Liposome technology: 2 Entrapment of drugs and other materials into liposomes
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Informa Healthcare
2007
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 397 S. Ill., graph. Darst. |
| ISBN: | 0849388287 9780849388286 |
Internformat
MARC
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| 245 | 1 | 0 | |a Liposome technology |n 2 |p Entrapment of drugs and other materials into liposomes |c ed. by Gregory Gregoriadis |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a New York [u.a.] |b Informa Healthcare |c 2007 | |
| 300 | |a XXI, 397 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 7 | |a Liposomes |2 ram | |
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Datensatz im Suchindex
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Contents
Preface . v
Acknowledgments . ix
Contributors . xvii
1. Amphipathic Weak Base Loading into Preformed Liposomes
Having a Transmembrane Ammonium Ion Gradient:
From the Bench to Approved Doxil 1
Yechezkel Barenholz
Introduction . 1
Mechanism of Remote Loading by AS Gradient . 2
The Doxil Example for Remote Loading of
Amphipathic Weak Base into Liposomes . 8
"Remote" Release . 11
Experimental Demonstration of DOX Remote
Loading to Form Doxil . 13
Summary of the Characterization of 100 nm DOX SSL
Remote Loaded with DOX via Transmembrane
AS Gradient . 21
References . 22
2. Encapsulation of Drugs Within Liposomes by
pH Gradient Techniques 27
David B. Fenske and Pieter R. Cullis
Introduction . 27
xi
xii Contents
The Formation of Large Unilamellar Vesicles by
Extrusion Methods . 30
Generation of pH Gradients via Internal
Citrate Buffer . 32
Generation of pH Gradients via Transmembrane
Ammonia Gradients . 38
Ionophore Mediated Generation of pH Gradients via
Transmembrane Ion Gradients . 40
Comparison of Loading Methods . 44
Conclusions . 45
References . 45
3. Incorporation of Lipophilic Antitumor and Antiviral
Drugs into the Lipid Bilayer of Small
Unilamellar Liposomes 5/
Reto Schwendener and Herbert Schott
Introduction . 51
Materials and Methods . 54
Results . 57
Conclusions and Prospects . 58
References . 59
4. Liposome Encapsulated Hemoglobin as an Artificial
Oxygen Carrier 63
Vibhudutta Awasthi, Beth A. Goins, and
William T. Phillips
Introduction . 63
Formulation Factors Influencing the Composition
of LEH . 65
Current Manufacturing Technology . 73
Freeze Drying LEH . 75
Storage Stability . 76
Evaluation Techniques . 77
Summary . 81
References . 82
5. An Original Lipid Complex System for Amphotericin B . . . 93
Malika Larabi, Philippe Legrand, and Gillian Barratt
Introduction . 93
Preparation of Lipid Complex of AmB . 96
Physical Characterization . 97
Evaluation of Toxicity . 102
Contents xiii
Evaluation of Activity . 105
Conclusion . 107
References . 108
6. Coupling of Peptides to the Surface of Liposomes—
Application to Liposome Based Synthetic Vaccines Ill
Francis Schuber, Fatouma Said Hassane, and Benoit Frisch
Introduction . Ill
Techniques for Coupling Peptides to the Surface
of Liposomes . 112
Targeted Liposome Peptide Constructs . 117
Application of Liposome Peptide Constructs
to Vaccination . 118
Conclusions . 123
References . 125
7. Encapsulation of Nucleic Acid Based Therapeutics 131
Norbert Maurer, Igor Zhigaltsev, and Pieter R. Cullis
Introduction . 131
Methodology . 132
Results . 135
Conclusions . 143
References . 146
8. Intraliposomal Trapping Agents for Improving In Vivo
Liposomal Drug Formulation Stability 149
Daryl C. Drummond, Mark E. Hayes, Charles O.
