Neurodegenerative diseases and metal ions:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2006
|
| Schriftenreihe: | Metal ions in life sciences
1 |
| Schlagworte: | |
| Online-Zugang: | Table of contents only Publisher description Inhaltsverzeichnis |
| Beschreibung: | XXIII, 463 S. Ill., graph. Darst. |
| ISBN: | 0470014881 9780470014882 |
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| 245 | 1 | 0 | |a Neurodegenerative diseases and metal ions |c ed. by Astrid Sigel ... |
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 2006 | |
| 300 | |a XXIII, 463 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Metal ions in life sciences |v 1 | |
| 650 | 7 | |a Metallion - Nervendegeneration - Aufsatzsammlung |2 swd | |
| 650 | 7 | |a Nervendegeneration - Metallion - Aufsatzsammlung |2 swd | |
| 650 | 4 | |a Nervous system |x Degeneration | |
| 650 | 4 | |a Nervous system |x Diseases | |
| 650 | 4 | |a Metal ions |x Health aspects | |
| 650 | 4 | |a Neurodegenerative Diseases |x chemically induced | |
| 650 | 4 | |a Metals |x adverse effects | |
| 650 | 4 | |a Metals |x metabolism | |
| 650 | 4 | |a Prion Diseases |x chemically induced | |
| 650 | 4 | |a Protein Folding | |
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Datensatz im Suchindex
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| adam_text | Contents
HISTORICAL DEVELOPMENT AND PERSPECTIVES
OF THE SERIES v
PREFACE TO VOLUME 1 vii
CONTRIBUTORS TO VOLUME 1 xv
TITLES OF VOLUMES 1^4 IN THE
METAL IONS IN BIOLOGICAL SYSTEMS SERIES xix
CONTENTS OF VOLUMES IN THE
METAL IONS IN LIFE SCIENCES SERIES xxi
1 THE ROLE OF METAL IONS IN NEUROLOGY.
AN INTRODUCTION 1
Dorothea Strozyk and Ashley I. Bush
1 Introductory Remarks 1
2 Comments on Metal Ions in Neurology 2
Acknowledgments 5
Abbreviations 5
References 5
2 PROTEIN FOLDING, MISFOLDING, AND DISEASE 9
Jennifer C. Lee, Judy E. Kim, Ekaterina V. Pletneva,
Jasmin Faraone Mennella, Harry B. Gray, and Jay R. Winkler
1 Introduction 10
2 Experimental Methods 10
3 The Denatured State 16
4 Protein Folding Dynamics 26
5 a Synuclein and Parkinson s Disease 45
6 Conclusions and Outlook 50
Acknowledgments 50
x CONTENTS
Abbreviations and Definitions 51
References 51
3 METAL ION BINDING PROPERTIES OF PROTEINS
RELATED TO NEURODEGENERATION 61
Henryk Kozlowski, Marek Luczkowski,
Daniela Valensin, and Gianni Valensin
1 Introduction 62
2 Cu2+ Interactions with Mammalian Prion Proteins and Their
Fragments 63
3 Interactions of Metal Ions with the Amyloid Precursor Protein
and Its Fragments 76
4 Concluding Remarks 82
Acknowledgments 83
Abbreviations 83
References 83
4 METALLIC PRIONS: MINING THE CORE OF
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES 89
David R. Brown
1 Introduction 89
2 Historical Connections Between Copper and Transmissible
Spongiform Encephalopathies 92
3 Copper Binding to Prion Protein 93
4 Copper Coordination by Prion Protein 95
5 Copper Uptake and Prion Protein Internalization 97
6 Prion Protein as an Antioxidant 101
7 Manganese Binding 104
8 Transmissible Spongiform Encephalopathies and Metals 107
9 Conclusions 109
Abbreviations 109
References 110
5 THE ROLE OF METAL IONS IN THE AMYLOID
PRECURSOR PROTEIN AND IN ALZHEIMER S
DISEASE 115
Thomas A. Bayer and Gerd Multhaup
1 Introduction 115
2 Amyloid Precursor Protein and Brain Copper Homeostasis 117
3 Amyloid Precursor Protein and Cu,Zn Superoxide Dismutase 1 119
4 General Conclusions 120
Abbreviations 121
References 122
CONTENTS xi
6 THE ROLE OF IRON IN THE PATHOGENESIS OF
