Surfactant and mechanical ventilation:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2007
|
| Schriftenreihe: | Clinics in perinatology
34,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 226 S. Ill., graph. Darst. |
| ISBN: | 1416042911 9781416042914 |
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| 245 | 1 | 0 | |a Surfactant and mechanical ventilation |c guest eds.: Steven M. Donn ... |
| 264 | 1 | |a Philadelphia [u.a.] |b Saunders |c 2007 | |
| 300 | |a XVI, 226 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Clinics in perinatology |v 34,1 | |
| 650 | 4 | |a Infant | |
| 650 | 4 | |a Infant, Newborn, Diseases |x therapy | |
| 650 | 4 | |a Pulmonary Surfactants | |
| 650 | 4 | |a Pulmonary Ventilation | |
| 650 | 4 | |a Respiration, Artificial | |
| 650 | 4 | |a Respirators (Medical equipment) | |
| 650 | 4 | |a Respiratory therapy for newborn infants | |
| 650 | 4 | |a Ventilators, Mechanical | |
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Datensatz im Suchindex
| _version_ | 1804136494465548288 |
|---|---|
| adam_text | SURl ACTAN I AND MECIIANICAl. VENTILATION
CONTENTS
Erratum xiii
Preface xv
Steven M. Donn and Thomas E. Wiswell
Real Time Pulmonary Graphic Monitoring 1
Michael A. Becker and Steven M. Donn
Real time pulmonary graphics allow breath to breath assessment
of pulmonary mechanics and patient ventilator interaction. It al¬
lows the clinician to customize ventilator settings based on patho
physiology and patient response, and may enable detection of
complications before they become clinically apparent. Graphics
also provide objective information about the efficacy of pharmaco
logic agents and changes in patient status over time.
Respiratory Gas Conditioning and Humidification 19
Andreas Schulze
Respiratory gas conditioning and humidification are important but
poorly understood aspects of mechanical ventilation. The physiolo¬
gic principles and the best methods to achieve appropriate gas con¬
ditioning are addressed in this article.
Matching Ventilatory Support Strategies to Respiratory
Pathophysiology 35
Anne Greenough and Steven M. Donn
Neonates can suffer from various diseases that impact differently on
lung function according to the specific pulmonary pathophysiology.
As a consequence, the optimal respiratory support will vary accord¬
ing to disorder. Most randomized trials have only included prema¬
turely born infants who have respiratory distress syndrome (RDS)
or infants who have severe respiratory failure. Meta analysis of
VOLUME 34 • NUMBER 1 • MARCH 2007 V
the results has demonstrated that for the prematurely born infant
who has RDS, prophylactic high frequency oscillatory ventilation
only results in a modest reduction in bronchopulmonary dysplasia,
and patient triggered ventilation (assist/control or synchronized in¬
termittent mandatory ventilation) reduces the duration of ventila¬
tion if started in the recovery phase. Whether the newer triggered
modes are more efficacious remains to be appropriately tested. In
term infants who have severe respiratory failure, extracorporeal
membrane oxygenation increases survival, but inhaled nitric oxide
only reduces the need for extracorporeal membrane oxygenation.
Research is required to identify the optimum respiratory strategy
for infants who have other respiratory disorders, particularly bron¬
chopulmonary dysplasia.
The Dreaded Desaturating Baby: A Difficult Problem
in Clinical Management 55
Alan R. Spitzer
There are various causes for frequent desaturations in infants. Fre¬
quent hypoxemia is a significant change in clinical status and must
be investigated carefully for possible etiology. When common ex¬
tra airway causes for desaturation are ruled out, one should at¬
tempt to distinguish between central apnea and obstructive
events. The most commonly overlooked obstructive event is tra
cheobronchomalacia, and steps should be initiated to understand
the scope of the problem through pulmonary function testing
and bronchoscopy. Adequate respiratory support for the infant
should be provided until adequate time passes to enable airway
growth and improved cartilaginous deposition to occur. Parents
must be carefully supported during this time; the stress of having
an infant who requires prolonged hospitalization and care for tra
cheobronchomalacia is substantial.
