Developmental biology of neoplastic growth: with 7 tables
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2005
|
| Schriftenreihe: | Progress in molecular and subcellular biology
40 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 3540250093 9783540250098 9783540276715 |
| DOI: | 10.1007/3-540-27671-8 |
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| 245 | 1 | 0 | |a Developmental biology of neoplastic growth |b with 7 tables |c Alvaro Macieira-Coelho (ed.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2005 | |
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| 490 | 1 | |a Progress in molecular and subcellular biology |v 40 | |
| 500 | |a Literaturangaben | ||
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Datensatz im Suchindex
| _version_ | 1804136525730938880 |
|---|---|
| adam_text | ALVARO MACIEIRA-COELHO
DEVELOPMENTA
L
BIOLOGY OF
NEOPLASTIC GROWTH
THE HEDGEHOG SIGNALING PATHWAY IN CANCER
...,
X YY ,,, ,,
1
J. VESTERGAARD, MADS BAK, L
.A. LARSEN
1
INTRODUCTION
1
2
THE HEDGEHOG SIGNALING PATHWAY
1
2.1
SYNTHESIS AND PROCESSING OF HH PROTEIN
2
2.2
MOVEMENT OF HH PROTEIN
2
2.3
RECEPTION OF HH SIGNALING
4
2.4
INTRACELLULAR SIGNAL TRANSDUCTION
5
3
HH SIGNALING IN TUMOR FORMATION AND GROWTH
6
3.1
DEFECTS IN HH SIGNALING CAUSES NEVOID BASAL-CELL
CARCINOMA SYNDROME
6
3.2
EXPERIMENTS WITH ANIMAL MODELS LINK HH SIGNALING
TO TUMORIGENESIS
7
3
.3
HH SIGNALING IN SPORADIC CANCERS
7
3.3.1
A SUBSET OF SPORADIC CANCERS HAVE MUTATIONS
IN GENES INVOLVED IN HH SIGNALING
$:
3.3.2
EXPRESSION ANALYSIS OF HH SIGNALING GENES
SUGGESTS DIVERSE MECHANISMS OF INVOLVEMENT IN CANCER
~-
8
3.4
MOLECULAR MECHANISMS
FOR HH-STIMULATED TUMOR GROWTH
11
3.4.1
SHH STIMULATES STEM CELL-LIKE PROGENITO
R
CELL PROLIFERATION
11
3.4.2
DO TUMORS ARISE FROM TRANSFORMATION OF STEM CELLS?
11
3.4.3
MOLECULAR TARGETS OF HH SIGNALING
12
4
SMALL-MOLECULE HH SIGNALING ANTAGONISTS
-
A THERAPEUTIC OPPORTUNITY?
15
4.1
DISCOVERY OF SMALL-MOLECULE HH ANTAGONISTS
16
4.2
INHIBITION OF TUMOR GROWTH BY HH ANTAGONISTS
16
5
FUTURE PROSPECTS
17
REFERENCES
18
RHO GTPASES AND CANCER
29
P. BUONGIORNO, B. BAPAT
1
INTRODUCTION
29
2
RHO PROTEINS AND TUMORIGENESIS
32
3
ELEVATED RHO GTPASE SIGNALING IN TUMORIGENESIS
32
4
UPSTREAM REGULATION OF RHO GTPASES
34
5
DOWNSTREAM SIGNALING PATHWAYS
36
5.1
RHO GTPASES AND CELL-CYCLE PROGRESSION
36
5.2
RHO GTPASES AND CELL SURVIVAL
39
5.3
RHO GTPASES AND INVASION/METASTASIS
40
6
CROSS TALK BETWEEN RACL AND WNT SIGNALING PATHWAYS
43
7
RHO GTPASES AS THERAPEUTIC TARGETS
44
8
FUTURE DIRECTIONS
46
REFERENCES
47
DEVELOPMENTAL BIOLOGY OF FIBROBLASTS AND NEOPLASTIC DISEASE
5
5
D. BROUTY-BOYE
1
INTRODUCTION
55
2
WHAT ARE FIBROBLASTS?
