Principles for evaluating health risks in children associated with exposure to chemicals:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2006
|
| Ausgabe: | 1. drafts |
| Schriftenreihe: | Environmental health criteria
237 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 329 S. graph. Darst. |
| ISBN: | 924157237x 9789241572378 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA ON
PRINCIPLES FOR EVALUATING HEALTH RISKS IN
CHILDREN ASSOCIATED WITH EXPOSURE TO
CHEMICALS
PREAMBLE xi
PREFACE xvii
ACRONYMS AND ABBREVIATIONS xix
1. SUMMARY, CONCLUSIONS, AND
RECOMMENDATIONS 1
1.1 Summary 1
1.2 Conclusions and recommendations 4
2. INTRODUCTION AND BACKGROUND 7
2.1 Introduction 7
2.2 Purpose and scope of document 9
2.3 Global burden of disease in children 12
2.4 Major environmental threats to children 14
2.4.1 Economic and nutritional factors 15
2.4.2 Social, cultural, demographic, and lifestyle
factors 16
2.4.3 Chemical hazards 17
2.5 Intrinsic factors 19
2.6 The significance of a developmental stage approach 20
2.7 Summary and conclusions 21
3. UNIQUE BIOLOGICAL CHARACTERISTICS OF
CHILDREN 22
3.1 General physical growth of children 22
3.1.1 Body weight and height 22
3.1.2 Organ weights/volumes 23
3.1.3 Skin 25
3.2 Anatomical and functional characteristics 25
3.3 Physiological characteristics 26
EHC 237: Principles for Evaluating Health Risks in Children
3.3.1 Breathing rate 26
3.3.2 Cardiac output 26
3.3.3 Blood flow to organs 27
3.3.4 Body composition 28
3.3.5 Tissue composition 29
3.3.6 Bone growth and composition 29
3.4 Metabolic characteristics 29
3.5 Toxicokinetics 31
3.5.1 Absorption, distribution, metabolism, and
elimination 31
3.5.2 Physiological changes in mothers and their
influence on toxicokinetics 33
3.5.2.1 Pregnancy 33
3.5.2.2 Lactation and breast milk 35
3.5.3 Dose to target 36
3.6 Normal development 39
3.6.1 Basic principles of normal development 39
3.6.2 Nervous system 40
3.6.3 Reproductive system 42
3.6.4 Endocrine system 44
3.6.4.1 Hypothalamic pituitary axis 44
3.6.4.2 Thyroid gland 46
3.6.4.3 Adrenal glands 47
3.6.4.4 Gonads 48
3.6.4.5 Somatotropin (growth hormone),
calcium homeostasis, and bone
development 48
3.6.4.6 Pancreas 48
3.6.5 Cardiovascular system 49
3.6.6 Immune system 49
3.6.7 Respiratory system 50
3.6.8 Kidney 52
3.7 Summary and conclusions 53
4. DEVELOPMENTAL STAGE SPECIFIC
SUSCEPTIBILITIES AND OUTCOMES IN CHILDREN 55
4.1 Introduction 55
4.2 Mortality, growth restriction, and birth defects 60
4.2.1 Mortality 60
4.2.2 Growth restriction 63
4.2.3 Birth defects (structural malformations) 64
iv
Contents
4.2.3.1 Etiology 66
4.2.3.2 Functional developmental toxicity 67
4.3 Specific organ systems 68
4.3.1 Nervous system 68
4.3.1.1 Periods of susceptibility and
consequences of exposures 69
4.3.1.2 Specific examples 72
4.3.2 Reproductive system 78
4.3.2.1 Periods of susceptibility 79
4.3.2.2 Consequences of exposures 80
4.3.3 Endocrine system 85
4.3.3.1 Periods of susceptibility 85
4.3.3.2 Consequences of exposures 92
4.3.4 Cardiovascular system 95
4.3.4.1 Periods of susceptibility 96
4.3.4.2 Consequences of exposures 96
4.3.5 Immune system 97
4.3.5.1 Periods of susceptibility 98
4.3.5.2 Consequences of exposures 101
4.3.6 Respiratory system 105
4.3.6.1 Periods of susceptibility 105
4.3.6.2 Consequences of exposures 106
4.3.7 Kidney 113
4.3.7.1 Periods of susceptibility 113
4.3.7.2 Consequences of exposures 114
4.4 Cancer 115
4.4.1 Childhood cancers that may have
environmental causes 116
