Controlled nanoscale motion: Nobel Symposium 131
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| Format: | Buch |
| Sprache: | English |
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Berlin [u.a.]
Springer
2007
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| Schriftenreihe: | Lecture notes in physics
711 |
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 409 S. Ill., graph. Darst. 235 mm x 155 mm |
| ISBN: | 9783540495215 3540495215 |
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Datensatz im Suchindex
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| adam_text | T; V ^ C-) 0 ^ -^^ ^ - P - 7 -1 P HEINERLINKE ALFMANSSON (EDS.)
CONTROLLED NANOSCALE MOTION NOBEL SYMPOSIUM 131 4Y SPRINGER
NOBELSYMPOSIA CONTENTS 1 NAVIGATION ON A MICRON SCALE H.C. BERG 1
REFERENCES 12 2 MYOSIN MOTORS: THE CHEMICAL RESTRAINTS IMPOSED BY ATP /.
RAYMENT AND J. ALLINGHAM 15 2.1 CHEMISTRY AND THERMODYNAMICS OF ATP
HYDROLYSIS 15 2.2 HYDROLYSIS OF MGATP 16 2.3 KINETIC CYCLE FOR MYOSIN 17
2.4 STRUCTURES OF MYOSIN 19 2.5 ACTIVE SITE OF MYOSIN 24 2.6 COMPARISON
WITH G-PROTEINS: MOLECULAR SWITCHES 28 2.7 KINESIN BASED MOTORS 31 2.8
CONCLUSIONS 36 REFERENCES 37 3 HOW LINEAR MOTOR PROTEINS WORK K. OIWA
AND D.J. MANSTEIN 41 3.1 INTRODUCTION 41 3.2 STRUCTURAL FEATURES OF
CYTOSKELETAL MOTOR PROTEINS 41 3.3 IN VITRO MOTILITY ASSAYS: A LINK
BETWEEN PHYSIOLOGY AND BIOCHEMISTRY 44 3.4 STRUCTURAL FEATURES OF THE
MYOSIN MOTOR DOMAIN 46 3.5 AMPLIFICATION OF THE WORKING STROKE BY A
LEVER ARM MECHANISM 47 3.6 BACKWARDS DIRECTED MOVEMENT 50 3.7
SURFACE-ALIGNMENT OF MOTOR PROTEINS AND THEIR TRACKS 51 3.8 CONTROLLING
THE DIRECTION OF PROTEIN FILAMENT MOVEMENT USING MEMS TECHNIQUES 52 3.9
CONCLUSIONS AND PERSPECTIVES 58 J X CONTENTS REFERENCES 59 4 AXONAL
TRANSPORT: IMAGING AND MODELING OF A NEURONAL PROCESS S.B. SHAH, G.
YANG, G. DANUSER, AND L.S.B. GOLDSTEIN 65 4.1 NEURONAL FUNCTION: A
TREMENDOUS TRANSPORT CHALLENGE 65 4.2 MEETING THE CHALLENGE: KEY PLAYERS
IN THE NEURONAL TRANSPORT SYSTEM 66 4.3 UNRAVELING MECHANISM: USING
IMAGING AND MODELING 68 4.4 IN VIVO TRAFFIC CAMERAS: IMAGING OF VESICLES
IN LARVAL SEGMENTAL NERVES 68 4.5 BREAKING DOWN THE FILM: VESICLE
TRACKING AND PARAMETER EXTRACTION 71 4.6 UNDERSTANDING THE DATA:
THEORETICAL MODELING OF AXONAL TRANSPORT 72 4.7 CONCLUSIONS AND FUTURE
DIRECTIONS 80 REFERENCES 82 5 INTRACELLULAR TRANSPORT AND KINESIN
SUPERFAMILY PROTEINS: STRUCTURE, FUNCTION AND DYNAMICS N. HIROKAWA AND
R. TAKEMURA 85 5.1 INTRODUCTION 85 5.2 MONOMERIC MOTORS AND THEIR
FUNCTIONS 88 5.3 DENDRITIC TRANSPORT AND MECHANISMS OF CARGO RECOGNITION
94 5.4 KIF3, LEFT-RIGHT DETERMINATION AND DEVELOPMENT 99 5.5 MONOMERIC
MOTOR - HO W CAN IT MOVE? 104 5.6 KIF2 - MICROTUBULE DEPOLYMERIZING
MOTOR 115 5.7 CONCLUSIONS AND FUTURE PERSPECTIVES 118 REFERENCES 119 6
STUDIES OF DNA-PROTEIN INTERACTIONS AT THE SINGLE MOLECULE LEVEL WITH
MAGNETIC TWEEZERS J.-F. ALLEMAND, D. BENSIMON, G. CHARVIN, V. CROQUETTE,
G. HA, T. LIONNET, K.C. NEUMAN, O.A. SALEH, AND H. YOKOTA 123 6.1
INTRODUCTION 123 6.2 MAGNETIC TWEEZERS 124 6.3 STRETCHING AND TWISTING
DNA 127 6.4 PROTEIN INDUCED DNA LOOPING 128 6.5 TYPE II TOPOISOMERASES
130 6.6 STUDY OF HELICASES 131 6.7 THE FASTEST KNOWN DNA TRANSLOCASE:
FTSK 134 6.8 CONCLUSION 137 REFERENCES 137 CONTENTS XI 7 MEMBRANE
NANOTUBES I. DERENYI, G. KOSTER, M.M. VAN DUIJN, A. CZO VEK, M.
