Biomarkers in breast cancer: molecular diagnostics for predicting and monitoring therapeutic effect
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2006
|
| Schriftenreihe: | Cancer drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | XI, 341 S. Ill., graph. Darst. |
| ISBN: | 1588292274 9781588292278 |
Internformat
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| 264 | 1 | |a Totowa, NJ |b Humana Press |c 2006 | |
| 300 | |a XI, 341 S. |b Ill., graph. Darst. | ||
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| 490 | 0 | |a Cancer drug discovery and development | |
| 650 | 4 | |a Breast |x Cancer |x Molecular diagnosis | |
| 650 | 4 | |a Breast |x Cancer |x Prognosis | |
| 650 | 4 | |a Tumor markers | |
| 650 | 0 | 7 | |a Biomarker |0 (DE-588)4425928-1 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Gasparini, Giampietro |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| adam_text | Contents
Preface v
Contributors ix
Part I. General Topics
1 Guidelines for the Design of Clinical Studies for the Development
and Validation of Therapeutically Relevant Biomarkers
and Biomarker Based Classification Systems 3
Richard M. Simon
2 Analytical Aspects of Biomarker Immunoassays
in Cancer Research 17
Fred C. G. J. Sweep, Chris M. G. Thomas,
and Manfred Schmitt
3 Tissue Microarrays: State of the Art, Pitfalls, and Promises 31
Chungyeul Kim and Soonmyung Paik
Part II. Assays for Gene Expression and Post Translational
Protein Abnormalities
4 Gene Expression Profiling with DNA Microarrays:
Revolutionary Tools to Help Diagnosis, Prognosis,
Treatment Guidance, and Drug Discovery 47
Michele De Bortoli and Nicoletta Biglia
Part III. Assays for DNA Abnormalities
5 Assays for Gene Amplification: State of the Art, Pitfalls,
and Promises 65
Chungyeul Kim, Yongkuk Song, and Soonmyung Paik
Part IV. Tissue Predictive Biomarkers
6 Cell Kinetics 81
Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori
1 Urokinase Type Plasminogen Activator and PAI 1:
Validated Prognostic Factors for Breast Cancer Ill
Michael J.Duffy
vii
viii Contents
8 Predictive Value of c erb B2 for Endocrine Therapy
and Chemotherapy in Breast Cancer 129
Vered Stearns
9 erb B2 as a Therapeutic Target 159
Robert Mass
10 The Epidermal Growth Factor Receptor Pathway as a Selective
Molecular Targeted Treatment in Human Breast Cancer 177
Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora
11 p53 as a Prognostic and Predictive Indicator 193
Daniela Kandioler and Raimund Jakesz
Part V. Predictive Biomarkers in Body Fluids
12 Occult Metastatic Cells in Breast Cancer Patients:
State of the Art, Pitfalls, and Promises 213
Stephan Braun, Julia Seeber, and Christian Marth
13 Circulating HER2/neu: Clinical Utility 235
Allan Lipton, Laurence Denters, Kim Leitzel, Suhail M. Ali,
Rainer Neumann, Christopher P. Price,
and Walter P. Carney
14 Circulating Vascular Endothelial Growth Factor:
Methods, Prognostic Significance, and Potential Application
for Antiangiogenic Therapy 267
Roberta Sarmiento, Roberta Franceschini, Sabrina Meo,
Massimo Gion, Raffele Longo, and Giampietro Gasparini
15 Detection of Early Tumor Dissemination in Patients
with Breast Cancer 293
Debra Hawes and Richard J. Cote
Part VI. Future Directions
16 New Technologies/New Markers/New Challenges 325
Daniel F. Hayes and Giampietro Gasparini
Index 333
|
| adam_txt |
Contents
Preface v
Contributors ix
Part I. General Topics
1 Guidelines for the Design of Clinical Studies for the Development
and Validation of Therapeutically Relevant Biomarkers
and Biomarker Based Classification Systems 3
Richard M. Simon
2 Analytical Aspects of Biomarker Immunoassays
in Cancer Research 17
Fred C. G. J. Sweep, Chris M. G. Thomas,
and Manfred Schmitt
3 Tissue Microarrays: State of the Art, Pitfalls, and Promises 31
Chungyeul Kim and Soonmyung Paik
Part II. Assays for Gene Expression and Post Translational
Protein Abnormalities
4 Gene Expression Profiling with DNA Microarrays:
Revolutionary Tools to Help Diagnosis, Prognosis,
Treatment Guidance, and Drug Discovery 47
Michele De Bortoli and Nicoletta Biglia