Continuous Positive Airway Pressure and Noninvasive
Ventilation 73
Sherry E. Courtney and Keith J. Barrington
Continuous positive airway pressure (CPAP) and noninvasive
ventilation (NIV) hold much promise as means to protect the
lungs of newborn infants who have respiratory distress from many
causes. A wide variety of options are available to the clinician, in¬
cluding CPAP, bilevel CPAP, and both synchronized and unsyn
chronized noninvasive mechanical breaths. Limited data are
available regarding the best ways to use CPAP and NIV in today s
NICU environment. This article reviews current information on
these modalities, including available options, possible risks, and
unanswered questions.
vi CONTENTS
Volume Targeted Ventilation of Newborns 93
Jaideep Singh, Sunil K. Sinha, and Steven M. Donn
Traditional management of neonatal respiratory failure has been ac¬
complished with mechanical ventilation delivered by time cycled,
pressure limited techniques. Although easy to use, this modality
results in the delivery of tidal volumes that vary according to pul¬
monary compliance. In contrast, volume targeted ventilation deli¬
vers a selected tidal volume at variable peak inspiratory pressure,
resulting in consistent tidal volume delivery, even in the face of chan¬
ging compliance. This article reviews salient features of volume tar¬
geted ventilation and a review of the evidence base.
Volume Guarantee Ventilation 107
Martin Keszler and Kabir M. Abubakar
Recognition that volume, not pressure, is the key factor in ventila¬
tor induced lung injury and the association of hypocarbia with
neonatal brain injury demonstrate the importance of better control
delivered tidal volume. New microprocessor based ventilator mod¬
alities combine advantages of pressure limited ventilation with
the ability to deliver a more consistent tidal volume. This article
discusses automatic weaning of peak inspiratory pressure in res¬
ponse to changing lung compliance and respiratory effort. More
consistent tidal volume, fewer excessively large breaths, lower peak
pressure, less hypocapnia, shorter duration of mechanical ventila¬
tion, and lower levels of inflammatory cytokines have been docu¬
mented in short term clinical trials. It remains to be seen if these
short term benefits ultimately lead to a reduced incidence of chronic
lung disease.
In Support of Pressure Support 117
Subrata Sarkar and Steven M. Donn
Present generation mechanical ventilators are available with ad¬
vanced microprocessor based technology. Greater emphasis is
being placed on the patient controlling the ventilator, rather than
the physician controlling it. Pressure support ventilation (PSV) is
a form of patient triggered ventilation that supports spontaneous
breathing during mechanical ventilation. It is flow cycled, allowing
the patient to determine the inspiratory time and rate. Each spon |
taneous breath is terminated when inspiratory flow decelerates to a |
predefined percentage of peak flow. At present, strict comparisons |
of the usefulness of PSV with other modalities of synchronized
ventilation in newborns remain limited. This article reviews the
principles and clinical applications of PSV for newborns who have |
respiratory failure. I
CONTENTS vii
The Role of High Frequency Ventilation in Neonates:
Evidence Based Recommendations 129
Andrea L. Lampland and Mark C. Mammel
High frequency ventilation (HFV) uses small tidal volumes and ex¬
tremely rapid ventilator rates. Despite the wealth of laboratory and
clinical research on HFV, there are no established guidelines for
prioritizing the use of HFV versus conventional mechanical venti¬
lation (CMV) in neonatal respiratory failure. Examination of the
currently available randomized controlled trials and meta analysis
of HFV versus CMV does not demonstrate any clear benefit of HFV
either as a primary mode or as a rescue mode of ventilation in
neonates who have respiratory insufficiency. The current literature
does support the preferential use of HFV over CMV in conjunction
with inhaled nitric oxide to maximize oxygenation in hypoxemic
respiratory failure, in particular, as a result of persistent pulmonary
hypertension.
