (HSD3B7)
HC Shea, KDR Setche/I, DW
Russel/
3
Role of oxysterols and cholestenoic acids in a crosstalk
between the brain and the liver
/
Björkhem,
S
Meaney,
M Heverín, U
Andersson,
M
Axelsson,
U
Panzenboeck, W
Sattler 8
Activation of a G-protein coupled receptor by conjugated
bile acids in primary hepatocytes and liver: effects on
glucose metabolism
PB
Hylemon,
Y
Fang,
E
Studer, WM
Pandák,
P
Dent
11
Discovery of a novel oxysterol,
ö-cholesten-Sß, 25-diol
3-sulphate, in nuclei and mitochondria following over-
expression of the gene encoding StarDI
S
Ren,
PB
Hylemon, X
Li, D
Rodríguez-Agudo,
H
Zhou,
S
Erickson,
G
Gil, WM
Pandák
20
SECTION II: HEPATOBILIARY TRANSPORT
OF BILE ACIDS
Chair:
W
Kramer, FJ
Suchy
Role of Ntcp phosphorylation in cAMP-mediated stimulation
of hepatic bile acid uptake
MS Anwer,
M
Ananthanarayanan, FJ
Suchy
39
CONTENTS
6
The concept of basolateral efflux pumps of the hepatocyte
D Keppler,
M
Rius
48
7
Insights into the regulation of expression of human
OSTa-OSTß
CJ Sorofca,
S
Хи,
S-Y
Cai,
N
Ballatori, JL
Boyer 53
8
Regulation of hepatobiliary transport proteins in chronic
cholestasis
R Kubitz, V Keitel, M Burdeiski, D
Häussinger 57
9
Assessment of inhibitory effect of many therapeutically
important drugs on bile acid transport by NTCP, BSEP and
other transporters
К
Maeda,
Y
Tian,
S Mita, H
Suzuki,
H Akita, H Hayashi,
R
Onuki,
AF
Hofmann,
У
Sugiyama
61
SECTION III: EXTRAHEPATOCYTIC TRANSPORT AND
ACTIONS OF BILE ACIDS
Chair: JL Boyer, PJ Meier-Abt
10
Extrahepatocytic transport of bile acids: the role of the
cholangiocyte
X Xia,
G
Alpini,
G LeSage
71
11
Molecular mechanisms of intestinal basolateral bile
acid transport
A Rao,
J
Haywood,
AL Craddock,
PA Dawson
76
12
Regulation of intestinal bile acid transport in health
and disease
BL Shneider
85
13
Evidence for a role of the FXR-driven intestinal regulatory
factor FGF-19 upon cholestyramine and chenodeoxycholic
acid treatment and during the diurnal regulation of bile
acid synthesis in humans
M
Rudllng,
T Lundåsen, B Angelin, C Gälman
92
SECTION IV: NUCLEAR RECEPTOR REGULATION
Chair:
DJ Mangelsdorf, DW
Russell
14
Bile acid-like hormones function as ligands for the
nematode orphan nuclear receptor DAF-12 and govern
dauer
formation, reproduction and lifespan
Z
Wang, CL Cummins, DL
Motóla,
DJ Mangelsdorf 99
CONTENTS
15 Regulation
of CYP7A1 by nuclear receptor signalling in
human liver cells
JYL Chiang,
Τ
Li,
K
-Н
Song,
M
Haghiac,
E
Owsley
109
16
Regulation of hepatic and intestinal bile acid transport
by FXR-controlled pathways
J J
Boränta, GA Kullak-Ublick
115
17
Regulation of bile acid homeostasis by the nuclear bile
acid receptor FXR and
fibroblast
growth factor
15
SR
Holmstrom,
M
Choi,
T
Inagaki,
DJ Mangelsdorf,
SAKIiewer
121
18
Bile salts activate endothelial NO synthase in sinusoidal
endothelial cells of the liver via the G-protein coupled
receptor TGR5
V Keitel,
R
Reinehr, D Häussinger,
R Kubitz
128
SECTION V: BILE ACIDS, CELLULAR INJURY,
AND DISEASE MECHANISMS
Chair:
M
Trauner,
U
Beuers
19
Bile salt-induced CD95 activation
D
Häussinger,
S
Becker,
D Graf, R
Reinehr 135
20
Role of Fas and caspase
8
in glycochenodeoxycholic acid-
induced hepatocellular apoptosis in human liver cell lines