4.4.1.1 Lymphoid tissues 116
4.4.1.2 Liver 118
4.4.1.3 Thyroid 118
4.4.1.4 Brain and nervous system 119
4.4.1.5 Other organ sites 119
4.4.2 Adult cancers related to childhood
exposures 120
4.4.2.1 Brain and nervous system 120
4.4.2.2 Thyroid 121
4.4.2.3 Female breast 122
4.4.2.4 Female reproductive tract 122
4.4.2.5 Integument 122
4.4.2.6 Other organ sites 123
v
EHC 237: Principles for Evaluating Health Risks in Children
4.4.3 Chemical exposures of special concern 123
4.5 Summary and conclusions 126
5. EXPOSURE ASSESSMENT OF CHILDREN 129
5.1 Introduction 129
5.2 General principles of exposure assessments 129
5.3 Methods for conducting exposure assessments 133
5.3.1 Direct methods 133
5.3.2 Biomarkers of exposure 136
5.3.3 Modelling 137
5.4 Unique characteristics of children that affect
exposure 139
5.5 Exposure as it relates to children around the world 144
5.5.1 Sources/geographical location 144
5.5.2 Pathways of exposure 145
5.5.2.1 Ambient air exposure pathway 145
5.5.2.2 Indoor exposure pathways 150
5.5.2.3 Water exposure pathway 152
5.5.2.4 Soil exposure pathway 153
5.5.2.5 Food chain exposure pathway 154
5.5.2.6 Human to human expo sure
pathways 155
5.5.3 Settings/microenvironments 156
5.5.3.1 Residential 157
5.5.3.2 School 157
5.5.3.3 Child care centres 157
5.5.3.4 Recreational 158
5.5.3.5 Special settings 159
5.5.4 Environmental equity factors (vulnerable
communities) 161
5.6 Special considerations for children s exposure:
case studies 162
5.6.1 Influence of activities 162
5.6.1.1 Arsenic 162
5.6.1.2 Insecticides 162
5.6.1.3 Environmental tobacco smoke
(ETS) 162
5.6.1.4 Lead 163
5.6.2 Hazardous waste sites 163
5.6.3 Aggregate exposure 164
5.6.3.1 Chlorpyrifos 164
w
Contents
5.6.3.2 Smelter areas 165
5.6.3.3 Malarious areas 165
5.6.4 Cumulative exposure 165
5.7 Summary and conclusions 166
6. METHODOLOGIES TO ASSESS HEALTH
OUTCOMES IN CHILDREN 168
6.1 Introduction 168
6.1.1 Methodological approaches for children s
health studies 168
6.1.1.1 Epidemiological methods 171
6.1.1.2 Comparison of study designs 171
6.1.1.3 Descriptive designs 176
6.1.1.4 Analytic designs 178
6.1.1.5 Unique methodological
considerations 180
6.1.2 Methodological approaches for animal
studies 181
6.1.2.1 Developmental stage susceptibility,
dosing periods, and assessment of
effects 184
6.1.2.2 Dosing of fetuses and pups 190
6.2 Growth and development 190
6.2.1 Human studies 190
6.2.1.1 Puberty 194
6.2.1.2 Birth defects 195
6.2.2 Animal studies 195
6.2.2.1 Body weight and postnatal growth 195
6.2.2.2 Pre , peri , and postnatal death 196
6.2.2.3 Physical and functional
developmental landmarks 196
6.2.2.4 Birth defects and malformations 198
6.3 Reproductive development and function 198
6.3.1 Human studies 198
6.3.2 Animal studies 202
6.3.2.1 Malformations of reproductive
organs 202
6.3.2.2 Anogenital distance 203
6.3.2.3 Nipple/areola retention 204
6.3.2.4 Sexual maturation and puberty 204
vii
EHC 237: Principles for Evaluating Health Risks in Children
6.3.2.5 Fertility 204
6.3.2.6 Histopathology of reproductive
organs 206
6.3.2.7 Sperm quality and estrous cyclicity 207
6.4 Neurological and behavioural effects 207
6.4.1 Human studies 207
6.4.2 Animal studies 208
6.4.2.1 Motor activity 208
6.4.2.2 Motor and sensory functions 209
6.4.2.3 Learning and memory 209
6.4.2.4 Evaluation of effects 210
6.5 Cancer 211
6.5.1 Human studies 211
6.5.2 Animal studies 212
6.6 Immune system effects 212
6.6.1 Human studies 212
6.6.2 Animal studies 213
6.7 Respiratory system effects 213