5
5
2.1
MATRIX DIVERSITY IN SITU
56
2.2
DIVERSITY OF FIBROBLAST PHENOTYPES IN SITU
57
2.2.1
CYTOSKELETON COMPOSITION
57
2.2.2
FUNCTIONALITIES OF CYTOSKELETAL PROTEINS
59
3
EVIDENCE OF FIBROBLAST DIVERSITY
IN A TWO-DIMENSIONAL (2-D) CULTURE MODEL
60
3.1
DIFFERENCES ASSOCIATED WITH CYTOSKELETAL
AND ECM COMPONENTS
6
1
3.2
EXPRESSION OF OTHER NON-MESENCHYMA
L
CYTOSKELETAL PROTEINS
63
3.3
BEHAVIORAL DISSIMILARITIES AMONG MFS
65
3.4
DIVERSITY ASSOCIATED WITH CELL SURFAC
E
AND SECRETED MOLECULES
66
4
FIBROBLASTS FROM NON-TUMORAL
AND TUMORAL BREAST TISSUE
67
4.1
QUANTITATIVE VARIATION OF GENE EXPRESSION
67
4.2
DISCRIMINATION OF FIBROBLAST SUBTYPES
BY MULTIVARIATE ANALYSIS OF GENE EXPRESSION
68
5
WHAT REALLY ARE FIBROBLASTS?
69
5.1
CURRENT OPINIONS
69
5.2
REVISITING FIBROBLAST DIVERSITY
71
6
ATTEMPTS TO STUDY FIBROBLAST-EPITHELIAL CELL INTERACTION
IN A NOVEL DIMENSION
7
2
REFERENCES
74
THE EXTRACELLULAR MATRIX DURING NORMAL DEVELOPMENT
AND NEOPLASTIC GROWTH
79
J
. LABAT-ROBERT, L. ROBERT
1
INTRODUCTION
79
2
EXTRACELLULAR MATRIX DURING DEVELOPMENT
80
2.1
FIBRONECTINS IN DEVELOPMENT
83
3
LAMININ ISOFORMS IN TUMOR PROGRESSION
84
3.1
FIBRONECTIN IN MALIGNANT GROWTH
86
4
PROTEOLYTIC DEGRADATION OF MATRIX COMPONENTS,
GENERATION OF BIOLOGICALLY ACTIVE PEPTIDES
: MATRICRYPTINS
88
5
TUMOR GROWTH AND MATRIX BIOSYNTHESIS
90
6
ROLE OF RECEPTOR SIGNALING IN CELL MATRIX INTERACTION
DURING NORMAL DEVELOPMENT AND TUMOR GROWTH
9
1
6.1
THE ELASTIN-LAMININ RECEPTOR
93
7
GLYCOSAMINOGLYCANS AND PROTEOGLYCANS
IN NORMAL DEVELOPMENT AND TUMOR PROGRESSION
9
5
8
DISCUSSION AND CONCLUSIONS
97
REFERENCES
99
WILMS
TUMOR: STARTING
OFF
THE KIDNEY
ALL
OVER AGAIN?
107
M. LITTLE
1
WILMS TUMOR AND THE WT1 GENE
10
7
2
A ROLE FOR OTHER GENES AND CHROMOSOMAL REGION
S
IN WILMS
TUMOR
110
3
SETTING THE STAGE - NORMAL KIDNEY DEVELOPMENT
11
1
4
A CASE FOR DISRUPTED DEVELOPMENT
114
4.1
HISTOLOGY SUGGESTING A RECAPITULATION OF DEVELOPMENT
114
4.2
NEPHROGENIC RESTS
114
4.3
PRESENTATION AND LOCATION
115
4.4
THE POTENTIAL ROLE OF WT1 GENE IN MET
115
4.5
CONTINUED EXPRESSION OF EARLY MARKERS
OF KIDNEY DEVELOPMENT
116
5
LESSONS TO BE LEARNED
120
5.1
TERATOMATOUS BEHAVIOR IN WILMS
TUMOR
120
5.2
PERSISTENCE OF A STEM CELL OR
MULTIPOTENTIAL
PROGENITOR?