С
Rust,
C Bernt, T
Vennegeerts,
U
Beuers
143
21
Disulphated progesterone metabolites in urine relate to
pruritus in intrahepatic cholestasis of pregnancy treated
with ursodeoxycholic acid
A Glantz, S-J Reilly,
L
Benthin,
F Lammert,
L
-А
Mattsson,
J
Sjövall,
Н
-U
Marschall 147
22 Adolf Windaus
Prize Lecture: Primary biliary cirrhosis:
from ursodeoxycholic acid towards targeting strategies
for therapies
R
Poupon
156
CONTENTS
SECTION
VI: BILE
ACIDS, CELLULAR INJURY,
AND HEPATIC FIBROSIS
Chair:
D
Häussinger, PLM Jansen
23
Bile acids and liver fibrosis
-
causative agent and
therapeutic tool
Ρ
Fickert, A Fuchsbichler,
Τ
Moustafa,
E Halilbasic,
С
Langner,
Η
Denk,
M Trauner
169
24
Mechanisms of bile acid-induced cell death in vivo and
in vitro
H
Moshage
175
25
Bile acids enhance cellular motility of the hepatic
myofibroblast-like cell through the regulation of
рЗб
/JNK
signalling
У
Zhang,
T
Ikegami, A Honda,
B Bouscarel,
Y Matsuzaki
179
SECTION
VII: BILE
ACIDS AS THERAPEUTIC AGENTS:
MECHANISMS AND ACTIONS
Chair: GP van
Berge Henegouwen,
A
Stiehl
26
Side-chain-shortened bile acids for the treatment of
cholestasis: lessons from nor-ursodeoxycholic acid
M
Trauner,
T
Moustafa,
Ρ
Fickert,
E
Halilbasic,
С
Guelly,
A Fuchsbichler,
Η
Denk,
К
Zatloukal,
M Wagner, G
Zollner 187
27
Ursodeoxycholic acid-disulphate
(SUDCA)
-
a
potent
chemopreventive agent
against
colon cancer
KDR Setchell, NM
Brown,
К
Bove
194
28
Prevention of cholesterol gallstones by the potent
cholesterol absorption inhibitor ezetimibe in gallstone-
susceptible C57L/J mice
HH Wang,
P Porťmcasa, DQ-H
Wang
201
29
Tauroursodeoxycholie acid antagonizes taurolithocholic
acid-induced cholestasis via a cooperative protein kinase
C- and protein kinase
А
-dependent signalling pathway in
the perfused rat liver
R
Wimmer,
S Hohenester, T
Pusi,
С
Rust,
U
Beuers 215
viü
CONTENTS
SECTION
VIII:
BILE
ACIDS IN THE TREATMENT OF
CHOLESTATIC LIVER DISEASE
Chair:
Н
-U
Marschall,
U
Leuschner
30
Ursodeoxycholic acid for the treatment of primary
scierosing cholangitis
KD Lindor
221
31
Role of polymorphisms in genes involved in bile acid
detoxification pathways in primary scierosing cholangitis
TH
Karlsen,
KM
Boberg,
E
Schrumpf 226
32
High-dose ursodeoxycholic acid in the treatment of primary
scierosing cholangitis
RW Chapman
238
33
Primary scierosing cholangitis: bile duct and
colonie
carcinomas after long-term ursodeoxycholic acid
A
Stiehl,
D
Rost,
H Kulaksiz
251
Index
257
About the Book
Since the last International Bile Acid Meeting in
Stockholm in
2004,
bile acid research has
continued to flourish and therapeutic use of bile
acids has attained a broader role. New insights
have been gained into ihe mechanisms
responsible for maintenance of bile acid
homeostasis, and effects of bile acids on the cell
signalling pathways have been further
elucidated. Knowledge of the genetic basis of
bile acid physiology has further increased.
Therapy of chronic cholestatic liver diseases
with ursodeoxycholic acid and new aspects of its
chemopreventive properties continue to
stimulate basic and clinical research and
contribute to the understanding of underlying
modes of action and to optimized treatment
schedules.