Animal Derived Surfactants Versus Past and Current
Synthetic Surfactants: Current Status 145
Fernando Moya and Andres Maturana
In this review, the authors assess major outcomes resulting from
head to head comparison trials of animal derived surfactants with
previous and newer synthetic surfactants and among them. They
also pay special attention to issues of study design and quality of
the trials reviewed. Animal derived surfactants that contain surfac¬
tant proteins (Survanta, Infasurf, and Curosurf) perform clinically
better than Exosurf, a synthetic surfactant containing only phos
pholipids, primarily in outcomes related to acute management of
respiratory distress syndrome (RDS; faster weaning and pneu
mothorax) but not in overall mortality or incidence of bronchopul
monary dysplasia (BPD). Trials comparing various animal derived
surfactants that provide different amounts of surface protein B (SP
B) or phospholipids have shown minor differences in outcomes re¬
lated to the management of RDS or none at all. The exception is the
suggestion of better survival using a high initial dose of Curosurf
when compared with Survanta. This observation is based on ana¬
lysis of trials of relatively lesser quality that have included a smal¬
ler number of infants than other surfactant comparisons, however.
Data from recent trials comparing a new generation synthetic sur¬
factant that contains a peptide mimicking the action of SP B, Sur
faxin, have shown that it performs better than Exosurf (faster
weaning and less BPD) and at least as well as the animal derived
surfactants Survanta and Curosurf. The ideal surfactant compari¬
son trial to demonstrate which surfactant is better has yet to be con¬
ducted. Future surfactant comparison trials should pay particular
attention to study design, be appropriately sized, and include
long term follow up.
vUi CONTENTS
Expanded Use of Surfactant Therapy in Newborns 179
Thierry Lacaze Masmonteil
Although there is no doubt that administration of exogenous sur¬
factant to very preterm babies who have respiratory distress syn¬
drome is safe and efficacious, surfactant inactivation or
deficiency plays a role in the pathophysiology of other pulmonary |
disorders affecting newborn infants. Preliminary data suggest that j
there may be a role for surfactant administration to babies who !
have meconium aspiration syndrome, pneumonia, and possibly i
bronchopulmonary dysplasia. Further investigation is necessary I
but seems warranted. j
j
i
Evidence Based Use of Adjunctive Therapies
to Ventilation 191
Thomas E. Wiswell, Win Tin, and Kirsten Ohler
Respiratory distress is the most common reason for admission to
newborn intensive care units. Over the past two decades, we have
witnessed a revolution in the therapies that are used to manage ;
neonates who have pulmonary disorders. Multiple adjunctive j
agents have also been used in an attempt to mitigate the course j
of neonatal lung disease. The disorders we discuss include respira j
tory distress syndrome, chronic lung disease/bronchopulmonary j
dysplasia, persistent pulmonary hypertension of the newborn, me !
conium aspiration syndrome, and transient tachypnea of the new j
born. We review the evidence that either supports or refutes the use I
of adjunctive therapies for these disorders. |
Long Term Outcomes: What Should the Focus Be? 205 I
Judy L. Aschner and Michele C. Walsh I
The neonatal intervention trials of the 1980s and early 1990s fo |
cused primarily on short term outcomes. Contemporary clinical j
trials have recognized the importance of longer term outcomes ,
but have rarely been powered to achieve that aim. This review dis j
cusses important and clinically relevant outcomes that future trials j
should be powered to address and identifies the challenges facing j
the neonatal clinical trials community. These challenges include
consensus definitions of relevant outcomes that are objective and
validated, variability among centers in populations and practices,
and the need for predictive surrogate markers of long term out¬
comes. Future trials must be designed and powered to address
the potential for harm as well as the prospect of benefit.
Index 219
CONTENTS «
|
| adam_txt |
SURl'ACTAN I" AND MECIIANICAl. VENTILATION
CONTENTS
Erratum xiii
Preface xv
Steven M. Donn and Thomas E. Wiswell
Real Time Pulmonary Graphic Monitoring 1
Michael A. Becker and Steven M. Donn
Real time pulmonary graphics allow breath to breath assessment
of pulmonary mechanics and patient ventilator interaction. It al¬
lows the clinician to customize ventilator settings based on patho
physiology and patient response, and may enable detection of
complications before they become clinically apparent. Graphics
also provide objective information about the efficacy of pharmaco
logic agents and changes in patient status over time.
Respiratory Gas Conditioning and Humidification 19
Andreas Schulze
Respiratory gas conditioning and humidification are important but
poorly understood aspects of mechanical ventilation. The physiolo¬
gic principles and the best methods to achieve appropriate gas con¬
ditioning are addressed in this article.
Matching Ventilatory Support Strategies to Respiratory
Pathophysiology 35
Anne Greenough and Steven M. Donn
Neonates can suffer from various diseases that impact differently on
lung function according to the specific pulmonary pathophysiology.