PARKINSON S DISEASE 125
Manfred Gerlach, Kay L. Double, Mario E. Gotz,
Moussa B. H. Youdim, and Peter Riederer
1 Introduction 126
2 Iron in the Etiology of Parkinson s Disease 128
3 Sources of Increased Iron in Parkinson s Disease 133
4 Consequences of Iron Overload in Parkinson s Disease 139
5 General Conclusions 141
Acknowledgments 142
Abbreviations and Definitions 142
References 143
7 IN VIVO ASSESSMENT OF IRON IN HUNTINGTON S
DISEASE AND OTHER AGE RELATED
NEURODEGENERATIVE BRAIN DISEASES 151
George Bartzokis, Po H. Lu, Todd A. Tishler, and
Susan Perlman
1 Introduction. Puzzling Changes in Cell Numbers in
Huntington s Disease Brain 152
2 Human Brain Development and Disease Phenotypes 154
3 Oligodendrocytes and Iron in Brain Development and
Degeneration 159
4 Transition Metal Metabolism and Proteinopathies 165
5 In Vivo Measurement of Brain Iron 166
6 Novel Treatment Considerations 168
7 Conclusions 168
Acknowledgments 169
Abbreviations 169
References 170
8 COPPER ZINC SUPEROXIDE DISMUTASE AND
FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS 179
Lisa J. Whitson and P. John Hart
1 Introduction 180
2 Molecular Mechanisms of fALS SOD 1 Pathogenesis 181
3 Structural Features of Human SOD1 187
4 Wild Type like fALS Mutants 190
5 Metal Binding Region fALS Mutants 191
6 Monomeric SOD1 and Pathogenesis 194
7 Conclusions 198
Acknowledgments 199
xii CONTENTS
Abbreviations 199
References 199
9 THE MALFUNCTIONING OF COPPER TRANSPORT IN
WILSON AND MENKES DISEASES 207
Bibudhendra Sarkar
1 Introduction 208
2 Clinical and Biochemical Features of Copper Transport
Disorders 210
3 Genes Identified in Copper Transport Disorders 212
4 Structure and Function of Copper Transporting ATPases 213
5 Treatment of Copper Transport Disorders 217
6 Conclusions 221
Acknowledgments 221
Abbreviations 221
References 221
10 IRON AND ITS ROLE IN NEURODEGENERATIVE
DISEASES 227
Roberta J. Ward and Robert R. Crichton
1 Introduction 228
2 The Inorganic Chemistry of Iron and Its Role in Human
Biology 229
3 Iron Metabolism 230
4 The Role of the Labile Iron Pool in Free Radical Production 238
5 The Importance of Iron in Brain 239
6 The Involvement of Iron in Neurodegenerative Diseases 244
7 Experimental Approaches to Brain Iron Loading 265
8 Conclusions 270
Acknowledgments 270
Abbreviations 270
References 272
11 THE CHEMICAL INTERPLAY BETWEEN
CATECHOLAMINES AND METAL IONS IN
NEUROLOGICAL DISEASES 281
Wolfgang Linert, Guy N. L. Jameson,
Reginald F. Jameson, and Kurt A. Jellinger
1 General Introduction 282
2 Neurodegenerative Diseases 283
3 Relevant in Vitro Chemistry 291
4 Iron and Parkinson s Disease 298
5 Relevant Manganese Chemistry 306
CONTENTS xiii
6 Manganese and Manganosis 306
7 Other Metal Ions and Catecholamines 308
8 Summary of the Effect of Metal Ions on Autoxidation of
Dopamine 311
9 Conclusions 312
Acknowledgments 313
Abbreviations and Definitions 314
References 315
12 ZINC METALLONEUROCHEMISTRY: PHYSIOLOGY,
PATHOLOGY, AND PROBES 321
Christopher J. Chang and Stephen J. Lippard
1 Introduction 322
2 Zinc in the Brain 323
3 Zinc Sensing for Neuroscience Applications 328
4 Biomolecule Fluorescent Probes for Zinc 329
5 Small Molecule Fluorescent Probes for Zinc 339
6 Concluding Remarks and Future Directions 359
Acknowledgments 360
Abbreviations 360
References 361
13 THE ROLE OF ALUMINUM IN NEUROTOXIC
AND NEURODEGENERATIVE PROCESSES 371
Tamds Kiss, Krisztina Gajda Schrantz, and Paolo F. Zatta
1 Introduction 372
2 Chemical Forms of Aluminum in Biological Systems 374