This book contains the presentations at the
1
9th
International Bile Acid Meeting, entitled 'Bile
Acids: Biological Actions and Clinical Relevance'
(Falk
Symposium
155),
which was held in
Freiburg, Germany, on October
6-7, 2006,
with
Gustav
Paumgartner
as president. As in
previous Bile Acid Meetings, this symposium
attracted a large number of basic scientists and
clinical hepatologists from all over the world.
Chapters reflect the recent progress in bile acid
metabolism and transport, nuclear receptor
regulation and signaling by bile acids, as well as
mechanisms of bile acid-induced cellular injury.
Bile acids as therapeutic agents, particularly for
the treatment of cholestaiic liver diseases, are
the focus of several clinically oriented
contributions. This volume in the
Falk
Symposium series therefore contributes
successfully to the bridging of basic science and
clinical hepatotogy in the field of bile acids. |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| building | Verbundindex |
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| callnumber-first | R - Medicine |
| callnumber-label | RC845 F19 V |
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| ctrlnum | (OCoLC)154712102 (DE-599)BVBBV022525799 |
| dewey-full | 573.38379 616.3/008 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 573 - Specific physiological systems in animals 616 - Diseases |
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| dewey-sort | 3573.38379 |
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| discipline | Biologie Chemie Medizin |
| discipline_str_mv | Biologie Chemie Medizin |
| format | Book |
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| genre | (DE-588)1071861417 Konferenzschrift 2006 Freiburg im Breisgau gnd-content |
| genre_facet | Konferenzschrift 2006 Freiburg im Breisgau |
| id | DE-604.BV022525799 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:04:48Z |
| indexdate | 2024-07-09T20:59:30Z |
| institution | BVB |
| isbn | 9781402062513 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015732479 |
| oclc_num | 154712102 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
| physical | XVII, 265 S. Ill., graph Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| record_format | marc |
| series | Falk Symposium |
| series2 | Falk Symposium |
| spelling | Bile acids biological actions and clinical relevance ed. by D. Keppler ... Dordrecht [u.a.] Springer 2007 XVII, 265 S. Ill., graph Darst. txt rdacontent n rdamedia nc rdacarrier Falk Symposium 155 Bile Acids and Salts Congresses Bile acids Congresses Gallensäuren (DE-588)4155851-0 gnd rswk-swf Lipidstoffwechsel (DE-588)4035875-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2006 Freiburg im Breisgau gnd-content Gallensäuren (DE-588)4155851-0 s Lipidstoffwechsel (DE-588)4035875-6 s b DE-604 Keppler, Dietrich Sonstige oth Falk Symposium 155 (DE-604)BV000001125 155 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015732479&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015732479&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Bile acids biological actions and clinical relevance Falk Symposium Bile Acids and Salts Congresses Bile acids Congresses Gallensäuren (DE-588)4155851-0 gnd Lipidstoffwechsel (DE-588)4035875-6 gnd |
| subject_GND | (DE-588)4155851-0 (DE-588)4035875-6 (DE-588)1071861417 |
| title | Bile acids biological actions and clinical relevance |
| title_auth | Bile acids biological actions and clinical relevance |
| title_exact_search | Bile acids biological actions and clinical relevance |
| title_exact_search_txtP | Bile acids biological actions and clinical relevance |
| title_full | Bile acids biological actions and clinical relevance ed. by D. Keppler ... |
| title_fullStr | Bile acids biological actions and clinical relevance ed. by D. Keppler ... |
| title_full_unstemmed | Bile acids biological actions and clinical relevance ed. by D. Keppler ... |
| title_short | Bile acids |
| title_sort | bile acids biological actions and clinical relevance |
| title_sub | biological actions and clinical relevance |
| topic | Bile Acids and Salts Congresses Bile acids Congresses Gallensäuren (DE-588)4155851-0 gnd Lipidstoffwechsel (DE-588)4035875-6 gnd |
| topic_facet | Bile Acids and Salts Congresses Bile acids Congresses Gallensäuren Lipidstoffwechsel Konferenzschrift 2006 Freiburg im Breisgau |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015732479&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015732479&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000001125 |
| work_keys_str_mv | AT kepplerdietrich bileacidsbiologicalactionsandclinicalrelevance |