121
5.3
EVIDENCE FOR RENAL STEM CELLS IN THE ADULT KIDNEY
124
5.4
LACK
OF
CLONOGENICITY
OFWILMS TUMOR
12
5
5.5
A WINDOW
OFOPPORTUNITY?
125
REFERENCES
126
TESTICULAR TERATOMAS: BACK TO PLURIPOTENT STEM CELLS
133
T. KIMURA, K
. MURAYAMA, T. NAKAMURA, S. WATANABE,
H
. UMEHARA, M. TOMOOKA, T. NAKANO
1
INTRODUCTION
133
2
CELLULAR BASIS
OFTERATOMA FORMATION
135
2.1
TERATOMAS IN THE MOUSE MODEL
135
2.1.1
THE 129/SV MOUSE
135
2.1.2
ORIGIN
OFTERATOMAS
135
2.2
HUMAN TESTICULAR CANCERS
136
2.3
ENVIRONMENTAL INFLUENCES ON TERATOMAS
137
3
EG
CELLS
137
3.1
BEHAVIOR
OFPGCS IN CULTURE
137
3.2
PGC GROWTH FACTORS
138
3.3
GENERATION
OF
EG
CELLS
138
3.4
HUMAN
EG
CELLS
139
3.5
GENOMIC IMPRINTING IN PGCS AND
EG
CELLS
140
4
GENETIC AND MOLECULAR BASES
OF
TERATOMA FORMATION
141
4.1
GENETIC TRAITS AND MENDELIAN INHERITANCE FACTORS
141
4.2
GENETIC CONTROL
OFTERATOMAS IN MICE
141
4.2.1
TER LOCUS
141
4.2.2
PI3 KINASE SIGNALING PATHWAY
142
4.2.3
TUMOR SUPPRESSOR TRP53
142
4.2.4
OCT-4
143
4.2
.5
GENETIC INTERACTIONS: IDENTIFICATION
OFTHE TGCTL AND PGCTL LOCI
144
4.3
GENETIC CONTROL
OF
TESTICULAR CANCER IN HUMANS
144
5
PERSPECTIVES: IMPLICATIONS FOR STEM CELL BIOLOGY
145
REFERENCES
146
TUMOR SUPPRESSORS APC AND VHL: GATEKEEPERS
OF THE INTESTINE AND KIDNEY
151
R.H. GILES, E.E. VOEST
1
INTRODUCTION AND BACKGROUND
15
1
2
COLORECTAL CANCER: CURRENT UNDERSTANDING
OFTHE MOLECULAR MECHANISM
152
2.1
WNT/(3-CATENIN SIGNALING
153
2.2
STEPWISE CRC PROGRESSION
154
2.3
THE APC PROTEIN
157
2.4
APC
IN CYTOSKELETAL DYNAMICS
160
2.5
ARCHITECTURAL CHANGES
IN
THE INTESTINE
160
3
CLEAR CELL RENAL CARCINOMA: CURRENT UNDERSTANDING
OF THE MOLECULAR MECHANISM
162
3
.1
THE VON HIPPEL-LINDAU (VHL) DISEASE
162
3.2
HIF SIGNALING
164
3.3
STEPWISE RCC PROGRESSION
166
3.4
VHL REGULATES MICROTUBULE STABILITY
167
3.5
RENAL CYSTS: PRECURSORS TO RCC?
169
3.6
VHL
MOUSE
MODELS
169
4
DISCUSSION
170
4.1
APC AND VHL
: OVERLAP IN FUNCTION
170
4.2
BALANCING ACTS: SIGNALING VS. CYTOSKELETON REGULATION
172
REFERENCES
172
HORMONAL AND STROMAL REGULATION
OF NORMAL AND NEOPLASTIC PROSTATIC GROWTH
183
W.A.