3 Aluminum Loading in Humans 377
4 Toxicology of Aluminum in Animals and Humans 380
5 Aluminum and Alzheimer s Disease 384
6 General Conclusions 387
Acknowledgments 388
Abbreviations 388
References 389
14 NEUROTOXICITY OF CADMIUM, LEAD, AND
MERCURY 395
Hana R. Pohl, Henry G. Abadin, and John F. Risher
1 Introduction 396
2 Cadmium 397
3 Lead 400
4 Mercury 409
5 Conclusions 415
xiv CONTENTS
Abbreviations 415
References 416
15 NEURODEGENERATIVE DISEASES AND METAL
IONS. A CONCLUDING OVERVIEW 427
Dorothea Strozyk and Ashley I. Bush
1 Introduction 428
2 The Medicinal Chemistry of Metal centered Brain Disorders 428
3 Other Neurological Disorders that May Involve Metals 430
4 Conclusion and Outlook 432
Acknowledgments 433
Abbreviations and Definitions 433
References 434
SUBJECT INDEX 437
|
| adam_txt |
Contents
HISTORICAL DEVELOPMENT AND PERSPECTIVES
OF THE SERIES v
PREFACE TO VOLUME 1 vii
CONTRIBUTORS TO VOLUME 1 xv
TITLES OF VOLUMES 1^4 IN THE
METAL IONS IN BIOLOGICAL SYSTEMS SERIES xix
CONTENTS OF VOLUMES IN THE
METAL IONS IN LIFE SCIENCES SERIES xxi
1 THE ROLE OF METAL IONS IN NEUROLOGY.
AN INTRODUCTION 1
Dorothea Strozyk and Ashley I. Bush
1 Introductory Remarks 1
2 Comments on Metal Ions in Neurology 2
Acknowledgments 5
Abbreviations 5
References 5
2 PROTEIN FOLDING, MISFOLDING, AND DISEASE 9
Jennifer C. Lee, Judy E. Kim, Ekaterina V. Pletneva,
Jasmin Faraone Mennella, Harry B. Gray, and Jay R. Winkler
1 Introduction 10
2 Experimental Methods 10
3 The Denatured State 16
4 Protein Folding Dynamics 26
5 a Synuclein and Parkinson's Disease 45
6 Conclusions and Outlook 50
Acknowledgments 50
x CONTENTS
Abbreviations and Definitions 51
References 51
3 METAL ION BINDING PROPERTIES OF PROTEINS
RELATED TO NEURODEGENERATION 61
Henryk Kozlowski, Marek Luczkowski,
Daniela Valensin, and Gianni Valensin
1 Introduction 62
2 Cu2+ Interactions with Mammalian Prion Proteins and Their
Fragments 63
3 Interactions of Metal Ions with the Amyloid Precursor Protein
and Its Fragments 76
4 Concluding Remarks 82
Acknowledgments 83
Abbreviations 83
References 83
4 METALLIC PRIONS: MINING THE CORE OF
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES 89
David R. Brown
1 Introduction 89
2 Historical Connections Between Copper and Transmissible
Spongiform Encephalopathies 92
3 Copper Binding to Prion Protein 93
4 Copper Coordination by Prion Protein 95
5 Copper Uptake and Prion Protein Internalization 97
6 Prion Protein as an Antioxidant 101
7 Manganese Binding 104
8 Transmissible Spongiform Encephalopathies and Metals 107
9 Conclusions 109
Abbreviations 109
References 110
5 THE ROLE OF METAL IONS IN THE AMYLOID
PRECURSOR PROTEIN AND IN ALZHEIMER'S
DISEASE 115
Thomas A. Bayer and Gerd Multhaup
1 Introduction 115
2 Amyloid Precursor Protein and Brain Copper Homeostasis 117
3 Amyloid Precursor Protein and Cu,Zn Superoxide Dismutase 1 119
4 General Conclusions 120
Abbreviations 121
References 122
CONTENTS xi
6 THE ROLE OF IRON IN THE PATHOGENESIS OF
PARKINSON'S DISEASE 125
Manfred Gerlach, Kay L. Double, Mario E. Gotz,
Moussa B. H. Youdim, and Peter Riederer
1 Introduction 126
2 Iron in the Etiology of Parkinson's Disease 128
3 Sources of Increased Iron in Parkinson's Disease 133
4 Consequences of Iron Overload in Parkinson's Disease 139
5 General Conclusions 141
Acknowledgments 142
Abbreviations and Definitions 142
References 143
7 IN VIVO ASSESSMENT OF IRON IN HUNTINGTON'S
DISEASE AND OTHER AGE RELATED
NEURODEGENERATIVE BRAIN DISEASES 151