6.7.1 Human studies 213
6.7.2 Animal studies 213
6.8 Haematopoietic/cardiovascular, hepatic/renal,
skin/musculoskeletal, and metabolic/endocrine
system effects 214
6.8.1 Human studies 214
6.8.2 Animal studies 214
6.9 Summary and conclusions 214
7. IMPLICATIONS AND STRATEGIES FOR RISK
ASSESSMENT FOR CHILDREN 217
7.1 Introduction 217
7.2 Problem formulation 220
7.3 Hazard identification 221
7.3.1 End points and critical periods of exposure 223
7.3.2 Human studies 224
7.3.3 Relevance of animal studies for assessing
potential hazards to children 225
7.3.4 Reversibility and latency 229
7.3.5 Characterization of the health related
database 230
7.4 Dose response assessment 230
7.4.1 Application of health outcome data 232
viii
Contents
7.4.2 Quantitative evaluation 233
7.4.2.1 Tolerable daily intake (TDI) and
reference dose (RfD)/reference
concentration (RfC) approaches 233
7.4.2.2 Benchmark dose (BMD)/benchmark
concentration (BMC) approach 236
7.4.2.3 Biologically based dose response
models 236
7.4.2.4 Duration adjustment 237
7.4.2.5 Toxicokinetics 237
7.5 Exposure assessment 238
7.5.1 Age specific exposures 238
7.5.2 Assessment methods 240
7.6 Risk characterization 242
7.7 Summary and conclusions 244
REFERENCES 247
ANNEX 1: WORKING DEFINITIONS OF KEY TERMS 310
RESUME, CONCLUSIONS ET RECOMMANDATIONS 315
RESUMEN, CONCLUSIONES Y RECOMENDACIONES 323
ix
|
| adam_txt |
CONTENTS
ENVIRONMENTAL HEALTH CRITERIA ON
PRINCIPLES FOR EVALUATING HEALTH RISKS IN
CHILDREN ASSOCIATED WITH EXPOSURE TO
CHEMICALS
PREAMBLE xi
PREFACE xvii
ACRONYMS AND ABBREVIATIONS xix
1. SUMMARY, CONCLUSIONS, AND
RECOMMENDATIONS 1
1.1 Summary 1
1.2 Conclusions and recommendations 4
2. INTRODUCTION AND BACKGROUND 7
2.1 Introduction 7
2.2 Purpose and scope of document 9
2.3 Global burden of disease in children 12
2.4 Major environmental threats to children 14
2.4.1 Economic and nutritional factors 15
2.4.2 Social, cultural, demographic, and lifestyle
factors 16
2.4.3 Chemical hazards 17
2.5 Intrinsic factors 19
2.6 The significance of a developmental stage approach 20
2.7 Summary and conclusions 21
3. UNIQUE BIOLOGICAL CHARACTERISTICS OF
CHILDREN 22
3.1 General physical growth of children 22
3.1.1 Body weight and height 22
3.1.2 Organ weights/volumes 23
3.1.3 Skin 25
3.2 Anatomical and functional characteristics 25
3.3 Physiological characteristics 26
EHC 237: Principles for Evaluating Health Risks in Children
3.3.1 Breathing rate 26
3.3.2 Cardiac output 26
3.3.3 Blood flow to organs 27
3.3.4 Body composition 28
3.3.5 Tissue composition 29
3.3.6 Bone growth and composition 29
3.4 Metabolic characteristics 29
3.5 Toxicokinetics 31
3.5.1 Absorption, distribution, metabolism, and
elimination 31
3.5.2 Physiological changes in mothers and their
influence on toxicokinetics 33
3.5.2.1 Pregnancy 33
3.5.2.2 Lactation and breast milk 35
3.5.3 Dose to target 36
3.6 Normal development 39
3.6.1 Basic principles of normal development 39
3.6.2 Nervous system 40
3.6.3 Reproductive system 42
3.6.4 Endocrine system 44
3.6.4.1 Hypothalamic pituitary axis 44
3.6.4.2 Thyroid gland 46
3.6.4.3 Adrenal glands 47
3.6.4.4 Gonads 48
3.6.4.5 Somatotropin (growth hormone),
calcium homeostasis, and bone
development 48
3.6.4.6 Pancreas 48
3.6.5 Cardiovascular system 49
3.6.6 Immune system 49
3.6.7 Respiratory system 50
3.6.8 Kidney 52
3.7 Summary and conclusions 53
4. DEVELOPMENTAL STAGE SPECIFIC
SUSCEPTIBILITIES AND OUTCOMES IN CHILDREN 55
4.1 Introduction 55
4.2 Mortality, growth restriction, and birth defects 60