RICKE,
Y. WANG, T. KURITA, S
.W
. HAYWARD, G
.R
. CUNH
A
1
INTRODUCTION
183
2
PROSTATIC GROWTH AND DEVELOPMENT
184
2.1
MESENCHYMAL-EPITHELIAL INTERACTIONS
IN PROSTATIC DEVELOPMENT
184
2.2
BUD FORMATION
184
2.3
PROSTATE LOBES AND REGIONS
18
5
2.4
ANDROGENS AND PROSTATIC DEVELOPMENT
187
2.5
STROMAL-EPITHELIAL INTERACTIONS IN MATURE PROSTATE
190
2.6
SMOOTH MUSCLE OF THE PROSTATE
192
2.7
ESTROGEN ACTION IN THE PROSTATE
193
2.8
PROSTATIC EPITHELIAL CYTODIFFERENTIATION
19
4
3
PROSTATE CANCER
195
3.1
THE ROLE OF STROMA IN CARCINOGENESIS:
A HISTORICAL PERSPECTIVE
195
3.2
STROMAL-EPITHELIAL INTERACTIONS DURING
PROSTATE CANCER PROGRESSION
198
3
.3
ROLE OF CARCINOMA-ASSOCIATED FIBROBLASTS
IN PROGRESSION OF HUMAN PROSTATE CANCER
200
3
.4
THE ROLE OF STEROID HORMONES AND STROMA
IN PROSTATE CANCER PROGRESSION
202
3
.5
ANDROGENS AND PROSTATE CANCER
203
3.6
ESTROGENS AND PROSTATE CANCER
203
3.7
MECHANISMS OF MICROENVIRONMENTAL
INFLUENCES DURING CARCINOGENESIS
204
4
CONCLUSION
207
REFERENCES
208
NEOPLASTIC GROWTH THROUGH THE
DEVELOPMENTAL STAGES OF THE ORGANISM
217
A. MACIEIRA-COELHO
1
DEVELOPMENTALLY AND NONDEVELOPMENTALL
Y
RELATED EVENTS IN THE NATURAL HISTORY OF CANCERS
217
1.1
CHILDHOOD CANCERS
218
1.2
CANCERS IN ADOLESCENTS
219
1.3
CANCERS OF THE REPRODUCTIVE STAGE
219
1.4
CANCERS OF THE POSTREPRODUCTIVE STAGE
223
1.5
CANCERS DURING SENESCENCE
225
2
PUTATIVE MECHANISMS OF DEVELOPMENTALLY
RELATED EVENTS IN THE NATURAL HISTORY OF CANCERS
225
2.1
CELL-RELATED MECHANISMS
226
2.1.1
CELLULAR SUSCEPTIBILITY TO CARCINOGENS
226
2.1.2
STEM CELLS
227
2.1.3
THE CELLULAR ENVIRONMENT
230
2
.2
MOLECULARLY -RELATED MECHANISMS
236
REFERENCES
240
SUBJECT INDEX
251
|
| adam_txt |
ALVARO MACIEIRA-COELHO
DEVELOPMENTA
L
BIOLOGY OF
NEOPLASTIC GROWTH
THE HEDGEHOG SIGNALING PATHWAY IN CANCER
.,
X YY ,,, ,,
1
J. VESTERGAARD, MADS BAK, L
.A. LARSEN
1
INTRODUCTION
1
2
THE HEDGEHOG SIGNALING PATHWAY
1
2.1
SYNTHESIS AND PROCESSING OF HH PROTEIN
2
2.2
MOVEMENT OF HH PROTEIN
2
2.3
RECEPTION OF HH SIGNALING
4
2.4
INTRACELLULAR SIGNAL TRANSDUCTION
5
3
HH SIGNALING IN TUMOR FORMATION AND GROWTH
6
3.1
DEFECTS IN HH SIGNALING CAUSES NEVOID BASAL-CELL
CARCINOMA SYNDROME
6
3.2
EXPERIMENTS WITH ANIMAL MODELS LINK HH SIGNALING
TO TUMORIGENESIS
7
3
.3
HH SIGNALING IN SPORADIC CANCERS
7
3.3.1
A SUBSET OF SPORADIC CANCERS HAVE MUTATIONS
IN GENES INVOLVED IN HH SIGNALING
$:
3.3.2
EXPRESSION ANALYSIS OF HH SIGNALING GENES
SUGGESTS DIVERSE MECHANISMS OF INVOLVEMENT IN CANCER
~-
8
3.4
MOLECULAR MECHANISMS
FOR HH-STIMULATED TUMOR GROWTH
11
3.4.1
SHH STIMULATES STEM CELL-LIKE PROGENITO
R
CELL PROLIFERATION
11
3.4.2
DO TUMORS ARISE FROM TRANSFORMATION OF STEM CELLS?