DOGTEROM, AND J. PROST 141 7.1 INTRODUCTION 141 7.2 THEORY OF MEMBRANE
TUBES 146 7.3 MEMBRANE TUBE FORMATION BY CYTOSKELETAL MOTOR PROTEINS 151
REFERENCES 156 8 MACROMOLECULAR MOTION AT THE NANOSCALE OF ENZYMES
WORKING ON POLYSACCHARIDES M. SLETMOEN, G. S.-BRCEK, AND B.T. STOKKE 161
8.1 INTRODUCTION 161 8.2 POLYSACCHARIDE MODIFYING ENZYMES 163 8.3 THE
ACTION PATTERNS OF POLYMER MODIFYING ENZYMES 164 8.4 POLYSACCHARIDE
DEGRADING PROCESSIVE ENZYMES 164 8.5 ENZYME-SUBSTRATE MOTION CAN EXPLAIN
THE FORMATION OF SPECIFIC SEQUENCE PATTERNS IN POLYSACCHARIDES 168 8.6
POSSIBLE SOURCES OF ENERGY FOR THE EPIMERISATION OF ALGINATES AT THE
POLYMER LEVEL 173 8.7 HIGH-ORDER MOLECULAR ASSEMBLY OF CELLULOSE 174 8.8
CONCLUSIONS 177 REFERENCES 178 9 BROWNIAN MOTION AFTER EINSTEIN: SOME
NEW APPLICATIONS AND NEW EXPERIMENTS D. SELMECZI, S. TOLIC-N0RRELYKKE,
E. SCHDFFER, P.H. HAGEDORN, S- MOSLER, K. BERG-S0RENSEN, N.B. LARSEN, H.
FLYVBJERG 181 9.1 INTRODUCTION 181 9.2 EINSTEIN S THEORY 182 9.3 THE
EINSTEIN-ORNSTEIN-UHLENBECK THEORY 182 9.4 COMPUTER SIMULATIONS: MORE
REALISTIC THAN REALITY 184 9.5 STOKES FRICTION FOR A SPHERE IN HARMONIC
RECTILINEAR MOTION .... 184 9.6 BEYOND EINSTEIN: BROWNIAN MOTION IN A
FLUID 185 9.7 POWER-LAW TAILS 188 9.8 IN SITU CALIBRATION OF OPTICAL
TWEEZERS BY FORCED NANO-SCALE MOTION 189 9.9 BIOLOGICAL RANDOM MOTION
191 9.10 ENTER COMPUTERS 193 9.11 TAILOR-MADE THEORY REPLACES ONE
THEORY FITS ALL 195 REFERENCES 198 10 NONEQUILIBRIUM FLUCTUATIONS OF A
SINGLE BIOMOLECULE C. JARZYNSKI 201 10.1 SETUP AND STATEMENT OF
THEORETICAL PREDICTIONS 202 XII CONTENTS 10.2 PROOF OF NONEQUILIBRIUM
WORK THEOREM FOR A THERMALLY ISOLATED SYSTEM 209 10.3 RELATION TO SECOND
LAW 211 10.4 CONCLUSION AND DISCUSSION 212 REFERENCES 215 11 WHEN IS A
DISTRIBUTION NOT A DISTRIBUTION, AND WHY WOULD YOU CARE: SINGLE-MOLECULE
MEASUREMENTS OF REPRESSOR PROTEIN 1-D DIFFUSION ON DNA Y.M. WANG, H.