George Bartzokis, Po H. Lu, Todd A. Tishler, and
Susan Perlman
1 Introduction. Puzzling Changes in Cell Numbers in
Huntington's Disease Brain 152
2 Human Brain Development and Disease Phenotypes 154
3 Oligodendrocytes and Iron in Brain Development and
Degeneration 159
4 Transition Metal Metabolism and Proteinopathies 165
5 In Vivo Measurement of Brain Iron 166
6 Novel Treatment Considerations 168
7 Conclusions 168
Acknowledgments 169
Abbreviations 169
References 170
8 COPPER ZINC SUPEROXIDE DISMUTASE AND
FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS 179
Lisa J. Whitson and P. John Hart
1 Introduction 180
2 Molecular Mechanisms of fALS SOD 1 Pathogenesis 181
3 Structural Features of Human SOD1 187
4 'Wild Type like' fALS Mutants 190
5 'Metal Binding Region' fALS Mutants 191
6 Monomeric SOD1 and Pathogenesis 194
7 Conclusions 198
Acknowledgments 199
xii CONTENTS
Abbreviations 199
References 199
9 THE MALFUNCTIONING OF COPPER TRANSPORT IN
WILSON AND MENKES DISEASES 207
Bibudhendra Sarkar
1 Introduction 208
2 Clinical and Biochemical Features of Copper Transport
Disorders 210
3 Genes Identified in Copper Transport Disorders 212
4 Structure and Function of Copper Transporting ATPases 213
5 Treatment of Copper Transport Disorders 217
6 Conclusions 221
Acknowledgments 221
Abbreviations 221
References 221
10 IRON AND ITS ROLE IN NEURODEGENERATIVE
DISEASES 227
Roberta J. Ward and Robert R. Crichton
1 Introduction 228
2 The Inorganic Chemistry of Iron and Its Role in Human
Biology 229
3 Iron Metabolism 230
4 The Role of the 'Labile Iron Pool' in Free Radical Production 238
5 The Importance of Iron in Brain 239
6 The Involvement of Iron in Neurodegenerative Diseases 244
7 Experimental Approaches to Brain Iron Loading 265
8 Conclusions 270
Acknowledgments 270
Abbreviations 270
References 272
11 THE CHEMICAL INTERPLAY BETWEEN
CATECHOLAMINES AND METAL IONS IN
NEUROLOGICAL DISEASES 281
Wolfgang Linert, Guy N. L. Jameson,
Reginald F. Jameson, and Kurt A. Jellinger
1 General Introduction 282
2 Neurodegenerative Diseases 283
3 Relevant in Vitro Chemistry 291
4 Iron and Parkinson's Disease 298
5 Relevant Manganese Chemistry 306
CONTENTS xiii
6 Manganese and Manganosis 306
7 Other Metal Ions and Catecholamines 308
8 Summary of the Effect of Metal Ions on Autoxidation of
Dopamine 311
9 Conclusions 312
Acknowledgments 313
Abbreviations and Definitions 314
References 315
12 ZINC METALLONEUROCHEMISTRY: PHYSIOLOGY,
PATHOLOGY, AND PROBES 321
Christopher J. Chang and Stephen J. Lippard
1 Introduction 322
2 Zinc in the Brain 323
3 Zinc Sensing for Neuroscience Applications 328
4 Biomolecule Fluorescent Probes for Zinc 329
5 Small Molecule Fluorescent Probes for Zinc 339
6 Concluding Remarks and Future Directions 359
Acknowledgments 360
Abbreviations 360
References 361
13 THE ROLE OF ALUMINUM IN NEUROTOXIC
AND NEURODEGENERATIVE PROCESSES 371
Tamds Kiss, Krisztina Gajda Schrantz, and Paolo F. Zatta
1 Introduction 372
2 Chemical Forms of Aluminum in Biological Systems 374
3 Aluminum Loading in Humans 377
4 Toxicology of Aluminum in Animals and Humans 380
5 Aluminum and Alzheimer's Disease 384
6 General Conclusions 387
Acknowledgments 388
Abbreviations 388
References 389
14 NEUROTOXICITY OF CADMIUM, LEAD, AND
MERCURY 395
Hana R. Pohl, Henry G. Abadin, and John F. Risher
1 Introduction 396
2 Cadmium 397
3 Lead 400
4 Mercury 409
5 Conclusions 415
xiv CONTENTS
Abbreviations 415
References 416
15 NEURODEGENERATIVE DISEASES AND METAL
IONS. A CONCLUDING OVERVIEW 427