Part III. Assays for DNA Abnormalities
5 Assays for Gene Amplification: State of the Art, Pitfalls,
and Promises 65
Chungyeul Kim, Yongkuk Song, and Soonmyung Paik
Part IV. Tissue Predictive Biomarkers
6 Cell Kinetics 81
Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori
1 Urokinase Type Plasminogen Activator and PAI 1:
Validated Prognostic Factors for Breast Cancer Ill
Michael J.Duffy
vii
viii Contents
8 Predictive Value of c erb B2 for Endocrine Therapy
and Chemotherapy in Breast Cancer 129
Vered Stearns
9 erb B2 as a Therapeutic Target 159
Robert Mass
10 The Epidermal Growth Factor Receptor Pathway as a Selective
Molecular Targeted Treatment in Human Breast Cancer 177
Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora
11 p53 as a Prognostic and Predictive Indicator 193
Daniela Kandioler and Raimund Jakesz
Part V. Predictive Biomarkers in Body Fluids
12 Occult Metastatic Cells in Breast Cancer Patients:
State of the Art, Pitfalls, and Promises 213
Stephan Braun, Julia Seeber, and Christian Marth
13 Circulating HER2/neu: Clinical Utility 235
Allan Lipton, Laurence Denters, Kim Leitzel, Suhail M. Ali,
Rainer Neumann, Christopher P. Price,
and Walter P. Carney
14 Circulating Vascular Endothelial Growth Factor:
Methods, Prognostic Significance, and Potential Application
for Antiangiogenic Therapy 267
Roberta Sarmiento, Roberta Franceschini, Sabrina Meo,
Massimo Gion, Raffele Longo, and Giampietro Gasparini
15 Detection of Early Tumor Dissemination in Patients
with Breast Cancer 293
Debra Hawes and Richard J. Cote
Part VI. Future Directions
16 New Technologies/New Markers/New Challenges 325
Daniel F. Hayes and Giampietro Gasparini
Index 333 |
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| index_date | 2024-07-02T17:44:11Z |
| indexdate | 2024-07-09T20:58:17Z |
| institution | BVB |
| isbn | 1588292274 9781588292278 |
| language | English |
| lccn | 2005001922 |
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| series2 | Cancer drug discovery and development |
| spelling | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect ed. by Giampietro Gasparini ... Totowa, NJ Humana Press 2006 XI, 341 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer drug discovery and development Breast Cancer Molecular diagnosis Breast Cancer Prognosis Tumor markers Biomarker (DE-588)4425928-1 gnd rswk-swf Brustkrebs (DE-588)4008528-4 gnd rswk-swf Brustkrebs (DE-588)4008528-4 s Biomarker (DE-588)4425928-1 s b DE-604 Gasparini, Giampietro Sonstige oth http://www.loc.gov/catdir/toc/ecip056/2005001922.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015677483&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect Breast Cancer Molecular diagnosis Breast Cancer Prognosis Tumor markers Biomarker (DE-588)4425928-1 gnd Brustkrebs (DE-588)4008528-4 gnd |
| subject_GND | (DE-588)4425928-1 (DE-588)4008528-4 |
| title | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect |
| title_auth | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect |
| title_exact_search | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect |
| title_exact_search_txtP | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect |
| title_full | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect ed. by Giampietro Gasparini ... |
| title_fullStr | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect ed. by Giampietro Gasparini ... |
| title_full_unstemmed | Biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect ed. by Giampietro Gasparini ... |
| title_short | Biomarkers in breast cancer |
| title_sort | biomarkers in breast cancer molecular diagnostics for predicting and monitoring therapeutic effect |
| title_sub | molecular diagnostics for predicting and monitoring therapeutic effect |
| topic | Breast Cancer Molecular diagnosis Breast Cancer Prognosis Tumor markers Biomarker (DE-588)4425928-1 gnd Brustkrebs (DE-588)4008528-4 gnd |
| topic_facet | Breast Cancer Molecular diagnosis Breast Cancer Prognosis Tumor markers Biomarker Brustkrebs |
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