FLYVBJERG, E. C. COX, AND R.H. AUSTIN 217 11.1 INTRODUCTION 217 11.2
RANDOM WALKS, RANDOM MOTION, DIFFUSION 218 11.3 EINSTEIN S THEORY FOR
BROWNIAN MOTION 220 11.4 THE PROBLEM OF TRACING SINGLE TRAJECTORIES 222
11.5 TIME AVERAGE VS ENSEMBLE AVERAGE 223 11.6 CHECK FIRST, INTERPRET
LATER 224 11.7 AND NOW WITH EXPERIMENTAL ERRORS 224 11.8 OVER-SAMPLING
226 11.9 ESTIMATING D 227 11.10 GIVE ME A RANDOM NUMBER BETWEEN 1 AND
10! SEVEN! SEVEN DOESN T LOOK RANDOM! 228 11.11 THE RANDOM
DIFFUSION OF TRANSCRIPTION FACTORS 229 11.12 REAL DISTRIBUTIONS? 236
REFERENCES 239 12 BIONEMS: NANOMECHANICAL SYSTEMS FOR SINGLE-MOLECULE
BIOPHYSICS J.L. ARLETT, M.R. PAUL, J.E. SOLOMON, M.C. CROSS, S.E.
FRASER, AND M.L. ROUKES 241 12.1 INTRODUCTION: MECHANICAL SENSORS FOR
BIOLOGY 241 12.2 MOTION TRANSDUCTION VIA PIEZORESISTIVE SENSING 244 12.3
NANOSCALE MECHANICAL DEVICES: BIONEMS 244 12.4 OVERVIEW: REALIZABLE
FORCE SENSITIVITY OF PIEZORESISTIVE BIONEMS DEVICES 245 12.5
FLUID-COUPLED NANOMECHANICAL DEVICES: ANALYSIS 245 12.6 ANALYTICAL
CALCULATIONS FOR EXPERIMENTALLY RELEVANT CONDITIONS 246 12.7 BIONEMS
DISPLACEMENT RESPONSE FUNCTIONS 247 12.8 TRANSDUCER PERFORMANCE AND
NOISE ANALYSIS 251 12.9 BIONEMS: PRACTICAL CONSIDERATIONS DETERMINING
REALIZABLE SENSITIVITY 253 12.10 SIMULATIONS OF THE STOCHASTIC DYNAMICS
OF FLUID-COUPLED NANOCANTILEVERS 257 12.11 STOCHASTIC DYNAMICS OF
FLUID-COUPLED NANOCANTILEVERS: THEORETICAL APPROACH 258 CONTENTS XIII
12.12 STOCHASTIC DYNAMICS OF FLUID-COUPLED NANOCANTILEVERS:
IMPLEMENTATION AND RESULTS 260 12.13 IMPLEMENTATION OF PRACTICAL
BIOSENSING PROTOCOLS 261 12.14 SPECIFICITY AND THE STOCHASTIC NATURE OF
SINGLE-ANALYTE BINDING EVENTS 267 REFERENCES 268 13 NANODEVICES FOR
SINGLE MOLECULE STUDIES H. G. CRAIGHEAD, S.M. STAVIS, AND K. T. SAMIEE
271 13.1 INTRODUCTION 271 13.2 NANOSTRUCTURES FOR OPTICAL CONFINEMENT
272 13.3 APPLICATIONS OF OPTICAL CONFINEMENT NANOSTRUCTURES 277 13.4
APPLICATIONS 286 13.5 NANOSTRUCTURES FOR MOLECULAR CONFINEMENT 288 13.6
ENTROPIC RECOIL 295 13.7 CONCLUSIONS 297 REFERENCES 298 14 ARTIFICIAL
DIPOLAR MOLECULAR ROTORS R.D. HORANSKY, T.F. MAGNERA, J.C. PRICE, AND J.