11
3.4.3
MOLECULAR TARGETS OF HH SIGNALING
12
4
SMALL-MOLECULE HH SIGNALING ANTAGONISTS
-
A THERAPEUTIC OPPORTUNITY?
15
4.1
DISCOVERY OF SMALL-MOLECULE HH ANTAGONISTS
16
4.2
INHIBITION OF TUMOR GROWTH BY HH ANTAGONISTS
16
5
FUTURE PROSPECTS
17
REFERENCES
18
RHO GTPASES AND CANCER
29
P. BUONGIORNO, B. BAPAT
1
INTRODUCTION
29
2
RHO PROTEINS AND TUMORIGENESIS
32
3
ELEVATED RHO GTPASE SIGNALING IN TUMORIGENESIS
32
4
UPSTREAM REGULATION OF RHO GTPASES
34
5
DOWNSTREAM SIGNALING PATHWAYS
36
5.1
RHO GTPASES AND CELL-CYCLE PROGRESSION
36
5.2
RHO GTPASES AND CELL SURVIVAL
39
5.3
RHO GTPASES AND INVASION/METASTASIS
40
6
CROSS TALK BETWEEN RACL AND WNT SIGNALING PATHWAYS
43
7
RHO GTPASES AS THERAPEUTIC TARGETS
44
8
FUTURE DIRECTIONS
46
REFERENCES
47
DEVELOPMENTAL BIOLOGY OF FIBROBLASTS AND NEOPLASTIC DISEASE
5
5
D. BROUTY-BOYE
1
INTRODUCTION
55
2
WHAT ARE FIBROBLASTS?
5
5
2.1
MATRIX DIVERSITY IN SITU
56
2.2
DIVERSITY OF FIBROBLAST PHENOTYPES IN SITU
57
2.2.1
CYTOSKELETON COMPOSITION
57
2.2.2
FUNCTIONALITIES OF CYTOSKELETAL PROTEINS
59
3
EVIDENCE OF FIBROBLAST DIVERSITY
IN A TWO-DIMENSIONAL (2-D) CULTURE MODEL
60
3.1
DIFFERENCES ASSOCIATED WITH CYTOSKELETAL
AND ECM COMPONENTS
6
1
3.2
EXPRESSION OF OTHER NON-MESENCHYMA
L
CYTOSKELETAL PROTEINS
63
3.3
BEHAVIORAL DISSIMILARITIES AMONG MFS
65
3.4
DIVERSITY ASSOCIATED WITH CELL SURFAC
E
AND SECRETED MOLECULES
66
4
FIBROBLASTS FROM NON-TUMORAL
AND TUMORAL BREAST TISSUE
67
4.1
QUANTITATIVE VARIATION OF GENE EXPRESSION
67
4.2
DISCRIMINATION OF FIBROBLAST SUBTYPES
BY MULTIVARIATE ANALYSIS OF GENE EXPRESSION
68
5
WHAT REALLY ARE FIBROBLASTS?