As a consequence, the optimal respiratory support will vary accord¬
ing to disorder. Most randomized trials have only included prema¬
turely born infants who have respiratory distress syndrome (RDS)
or infants who have severe respiratory failure. Meta analysis of
VOLUME 34 • NUMBER 1 • MARCH 2007 V
the results has demonstrated that for the prematurely born infant
who has RDS, prophylactic high frequency oscillatory ventilation
only results in a modest reduction in bronchopulmonary dysplasia,
and patient triggered ventilation (assist/control or synchronized in¬
termittent mandatory ventilation) reduces the duration of ventila¬
tion if started in the recovery phase. Whether the newer triggered
modes are more efficacious remains to be appropriately tested. In
term infants who have severe respiratory failure, extracorporeal
membrane oxygenation increases survival, but inhaled nitric oxide
only reduces the need for extracorporeal membrane oxygenation.
Research is required to identify the optimum respiratory strategy
for infants who have other respiratory disorders, particularly bron¬
chopulmonary dysplasia.
The Dreaded Desaturating Baby: A Difficult Problem
in Clinical Management 55
Alan R. Spitzer
There are various causes for frequent desaturations in infants. Fre¬
quent hypoxemia is a significant change in clinical status and must
be investigated carefully for possible etiology. When common ex¬
tra airway causes for desaturation are ruled out, one should at¬
tempt to distinguish between central apnea and obstructive
events. The most commonly overlooked obstructive event is tra
cheobronchomalacia, and steps should be initiated to understand
the scope of the problem through pulmonary function testing
and bronchoscopy. Adequate respiratory support for the infant
should be provided until adequate time passes to enable airway
growth and improved cartilaginous deposition to occur. Parents
must be carefully supported during this time; the stress of having
an infant who requires prolonged hospitalization and care for tra
cheobronchomalacia is substantial.
Continuous Positive Airway Pressure and Noninvasive
Ventilation 73
Sherry E. Courtney and Keith J. Barrington
Continuous positive airway pressure (CPAP) and noninvasive
ventilation (NIV) hold much promise as means to protect the
lungs of newborn infants who have respiratory distress from many
causes. A wide variety of options are available to the clinician, in¬
cluding CPAP, bilevel CPAP, and both synchronized and unsyn
chronized noninvasive mechanical breaths. Limited data are
available regarding the best ways to use CPAP and NIV in today's
NICU environment. This article reviews current information on
these modalities, including available options, possible risks, and
unanswered questions.
vi CONTENTS
Volume Targeted Ventilation of Newborns 93
Jaideep Singh, Sunil K. Sinha, and Steven M. Donn
Traditional management of neonatal respiratory failure has been ac¬
complished with mechanical ventilation delivered by time cycled,
pressure limited techniques. Although easy to use, this modality
results in the delivery of tidal volumes that vary according to pul¬
monary compliance. In contrast, volume targeted ventilation deli¬
vers a selected tidal volume at variable peak inspiratory pressure,
resulting in consistent tidal volume delivery, even in the face of chan¬
ging compliance. This article reviews salient features of volume tar¬
geted ventilation and a review of the evidence base.
Volume Guarantee Ventilation 107
Martin Keszler and Kabir M. Abubakar
Recognition that volume, not pressure, is the key factor in ventila¬
tor induced lung injury and the association of hypocarbia with
neonatal brain injury demonstrate the importance of better control
delivered tidal volume. New microprocessor based ventilator mod¬
alities combine advantages of pressure limited ventilation with
the ability to deliver a more consistent tidal volume. This article
discusses automatic weaning of peak inspiratory pressure in res¬
ponse to changing lung compliance and respiratory effort. More
consistent tidal volume, fewer excessively large breaths, lower peak
pressure, less hypocapnia, shorter duration of mechanical ventila¬
tion, and lower levels of inflammatory cytokines have been docu¬
mented in short term clinical trials. It remains to be seen if these
short term benefits ultimately lead to a reduced incidence of chronic
lung disease.