MICHL 303 14.1 INTRODUCTION 303 14.2 EXAMPLES OF MOLECULAR DIPOLAR
ROTORS 304 14.3 BEHAVIOR OF NON-INTERACTING DIPOLAR MOLECULAR ROTORS 317
14.4 DETECTION OF ROTATION BY DIELECTRIC SPECTROSCOPY 322 14.5 SUMMARY
328 REFERENCES 329 15 USING DNA TO POWER THE NANOWORLD B. YURKE 331 15.1
INTRODUCTION 331 15.2 STRUCTURAL PROPERTIES OF DNA 332 15.3 REOPENING
THE MOTORIZED DNA-BASED TWEEZERS 337 15.4 A THREE-STATE MACHINE 340 15.5
TOWARDS APPLICATIONS 342 REFERENCES 345 16 TUNING ION CURRENT
RECTIFICATION IN SYNTHETIC NANOTUBES Z.S. SIWY AND C.R. MARTIN 349 16.1
INTRODUCTION 349 16.2 SYSTEM OF SINGLE CONICAL NANOPORES IN POLYMER
FILMS 351 16.3 TRANSPORT PROPERTIES OF SINGLE CONICAL PORES 353 16.4
MECHANISM OF ION CURRENT RECTIFICATION 355 16.5 GOLD TUBES WITH TAILORED
SURFACE CHARGE - AN IONIC ROCKING RATCHET 357 XIV CONTENTS 16.6 DNA-AU
TUBES RECTIFY BECAUSE OF PRESENCE OF ELECTROCHEMICAL GATE 359 16.7
APPLICATION OF CONICAL NANOPORES IN BUILDING SINGLE MOLECULE SENSORS 359
16.8 CONCLUSIONS 362 REFERENCES 363 17 NANOSHUTTLES: HARNESSING MOTOR
PROTEINS TO TRANSPORT CARGO IN SYNTHETIC ENVIRONMENTS V. VOGEL AND H.
HESS 367 17.1 INTRODUCTION 367 17.2 ENGINEERING CONCEPTS TO REALIZE
MOTOR PROTEIN DRIVEN NANOSHUTTLES 369 17.3 FIRST APPLICATIONS OF
NANOSHUTTLES 377 17.4 CONCLUSIONS 380 REFERENCES 380 18 NANOTECHNOLOGY
ENHANCED FUNCTIONAL ASSAYS OF ACTOMYOSIN MOTILITY * POTENTIALS AND
CHALLENGES A. MDNSSON, LA. NICHOLLS P. OMLING, S. TDGERUD, AND L.
MONTELIUS ... 385 18.1 GENERAL INTRODUCTION 385 18.2 ACTOMYOSIN
INTERACTIONS IN THE MUSCLE CELL 386 18.3 ACTIN AND THE THIN FILAMENTS
388 18.4 MYOSIN II AND THE THICK FILAMENTS 388 18.5 THE IN VITRO
MOTILITY ASSAY AND SINGLE MOLECULE MECHANICS 389 18.6 AN IDEAL ORDERED
IN VITRO MOTILITY ASSAY SYSTEM 391 18.7 RECENT DEVELOPMENTS OF
NANOTECHNOLOGY ENHANCED IN VITRO MOTILITY ASSAYS 392 18.8 NANOTECHNOLOGY
ENHANCED IN VITRO MOTILITY ASSAYS - FUTURE DIRECTIONS 397 18.9
CONCLUSIONS 401 REFERENCES 401 INDEX 407
|
| adam_txt |
T; V ^ C-) 0'^ -^^ ^ - P'- 7 -1 P HEINERLINKE ALFMANSSON (EDS.)
CONTROLLED NANOSCALE MOTION NOBEL SYMPOSIUM 131 4Y SPRINGER
NOBELSYMPOSIA CONTENTS 1 NAVIGATION ON A MICRON SCALE H.C. BERG 1
REFERENCES 12 2 MYOSIN MOTORS: THE CHEMICAL RESTRAINTS IMPOSED BY ATP /.
RAYMENT AND J. ALLINGHAM 15 2.1 CHEMISTRY AND THERMODYNAMICS OF ATP
HYDROLYSIS 15 2.2 HYDROLYSIS OF MGATP 16 2.3 KINETIC CYCLE FOR MYOSIN 17
2.4 STRUCTURES OF MYOSIN 19 2.5 ACTIVE SITE OF MYOSIN 24 2.6 COMPARISON
WITH G-PROTEINS: MOLECULAR SWITCHES 28 2.7 KINESIN BASED MOTORS 31 2.8
CONCLUSIONS 36 REFERENCES 37 3 HOW LINEAR MOTOR PROTEINS WORK K. OIWA
AND D.J. MANSTEIN 41 3.1 INTRODUCTION 41 3.2 STRUCTURAL FEATURES OF
CYTOSKELETAL MOTOR PROTEINS 41 3.3 IN VITRO MOTILITY ASSAYS: A LINK
BETWEEN PHYSIOLOGY AND BIOCHEMISTRY 44 3.4 STRUCTURAL FEATURES OF THE
MYOSIN MOTOR DOMAIN 46 3.5 AMPLIFICATION OF THE WORKING STROKE BY A
LEVER ARM MECHANISM 47 3.6 BACKWARDS DIRECTED MOVEMENT 50 3.7
SURFACE-ALIGNMENT OF MOTOR PROTEINS AND THEIR TRACKS 51 3.8 CONTROLLING
THE DIRECTION OF PROTEIN FILAMENT MOVEMENT USING MEMS TECHNIQUES 52 3.9
CONCLUSIONS AND PERSPECTIVES 58 J X CONTENTS REFERENCES 59 4 AXONAL
TRANSPORT: IMAGING AND MODELING OF A NEURONAL PROCESS S.B. SHAH, G.