4.2.1 Mortality 60
4.2.2 Growth restriction 63
4.2.3 Birth defects (structural malformations) 64
iv
Contents
4.2.3.1 Etiology 66
4.2.3.2 Functional developmental toxicity 67
4.3 Specific organ systems 68
4.3.1 Nervous system 68
4.3.1.1 Periods of susceptibility and
consequences of exposures 69
4.3.1.2 Specific examples 72
4.3.2 Reproductive system 78
4.3.2.1 Periods of susceptibility 79
4.3.2.2 Consequences of exposures 80
4.3.3 Endocrine system 85
4.3.3.1 Periods of susceptibility 85
4.3.3.2 Consequences of exposures 92
4.3.4 Cardiovascular system 95
4.3.4.1 Periods of susceptibility 96
4.3.4.2 Consequences of exposures 96
4.3.5 Immune system 97
4.3.5.1 Periods of susceptibility 98
4.3.5.2 Consequences of exposures 101
4.3.6 Respiratory system 105
4.3.6.1 Periods of susceptibility 105
4.3.6.2 Consequences of exposures 106
4.3.7 Kidney 113
4.3.7.1 Periods of susceptibility 113
4.3.7.2 Consequences of exposures 114
4.4 Cancer 115
4.4.1 Childhood cancers that may have
environmental causes 116
4.4.1.1 Lymphoid tissues 116
4.4.1.2 Liver 118
4.4.1.3 Thyroid 118
4.4.1.4 Brain and nervous system 119
4.4.1.5 Other organ sites 119
4.4.2 Adult cancers related to childhood
exposures 120
4.4.2.1 Brain and nervous system 120
4.4.2.2 Thyroid 121
4.4.2.3 Female breast 122
4.4.2.4 Female reproductive tract 122
4.4.2.5 Integument 122
4.4.2.6 Other organ sites 123
v
EHC 237: Principles for Evaluating Health Risks in Children
4.4.3 Chemical exposures of special concern 123
4.5 Summary and conclusions 126
5. EXPOSURE ASSESSMENT OF CHILDREN 129
5.1 Introduction 129
5.2 General principles of exposure assessments 129
5.3 Methods for conducting exposure assessments 133
5.3.1 Direct methods 133
5.3.2 Biomarkers of exposure 136
5.3.3 Modelling 137
5.4 Unique characteristics of children that affect
exposure 139
5.5 Exposure as it relates to children around the world 144
5.5.1 Sources/geographical location 144
5.5.2 Pathways of exposure 145
5.5.2.1 Ambient air exposure pathway 145
5.5.2.2 Indoor exposure pathways 150
5.5.2.3 Water exposure pathway 152
5.5.2.4 Soil exposure pathway 153
5.5.2.5 Food chain exposure pathway 154
5.5.2.6 Human to human expo sure
pathways 155
5.5.3 Settings/microenvironments 156
5.5.3.1 Residential 157
5.5.3.2 School 157
5.5.3.3 Child care centres 157
5.5.3.4 Recreational 158
5.5.3.5 Special settings 159
5.5.4 Environmental equity factors (vulnerable
communities) 161
5.6 Special considerations for children's exposure:
case studies 162
5.6.1 Influence of activities 162
5.6.1.1 Arsenic 162
5.6.1.2 Insecticides 162
5.6.1.3 Environmental tobacco smoke
(ETS) 162
5.6.1.4 Lead 163
5.6.2 Hazardous waste sites 163
5.6.3 Aggregate exposure 164
5.6.3.1 Chlorpyrifos 164
w
Contents
5.6.3.2 Smelter areas 165
5.6.3.3 Malarious areas 165
5.6.4 Cumulative exposure 165
5.7 Summary and conclusions 166
6. METHODOLOGIES TO ASSESS HEALTH
OUTCOMES IN CHILDREN 168
6.1 Introduction 168
6.1.1 Methodological approaches for children's
health studies 168
6.1.1.1 Epidemiological methods 171
6.1.1.2 Comparison of study designs 171
6.1.1.3 Descriptive designs 176
6.1.1.4 Analytic designs 178
6.1.1.5 Unique methodological
considerations 180
6.1.2 Methodological approaches for animal
studies 181
6.1.2.1 Developmental stage susceptibility,
dosing periods, and assessment of
effects 184
6.1.2.2 Dosing of fetuses and pups 190
6.2 Growth and development 190
6.2.1 Human studies 190
6.2.1.1 Puberty 194
6.2.1.2 Birth defects 195
6.2.2 Animal studies 195