In Support of Pressure Support 117
Subrata Sarkar and Steven M. Donn
Present generation mechanical ventilators are available with ad¬
vanced microprocessor based technology. Greater emphasis is
being placed on the patient controlling the ventilator, rather than
the physician controlling it. Pressure support ventilation (PSV) is
a form of patient triggered ventilation that supports spontaneous
breathing during mechanical ventilation. It is flow cycled, allowing
the patient to determine the inspiratory time and rate. Each spon |
taneous breath is terminated when inspiratory flow decelerates to a |
predefined percentage of peak flow. At present, strict comparisons |
of the usefulness of PSV with other modalities of synchronized
ventilation in newborns remain limited. This article reviews the
principles and clinical applications of PSV for newborns who have |
respiratory failure. I
CONTENTS vii
The Role of High Frequency Ventilation in Neonates:
Evidence Based Recommendations 129
Andrea L. Lampland and Mark C. Mammel
High frequency ventilation (HFV) uses small tidal volumes and ex¬
tremely rapid ventilator rates. Despite the wealth of laboratory and
clinical research on HFV, there are no established guidelines for
prioritizing the use of HFV versus conventional mechanical venti¬
lation (CMV) in neonatal respiratory failure. Examination of the
currently available randomized controlled trials and meta analysis
of HFV versus CMV does not demonstrate any clear benefit of HFV
either as a primary mode or as a "rescue" mode of ventilation in
neonates who have respiratory insufficiency. The current literature
does support the preferential use of HFV over CMV in conjunction
with inhaled nitric oxide to maximize oxygenation in hypoxemic
respiratory failure, in particular, as a result of persistent pulmonary
hypertension.
Animal Derived Surfactants Versus Past and Current
Synthetic Surfactants: Current Status 145
Fernando Moya and Andres Maturana
In this review, the authors assess major outcomes resulting from
head to head comparison trials of animal derived surfactants with
previous and newer synthetic surfactants and among them. They
also pay special attention to issues of study design and quality of
the trials reviewed. Animal derived surfactants that contain surfac¬
tant proteins (Survanta, Infasurf, and Curosurf) perform clinically
better than Exosurf, a synthetic surfactant containing only phos
pholipids, primarily in outcomes related to acute management of
respiratory distress syndrome (RDS; faster weaning and pneu
mothorax) but not in overall mortality or incidence of bronchopul
monary dysplasia (BPD). Trials comparing various animal derived
surfactants that provide different amounts of surface protein B (SP
B) or phospholipids have shown minor differences in outcomes re¬
lated to the management of RDS or none at all. The exception is the
suggestion of better survival using a high initial dose of Curosurf
when compared with Survanta. This observation is based on ana¬
lysis of trials of relatively lesser quality that have included a smal¬
ler number of infants than other surfactant comparisons, however.
Data from recent trials comparing a new generation synthetic sur¬
factant that contains a peptide mimicking the action of SP B, Sur
faxin, have shown that it performs better than Exosurf (faster
weaning and less BPD) and at least as well as the animal derived
surfactants Survanta and Curosurf. The ideal surfactant compari¬
son trial to demonstrate which surfactant is better has yet to be con¬
ducted. Future surfactant comparison trials should pay particular
attention to study design, be appropriately sized, and include
long term follow up.
vUi CONTENTS
Expanded Use of Surfactant Therapy in Newborns 179
Thierry Lacaze Masmonteil
Although there is no doubt that administration of exogenous sur¬
factant to very preterm babies who have respiratory distress syn¬
drome is safe and efficacious, surfactant inactivation or
deficiency plays a role in the pathophysiology of other pulmonary |
disorders affecting newborn infants. Preliminary data suggest that j
there may be a role for surfactant administration to babies who !
have meconium aspiration syndrome, pneumonia, and possibly i
bronchopulmonary dysplasia. Further investigation is necessary I
but seems warranted. j
j
i
Evidence Based Use of Adjunctive Therapies
to Ventilation 191
Thomas E. Wiswell, Win Tin, and Kirsten Ohler
Respiratory distress is the most common reason for admission to
newborn intensive care units. Over the past two decades, we have
witnessed a revolution in the therapies that are used to manage ;
neonates who have pulmonary disorders. Multiple adjunctive j
agents have also been used in an attempt to mitigate the course j
of neonatal lung disease. The disorders we discuss include respira j
tory distress syndrome, chronic lung disease/bronchopulmonary j
dysplasia, persistent pulmonary hypertension of the newborn, me !