YANG, G. DANUSER, AND L.S.B. GOLDSTEIN 65 4.1 NEURONAL FUNCTION: A
TREMENDOUS TRANSPORT CHALLENGE 65 4.2 MEETING THE CHALLENGE: KEY PLAYERS
IN THE NEURONAL TRANSPORT SYSTEM 66 4.3 UNRAVELING MECHANISM: USING
IMAGING AND MODELING 68 4.4 IN VIVO TRAFFIC CAMERAS: IMAGING OF VESICLES
IN LARVAL SEGMENTAL NERVES 68 4.5 BREAKING DOWN THE FILM: VESICLE
TRACKING AND PARAMETER EXTRACTION 71 4.6 UNDERSTANDING THE DATA:
THEORETICAL MODELING OF AXONAL TRANSPORT 72 4.7 CONCLUSIONS AND FUTURE
DIRECTIONS 80 REFERENCES 82 5 INTRACELLULAR TRANSPORT AND KINESIN
SUPERFAMILY PROTEINS: STRUCTURE, FUNCTION AND DYNAMICS N. HIROKAWA AND
R. TAKEMURA 85 5.1 INTRODUCTION 85 5.2 MONOMERIC MOTORS AND THEIR
FUNCTIONS 88 5.3 DENDRITIC TRANSPORT AND MECHANISMS OF CARGO RECOGNITION
94 5.4 KIF3, LEFT-RIGHT DETERMINATION AND DEVELOPMENT 99 5.5 MONOMERIC
MOTOR - HO W CAN IT MOVE? 104 5.6 KIF2 - MICROTUBULE DEPOLYMERIZING
MOTOR 115 5.7 CONCLUSIONS AND FUTURE PERSPECTIVES 118 REFERENCES 119 6
STUDIES OF DNA-PROTEIN INTERACTIONS AT THE SINGLE MOLECULE LEVEL WITH
MAGNETIC TWEEZERS J.-F. ALLEMAND, D. BENSIMON, G. CHARVIN, V. CROQUETTE,
G. HA, T. LIONNET, K.C. NEUMAN, O.A. SALEH, AND H. YOKOTA 123 6.1
INTRODUCTION 123 6.2 MAGNETIC TWEEZERS 124 6.3 STRETCHING AND TWISTING
DNA 127 6.4 PROTEIN INDUCED DNA LOOPING 128 6.5 TYPE II TOPOISOMERASES
130 6.6 STUDY OF HELICASES 131 6.7 THE FASTEST KNOWN DNA TRANSLOCASE:
FTSK 134 6.8 CONCLUSION 137 REFERENCES 137 CONTENTS XI 7 MEMBRANE
NANOTUBES I. DERENYI, G. KOSTER, M.M. VAN DUIJN, A. CZO'VEK, M.