Noble IV, John W. Park, Dmitri B. Kirpotin,
and Zexiong Guoand
Introduction . 149
Methods . 151
Factors Influencing In Vivo Drug Retention . 159
Colloidal and Chemical Stability
Considerations . 164
Conclusions . 164
References . 166
9. Radiolabeling of Liposomes for Scintigraphic Imaging . . . 169
Peter Laverman, Gert Storm, William T. Phillips,
Ande Bao, and Beth A. Goins
Introduction . 169
Scintigraphic Imaging . 170
xiv Contents
The Choice of the Radionuclide . 171
Labeling Methods . 172
Concluding Remarks . 181
References . 183
10. Liposomal Bisphosphonates for the Treatment
of Restenosis 187
Hila Epstein, Eyal Afergan, Nickolay Koroukhov, Galit
Eisenberg, Dikla Gutman, and Gershon Golomb
Introduction . 187
Inflammation and Restenosis . 189
Macrophage/Monocyte Inhibition by Liposomal Delivery
System of BPs . 191
Inhibition of Restenosis . 197
Conclusion . 199
References . 200
11. Development of a Liposomal Vaccination System
for Immunity Modulating Antitumor Therapy 207
Andreas Graser, Abdo Konur, and Alfred Fahr
Introduction . 207
Methodology . 208
Results and Discussion . 212
Summary . 218
References . 219
12. Influenza Virosomes as Adjuvants in Cancer Immunotherapy 221
Reto Schumacher, Giulio C. Spagnoli, and Michel Adamina
Introduction . 221
Production of IRIV . 222
In Vitro Characterization of IRIV . 222
In Vitro Evaluation of IRIV Cytotoxic
T Cell Adjuvance . 226
Discussion . 229
References . 231
13. Liposome Based DNA/Protein Vaccines: Procedures for
Entrapment and Immunization Studies 233
Gregory Gregoriadis, Andrew Bacon, Brenda McCormack,
Peter Laing, Benoit Frisch, and Francis Schuber
Introduction . 233
Materials . 235
Contents xv
Entrapment of Plasmid DNA and Protein Vaccines into
Liposomes by the Dehydration Rehydration
Procedure . 235
Immunization Studies . 241
References . 243
14. Liposome Polycation DNA: A Nonviral Gene Vector
Turned into a Potent Vaccine Carrier 245
Lisa M. Shollenberger and Leaf Huang
Liposome Polycation DNA Complexes . 245
LPDI and the Immune System . 247
Summary . 250
References . 251
15. Automated Screening of Cationic Lipid Formulations
for Transfection 253
Ulrich Massing and Peter Jantscheff
Introduction . 253
Screening for Improved Cationic Lipids . 259
Combination of the Screening Approach with
Combinatorial Solid Phase Synthesis of
Cationic Lipids . 263
Conclusion and Future Directions . 269
References . 269
16. Incorporation of Poly(EthyIene Glycol) Lipid into
Lipoplexes: On Line Incorporation Assessment and
Pharmacokinetics Advantages 273
Nathalie Mignet, Mamonjy Cadet, Michel Bessodes, and
Daniel Scherman
Introduction . 273
Why Lipoplex PEGylation Is Needed . 274
Examples of PEG Lipids Suitable for Lipoplex
Incorporation . 276
PEG Lipid Incorporation into Lipoplexes: Protocols and
Monitoring . 283
Pharmacokinetic Properties of
PEG Lipoplexes . 285
PEG Lipoplexes: What More Is Needed? . 286
References . 289
xvi Contents
17. Efficient Gene Transfer by Lipid/Peptide
Transfection Complexes 293
Scott A. Irvine, Stephen L. Hart, Jean R. McEwan, and
Faiza Afzal
Introduction . 293
Therapeutic Gene Transfer . 294
Liposome and Peptides . 294
Complex Formation . 295
Targeting . 297
Nuclear Localization Sequence . 305
Summary . 307
References . 308
18. Phospholipid and Nonphospholipid Based Vesicles
for Drug and DNA Delivery to Mitochondria in
Living Mammalian Cells 317
Volkmar Weissig, Sarathi V. Boddapati, Shing Ming Cheng,
Gerard G. M. D'Souza, and Vladimir P. Torchilin
Introduction . 317
Mitochondriotropic Liposomes . 322
Bola Lipid Based Mitochondria Specific
Delivery Systems . 325
Summary and Conclusion . 335
References . 336
19. Spectral Imaging for the Investigation of the Intracellular
Fate of Liposomes 341
Ulrich S. Huth, Rolf Schubert, and Regine Peschka Suss
Introduction . 341
Initial Mode of Internalization . 345
Intracellular Trafficking . 359
Metabolic Activity . 365
Transcytosis . 366
General Considerations . 368
Conclusion . 371
References . 372
Index . 383 |
| adam_txt |
Contents
Preface . v
Acknowledgments . ix
Contributors . xvii
1. Amphipathic Weak Base Loading into Preformed Liposomes
Having a Transmembrane Ammonium Ion Gradient:
From the Bench to Approved Doxil 1