conium aspiration syndrome, and transient tachypnea of the new j
born. We review the evidence that either supports or refutes the use I
of adjunctive therapies for these disorders. |
Long Term Outcomes: What Should the Focus Be? 205 I
Judy L. Aschner and Michele C. Walsh I
The neonatal intervention trials of the 1980s and early 1990s fo |
cused primarily on short term outcomes. Contemporary clinical j
trials have recognized the importance of longer term outcomes ,
but have rarely been powered to achieve that aim. This review dis j
cusses important and clinically relevant outcomes that future trials j
should be powered to address and identifies the challenges facing j
the neonatal clinical trials community. These challenges include
consensus definitions of relevant outcomes that are objective and
validated, variability among centers in populations and practices,
and the need for predictive surrogate markers of long term out¬
comes. Future trials must be designed and powered to address
the potential for harm as well as the prospect of benefit.
Index 219
CONTENTS « |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV022424170 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:26:52Z |
| indexdate | 2024-07-09T20:57:18Z |
| institution | BVB |
| isbn | 1416042911 9781416042914 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015632447 |
| oclc_num | 129879281 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-20 |
| physical | XVI, 226 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Saunders |
| record_format | marc |
| series | Clinics in perinatology |
| series2 | Clinics in perinatology |
| spelling | Surfactant and mechanical ventilation guest eds.: Steven M. Donn ... Philadelphia [u.a.] Saunders 2007 XVI, 226 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Clinics in perinatology 34,1 Infant Infant, Newborn, Diseases therapy Pulmonary Surfactants Pulmonary Ventilation Respiration, Artificial Respirators (Medical equipment) Respiratory therapy for newborn infants Ventilators, Mechanical Membransyndrom des Früh- und Neugeborenen (DE-588)4356507-4 gnd rswk-swf Künstliche Beatmung (DE-588)4033439-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Membransyndrom des Früh- und Neugeborenen (DE-588)4356507-4 s Künstliche Beatmung (DE-588)4033439-9 s b DE-604 Donn, Steven M. Sonstige oth Clinics in perinatology 34,1 (DE-604)BV000003382 34,1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015632447&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Surfactant and mechanical ventilation Clinics in perinatology Infant Infant, Newborn, Diseases therapy Pulmonary Surfactants Pulmonary Ventilation Respiration, Artificial Respirators (Medical equipment) Respiratory therapy for newborn infants Ventilators, Mechanical Membransyndrom des Früh- und Neugeborenen (DE-588)4356507-4 gnd Künstliche Beatmung (DE-588)4033439-9 gnd |
| subject_GND | (DE-588)4356507-4 (DE-588)4033439-9 (DE-588)4143413-4 |
| title | Surfactant and mechanical ventilation |
| title_auth | Surfactant and mechanical ventilation |
| title_exact_search | Surfactant and mechanical ventilation |
| title_exact_search_txtP | Surfactant and mechanical ventilation |
| title_full | Surfactant and mechanical ventilation guest eds.: Steven M. Donn ... |
| title_fullStr | Surfactant and mechanical ventilation guest eds.: Steven M. Donn ... |
| title_full_unstemmed | Surfactant and mechanical ventilation guest eds.: Steven M. Donn ... |
| title_short | Surfactant and mechanical ventilation |
| title_sort | surfactant and mechanical ventilation |
| topic | Infant Infant, Newborn, Diseases therapy Pulmonary Surfactants Pulmonary Ventilation Respiration, Artificial Respirators (Medical equipment) Respiratory therapy for newborn infants Ventilators, Mechanical Membransyndrom des Früh- und Neugeborenen (DE-588)4356507-4 gnd Künstliche Beatmung (DE-588)4033439-9 gnd |
| topic_facet | Infant Infant, Newborn, Diseases therapy Pulmonary Surfactants Pulmonary Ventilation Respiration, Artificial Respirators (Medical equipment) Respiratory therapy for newborn infants Ventilators, Mechanical Membransyndrom des Früh- und Neugeborenen Künstliche Beatmung Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015632447&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003382 |
| work_keys_str_mv | AT donnstevenm surfactantandmechanicalventilation |