DOGTEROM, AND J. PROST 141 7.1 INTRODUCTION 141 7.2 THEORY OF MEMBRANE
TUBES 146 7.3 MEMBRANE TUBE FORMATION BY CYTOSKELETAL MOTOR PROTEINS 151
REFERENCES 156 8 MACROMOLECULAR MOTION AT THE NANOSCALE OF ENZYMES
WORKING ON POLYSACCHARIDES M. SLETMOEN, G. S.-BRCEK, AND B.T. STOKKE 161
8.1 INTRODUCTION 161 8.2 POLYSACCHARIDE MODIFYING ENZYMES 163 8.3 THE
ACTION PATTERNS OF POLYMER MODIFYING ENZYMES 164 8.4 POLYSACCHARIDE
DEGRADING PROCESSIVE ENZYMES 164 8.5 ENZYME-SUBSTRATE MOTION CAN EXPLAIN
THE FORMATION OF SPECIFIC SEQUENCE PATTERNS IN POLYSACCHARIDES 168 8.6
POSSIBLE SOURCES OF ENERGY FOR THE EPIMERISATION OF ALGINATES AT THE
POLYMER LEVEL 173 8.7 HIGH-ORDER MOLECULAR ASSEMBLY OF CELLULOSE 174 8.8
CONCLUSIONS 177 REFERENCES 178 9 BROWNIAN MOTION AFTER EINSTEIN: SOME
NEW APPLICATIONS AND NEW EXPERIMENTS D. SELMECZI, S. TOLIC-N0RRELYKKE,
E. SCHDFFER, P.H. HAGEDORN, S- MOSLER, K. BERG-S0RENSEN, N.B. LARSEN, H.
FLYVBJERG 181 9.1 INTRODUCTION 181 9.2 EINSTEIN'S THEORY 182 9.3 THE
EINSTEIN-ORNSTEIN-UHLENBECK THEORY 182 9.4 COMPUTER SIMULATIONS: MORE
REALISTIC THAN REALITY 184 9.5 STOKES FRICTION FOR A SPHERE IN HARMONIC
RECTILINEAR MOTION . 184 9.6 BEYOND EINSTEIN: BROWNIAN MOTION IN A
FLUID 185 9.7 POWER-LAW TAILS 188 9.8 IN SITU CALIBRATION OF OPTICAL
TWEEZERS BY FORCED NANO-SCALE MOTION 189 9.9 BIOLOGICAL RANDOM MOTION
191 9.10 ENTER COMPUTERS 193 9.11 TAILOR-MADE THEORY REPLACES "ONE
THEORY FITS ALL" 195 REFERENCES 198 10 NONEQUILIBRIUM FLUCTUATIONS OF A
SINGLE BIOMOLECULE C. JARZYNSKI 201 10.1 SETUP AND STATEMENT OF
THEORETICAL PREDICTIONS 202 XII CONTENTS 10.2 PROOF OF NONEQUILIBRIUM
WORK THEOREM FOR A THERMALLY ISOLATED SYSTEM 209 10.3 RELATION TO SECOND
LAW 211 10.4 CONCLUSION AND DISCUSSION 212 REFERENCES 215 11 WHEN IS A
DISTRIBUTION NOT A DISTRIBUTION, AND WHY WOULD YOU CARE: SINGLE-MOLECULE
MEASUREMENTS OF REPRESSOR PROTEIN 1-D DIFFUSION ON DNA Y.M. WANG, H.
FLYVBJERG, E. C. COX, AND R.H. AUSTIN 217 11.1 INTRODUCTION 217 11.2
RANDOM WALKS, RANDOM MOTION, DIFFUSION 218 11.3 EINSTEIN'S THEORY FOR
BROWNIAN MOTION 220 11.4 THE PROBLEM OF TRACING SINGLE TRAJECTORIES 222
11.5 TIME AVERAGE VS ENSEMBLE AVERAGE 223 11.6 CHECK FIRST, INTERPRET
LATER 224 11.7 AND NOW WITH EXPERIMENTAL ERRORS 224 11.8 OVER-SAMPLING
226 11.9 ESTIMATING D 227 11.10 "GIVE ME A RANDOM NUMBER BETWEEN 1 AND
10!" "SEVEN!" " SEVEN DOESN'T LOOK RANDOM!" 228 11.11 THE RANDOM
DIFFUSION OF TRANSCRIPTION FACTORS 229 11.12 REAL DISTRIBUTIONS? 236
REFERENCES 239 12 BIONEMS: NANOMECHANICAL SYSTEMS FOR SINGLE-MOLECULE
BIOPHYSICS J.L. ARLETT, M.R. PAUL, J.E. SOLOMON, M.C. CROSS, S.E.