Yechezkel Barenholz
Introduction . 1
Mechanism of Remote Loading by AS Gradient . 2
The Doxil Example for Remote Loading of
Amphipathic Weak Base into Liposomes . 8
"Remote" Release . 11
Experimental Demonstration of DOX Remote
Loading to Form Doxil . 13
Summary of the Characterization of 100 nm DOX SSL
Remote Loaded with DOX via Transmembrane
AS Gradient . 21
References . 22
2. Encapsulation of Drugs Within Liposomes by
pH Gradient Techniques 27
David B. Fenske and Pieter R. Cullis
Introduction . 27
xi
xii Contents
The Formation of Large Unilamellar Vesicles by
Extrusion Methods . 30
Generation of pH Gradients via Internal
Citrate Buffer . 32
Generation of pH Gradients via Transmembrane
Ammonia Gradients . 38
Ionophore Mediated Generation of pH Gradients via
Transmembrane Ion Gradients . 40
Comparison of Loading Methods . 44
Conclusions . 45
References . 45
3. Incorporation of Lipophilic Antitumor and Antiviral
Drugs into the Lipid Bilayer of Small
Unilamellar Liposomes 5/
Reto Schwendener and Herbert Schott
Introduction . 51
Materials and Methods . 54
Results . 57
Conclusions and Prospects . 58
References . 59
4. Liposome Encapsulated Hemoglobin as an Artificial
Oxygen Carrier 63
Vibhudutta Awasthi, Beth A. Goins, and
William T. Phillips
Introduction . 63
Formulation Factors Influencing the Composition
of LEH . 65
Current Manufacturing Technology . 73
Freeze Drying LEH . 75
Storage Stability . 76
Evaluation Techniques . 77
Summary . 81
References . 82
5. An Original Lipid Complex System for Amphotericin B . . . 93
Malika Larabi, Philippe Legrand, and Gillian Barratt
Introduction . 93
Preparation of Lipid Complex of AmB . 96
Physical Characterization . 97
Evaluation of Toxicity . 102
Contents xiii
Evaluation of Activity . 105
Conclusion . 107
References . 108
6. Coupling of Peptides to the Surface of Liposomes—
Application to Liposome Based Synthetic Vaccines Ill
Francis Schuber, Fatouma Said Hassane, and Benoit Frisch
Introduction . Ill
Techniques for Coupling Peptides to the Surface
of Liposomes . 112
Targeted Liposome Peptide Constructs . 117
Application of Liposome Peptide Constructs
to Vaccination . 118
Conclusions . 123
References . 125
7. Encapsulation of Nucleic Acid Based Therapeutics 131
Norbert Maurer, Igor Zhigaltsev, and Pieter R. Cullis
Introduction . 131
Methodology . 132
Results . 135
Conclusions . 143
References . 146
8. Intraliposomal Trapping Agents for Improving In Vivo
Liposomal Drug Formulation Stability 149
Daryl C. Drummond, Mark E. Hayes, Charles O.
Noble IV, John W. Park, Dmitri B. Kirpotin,
and Zexiong Guoand
Introduction . 149
Methods . 151
Factors Influencing In Vivo Drug Retention . 159
Colloidal and Chemical Stability
Considerations . 164
Conclusions . 164
References . 166
9. Radiolabeling of Liposomes for Scintigraphic Imaging . . . 169
Peter Laverman, Gert Storm, William T. Phillips,
Ande Bao, and Beth A. Goins
Introduction . 169
Scintigraphic Imaging . 170
xiv Contents
The Choice of the Radionuclide . 171
Labeling Methods . 172
Concluding Remarks . 181
References . 183
10. Liposomal Bisphosphonates for the Treatment
of Restenosis 187
Hila Epstein, Eyal Afergan, Nickolay Koroukhov, Galit
Eisenberg, Dikla Gutman, and Gershon Golomb
Introduction . 187
Inflammation and Restenosis . 189
Macrophage/Monocyte Inhibition by Liposomal Delivery
System of BPs . 191
Inhibition of Restenosis . 197
Conclusion . 199
References . 200
11. Development of a Liposomal Vaccination System
for Immunity Modulating Antitumor Therapy 207
Andreas Graser, Abdo Konur, and Alfred Fahr
Introduction . 207
Methodology . 208
Results and Discussion . 212
Summary . 218
References . 219
12. Influenza Virosomes as Adjuvants in Cancer Immunotherapy 221
Reto Schumacher, Giulio C. Spagnoli, and Michel Adamina
Introduction . 221
Production of IRIV . 222
In Vitro Characterization of IRIV . 222
In Vitro Evaluation of IRIV Cytotoxic
T Cell Adjuvance . 226
Discussion . 229
References . 231
13. Liposome Based DNA/Protein Vaccines: Procedures for
Entrapment and Immunization Studies 233
Gregory Gregoriadis, Andrew Bacon, Brenda McCormack,
Peter Laing, Benoit Frisch, and Francis Schuber
Introduction . 233
Materials . 235
Contents xv