69
5.1
CURRENT OPINIONS
69
5.2
REVISITING FIBROBLAST DIVERSITY
71
6
ATTEMPTS TO STUDY FIBROBLAST-EPITHELIAL CELL INTERACTION
IN A NOVEL DIMENSION
7
2
REFERENCES
74
THE EXTRACELLULAR MATRIX DURING NORMAL DEVELOPMENT
AND NEOPLASTIC GROWTH
79
J
. LABAT-ROBERT, L. ROBERT
1
INTRODUCTION
79
2
EXTRACELLULAR MATRIX DURING DEVELOPMENT
80
2.1
FIBRONECTINS IN DEVELOPMENT
83
3
LAMININ ISOFORMS IN TUMOR PROGRESSION
84
3.1
FIBRONECTIN IN MALIGNANT GROWTH
86
4
PROTEOLYTIC DEGRADATION OF MATRIX COMPONENTS,
GENERATION OF BIOLOGICALLY ACTIVE PEPTIDES
: MATRICRYPTINS
88
5
TUMOR GROWTH AND MATRIX BIOSYNTHESIS
90
6
ROLE OF RECEPTOR SIGNALING IN CELL MATRIX INTERACTION
DURING NORMAL DEVELOPMENT AND TUMOR GROWTH
9
1
6.1
THE ELASTIN-LAMININ RECEPTOR
93
7
GLYCOSAMINOGLYCANS AND PROTEOGLYCANS
IN NORMAL DEVELOPMENT AND TUMOR PROGRESSION
9
5
8
DISCUSSION AND CONCLUSIONS
97
REFERENCES
99
WILMS'
TUMOR: STARTING
OFF
THE KIDNEY
ALL
OVER AGAIN?
107
M. LITTLE
1
WILMS' TUMOR AND THE WT1 GENE
10
7
2
A ROLE FOR OTHER GENES AND CHROMOSOMAL REGION
S
IN WILMS'
TUMOR
110
3
SETTING THE STAGE - NORMAL KIDNEY DEVELOPMENT
11
1
4
A CASE FOR DISRUPTED DEVELOPMENT
114
4.1
HISTOLOGY SUGGESTING A RECAPITULATION OF DEVELOPMENT
114
4.2
NEPHROGENIC RESTS
114
4.3
PRESENTATION AND LOCATION
115
4.4
THE POTENTIAL ROLE OF WT1 GENE IN MET
115
4.5
CONTINUED EXPRESSION OF EARLY MARKERS
OF KIDNEY DEVELOPMENT
116
5
LESSONS TO BE LEARNED
120
5.1
TERATOMATOUS BEHAVIOR IN WILMS'
TUMOR
120
5.2
PERSISTENCE OF A STEM CELL OR
MULTIPOTENTIAL
PROGENITOR?
121
5.3
EVIDENCE FOR RENAL STEM CELLS IN THE ADULT KIDNEY
124
5.4
LACK
OF
CLONOGENICITY
OFWILMS' TUMOR
12
5
5.5
A WINDOW
OFOPPORTUNITY?
125
REFERENCES
126
TESTICULAR TERATOMAS: BACK TO PLURIPOTENT STEM CELLS
133
T. KIMURA, K
. MURAYAMA, T. NAKAMURA, S. WATANABE,
H
. UMEHARA, M. TOMOOKA, T. NAKANO
1
INTRODUCTION
133
2
CELLULAR BASIS
OFTERATOMA FORMATION
135
2.1
TERATOMAS IN THE MOUSE MODEL
135
2.1.1
THE 129/SV MOUSE
135
2.1.2
ORIGIN
OFTERATOMAS
135
2.2
HUMAN TESTICULAR CANCERS
136
2.3
ENVIRONMENTAL INFLUENCES ON TERATOMAS
137
3
EG
CELLS
137
3.1
BEHAVIOR
OFPGCS IN CULTURE
137
3.2
PGC GROWTH FACTORS
138
3.3
GENERATION
OF
EG
CELLS
138
3.4
HUMAN
EG
CELLS
139
3.5
GENOMIC IMPRINTING IN PGCS AND
EG
CELLS
140
4
GENETIC AND MOLECULAR BASES
OF
TERATOMA FORMATION
141
4.1
GENETIC TRAITS AND MENDELIAN INHERITANCE FACTORS
141
4.2
GENETIC CONTROL
OFTERATOMAS IN MICE
141
4.2.1
TER LOCUS
141
4.2.2
PI3 KINASE SIGNALING PATHWAY
142
4.2.3
TUMOR SUPPRESSOR TRP53
142
4.2.4
OCT-4
143
4.2
.5
GENETIC INTERACTIONS: IDENTIFICATION
OFTHE TGCTL AND PGCTL LOCI
144
4.3
GENETIC CONTROL
OF
TESTICULAR CANCER IN HUMANS
144
5
PERSPECTIVES: IMPLICATIONS FOR STEM CELL BIOLOGY
145
REFERENCES
146
TUMOR SUPPRESSORS APC AND VHL: GATEKEEPERS