FRASER, AND M.L. ROUKES 241 12.1 INTRODUCTION: MECHANICAL SENSORS FOR
BIOLOGY 241 12.2 MOTION TRANSDUCTION VIA PIEZORESISTIVE SENSING 244 12.3
NANOSCALE MECHANICAL DEVICES: BIONEMS 244 12.4 OVERVIEW: REALIZABLE
FORCE SENSITIVITY OF PIEZORESISTIVE BIONEMS DEVICES 245 12.5
FLUID-COUPLED NANOMECHANICAL DEVICES: ANALYSIS 245 12.6 ANALYTICAL
CALCULATIONS FOR EXPERIMENTALLY RELEVANT CONDITIONS 246 12.7 BIONEMS
DISPLACEMENT RESPONSE FUNCTIONS 247 12.8 TRANSDUCER PERFORMANCE AND
NOISE ANALYSIS 251 12.9 BIONEMS: PRACTICAL CONSIDERATIONS DETERMINING
REALIZABLE SENSITIVITY 253 12.10 SIMULATIONS OF THE STOCHASTIC DYNAMICS
OF FLUID-COUPLED NANOCANTILEVERS 257 12.11 STOCHASTIC DYNAMICS OF
FLUID-COUPLED NANOCANTILEVERS: THEORETICAL APPROACH 258 CONTENTS XIII
12.12 STOCHASTIC DYNAMICS OF FLUID-COUPLED NANOCANTILEVERS:
IMPLEMENTATION AND RESULTS 260 12.13 IMPLEMENTATION OF PRACTICAL
BIOSENSING PROTOCOLS 261 12.14 SPECIFICITY AND THE STOCHASTIC NATURE OF
SINGLE-ANALYTE BINDING EVENTS 267 REFERENCES 268 13 NANODEVICES FOR
SINGLE MOLECULE STUDIES H. G. CRAIGHEAD, S.M. STAVIS, AND K. T. SAMIEE
271 13.1 INTRODUCTION 271 13.2 NANOSTRUCTURES FOR OPTICAL CONFINEMENT
272 13.3 APPLICATIONS OF OPTICAL CONFINEMENT NANOSTRUCTURES 277 13.4
APPLICATIONS 286 13.5 NANOSTRUCTURES FOR MOLECULAR CONFINEMENT 288 13.6
ENTROPIC RECOIL 295 13.7 CONCLUSIONS 297 REFERENCES 298 14 ARTIFICIAL
DIPOLAR MOLECULAR ROTORS R.D. HORANSKY, T.F. MAGNERA, J.C. PRICE, AND J.
MICHL 303 14.1 INTRODUCTION 303 14.2 EXAMPLES OF MOLECULAR DIPOLAR
ROTORS 304 14.3 BEHAVIOR OF NON-INTERACTING DIPOLAR MOLECULAR ROTORS 317
14.4 DETECTION OF ROTATION BY DIELECTRIC SPECTROSCOPY 322 14.5 SUMMARY
328 REFERENCES 329 15 USING DNA TO POWER THE NANOWORLD B. YURKE 331 15.1
INTRODUCTION 331 15.2 STRUCTURAL PROPERTIES OF DNA 332 15.3 REOPENING
THE MOTORIZED DNA-BASED TWEEZERS 337 15.4 A THREE-STATE MACHINE 340 15.5
TOWARDS APPLICATIONS 342 REFERENCES 345 16 TUNING ION CURRENT
RECTIFICATION IN SYNTHETIC NANOTUBES Z.S. SIWY AND C.R. MARTIN 349 16.1
INTRODUCTION 349 16.2 SYSTEM OF SINGLE CONICAL NANOPORES IN POLYMER
FILMS 351 16.3 TRANSPORT PROPERTIES OF SINGLE CONICAL PORES 353 16.4
MECHANISM OF ION CURRENT RECTIFICATION 355 16.5 GOLD TUBES WITH TAILORED
SURFACE CHARGE - AN IONIC "ROCKING RATCHET" 357 XIV CONTENTS 16.6 DNA-AU
TUBES RECTIFY BECAUSE OF PRESENCE OF ELECTROCHEMICAL GATE 359 16.7
APPLICATION OF CONICAL NANOPORES IN BUILDING SINGLE MOLECULE SENSORS 359
16.8 CONCLUSIONS 362 REFERENCES 363 17 NANOSHUTTLES: HARNESSING MOTOR
PROTEINS TO TRANSPORT CARGO IN SYNTHETIC ENVIRONMENTS V. VOGEL AND H.
HESS 367 17.1 INTRODUCTION 367 17.2 ENGINEERING CONCEPTS TO REALIZE
MOTOR PROTEIN DRIVEN NANOSHUTTLES 369 17.3 FIRST APPLICATIONS OF
NANOSHUTTLES 377 17.4 CONCLUSIONS 380 REFERENCES 380 18 NANOTECHNOLOGY
ENHANCED FUNCTIONAL ASSAYS OF ACTOMYOSIN MOTILITY * POTENTIALS AND
CHALLENGES A. MDNSSON, LA. NICHOLLS P. OMLING, S. TDGERUD, AND L.