Entrapment of Plasmid DNA and Protein Vaccines into
Liposomes by the Dehydration Rehydration
Procedure . 235
Immunization Studies . 241
References . 243
14. Liposome Polycation DNA: A Nonviral Gene Vector
Turned into a Potent Vaccine Carrier 245
Lisa M. Shollenberger and Leaf Huang
Liposome Polycation DNA Complexes . 245
LPDI and the Immune System . 247
Summary . 250
References . 251
15. Automated Screening of Cationic Lipid Formulations
for Transfection 253
Ulrich Massing and Peter Jantscheff
Introduction . 253
Screening for Improved Cationic Lipids . 259
Combination of the Screening Approach with
Combinatorial Solid Phase Synthesis of
Cationic Lipids . 263
Conclusion and Future Directions . 269
References . 269
16. Incorporation of Poly(EthyIene Glycol) Lipid into
Lipoplexes: On Line Incorporation Assessment and
Pharmacokinetics Advantages 273
Nathalie Mignet, Mamonjy Cadet, Michel Bessodes, and
Daniel Scherman
Introduction . 273
Why Lipoplex PEGylation Is Needed . 274
Examples of PEG Lipids Suitable for Lipoplex
Incorporation . 276
PEG Lipid Incorporation into Lipoplexes: Protocols and
Monitoring . 283
Pharmacokinetic Properties of
PEG Lipoplexes . 285
PEG Lipoplexes: What More Is Needed? . 286
References . 289
xvi Contents
17. Efficient Gene Transfer by Lipid/Peptide
Transfection Complexes 293
Scott A. Irvine, Stephen L. Hart, Jean R. McEwan, and
Faiza Afzal
Introduction . 293
Therapeutic Gene Transfer . 294
Liposome and Peptides . 294
Complex Formation . 295
Targeting . 297
Nuclear Localization Sequence . 305
Summary . 307
References . 308
18. Phospholipid and Nonphospholipid Based Vesicles
for Drug and DNA Delivery to Mitochondria in
Living Mammalian Cells 317
Volkmar Weissig, Sarathi V. Boddapati, Shing Ming Cheng,
Gerard G. M. D'Souza, and Vladimir P. Torchilin
Introduction . 317
Mitochondriotropic Liposomes . 322
Bola Lipid Based Mitochondria Specific
Delivery Systems . 325
Summary and Conclusion . 335
References . 336
19. Spectral Imaging for the Investigation of the Intracellular
Fate of Liposomes 341
Ulrich S. Huth, Rolf Schubert, and Regine Peschka Suss
Introduction . 341
Initial Mode of Internalization . 345
Intracellular Trafficking . 359
Metabolic Activity . 365
Transcytosis . 366
General Considerations . 368
Conclusion . 371
References . 372
Index . 383 |
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| illustrated | Illustrated |
| index_date | 2024-07-02T17:37:27Z |
| indexdate | 2024-08-17T00:14:20Z |
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| isbn | 0849388287 9780849388286 |
| language | English |
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| physical | XXI, 397 S. Ill., graph. Darst. |
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| spelling | Liposome technology 2 Entrapment of drugs and other materials into liposomes ed. by Gregory Gregoriadis 3. ed. New York [u.a.] Informa Healthcare 2007 XXI, 397 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Liposomes ram Vecteurs de médicaments ram Gregoriadis, Gregory 1937- Sonstige (DE-588)107725797X oth (DE-604)BV022453352 2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015661359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Liposome technology Liposomes ram Vecteurs de médicaments ram |
| title | Liposome technology |
| title_auth | Liposome technology |
| title_exact_search | Liposome technology |
| title_exact_search_txtP | Liposome technology |
| title_full | Liposome technology 2 Entrapment of drugs and other materials into liposomes ed. by Gregory Gregoriadis |
| title_fullStr | Liposome technology 2 Entrapment of drugs and other materials into liposomes ed. by Gregory Gregoriadis |
| title_full_unstemmed | Liposome technology 2 Entrapment of drugs and other materials into liposomes ed. by Gregory Gregoriadis |
| title_short | Liposome technology |
| title_sort | liposome technology entrapment of drugs and other materials into liposomes |
| topic | Liposomes ram Vecteurs de médicaments ram |
| topic_facet | Liposomes Vecteurs de médicaments |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015661359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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