6.2.2.1 Body weight and postnatal growth 195
6.2.2.2 Pre , peri , and postnatal death 196
6.2.2.3 Physical and functional
developmental landmarks 196
6.2.2.4 Birth defects and malformations 198
6.3 Reproductive development and function 198
6.3.1 Human studies 198
6.3.2 Animal studies 202
6.3.2.1 Malformations of reproductive
organs 202
6.3.2.2 Anogenital distance 203
6.3.2.3 Nipple/areola retention 204
6.3.2.4 Sexual maturation and puberty 204
vii
EHC 237: Principles for Evaluating Health Risks in Children
6.3.2.5 Fertility 204
6.3.2.6 Histopathology of reproductive
organs 206
6.3.2.7 Sperm quality and estrous cyclicity 207
6.4 Neurological and behavioural effects 207
6.4.1 Human studies 207
6.4.2 Animal studies 208
6.4.2.1 Motor activity 208
6.4.2.2 Motor and sensory functions 209
6.4.2.3 Learning and memory 209
6.4.2.4 Evaluation of effects 210
6.5 Cancer 211
6.5.1 Human studies 211
6.5.2 Animal studies 212
6.6 Immune system effects 212
6.6.1 Human studies 212
6.6.2 Animal studies 213
6.7 Respiratory system effects 213
6.7.1 Human studies 213
6.7.2 Animal studies 213
6.8 Haematopoietic/cardiovascular, hepatic/renal,
skin/musculoskeletal, and metabolic/endocrine
system effects 214
6.8.1 Human studies 214
6.8.2 Animal studies 214
6.9 Summary and conclusions 214
7. IMPLICATIONS AND STRATEGIES FOR RISK
ASSESSMENT FOR CHILDREN 217
7.1 Introduction 217
7.2 Problem formulation 220
7.3 Hazard identification 221
7.3.1 End points and critical periods of exposure 223
7.3.2 Human studies 224
7.3.3 Relevance of animal studies for assessing
potential hazards to children 225
7.3.4 Reversibility and latency 229
7.3.5 Characterization of the health related
database 230
7.4 Dose response assessment 230
7.4.1 Application of health outcome data 232
viii
Contents
7.4.2 Quantitative evaluation 233
7.4.2.1 Tolerable daily intake (TDI) and
reference dose (RfD)/reference
concentration (RfC) approaches 233
7.4.2.2 Benchmark dose (BMD)/benchmark
concentration (BMC) approach 236
7.4.2.3 Biologically based dose response
models 236
7.4.2.4 Duration adjustment 237
7.4.2.5 Toxicokinetics 237
7.5 Exposure assessment 238
7.5.1 Age specific exposures 238
7.5.2 Assessment methods 240
7.6 Risk characterization 242
7.7 Summary and conclusions 244
REFERENCES 247
ANNEX 1: WORKING DEFINITIONS OF KEY TERMS 310
RESUME, CONCLUSIONS ET RECOMMANDATIONS 315
RESUMEN, CONCLUSIONES Y RECOMENDACIONES 323
ix |
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| id | DE-604.BV022499130 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:54:47Z |
| indexdate | 2024-07-09T20:58:56Z |
| institution | BVB |
| isbn | 924157237x 9789241572378 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015706218 |
| oclc_num | 180982600 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XXII, 329 S. graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Principles for evaluating health risks in children associated with exposure to chemicals prepared by Germaine Buck Louis ... 