OF THE INTESTINE AND KIDNEY
151
R.H. GILES, E.E. VOEST
1
INTRODUCTION AND BACKGROUND
15
1
2
COLORECTAL CANCER: CURRENT UNDERSTANDING
OFTHE MOLECULAR MECHANISM
152
2.1
WNT/(3-CATENIN SIGNALING
153
2.2
STEPWISE CRC PROGRESSION
154
2.3
THE APC PROTEIN
157
2.4
APC
IN CYTOSKELETAL DYNAMICS
160
2.5
ARCHITECTURAL CHANGES
IN
THE INTESTINE
160
3
CLEAR CELL RENAL CARCINOMA: CURRENT UNDERSTANDING
OF THE MOLECULAR MECHANISM
162
3
.1
THE VON HIPPEL-LINDAU (VHL) DISEASE
162
3.2
HIF SIGNALING
164
3.3
STEPWISE RCC PROGRESSION
166
3.4
VHL REGULATES MICROTUBULE STABILITY
167
3.5
RENAL CYSTS: PRECURSORS TO RCC?
169
3.6
VHL
MOUSE
MODELS
169
4
DISCUSSION
170
4.1
APC AND VHL
: OVERLAP IN FUNCTION
170
4.2
BALANCING ACTS: SIGNALING VS. CYTOSKELETON REGULATION
172
REFERENCES
172
HORMONAL AND STROMAL REGULATION
OF NORMAL AND NEOPLASTIC PROSTATIC GROWTH
183
W.A.
RICKE,
Y. WANG, T. KURITA, S
.W
. HAYWARD, G
.R
. CUNH
A
1
INTRODUCTION
183
2
PROSTATIC GROWTH AND DEVELOPMENT
184
2.1
MESENCHYMAL-EPITHELIAL INTERACTIONS
IN PROSTATIC DEVELOPMENT
184
2.2
BUD FORMATION
184
2.3
PROSTATE LOBES AND REGIONS
18
5
2.4
ANDROGENS AND PROSTATIC DEVELOPMENT
187
2.5
STROMAL-EPITHELIAL INTERACTIONS IN MATURE PROSTATE
190
2.6
SMOOTH MUSCLE OF THE PROSTATE
192
2.7
ESTROGEN ACTION IN THE PROSTATE
193
2.8
PROSTATIC EPITHELIAL CYTODIFFERENTIATION
19
4
3
PROSTATE CANCER
195
3.1
THE ROLE OF STROMA IN CARCINOGENESIS:
A HISTORICAL PERSPECTIVE
195
3.2
STROMAL-EPITHELIAL INTERACTIONS DURING
PROSTATE CANCER PROGRESSION
198
3
.3
ROLE OF CARCINOMA-ASSOCIATED FIBROBLASTS
IN PROGRESSION OF HUMAN PROSTATE CANCER
200
3
.4
THE ROLE OF STEROID HORMONES AND STROMA
IN PROSTATE CANCER PROGRESSION
202
3
.5
ANDROGENS AND PROSTATE CANCER
203
3.6
ESTROGENS AND PROSTATE CANCER
203
3.7
MECHANISMS OF MICROENVIRONMENTAL
INFLUENCES DURING CARCINOGENESIS
204
4
CONCLUSION
207
REFERENCES
208
NEOPLASTIC GROWTH THROUGH THE
DEVELOPMENTAL STAGES OF THE ORGANISM
217
A. MACIEIRA-COELHO
1
DEVELOPMENTALLY AND NONDEVELOPMENTALL
Y
RELATED EVENTS IN THE NATURAL HISTORY OF CANCERS
217
1.1
CHILDHOOD CANCERS
218
1.2
CANCERS IN ADOLESCENTS
219
1.3
CANCERS OF THE REPRODUCTIVE STAGE
219
1.4
CANCERS OF THE POSTREPRODUCTIVE STAGE
223
1.5
CANCERS DURING SENESCENCE
225
2
PUTATIVE MECHANISMS OF DEVELOPMENTALLY
RELATED EVENTS IN THE NATURAL HISTORY OF CANCERS
225
2.1
CELL-RELATED MECHANISMS
226
2.1.1
CELLULAR SUSCEPTIBILITY TO CARCINOGENS
226
2.1.2
STEM CELLS
227
2.1.3
THE CELLULAR ENVIRONMENT
230
2
.2
MOLECULARLY -RELATED MECHANISMS
236
REFERENCES
240
SUBJECT INDEX
251 |
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| id | DE-604.BV022447409 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T17:35:03Z |
| indexdate | 2024-07-09T20:57:47Z |
