Structural neuroimaging studies in subjects with mild cognitive impairment:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enth. Beitr. aus versch. Zeitschr. - Leipzig, Univ., Habil.-Schr., 2007 |
| Beschreibung: | Ill., graph. Darst. |
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Datensatz im Suchindex
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| adam_text | Contents
Bibliographische Beschreibung/ German Abstract 3
English Abstract 4
List of orignial papers in this thesis 6
Abbreviations 7
Glossary 8
1 Problem Statement 12
2 Scientific Background 13
2.1 Mild cognitive impairment Concept and Definition 13
2.2 Measurement and operationalisation of MCI 16
2.3 Outcome variability and aetiological heterogeneity in MCI 17
2.4 MCI a clinical paradigm to study preclinical Alzheimer s disease? 19
2.4.1 Definition and phenomenology of AD 19
2.4.2 Current diagnosis of AD 20
2.4.3 The evolution of AD consequences for diagnostic approaches 21
2.5 Co occurrence of pathologies in old age 23
2.6 The potential of structural neuroimaging to detect lesions of significance in MCI.... 23
2.6.1 Imaging indices of Alzheimer type pathology? 24
2.6.2 Structural imaging indices of vascular pathology 26
2.6.3 Neuroimaging studies in MCI 31
3 Project design 32
3.1 Study Frame, Specific Aims and Hypotheses 32
3.2 Study designs 34
3.2.1 The pilot study 34
3.2.2 TheLEILA MCI Study 35
3.2.3 Replication study 36
3.3 Short summary of original studies 38
4 Original Work 39
4.1 Study I (Pilot Study) Impact of medial temporal lobe atrophy and white matter lesions
on the progression of MCI 39
4.2 Study II and III Structural correlates of MCI 50
4.3 Study IV Global brain volume is associated with the rate of cognitive decline in
nondemented elderly subjects 73
4.4 Studies V and VI Intracranial and head volumes as indices of premorbid brain volume
Evidence for brain reserve? 83
4.5 Studies VII and VIII Association between serum lipids and hippocampal volume. The
link to Alzheimer s disease? 104
5 Discussion 110
5.1 General methodological discussion 110
5.1.1 Sample selection 110
5.1.2 Definitions of MCI 110
5.1.3 Definitions of MCI progression 112
5.1.4 Neuroimaging methods 113
Page 10
5.2 Hippocampal atrophy in MCI 114
5.3 What is the role of cerebrovascular factors in MCI? 116
5.4 Brain reserve in MCI? 116
5.5 Added clinical value? 119
6 Conclusions and outlook 121
7 References 122
8 Thesen (in German) 133
9 Appendix 136
9.1 Acknowledgments 136
9.2 Selbstandigkeitserklarung 138
9.3 Lebenslauf 139
Page 11
|
| adam_txt |
Contents
Bibliographische Beschreibung/ German Abstract 3
English Abstract 4
List of orignial papers in this thesis 6
Abbreviations 7
Glossary 8
1 Problem Statement 12
2 Scientific Background 13
2.1 Mild cognitive impairment Concept and Definition 13
2.2 Measurement and operationalisation of MCI 16
2.3 Outcome variability and aetiological heterogeneity in MCI 17
2.4 MCI a clinical paradigm to study preclinical Alzheimer's disease? 19
2.4.1 Definition and phenomenology of AD 19
2.4.2 Current diagnosis of AD 20
2.4.3 The evolution of AD consequences for diagnostic approaches 21
2.5 Co occurrence of pathologies in old age 23
2.6 The potential of structural neuroimaging to detect lesions of significance in MCI. 23
2.6.1 Imaging indices of Alzheimer type pathology? 24
2.6.2 Structural imaging indices of vascular pathology 26
2.6.3 Neuroimaging studies in MCI 31
3 Project design 32
3.1 Study Frame, Specific Aims and Hypotheses 32
3.2 Study designs 34
3.2.1 The pilot study 34
3.2.2 TheLEILA MCI Study 35
3.2.3 Replication study 36
3.3 Short summary of original studies 38
4 Original Work 39
4.1 Study I (Pilot Study) Impact of medial temporal lobe atrophy and white matter lesions
on the progression of MCI 39
4.2 Study II and III Structural correlates of MCI 50
4.3 Study IV Global brain volume is associated with the rate of cognitive decline in
nondemented elderly subjects 73
4.4 Studies V and VI Intracranial and head volumes as indices of premorbid brain volume
Evidence for brain reserve? 83
4.5 Studies VII and VIII Association between serum lipids and hippocampal volume. The
link to Alzheimer's disease? 104
5 Discussion 110
5.1 General methodological discussion 110
5.1.1 Sample selection 110
5.1.2 Definitions of MCI 110
5.1.3 Definitions of MCI progression 112
5.1.4 Neuroimaging methods 113
Page 10
5.2 Hippocampal atrophy in MCI 114
5.3 What is the role of cerebrovascular factors in MCI? 116
5.4 Brain reserve in MCI? 116
5.5 Added clinical value? 119
6 Conclusions and outlook 121
7 References 122
8 Thesen (in German) 133
9 Appendix 136
9.1 Acknowledgments 136
9.2 Selbstandigkeitserklarung 138
9.3 Lebenslauf 139
Page 11 |
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| title | Structural neuroimaging studies in subjects with mild cognitive impairment |
| title_auth | Structural neuroimaging studies in subjects with mild cognitive impairment |
| title_exact_search | Structural neuroimaging studies in subjects with mild cognitive impairment |
| title_exact_search_txtP | Structural neuroimaging studies in subjects with mild cognitive impairment |
| title_full | Structural neuroimaging studies in subjects with mild cognitive impairment vorgelegt von Henrike Wolf |
| title_fullStr | Structural neuroimaging studies in subjects with mild cognitive impairment vorgelegt von Henrike Wolf |
| title_full_unstemmed | Structural neuroimaging studies in subjects with mild cognitive impairment vorgelegt von Henrike Wolf |
| title_short | Structural neuroimaging studies in subjects with mild cognitive impairment |
| title_sort | structural neuroimaging studies in subjects with mild cognitive impairment |
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