Dorothea Strozyk and Ashley I. Bush
1 Introduction 428
2 The Medicinal Chemistry of Metal centered Brain Disorders 428
3 Other Neurological Disorders that May Involve Metals 430
4 Conclusion and Outlook 432
Acknowledgments 433
Abbreviations and Definitions 433
References 434
SUBJECT INDEX 437 |
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| illustrated | Illustrated |
| index_date | 2024-07-02T18:00:48Z |
| indexdate | 2024-07-09T20:59:16Z |
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| series | Metal ions in life sciences |
| series2 | Metal ions in life sciences |
| spelling | Neurodegenerative diseases and metal ions ed. by Astrid Sigel ... Chichester [u.a.] Wiley 2006 XXIII, 463 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Metal ions in life sciences 1 Metallion - Nervendegeneration - Aufsatzsammlung swd Nervendegeneration - Metallion - Aufsatzsammlung swd Nervous system Degeneration Nervous system Diseases Metal ions Health aspects Neurodegenerative Diseases chemically induced Metals adverse effects Metals metabolism Prion Diseases chemically induced Protein Folding Sigel, Astrid Sonstige (DE-588)103367866X oth Metal ions in life sciences 1 (DE-604)BV022275400 1 http://www.loc.gov/catdir/toc/ecip063/2005032056.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0623/2005032056-d.html Publisher description HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015721541&sequence=000012&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurodegenerative diseases and metal ions Metal ions in life sciences Metallion - Nervendegeneration - Aufsatzsammlung swd Nervendegeneration - Metallion - Aufsatzsammlung swd Nervous system Degeneration Nervous system Diseases Metal ions Health aspects Neurodegenerative Diseases chemically induced Metals adverse effects Metals metabolism Prion Diseases chemically induced Protein Folding |
| title | Neurodegenerative diseases and metal ions |
| title_auth | Neurodegenerative diseases and metal ions |
| title_exact_search | Neurodegenerative diseases and metal ions |
| title_exact_search_txtP | Neurodegenerative diseases and metal ions |
| title_full | Neurodegenerative diseases and metal ions ed. by Astrid Sigel ... |
| title_fullStr | Neurodegenerative diseases and metal ions ed. by Astrid Sigel ... |
| title_full_unstemmed | Neurodegenerative diseases and metal ions ed. by Astrid Sigel ... |
| title_short | Neurodegenerative diseases and metal ions |
| title_sort | neurodegenerative diseases and metal ions |
| topic | Metallion - Nervendegeneration - Aufsatzsammlung swd Nervendegeneration - Metallion - Aufsatzsammlung swd Nervous system Degeneration Nervous system Diseases Metal ions Health aspects Neurodegenerative Diseases chemically induced Metals adverse effects Metals metabolism Prion Diseases chemically induced Protein Folding |
| topic_facet | Metallion - Nervendegeneration - Aufsatzsammlung Nervendegeneration - Metallion - Aufsatzsammlung Nervous system Degeneration Nervous system Diseases Metal ions Health aspects Neurodegenerative Diseases chemically induced Metals adverse effects Metals metabolism Prion Diseases chemically induced Protein Folding |
| url | http://www.loc.gov/catdir/toc/ecip063/2005032056.html http://www.loc.gov/catdir/enhancements/fy0623/2005032056-d.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015721541&sequence=000012&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV022275400 |
| work_keys_str_mv | AT sigelastrid neurodegenerativediseasesandmetalions |