MONTELIUS . 385 18.1 GENERAL INTRODUCTION 385 18.2 ACTOMYOSIN
INTERACTIONS IN THE MUSCLE CELL 386 18.3 ACTIN AND THE THIN FILAMENTS
388 18.4 MYOSIN II AND THE THICK FILAMENTS 388 18.5 THE IN VITRO
MOTILITY ASSAY AND SINGLE MOLECULE MECHANICS 389 18.6 AN IDEAL ORDERED
IN VITRO MOTILITY ASSAY SYSTEM 391 18.7 RECENT DEVELOPMENTS OF
NANOTECHNOLOGY ENHANCED IN VITRO MOTILITY ASSAYS 392 18.8 NANOTECHNOLOGY
ENHANCED IN VITRO MOTILITY ASSAYS - FUTURE DIRECTIONS 397 18.9
CONCLUSIONS 401 REFERENCES 401 INDEX 407 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author2 | Linke, Heiner |
| author2_role | edt |
| author2_variant | h l hl |
| author_facet | Linke, Heiner |
| building | Verbundindex |
| bvnumber | BV022451338 |
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| dewey-full | 531 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 531 - Classical mechanics |
| dewey-raw | 531 |
| dewey-search | 531 |
| dewey-sort | 3531 |
| dewey-tens | 530 - Physics |
| discipline | Physik Technik Biologie |
| discipline_str_mv | Physik Technik Biologie |
| format | Book |
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| genre_facet | Konferenzschrift 2005 Kristianstad |
| id | DE-604.BV022451338 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:36:35Z |
| indexdate | 2024-07-09T20:57:52Z |
| institution | BVB |
| isbn | 9783540495215 3540495215 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015659196 |
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| physical | XX, 409 S. Ill., graph. Darst. 235 mm x 155 mm |
| publishDate | 2007 |
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| publisher | Springer |
| record_format | marc |
| series | Lecture notes in physics |
| series2 | Lecture notes in physics |
| spelling | Controlled nanoscale motion Nobel Symposium 131 Heiner Linke ... (Eds.) Berlin [u.a.] Springer 2007 XX, 409 S. Ill., graph. Darst. 235 mm x 155 mm Lecture notes in physics 711 Molekularer Motor (DE-588)4720488-6 gnd rswk-swf Bewegung (DE-588)4006311-2 gnd rswk-swf Nanometerbereich (DE-588)4327473-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2005 Kristianstad gnd-content Bewegung (DE-588)4006311-2 s Nanometerbereich (DE-588)4327473-0 s DE-604 Molekularer Motor (DE-588)4720488-6 s Linke, Heiner edt Nobel Symposium <131, 2005> Sonstige oth Lecture notes in physics 711 (DE-604)BV000003166 711 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015659196&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Controlled nanoscale motion Nobel Symposium 131 Lecture notes in physics Molekularer Motor (DE-588)4720488-6 gnd Bewegung (DE-588)4006311-2 gnd Nanometerbereich (DE-588)4327473-0 gnd |
| subject_GND | (DE-588)4720488-6 (DE-588)4006311-2 (DE-588)4327473-0 (DE-588)1071861417 |
| title | Controlled nanoscale motion Nobel Symposium 131 |
| title_auth | Controlled nanoscale motion Nobel Symposium 131 |
| title_exact_search | Controlled nanoscale motion Nobel Symposium 131 |
| title_exact_search_txtP | Controlled nanoscale motion Nobel Symposium 131 |
| title_full | Controlled nanoscale motion Nobel Symposium 131 Heiner Linke ... (Eds.) |
| title_fullStr | Controlled nanoscale motion Nobel Symposium 131 Heiner Linke ... (Eds.) |
| title_full_unstemmed | Controlled nanoscale motion Nobel Symposium 131 Heiner Linke ... (Eds.) |
| title_short | Controlled nanoscale motion |
| title_sort | controlled nanoscale motion nobel symposium 131 |
| title_sub | Nobel Symposium 131 |
| topic | Molekularer Motor (DE-588)4720488-6 gnd Bewegung (DE-588)4006311-2 gnd Nanometerbereich (DE-588)4327473-0 gnd |
| topic_facet | Molekularer Motor Bewegung Nanometerbereich Konferenzschrift 2005 Kristianstad |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015659196&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003166 |
| work_keys_str_mv | AT linkeheiner controllednanoscalemotionnobelsymposium131 AT nobelsymposium1312005 controllednanoscalemotionnobelsymposium131 |