1. drafts Geneva World Health Organization 2006 XXII, 329 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 237 Arbeidshygiëne gtt Blootstelling gtt Compostos inorgânicos larpcal Gezondheidseffecten gtt Kinderen gtt Risico's gtt Saúde ambiental larpcal Toxiciteit gtt Kind Child Child Development drug effects Environmental Pollutants adverse effects Environmental health Hazardous Substances adverse effects Inorganic compounds Organic compounds Risk Assessment methods Risk assessment Gesundheitsgefährdung (DE-588)4071808-6 gnd rswk-swf Kind (DE-588)4030550-8 gnd rswk-swf Umweltkrankheit (DE-588)4131100-0 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 s Gesundheitsgefährdung (DE-588)4071808-6 s Kind (DE-588)4030550-8 s DE-604 Umweltkrankheit (DE-588)4131100-0 s b DE-604 Louis, Germaine Buck Sonstige oth Environmental health criteria 237 (DE-604)BV000011459 237 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015706218&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Principles for evaluating health risks in children associated with exposure to chemicals Environmental health criteria Arbeidshygiëne gtt Blootstelling gtt Compostos inorgânicos larpcal Gezondheidseffecten gtt Kinderen gtt Risico's gtt Saúde ambiental larpcal Toxiciteit gtt Kind Child Child Development drug effects Environmental Pollutants adverse effects Environmental health Hazardous Substances adverse effects Inorganic compounds Organic compounds Risk Assessment methods Risk assessment Gesundheitsgefährdung (DE-588)4071808-6 gnd Kind (DE-588)4030550-8 gnd Umweltkrankheit (DE-588)4131100-0 gnd Umweltchemikalie (DE-588)4117281-4 gnd |
| subject_GND | (DE-588)4071808-6 (DE-588)4030550-8 (DE-588)4131100-0 (DE-588)4117281-4 |
| title | Principles for evaluating health risks in children associated with exposure to chemicals |
| title_auth | Principles for evaluating health risks in children associated with exposure to chemicals |
| title_exact_search | Principles for evaluating health risks in children associated with exposure to chemicals |
| title_exact_search_txtP | Principles for evaluating health risks in children associated with exposure to chemicals |
| title_full | Principles for evaluating health risks in children associated with exposure to chemicals prepared by Germaine Buck Louis ... |
| title_fullStr | Principles for evaluating health risks in children associated with exposure to chemicals prepared by Germaine Buck Louis ... |
| title_full_unstemmed | Principles for evaluating health risks in children associated with exposure to chemicals prepared by Germaine Buck Louis ... |
| title_short | Principles for evaluating health risks in children associated with exposure to chemicals |
| title_sort | principles for evaluating health risks in children associated with exposure to chemicals |
| topic | Arbeidshygiëne gtt Blootstelling gtt Compostos inorgânicos larpcal Gezondheidseffecten gtt Kinderen gtt Risico's gtt Saúde ambiental larpcal Toxiciteit gtt Kind Child Child Development drug effects Environmental Pollutants adverse effects Environmental health Hazardous Substances adverse effects Inorganic compounds Organic compounds Risk Assessment methods Risk assessment Gesundheitsgefährdung (DE-588)4071808-6 gnd Kind (DE-588)4030550-8 gnd Umweltkrankheit (DE-588)4131100-0 gnd Umweltchemikalie (DE-588)4117281-4 gnd |
| topic_facet | Arbeidshygiëne Blootstelling Compostos inorgânicos Gezondheidseffecten Kinderen Risico's Saúde ambiental Toxiciteit Kind Child Child Development drug effects Environmental Pollutants adverse effects Environmental health Hazardous Substances adverse effects Inorganic compounds Organic compounds Risk Assessment methods Risk assessment Gesundheitsgefährdung Umweltkrankheit Umweltchemikalie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015706218&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000011459 |
| work_keys_str_mv | AT louisgermainebuck principlesforevaluatinghealthrisksinchildrenassociatedwithexposuretochemicals |