| institution | BVB |
| isbn | 3540250093 9783540250098 9783540276715 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015655362 |
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| psigel | ZDB-2-SBL |
| publishDate | 2005 |
| publishDateSearch | 2005 |
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| publisher | Springer |
| record_format | marc |
| series | Progress in molecular and subcellular biology |
| series2 | Progress in molecular and subcellular biology |
| spelling | Developmental biology of neoplastic growth with 7 tables Alvaro Macieira-Coelho (ed.) Berlin [u.a.] Springer 2005 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Progress in molecular and subcellular biology 40 Literaturangaben Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Tumorwachstum (DE-588)4186432-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Tumorwachstum (DE-588)4186432-3 s Entwicklungsbiologie (DE-588)4152440-8 s DE-604 Macieira-Coelho, Alvaro 1932- Sonstige (DE-588)120401126 oth Progress in molecular and subcellular biology 40 (DE-604)BV002534931 40 https://doi.org/10.1007/3-540-27671-8 Verlag Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015655362&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Developmental biology of neoplastic growth with 7 tables Progress in molecular and subcellular biology Entwicklungsbiologie (DE-588)4152440-8 gnd Tumorwachstum (DE-588)4186432-3 gnd |
| subject_GND | (DE-588)4152440-8 (DE-588)4186432-3 (DE-588)4143413-4 |
| title | Developmental biology of neoplastic growth with 7 tables |
| title_auth | Developmental biology of neoplastic growth with 7 tables |
| title_exact_search | Developmental biology of neoplastic growth with 7 tables |
| title_exact_search_txtP | Developmental biology of neoplastic growth with 7 tables |
| title_full | Developmental biology of neoplastic growth with 7 tables Alvaro Macieira-Coelho (ed.) |
| title_fullStr | Developmental biology of neoplastic growth with 7 tables Alvaro Macieira-Coelho (ed.) |
| title_full_unstemmed | Developmental biology of neoplastic growth with 7 tables Alvaro Macieira-Coelho (ed.) |
| title_short | Developmental biology of neoplastic growth |
| title_sort | developmental biology of neoplastic growth with 7 tables |
| title_sub | with 7 tables |
| topic | Entwicklungsbiologie (DE-588)4152440-8 gnd Tumorwachstum (DE-588)4186432-3 gnd |
| topic_facet | Entwicklungsbiologie Tumorwachstum Aufsatzsammlung |
| url | https://doi.org/10.1007/3-540-27671-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015655362&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002534931 |
| work_keys_str_mv | AT macieiracoelhoalvaro developmentalbiologyofneoplasticgrowthwith7tables |